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  1. Article: Apprendre en s’amusant à l’hôpital : réalité ou illusion ?

    Merlin Hofmann, Christelle / Naro, Mickaël

    Revue de l'infirmiere

    2020  Volume 70, Issue 268, Page(s) 40–41

    Abstract: Healthcare professionals have an obligation to maintain their knowledge at the highest level throughout their careers. To this end, the hospital team of a pharmacy for indoor use has developed an original and entertaining training course, mainly intended ...

    Title translation Learning through play in the hospital: reality or illusion?
    Abstract Healthcare professionals have an obligation to maintain their knowledge at the highest level throughout their careers. To this end, the hospital team of a pharmacy for indoor use has developed an original and entertaining training course, mainly intended for nurses, on the subject of analgesics.
    MeSH term(s) Humans ; Learning ; Nursing Evaluation Research ; Nursing Staff, Hospital/education ; Nursing Staff, Hospital/psychology ; Play and Playthings
    Language French
    Publishing date 2020-12-24
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2020.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Occurrence of ticks and prevalence of Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in three types of urban biotopes: forests, parks and cemeteries.

    Hornok, Sándor / Meli, Marina L / Gönczi, Enikő / Halász, Edina / Takács, Nóra / Farkas, Róbert / Hofmann-Lehmann, Regina

    Ticks and tick-borne diseases

    2014  Volume 5, Issue 6, Page(s) 785–789

    Abstract: ... of this tick species the prevalence rates of Anaplasma phagocytophilum and Borrelia burgdorferi s.l. were ...

    Abstract The aim of the present study was to compare different urban biotopes for the occurrence of ixodid tick species, for the population density of Ixodes ricinus and for the prevalence rates of two emerging, zoonotic pathogens. Altogether 2455 ticks were collected from the vegetation on 30 places (forests, parks, cemeteries) of Budapest, Hungary. I. ricinus and Haemaphysalis concinna were collected in all three biotope types, but Dermacentor reticulatus only in parks and forests, and D. marginatus only in a forest. Highest population density of I. ricinus was observed in neglected parts of cemeteries. In females of this tick species the prevalence rates of Anaplasma phagocytophilum and Borrelia burgdorferi s.l. were significantly lower in cemeteries, than in parks or forests. In conclusion, risks associated with the presence of ticks and tick-borne pathogens may be high in a city, but this depends on biotope types, due to habitat-related differences in the vegetation, as well as in the availability of tick hosts and pathogen reservoirs.
    MeSH term(s) Anaplasma phagocytophilum/genetics ; Anaplasma phagocytophilum/isolation & purification ; Animals ; Arachnid Vectors/microbiology ; Borrelia burgdorferi/genetics ; Borrelia burgdorferi/isolation & purification ; Cemeteries ; Dermacentor/microbiology ; Ecosystem ; Ehrlichiosis/epidemiology ; Female ; Forests ; Humans ; Hungary/epidemiology ; Ixodes/microbiology ; Ixodidae/microbiology ; Lyme Disease/epidemiology ; Male ; Prevalence ; Tick-Borne Diseases/epidemiology ; Tick-Borne Diseases/microbiology ; Zoonoses
    Language English
    Publishing date 2014-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2014.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Theoretical and experimental studies on alpha/epsilon-hybrid peptides: design of a 14/12-helix from peptides with alternating (S)-C-linked carbo-epsilon-amino acid [(S)-epsilon-Caa((x))] and L-ala.

    Sharma, Gangavaram V M / Babu, Bommagani Shoban / Chatterjee, Deepak / Ramakrishna, Kallaganti V S / Kunwar, Ajit C / Schramm, Peter / Hofmann, Hans-Jörg

    The Journal of organic chemistry

    2009  Volume 74, Issue 17, Page(s) 6703–6713

    Abstract: An (S)-C-linked carbo-epsilon-amino acid [(S)-epsilon-Caa((x))] was prepared from the known (S ... delta-Caa. This monomer was utilized together with l-Ala to give novel alpha/epsilon-hybrid peptides ...

    Abstract An (S)-C-linked carbo-epsilon-amino acid [(S)-epsilon-Caa((x))] was prepared from the known (S)-delta-Caa. This monomer was utilized together with l-Ala to give novel alpha/epsilon-hybrid peptides in 1:1 alternation. Conformational analysis on penta- and hexapeptides by NMR (in CDCl(3)), CD, and MD studies led to the identification of robust 14/12-mixed helices. This is in agreement with the data from a theoretical conformational analysis on the basis of ab initio MO theory providing a complete overview on all formally possible hydrogen-bonded helix patterns of alpha/epsilon-hybrid peptides with 1:1 backbone alternation. The "new motif" of a mixed 14/12-helix was predicted as most stable in vacuum. Obviously, the formation of ordered secondary structures is also possible in peptide foldamers with amino acid constituents of considerable backbone lengths. Thus, alpha/epsilon-hybrid peptides expand the domain of foldamers and allow the introduction of desired functionalities via the alpha-amino acid constituents.
    MeSH term(s) Alanine/chemistry ; Amino Acid Motifs ; Amino Acids/chemistry ; Chemistry, Organic/methods ; Circular Dichroism ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Methanol/chemistry ; Models, Chemical ; Molecular Conformation ; Molecular Structure ; Peptides/chemistry ; Protein Folding ; Protein Structure, Secondary
    Chemical Substances Amino Acids ; Peptides ; Alanine (OF5P57N2ZX) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2009-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo901277a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov.

    Fingerle, Volker / Schulte-Spechtel, Ulrike C / Ruzic-Sabljic, Eva / Leonhard, Sarah / Hofmann, Heidelore / Weber, Klaus / Pfister, Kurt / Strle, Franc / Wilske, Bettina

    International journal of medical microbiology : IJMM

    2008  Volume 298, Issue 3-4, Page(s) 279–290

    Abstract: In 475 Borrelia-infected Ixodes ricinus (2155 ticks investigated) from southern Germany the most common Borrelia burgdorferi sensu lato species was B. garinii (34.3%) followed by B. afzelii (25.1%), B. burgdorferi sensu stricto (22.0%), and B. valaisiana ...

    Abstract In 475 Borrelia-infected Ixodes ricinus (2155 ticks investigated) from southern Germany the most common Borrelia burgdorferi sensu lato species was B. garinii (34.3%) followed by B. afzelii (25.1%), B. burgdorferi sensu stricto (22.0%), and B. valaisiana (12.7%). B. spielmanii sp. nov. was detected in 5.9% of the 475 infected ticks. Hints for a focal distribution were found for B. spielmanii sp. nov. and B. garinii OspA type 4. In 242 patient isolates, dominance (66.9%) of B. afzelii for skin could be confirmed, while frequency of B. garinii in cerebrospinal fluid (CSF) isolates (51.1%) was comparable to the frequency in nymphal ticks (51.6%). Four patient isolates from southern Germany and two from Slovenia, all isolated from erythema migrans, could be assigned to B. spielmanii sp. nov. Within this new species high sequence identities were found for rrs, fla, and ospA while rrf-rrl, ospC, and dbpA were less conserved: three new ospC and two new dbpA sequence types were found. This genetic heterogeneity reveals that B. spielmanii sp. nov. did not evolve just recently.
    MeSH term(s) Animals ; Base Sequence ; Borrelia burgdorferi Group/genetics ; Borrelia burgdorferi Group/isolation & purification ; Cerebrospinal Fluid/microbiology ; Erythema Chronicum Migrans/microbiology ; Genes, Bacterial/genetics ; Germany ; Humans ; Ixodes/microbiology ; Molecular Epidemiology ; Molecular Sequence Data ; Polymorphism, Restriction Fragment Length ; Sequence Alignment
    Language English
    Publishing date 2008-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2007.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Seroprevalence of infection with Borrelia burgdorferi s. l. in two adjacent regions of eastern France and southwestern Germany.

    Nübling, M / Rieger, M A / Batsford, S / Wagner, M / Wertenschlag, E / Hofmann, F

    International journal of medical microbiology : IJMM

    2002  Volume 291 Suppl 33, Page(s) 218

    MeSH term(s) Antibodies, Bacterial/blood ; Borrelia burgdorferi Group/immunology ; Cross-Sectional Studies ; Female ; Fluorescent Antibody Technique, Indirect ; France/epidemiology ; Germany/epidemiology ; Humans ; Leisure Activities ; Lyme Disease/epidemiology ; Male ; Occupational Diseases/epidemiology ; Occupational Exposure ; Seroepidemiologic Studies ; Surveys and Questionnaires
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2002-07-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/s1438-4221(02)80057-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hepatocyte-specific binding of L/S-HBV particles expressed in insect cells.

    Hofmann, C / Sandig, V / Kirillova, I / Jennings, G / Rudolph, M / Schlag, P / Strauss, M

    Biological chemistry Hoppe-Seyler

    1995  Volume 376, Issue 3, Page(s) 173–178

    Abstract: ... essential components of infectious viral particles. Whereas expression of the small (S) antigen led ...

    Abstract The genome of hepatitis B virus (HBV) codes for three surface antigen proteins. Two of them are essential components of infectious viral particles. Whereas expression of the small (S) antigen led to formation of virus-like particles in different systems so far, secretion of neither the large antigen nor budding of virus-like particles containing both antigens could be observed. Using modified large antigen genes in dual expression vectors we were able to demonstrate secretion of virus-like particles in the baculovirus insect cell system. N-terminal fusion of an insect protein (melittin) derived signal sequence and destruction of the myristylation site resulted in secretion of the large antigen. Particles consisting of about 95% small and 5% large antigen bind specifically to hepatocytes. These pseudovirions could serve as a HBV vaccine and as a useful component of future hepatocyte-specific gene transfer vehicles.
    MeSH term(s) Animals ; Base Sequence ; Blotting, Western ; Cell Line ; Cells, Cultured ; Gene Expression Regulation, Viral ; Genetic Vectors ; Hepatitis B Surface Antigens/biosynthesis ; Hepatitis B virus/immunology ; Hepatitis B virus/metabolism ; Hepatitis B virus/ultrastructure ; Humans ; Liver/metabolism ; Molecular Sequence Data ; Precipitin Tests ; Recombination, Genetic ; Spodoptera/metabolism ; Viral Proteins/biosynthesis
    Chemical Substances Hepatitis B Surface Antigens ; Viral Proteins
    Language English
    Publishing date 1995-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605960-0
    ISSN 0177-3593
    ISSN 0177-3593
    DOI 10.1515/bchm3.1995.376.3.173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Seroprevalence of antibodies against Borrelia burgdorferi s. l. and tick-borne encephalitis virus in the Bergische Land region of Northrhine Westfalia.

    Rieger, M A / Nübling, M / Hess, S / Batsford, S / Hofmann, F

    International journal of medical microbiology : IJMM

    2002  Volume 291 Suppl 33, Page(s) 216–217

    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Antibodies, Viral/blood ; Arachnid Vectors ; Borrelia burgdorferi Group/immunology ; Cross-Sectional Studies ; Encephalitis Viruses, Tick-Borne/immunology ; Encephalitis, Tick-Borne/epidemiology ; Female ; Germany/epidemiology ; Humans ; Leisure Activities ; Lyme Disease/epidemiology ; Male ; Occupational Diseases/epidemiology ; Occupational Diseases/microbiology ; Occupational Exposure ; Risk Factors ; Seroepidemiologic Studies ; Surveys and Questionnaires ; Ticks
    Chemical Substances Antibodies, Bacterial ; Antibodies, Viral
    Language English
    Publishing date 2002-07-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/s1438-4221(02)80056-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Syntheses of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-cysteine and of some isotopically labelled (2H, 13C) analogues.

    Meese, C O / Specht, D / Hofmann, U

    Archiv der Pharmazie

    1990  Volume 323, Issue 12, Page(s) 957–965

    Abstract: The chemical syntheses of human metabolites of S-carboxymethyl-L-cysteine (3) and S-methyl-L ...

    Abstract The chemical syntheses of human metabolites of S-carboxymethyl-L-cysteine (3) and S-methyl-L-cysteine (12) are described. The additional preparation of some 2H- and 13C-labelled isotopomers enabled the direct evaluation of the stabilities of 3 and 12 under physiological conditions and also facilitated the unambiguous assignments of the signals in the 13C-NMR spectra of all compounds mentioned.
    MeSH term(s) Carbocysteine/chemical synthesis ; Carbocysteine/metabolism ; Cysteine/analogs & derivatives ; Cysteine/chemical synthesis ; Cysteine/metabolism ; Magnetic Resonance Spectroscopy
    Chemical Substances Carbocysteine (740J2QX53R) ; S-methylcysteine (A34I1H07YM) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 1990-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.19903231205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sedimentological and biostratigraphical analyses of short sediment cores from Hagelseewli (2339 m a.s.l.) in the Swiss Alps

    Jacqueline F.N. VAN LEEUWEN / Willem O. VAN DER KNAAP / Christian OHLENDORF / Michael STURM / Andrea LAMI / Christian KAMENIK / Wolfgang HOFMANN / André F. LOTTER

    Journal of Limnology, Vol 59, Iss 1s, Pp 53-

    2000  Volume 64

    Abstract: ... in the Swiss Alps at an elevation of 2339 m a.s.l. were correlated according to their organic matter content ...

    Abstract Several short sediment cores of between 35 and 40 cm from Hagelseewli, a small, remote lake in the Swiss Alps at an elevation of 2339 m a.s.l. were correlated according to their organic matter content. The sediments are characterized by organic silts and show in their uppermost part a surprisingly high amount of organic matter (30-35%). Synchronous changes, occurring in pollen from snow-bed vegetation, the alga Pediastrum, chironomids, and grain-size composition, point to a climatic change interpreted as cooler or shorter summers that led to prolonged ice-cover on the lake. According to palynological results the sediments date back to at least the early 15th century A.D., with the cooling phase encompassing the period between late 16th and the mid-19th century thus coinciding with the Little Ice Age. Low concentrations of both chironomid head capsules and cladoceran remains in combination with results from fossil pigment analyses point to longer periods of bottom-water anoxia as a result of long-lasting ice-cover that prevented mixing of the water column. According to our results aquatic biota in Hagelseewli are mainly indirectly influenced by climate change. The duration of ice-cover on the lake controls the mixing of the water column as well as light-availability for phytoplankton blooms.
    Keywords diatoms ; pollen ; chironomids ; cladocera ; chrysophyte cysts ; grain-size analysis ; Geography. Anthropology. Recreation ; G ; Physical geography ; GB3-5030 ; Environmental sciences ; GE1-350
    Subject code 550
    Language English
    Publishing date 2000-09-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Exposure to tick-borne encephalitis (TBE) virus and Borrelia burgdorferi s.l. in agricultural workers in southwestern Germany

    Rieger, M.A / Nubling, M / Wangerin, W / Hofmann, F / Kampa, D / Batsford, S / Neumann-Haefelin, D

    Journal of agricultural safety and health. Feb 1999. v. 5 (1)

    1999  

    Keywords seroprevalence ; risk assessment ; serological surveys
    Language English
    Dates of publication 1999-02
    Size p. 49-58.
    Document type Article
    Note Paper presented, in part, at the 4th International Symposium: "Rural Health and Safety in a Changing World", held October 18-22, 1998, Saskatoon, Saskatchewan, Canada.
    ZDB-ID 1501979-2
    ISSN 1943-7846 ; 1074-7583
    ISSN (online) 1943-7846
    ISSN 1074-7583
    Database NAL-Catalogue (AGRICOLA)

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