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  1. Article ; Online: The Influence of Technological Innovation on the Profitability of Enterprises

    Li Shasha

    E3S Web of Conferences, Vol 235, p

    2021  Volume 02075

    Abstract: This paper studies whether the investment intensity of R&D expenses of listed companies can improve the profitability of enterprises. The data indicators of listed companies from 2015 to 2017 are obtained by using CSMAR database. R&D investment is ... ...

    Abstract This paper studies whether the investment intensity of R&D expenses of listed companies can improve the profitability of enterprises. The data indicators of listed companies from 2015 to 2017 are obtained by using CSMAR database. R&D investment is divided into two indicators: relative number index and absolute number index, and regression analysis is carried out by establishing the econometric analysis model of profitability and absolute number index and relative number index of R&D investment. It is found that the intensity of R&D investment has a positive effect on the profitability of enterprises. Therefore, enterprises can improve their profitability through technological innovation and increasing R&D investment.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A survey of Chinese Residents' knowledge, attitudes and behaviors toward COVID-19: A National cross-sectional study.

    Liu, Zhanshu / Li, Ying / Li, Xin / Shasha, Wang

    Asian journal of surgery

    2022  Volume 45, Issue 8, Page(s) 1646–1647

    MeSH term(s) COVID-19 ; China/epidemiology ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Humans ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-28
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.03.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury

    Alice Shasha Cheng / Xiaogang Li

    International Journal of Molecular Sciences, Vol 24, Iss 8254, p

    2023  Volume 8254

    Abstract: Contrast-induced acute kidney injury (CI−AKI) is manifested by an abrupt decline in kidney function as a consequence of intravascular exposure to contrast media. With the increased applicability of medical imaging and interventional procedures that ... ...

    Abstract Contrast-induced acute kidney injury (CI−AKI) is manifested by an abrupt decline in kidney function as a consequence of intravascular exposure to contrast media. With the increased applicability of medical imaging and interventional procedures that utilize contrast media for clinical diagnosis, CI−AKI is becoming the leading cause of renal dysfunction. The pathophysiological mechanism associated with CI−AKI involves renal medullary hypoxia, the direct toxicity of contrast agents, oxidative stress, apoptosis, inflammation, and epigenetic regulation. To date, there is no effective therapy for CI−AKI, except for the development of strategies that could reduce the toxicity profiles of contrast media. While most of these strategies have failed, evidence has shown that the proper use of personalized hydration, contrast medium, and high-dose statins may reduce the occurrence of CI−AKI. However, adequate risk predication and attempts to develop preventive strategies can be considered as the key determinants that can help eliminate CI−AKI. Additionally, a deeper understanding of the pathophysiological mechanism of CI−AKI is crucial to uncover molecular targets for the prevention of CI−AKI. This review has taken a step further to solidify the current known molecular mechanisms of CI−AKI and elaborate the biomarkers that are used to detect early-stage CI−AKI. On this foundation, this review will analyze the molecular targets relating to apoptosis, inflammation, oxidative stress, and epigenetics, and, thus, provide a strong rationale for therapeutic intervention in the prevention of CI−AKI.
    Keywords contrast-induced acute kidney injury (CI−AKI) ; contrast media ; inflammation ; oxidative stress ; biotherapeutic targets ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury.

    Cheng, Alice Shasha / Li, Xiaogang

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Contrast-induced acute kidney injury (CI-AKI) is manifested by an abrupt decline in kidney function as a consequence of intravascular exposure to contrast media. With the increased applicability of medical imaging and interventional procedures that ... ...

    Abstract Contrast-induced acute kidney injury (CI-AKI) is manifested by an abrupt decline in kidney function as a consequence of intravascular exposure to contrast media. With the increased applicability of medical imaging and interventional procedures that utilize contrast media for clinical diagnosis, CI-AKI is becoming the leading cause of renal dysfunction. The pathophysiological mechanism associated with CI-AKI involves renal medullary hypoxia, the direct toxicity of contrast agents, oxidative stress, apoptosis, inflammation, and epigenetic regulation. To date, there is no effective therapy for CI-AKI, except for the development of strategies that could reduce the toxicity profiles of contrast media. While most of these strategies have failed, evidence has shown that the proper use of personalized hydration, contrast medium, and high-dose statins may reduce the occurrence of CI-AKI. However, adequate risk predication and attempts to develop preventive strategies can be considered as the key determinants that can help eliminate CI-AKI. Additionally, a deeper understanding of the pathophysiological mechanism of CI-AKI is crucial to uncover molecular targets for the prevention of CI-AKI. This review has taken a step further to solidify the current known molecular mechanisms of CI-AKI and elaborate the biomarkers that are used to detect early-stage CI-AKI. On this foundation, this review will analyze the molecular targets relating to apoptosis, inflammation, oxidative stress, and epigenetics, and, thus, provide a strong rationale for therapeutic intervention in the prevention of CI-AKI.
    MeSH term(s) Humans ; Contrast Media/therapeutic use ; Epigenesis, Genetic ; Acute Kidney Injury/therapy ; Oxidative Stress ; Inflammation ; Risk Factors
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hydrogen sulfide affects aortic vasodilation in rats by mediating PI3K-Akt signaling pathway.

    Sun, Jingyi / Mei, Jiajie / Zhang, Jingsi / Lou, Yu / Jiang, Shasha / Li, Yang / Fu, Xiaodan

    Minerva medica

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.23.08955-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: UV radiation and temperature increase alter the PSII function and defense mechanisms in a bloom-forming cyanobacterium

    Yan, Fang / Li, Mingze / Zang, Shasha / Xu, Zhiguang / Bao, Menglin / Wu, Hongyan

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1351796

    Abstract: The aim was to determine the response of a bloom- ... ...

    Abstract The aim was to determine the response of a bloom-forming
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1351796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unravelling the underlying mechanism of the reduction of aldehydes/ketones with metal borohydride in an aprotic solvent.

    Li, Xinying / Kang, Jia-Xin / Liang, Shasha / Long, Xi-Hong / Ma, Yan-Na / Chen, Xuenian

    Chemical communications (Cambridge, England)

    2024  

    Abstract: The reduction mechanism of aldehyde/ketones with M( ... ...

    Abstract The reduction mechanism of aldehyde/ketones with M(BH
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc06108f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Corrigendum to 'Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming' [Ecotoxicol. Environ. Saf. (2024) 271].

    Li, Qianmin / Ling, Yi / Ma, Yu / Zhang, Tao / Yang, Youjing / Tao, Shasha

    Ecotoxicology and environmental safety

    2024  Volume 275, Page(s) 116267

    Language English
    Publishing date 2024-04-01
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116267
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  9. Article ; Online: Analysis of risk factors associated with primary bile reflux

    Qiang Dong / Songbo Li / Shasha Chen / Xiaodong Qu / Xingyu Zhao / Yani Li / Shasha Wang / Yongquan Shi / Yuanyuan Ji

    Chinese Medical Journal, Vol 136, Iss 14, Pp 1741-

    A multicenter cross-sectional study

    2023  Volume 1743

    Keywords Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Editorial: Recent progress in polymer-based biomaterials as adhesives.

    Li, Xiaoyuan / Ding, Jianxun / Xie, Denghui / He, Shasha / Guo, Jinshan

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1305531

    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1305531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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