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  1. Book ; Thesis: Funktionsdiagnostik der Schilddrüse bei Patienten mit schweren nichtthyroidalen Erkrankungen

    Hering, Steffen Georg

    Untersuchungen zum Krankheitsverlauf und Stoffwechsel unter besonderer Berücksichtigung der freien Fettsäuren

    1990  

    Author's details vorgelegt von Steffen Georg Hering
    Size 78 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1990
    HBZ-ID HT003954026
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Corrigendum to "Residual gammaH2AX foci in head and neck squamous cell carcinomas as predictors for tumour radiosensitivity: Evaluation in pre-clinical xenograft models and clinical specimens" [Radiother. Oncol. 137 (2019) 24-31].

    Meneceur, Sarah / Löck, Steffen / Gudziol, Volker / Hering, Sandra / Bütof, Rebecca / Rehm, Maximilian / Baumann, Michael / Krause, Mechthild / von Neubeck, Cläre

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2023  Volume 183, Page(s) 109619

    Language English
    Publishing date 2023-03-29
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2023.109619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1926: Show issues Location:
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  3. Article ; Online: Apo2ph4

    Heider, Jörg / Kilian, Jonas / Garifulina, Aleksandra / Hering, Steffen / Langer, Thierry / Seidel, Thomas

    Journal of chemical information and modeling

    2022  Volume 63, Issue 1, Page(s) 101–110

    Abstract: Pharmacophore models are widely used as efficient virtual screening (VS) filters for the target-directed enrichment of large compound libraries. However, the generation of pharmacophore models that have the power to discriminate between active and ... ...

    Abstract Pharmacophore models are widely used as efficient virtual screening (VS) filters for the target-directed enrichment of large compound libraries. However, the generation of pharmacophore models that have the power to discriminate between active and inactive molecules traditionally requires structural information about ligand-target complexes or at the very least knowledge of one active ligand. The fact that the discovery of the first known active ligand of a newly investigated target represents a major hurdle at the beginning of every drug discovery project underscores the need for methods that are able to derive high-quality pharmacophore models even without the prior knowledge of any active ligand structures. In this work, we introduce a novel workflow, called
    MeSH term(s) Pharmacophore ; Ligands ; Workflow ; Retrospective Studies ; Drug Discovery
    Chemical Substances Ligands
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.2c00814
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    Zs.A 1230: Show issues Location:
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  4. Article ; Online: A neolignan from Connarus tuberosus as an allosteric GABA

    Faleschini, Teresa / Syafni, Nova / Schulte, Heidi Luise / Garifulina, Aleksandra / Hering, Steffen / Espindola, Laila Salmen / Hamburger, Matthias

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 161, Page(s) 114498

    Abstract: In a screening of a small library of extracts from plants of the Amazonian and Cerrado biomes, a hexane extract of Connarus tuberosus roots was found to significantly potentiate the GABA induced fluorescence in a fluorescence (FLIPR) assay in CHO cells ... ...

    Abstract In a screening of a small library of extracts from plants of the Amazonian and Cerrado biomes, a hexane extract of Connarus tuberosus roots was found to significantly potentiate the GABA induced fluorescence in a fluorescence (FLIPR) assay in CHO cells stably expressing the α
    MeSH term(s) Animals ; Cricetinae ; Humans ; Receptors, GABA-A/metabolism ; Connaraceae ; Neurosteroids/metabolism ; GABA Modulators/pharmacology ; Cricetulus ; Binding Sites ; gamma-Aminobutyric Acid/pharmacology ; gamma-Aminobutyric Acid/metabolism ; Oocytes
    Chemical Substances Receptors, GABA-A ; Neurosteroids ; GABA Modulators ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-03-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: β subunits of GABA

    Garifulina, Aleksandra / Friesacher, Theres / Stadler, Marco / Zangerl-Plessl, Eva-Maria / Ernst, Margot / Stary-Weinzinger, Anna / Willam, Anita / Hering, Steffen

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 784

    Abstract: Gamma-aminobutyric acid type A receptors ( ... ...

    Abstract Gamma-aminobutyric acid type A receptors (GABA
    MeSH term(s) Chloride Channels/genetics ; Chlorides ; Kinetics ; Protons ; Receptors, GABA ; Receptors, GABA-A/genetics ; Receptors, GABA-A/metabolism ; gamma-Aminobutyric Acid
    Chemical Substances Chloride Channels ; Chlorides ; Protons ; Receptors, GABA ; Receptors, GABA-A ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03720-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clerodane Diterpenes from

    Syafni, Nova / Faleschini, Maria Teresa / Garifulina, Aleksandra / Danton, Ombeline / Gupta, Mahabir P / Hering, Steffen / Hamburger, Matthias

    Journal of natural products

    2022  Volume 85, Issue 5, Page(s) 1201–1210

    Abstract: An EtOAc extract ... ...

    Abstract An EtOAc extract of
    MeSH term(s) Animals ; Benzodiazepines/pharmacology ; CHO Cells ; Casearia ; Cricetinae ; Cricetulus ; Diterpenes, Clerodane/pharmacology ; Flumazenil/metabolism ; Flumazenil/pharmacology ; GABA Modulators/pharmacology ; Oocytes/metabolism ; Receptors, GABA-A ; Xenopus laevis/metabolism ; gamma-Aminobutyric Acid/metabolism ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Diterpenes, Clerodane ; GABA Modulators ; Receptors, GABA-A ; Benzodiazepines (12794-10-4) ; Flumazenil (40P7XK9392) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.1c00840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1144: Show issues Location:
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  7. Article ; Online: Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12

    Baltov, Bozhidar / Beyl, Stanislav / Baburin, Igor / Reinhardt, Jakob / Szkokan, Phillip / Garifulina, Aleksandra / Timin, Eugen / Kraushaar, Udo / Potterat, Olivier / Hamburger, Matthias / Kügler, Philipp / Hering, Steffen

    Toxicology reports

    2023  Volume 10, Page(s) 589–599

    Abstract: Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of ... ...

    Abstract Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of proarrhythmic effects of herbal products. Here, we propose a cardiac safety assay for the detection of proarrhythmic effects of plant extracts based on the experimental approaches described in the Comprehensive
    Language English
    Publishing date 2023-04-26
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2023.04.014
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  8. Article ; Conference proceedings: Menschenwuerde im Angesicht neuer Technologien

    Hering, Steffen / Schultz, Nora / Galert, Thorsten

    Ethik in der Medizin

    2018  Volume 30, Issue 4, Page(s) 375–383

    Title translation Human dignity in the presence of new technologies
    Keywords biomedical technologies ; biomedical research ; medical ethics ; ethics committees ; data banks ; brain ; genetic intervention ; genetic enhancement ; preimplantation diagnosis ; commodification ; human body ; legal aspects ; deutscher ethikrat<berlin>
    Subject code AN
    Language German
    Document type Article ; Conference proceedings
    Note Die urspruengliche Fassung des Beitrags ³Menschenwuerde im Angesicht neuer TechnologienÊ wurde herausgegeben im Infobrief Nr. 23, 02 I 2018 des Deutschen Ethikrates unter der ISSN 1868-9000. Jahrestagung des Deutschen Ethikrats 27.-28.06.2018 in Berlin.
    ZDB-ID 95932-7
    ISSN 1437-1618 ; 0935-7335
    ISSN (online) 1437-1618
    ISSN 0935-7335
    Database Ethics in Medicine (ETHMED)

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  9. Article ; Online: β subunits of GABAA receptors form proton-gated chloride channels

    Aleksandra Garifulina / Theres Friesacher / Marco Stadler / Eva-Maria Zangerl-Plessl / Margot Ernst / Anna Stary-Weinzinger / Anita Willam / Steffen Hering

    Communications Biology, Vol 5, Iss 1, Pp 1-

    Insights into the molecular basis

    2022  Volume 10

    Abstract: Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue. ...

    Abstract Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations

    Baltov, Bozhidar / Beyl, Stanislav / Baburin, Igor / Reinhardt, Jakob / Szkokan, Phillip / Garifulina, Aleksandra / Timin, Eugen / Kraushaar, Udo / Potterat, Olivier / Hamburger, Matthias / Kügler, Philipp / Hering, Steffen

    Toxicology Reports. 2023, v. 10 p.589-599

    2023  

    Abstract: Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of ... ...

    Abstract Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of proarrhythmic effects of herbal products. Here, we propose a cardiac safety assay for the detection of proarrhythmic effects of plant extracts based on the experimental approaches described in the Comprehensive In vitro Proarrhythmia Assay (CiPA). Microelectrode array studies (MEAs) and voltage sensing optical technique on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were combined with ionic current measurements in mammalian cell lines, In-silico simulations of cardiac action potentials (APs) and statistic regression analysis. Proarrhythmic effects of 12 Evodia preparations, containing different amounts of the hERG inhibitors dehydroevodiamine (DHE) and hortiamine were analysed. Extracts produced different prolongation of the AP, occurrence of early after depolarisations and triangulation of the AP in hiPSC-CMs depending on the contents of the hERG inhibitors. DHE and hortiamine dose-dependently prolonged the field potential duration in hiPSC-CMs studied with MEAs. In-silico simulations of ventricular AP support a scenario where proarrhythmic effects of Evodia extracts are predominantly caused by the content of the selective hERG inhibitors. Statistic regression analysis revealed a high torsadogenic risk for both compounds that was comparable to drugs assigned to the high-risk category in a CiPA study.
    Keywords Euodia ; cardiomyocytes ; case studies ; computer simulation ; drug development ; electric potential difference ; humans ; regression analysis ; research planning ; risk ; toxicology ; CiPA ; APD ; FPD ; MICE ; MEA ; VSO ; hiPSC-CMs ; DHE ; TCM ; EAD ; ASE ; CHO ; EFTPC ; EF ; EP ; DER ; FPC ; Evodia rutaecarpa ; Cardiac safety ; HERG ; TdP ; HiPSC-CMs
    Language English
    Size p. 589-599.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2023.04.014
    Database NAL-Catalogue (AGRICOLA)

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