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Article: Causal Mediation Programs in R, M

Valente, Matthew J / Rijnhart, Judith J M / Smyth, Heather L / Muniz, Felix B / MacKinnon, David P

Structural equation modeling : a multidisciplinary journal

2020 Volume 27, Issue 6, Page(s) 975–984

Abstract: Mediation analysis is a methodology used to understand how and why an independent variable ( ...

Abstract	Mediation analysis is a methodology used to understand how and why an independent variable (
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Journal Article
ISSN	1070-5511
ISSN	1070-5511
DOI	10.1080/10705511.2020.1777133
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Article: Teacher's Corner: An R Shiny App for Sensitivity Analysis for Latent Growth Curve Mediation.

Kruger, Eric S / Tofighi, Davood / Hsiao, Yu-Yu / MacKinnon, David P / Lee Van Horn, M / Witkiewitz, Katie

Structural equation modeling : a multidisciplinary journal

2022 Volume 29, Issue 6, Page(s) 944–952

Abstract: Mechanisms of behavior change are the processes through which interventions are hypothesized to cause changes in outcomes. Latent growth curve mediation models (LGCMM) are recommended for investigating the mechanisms of behavior change because LGCMM ... ...

Abstract	Mechanisms of behavior change are the processes through which interventions are hypothesized to cause changes in outcomes. Latent growth curve mediation models (LGCMM) are recommended for investigating the mechanisms of behavior change because LGCMM models establish temporal precedence of change from the mediator to the outcome variable. The Correlated Augmented Mediation Sensitivity Analyses (CAMSA) App implements sensitivity analysis for LGCMM models to evaluate if a mediating path (mechanism) is robust to potential confounding variables. The CAMSA approach is described and applied to simulated data, and data from a research study exploring a mechanism of change in the treatment of substance use disorder.
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article
ISSN	1070-5511
ISSN	1070-5511
DOI	10.1080/10705511.2022.2045203
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Article ; Online: Implementing a Patient-Reported Outcome Measure for Hemodialysis Patients in Routine Clinical Care: Perspectives of Patients and Providers on ESAS-r:Renal.

Evans, Jenna M / Glazer, Alysha / Lum, Rebecca / Heale, Esti / MacKinnon, Marnie / Blake, Peter G / Walsh, Michael

Clinical journal of the American Society of Nephrology : CJASN

2020 Volume 15, Issue 9, Page(s) 1299–1309

Abstract: Background and objectives: The Edmonton Symptom Assessment System Revised: Renal is a patient-reported outcome measure used to assess physical and psychosocial symptom burden in patients treated with maintenance dialysis. Studies of patient-reported ... ...

Abstract	Background and objectives: The Edmonton Symptom Assessment System Revised: Renal is a patient-reported outcome measure used to assess physical and psychosocial symptom burden in patients treated with maintenance dialysis. Studies of patient-reported outcome measures suggest the need for deeper understanding of how to optimize their implementation and use. This study examines patient and provider perspectives of the implementation process and the influence of the Edmonton Symptom Assessment System Revised: Renal on symptom management, patient-provider communication, and interdisciplinary communication. Design, setting, participants, & measurements: Eight in-facility hemodialysis programs in Ontario, Canada, assessed patients using the Edmonton Symptom Assessment System Revised: Renal every 4-6 weeks for 1 year. Screening and completion rates were tracked, and pre- and postimplementation surveys and midimplementation interviews were conducted with patients and providers. A chart audit was conducted 12 months postimplementation. Results: In total, 1459 patients completed the Edmonton Symptom Assessment System Revised: Renal; 58% of eligible patients completed the preimplementation survey ( Conclusions: The Edmonton Symptom Assessment System Revised: Renal patient-reported outcome measure may be useful to standardize symptom screening, enhance awareness of psychosocial symptoms among patients and providers, and empower patients rather than to reduce symptom burden.
MeSH term(s)	Aged ; Attitude of Health Personnel ; Female ; Health Knowledge, Attitudes, Practice ; Health Status ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/physiopathology ; Kidney Diseases/psychology ; Kidney Diseases/therapy ; Longitudinal Studies ; Male ; Mental Health ; Ontario ; Patient Participation ; Patient Reported Outcome Measures ; Renal Dialysis/adverse effects ; Symptom Assessment ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.01840220
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Article ; Online: RMediation: an R package for mediation analysis confidence intervals.

Tofighi, Davood / MacKinnon, David P

Behavior research methods

2011 Volume 43, Issue 3, Page(s) 692–700

Abstract: ... for several cases. RMediation described herein is based on the widely available R software, includes ...

Abstract	This article describes the RMediation package,which offers various methods for building confidence intervals (CIs) for mediated effects. The mediated effect is the product of two regression coefficients. The distribution-of-the-product method has the best statistical performance of existing methods for building CIs for the mediated effect. RMediation produces CIs using methods based on the distribution of product, Monte Carlo simulations, and an asymptotic normal distribution. Furthermore, RMediation generates percentiles, quantiles, and the plot of the distribution and CI for the mediated effect. An existing program, called PRODCLIN, published in Behavior Research Methods, has been widely cited and used by researchers to build accurate CIs. PRODCLIN has several limitations: The program is somewhat cumbersome to access and yields no result for several cases. RMediation described herein is based on the widely available R software, includes several capabilities not available in PRODCLIN, and provides accurate results that PRODCLIN could not.
MeSH term(s)	Confidence Intervals ; Models, Statistical ; Probability ; Research Design ; Software
Language	English
Publishing date	2011-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	231560-9
ISSN	1554-3528 ; 0743-3808 ; 1554-351X
ISSN (online)	1554-3528
ISSN	0743-3808 ; 1554-351X
DOI	10.3758/s13428-011-0076-x
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Article: Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.

Hodkinson, Philip S / Elliott, Paul A / Lad, Yatish / McHugh, Brian J / MacKinnon, Alison C / Haslett, Christopher / Sethi, Tariq

The Journal of biological chemistry

2007 Volume 282, Issue 39, Page(s) 28991–29001

Abstract: ... that activates R-Ras, independent of CSL-transcription. Notch also reverses H-Ras and Raf-mediated integrin ... or intracellular Notch mutants lacking the ankyrin repeat sequence do not activate R-Ras or integrins ... transcriptional activity without affecting integrin activation. Notch ligand, Delta-like ligand-4, stimulates R-Ras ...

Abstract	Notch is a central regulator of important cell fate decisions. Notch activation produces diverse cellular effects suggesting the presence of context-dependent control mechanisms. Genetic studies have demonstrated that Notch and integrin mutations have related phenotypes in key developmental processes such as vascular development and somitogenesis. We show that the intracellular domain of mammalian Notch-1 activates integrins without affecting integrin expression. Integrin activation is dependent on gamma-secretase-mediated intramembranous cleavage of membrane-bound Notch releasing intracellular Notch that activates R-Ras, independent of CSL-transcription. Notch also reverses H-Ras and Raf-mediated integrin suppression without affecting ERK phosphorylation. Membrane-bound Notch mutants that are inefficiently cleaved or intracellular Notch mutants lacking the ankyrin repeat sequence do not activate R-Ras or integrins. Co-expression of Msx2-interacting nuclear target (MINT) protein with Notch or expression of intracellular Notch-1 truncation mutants lacking the C-terminal transactivation/PEST domain suppresses Notch transcriptional activity without affecting integrin activation. Notch ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway. This new CSL-independent Notch/R-Ras pathway provides a molecular mechanism to explain Notch, integrin, and Ras cross-talk during the development of multicellular organisms.
MeSH term(s)	Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; CHO Cells ; Cell Adhesion/physiology ; Cricetinae ; Cricetulus ; DNA-Binding Proteins ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism ; Integrin alpha5beta1/genetics ; Integrin alpha5beta1/metabolism ; Mice ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Structure, Tertiary/physiology ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; RNA-Binding Proteins ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; ras Proteins/genetics ; ras Proteins/metabolism
Chemical Substances	DNA-Binding Proteins ; Homeodomain Proteins ; Immunoglobulin J Recombination Signal Sequence-Binding Protein ; Integrin alpha5beta1 ; Muscle Proteins ; NOTCH1 protein, human ; Notch1 protein, mouse ; Nuclear Proteins ; RBPJ protein, human ; RNA-Binding Proteins ; Receptor, Notch1 ; SPEN protein, human ; Smpx protein, mouse ; Spen protein, mouse ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; RRAS protein, human (EC 3.6.1.-) ; Rras protein, mouse (EC 3.6.1.-) ; Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2007-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M703601200
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Article: A survey of dementia in the Canberra population: experience with ICD-10 and DSM-III-R criteria.

Henderson, A S / Jorm, A F / Mackinnon, A / Christensen, H / Scott, L R / Korten, A E / Doyle, C

Psychological medicine

1994 Volume 24, Issue 2, Page(s) 473–482

Abstract: ... by ICD-10 than by DSM-III-R. Both criteria showed a similar rise in prevalence with age, and no gender ... to important differences between ICD-10 and DSM-III-R diagnoses of dementia. ...

Abstract	A community survey of 1045 persons aged 70 years and over was conducted to identify cases of dementia in the cities of Canberra and Queanbeyan. Cases were identified using the Canberra Interview for the Elderly, administered by lay interviewers. When diagnostic criteria were rigidly applied, the point prevalence of dementia in the combined sample of community and institutional residents was considerably lower by ICD-10 than by DSM-III-R. Both criteria showed a similar rise in prevalence with age, and no gender difference. Agreement between the two systems had a kappa of only 0.48. 'Probable' cases by either criteria were identified solely from respondent-provided information in order to include persons for whom no informant was available. The point prevalence of such 'probable' cases was more similar for the two systems, and the kappa coefficient of agreement rose to 0.80. Analysis of the various components required for a diagnosis of dementia showed that the prevalence of all increased with age. Components involving cognitive assessment were correlated with education, but other components were not. The results of the study point to important differences between ICD-10 and DSM-III-R diagnoses of dementia.
MeSH term(s)	Aged ; Aged, 80 and over ; Australia/epidemiology ; Cross-Sectional Studies ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/psychology ; Female ; Humans ; Incidence ; Male ; Mental Status Schedule/statistics & numerical data ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	1994-05
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/s0033291700027446
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Book ; Online ; E-Book: The application of science in environmental impact assessment

MacKinnon, Aaron J. / Duinker, Peter N. / Walker, Tony R.

(Routledge focus on environment and sustainability)

2018

Author's details	Aaron J. MacKinnon, Peter N. Duinker and Tony R. Walker
Series title	Routledge focus on environment and sustainability
Language	English
Size	1 Online-Ressource (vii, 141 Seiten)
Publisher	Routledge, Taylor & Francis Group
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019601381
ISBN	978-1-351-17343-8 ; 978-1-351-17344-5 ; 9780815387299 ; 1-351-17343-X ; 1-351-17344-8 ; 0815387296
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Mammalian NOTCH-1 Activates β1 Integrins via the Small GTPase R-Ras

Hodkinson, Philip S / Elliott, Paul.A / Lad, Yatish / McHugh, Brian J / MacKinnon, Alison C / Haslett, Christopher / Sethi, Tariq

Journal of biological chemistry. 2007 Sept. 28, v. 282, no. 39

2007

Abstract: ... mediated intramembranous cleavage of membrane-bound Notch releasing intracellular Notch that activates R ... Notch mutants lacking the ankyrin repeat sequence do not activate R-Ras or integrins. Co-expression ... transcriptional activity without affecting integrin activation. Notch ligand, Delta-like ligand-4, stimulates R-Ras ...

Abstract	Notch is a central regulator of important cell fate decisions. Notch activation produces diverse cellular effects suggesting the presence of context-dependent control mechanisms. Genetic studies have demonstrated that Notch and integrin mutations have related phenotypes in key developmental processes such as vascular development and somitogenesis. We show that the intracellular domain of mammalian Notch-1 activates integrins without affecting integrin expression. Integrin activation is dependent on γ-secretase-mediated intramembranous cleavage of membrane-bound Notch releasing intracellular Notch that activates R-Ras, independent of CSL-transcription. Notch also reverses H-Ras and Raf-mediated integrin suppression without affecting ERK phosphorylation. Membrane-bound Notch mutants that are inefficiently cleaved or intracellular Notch mutants lacking the ankyrin repeat sequence do not activate R-Ras or integrins. Co-expression of Msx2-interacting nuclear target (MINT) protein with Notch or expression of intracellular Notch-1 truncation mutants lacking the C-terminal transactivation/PEST domain suppresses Notch transcriptional activity without affecting integrin activation. Notch ligand, Delta-like ligand-4, stimulates R-Ras-dependent α5β1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway. This new CSL-independent Notch/R-Ras pathway provides a molecular mechanism to explain Notch, integrin, and Ras cross-talk during the development of multicellular organisms.
Language	English
Dates of publication	2007-0928
Size	p. 28991-29001.
Publishing place	American Society for Biochemistry and Molecular Biology
Document type	Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Patient Outcomes After Peripheral Nerve Injury Depend on Bimanual Dexterity and Preserved Use of the Affected Hand.

Kim, Taewon / Lohse, Keith R / Mackinnon, Susan E / Philip, Benjamin A

Neurorehabilitation and neural repair

2024 Volume 38, Issue 2, Page(s) 134–147

Abstract: ... To identify the relationship between hand use (L/R choices), motor performance, and patient-centered outcomes ...

Abstract	Background: Little is known about how peripheral nerve injury affects human performance, behavior, and life. Hand use choices are important for rehabilitation after unilateral impairment, but rarely measured, and are not changed by the normal course of rehabilitation and daily life. Objective: To identify the relationship between hand use (L/R choices), motor performance, and patient-centered outcomes. Methods: Participants (n = 48) with unilateral peripheral nerve injury were assessed for hand use via Block Building Task, Motor Activity Log, and Edinburgh Handedness Inventory; dexterity (separately for each hand) via Nine-Hole Peg Test, Jebsen Taylor Hand Function Test, and a precision drawing task; patient-centered outcomes via surveys of disability, activity participation, and health-related quality of life; and injury-related factors including injury cause and affected nerve. Factor Analysis of Mixed Data was used to explore relationships between these variables. The data were analyzed under 2 approaches: comparing dominant hand (DH) versus non-dominant hand (NH), or affected versus unaffected hand. Results: The data were best explained by 5 dimensions. Good patient outcomes were associated with NH performance, DH performance (separately and secondarily to NH performance), and preserved function and use of the affected hand; whereas poor patient outcomes were associated with preserved but unused function of the affected hand. Conclusion: After unilateral peripheral nerve injury, hand function, hand usage, and patient life arise from a complex interaction of many factors. To optimize rehabilitation after unilateral impairment, new rehabilitation methods are needed to promote performance and use with the NH, as well as the injured hand.
MeSH term(s)	Humans ; Peripheral Nerve Injuries ; Quality of Life ; Hand ; Upper Extremity ; Functional Laterality/physiology
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491637-x
ISSN	1552-6844 ; 1545-9683 ; 0888-4390
ISSN (online)	1552-6844
ISSN	1545-9683 ; 0888-4390
DOI	10.1177/15459683241227222
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Article ; Online: Comment on: Clinical characteristics and risk factors of acute acquired concomitant esotropia in last 5 years: a retrospective case-control study.

MacKinnon, Jane R / McCulloch, Jean

Eye (London, England)

2023 Volume 37, Issue 15, Page(s) 3296

MeSH term(s)	Humans ; Retrospective Studies ; Case-Control Studies ; Esotropia/epidemiology ; Esotropia/etiology ; Depth Perception ; Oculomotor Muscles ; Risk Factors ; Acute Disease
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-023-02501-3
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