LIVIVO - Search results -

Search results

Result 1 - 10 of total 991

Search options

Article: Comparison of nasal valve dysfunction treatment outcomes for temperature-controlled radiofrequency and functional rhinoplasty surgery: a systematic review and meta-analyses.

Han, J K / Perkins, J / Lerner, D / Yim, M T / Ishii, L E

2024

Abstract: Background: Nasal valve dysfunction (NVD) is a substantial contributor to nasal airway obstruction. Minimally-invasive temp-erature-controlled radiofrequency (TCRF) treatment of the nasal valve is available and comparison with surgical techniques is ... ...

Abstract	Background: Nasal valve dysfunction (NVD) is a substantial contributor to nasal airway obstruction. Minimally-invasive temp-erature-controlled radiofrequency (TCRF) treatment of the nasal valve is available and comparison with surgical techniques is warranted. Methodology: Databases: Medline (PubMed), Embase, Cochrane Library. Population: adults with preprocedural nasal obstruction symptom evaluation (NOSE) score ≥45. Treatment effects were derived from a random effects model and reported as weighted mean difference in NOSE score between baseline; 3, 6, and 12 months postprocedure. Results: Of 2529 initial articles, 5 studies describing TCRF treatment and 63 studies describing functional rhinoplasty were included. Pooled effect sizes for TCRF treatment and functional rhinoplasty were comparable in all analyses. Conclusions: TCRF treatment of the internal nasal valve for NVD was associated with sustained effects comparable to functional rhinoplasty addressing the nasal valve only, rhinoplasty without concomitant turbinate treatment, and all rhinoplasty.
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin23.261
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1080: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: R$\rm{^{{\ast}}_{4}}$Tl(3)Cl and R$\rm{^{{\ast}}_{6}}$Tl(6)Cl(2) (R*=SitBu(3))-The First Compounds with Larger Clusters Containing Covalently Linked Thallium Atoms Compounds of Silicon, Part 143. Supersilyl Compounds of Boron and Its Homologues, Part 12. This work was supported by the Deutsche Forschungsgemeinschaft and by the Fonds der Chemischen Industrie. Part 42: N. Wiberg, W. Niedermayer, J. Organomet. Chem. 2001, in press; Part 11. M. Kehrwald, W. Köstler, A. Rodig, G. Linti, T. Blank, N. Wiberg, Organometallics 2001, in press.

Wiberg, Nils / Blank, Thomas / Lerner, Hans-Wolfram / Fenske, Dieter / Linti, Gerald

Angewandte Chemie (International ed. in English)

2001 Volume 40, Issue 7, Page(s) 1232–1235

Language	English
Publishing date	2001-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A biome-dependent distribution gradient of tree species range edges is strongly dictated by climate spatial heterogeneity.

Lerner, David / Martínez, Marcos Fernández / Livne-Luzon, Stav / Belmaker, Jonathan / Peñuelas, Josep / Klein, Tamir

Nature plants

2023 Volume 9, Issue 4, Page(s) 544–553

Abstract: Understanding the causes of the arrest of species distributions has been a fundamental question in ecology and evolution. These questions are of particular interest for trees owing to their long lifespan and sessile nature. A surge in data availability ... ...

Abstract	Understanding the causes of the arrest of species distributions has been a fundamental question in ecology and evolution. These questions are of particular interest for trees owing to their long lifespan and sessile nature. A surge in data availability evokes a macro-ecological analysis to determine the underlying forces limiting distributions. Here we analyse the spatial distribution of >3,600 major tree species to determine geographical areas of range-edge hotspots and find drivers for their arrest. We confirmed biome edges to be strong delineators of distributions. Importantly, we identified a stronger contribution of temperate than tropical biomes to range edges, adding strength to the notion that tropical areas are centres of radiation. We subsequently identified a strong association of range-edge hotspots with steep spatial climatic gradients. We linked spatial and temporal homogeneity and high potential evapotranspiration in the tropics as the strongest predictors of this phenomenon. We propose that the poleward migration of species in light of climate change might be hindered because of steep climatic gradients.
MeSH term(s)	Trees ; Ecosystem ; Climate Change
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2055-0278
ISSN (online)	2055-0278
DOI	10.1038/s41477-023-01369-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A Multicentric, Retrospective, Real-world Study on Immune-related Adverse Events in Patients with Advanced Non-small Cell Lung Cancers Treated with Pembrolizumab Monotherapy.

Lerner, A / Lee, A J X / Yan, H / Van Griethuysen, J / Bartlett, A D / Veli, M / Jiang, Y / Luong, M / Naban, N / Kane, C / Conibear, J / Papadatos-Pastos, D / Ahmad, T / Chao, D / Anand, G / Asghar, U S

Clinical oncology (Royal College of Radiologists (Great Britain))

2024 Volume 36, Issue 3, Page(s) 193–199

Abstract: Aims: We present 7 years of clinical experience with single-agent pembrolizumab immune checkpoint inhibitor immunotherapy in non-small cell lung cancers (NSCLC) from four UK cancer centres.: Materials and methods: This multi-institutional ... ...

Abstract	Aims: We present 7 years of clinical experience with single-agent pembrolizumab immune checkpoint inhibitor immunotherapy in non-small cell lung cancers (NSCLC) from four UK cancer centres. Materials and methods: This multi-institutional retrospective cohort study included 226 metastatic NSCLC patients. Outcomes were number and severity of immune-related adverse events (irAEs), median progression-free survival (mPFS) and median overall survival (mOS). Results: Within our cohort, 119/226 (53%) patients developed irAEs. Of these, 54/119 (45%) experienced irAEs affecting two or more organ systems. The most common irAEs were diarrhoea and rash. The development of an irAE was associated with better mOS (20.7 versus 8.0 months; P < 0.001) and mPFS (12.0 versus 3.9 months; P < 0.001). The development of grade 3/4 toxicities was associated with worse outcomes compared with the development of grade 1/2 toxicities (mOS 6.1 months versus 25.2 months, P < 0.01; mPFS 5.6 months versus 19.3 months, P = 0.01, respectively). Females had a higher proportion of reported grade 3/4 toxicities (13/44 [29.5%] versus 10/74 [13.5%], P = 0.03). Using a multiple Cox regression model, the presence of irAEs was associated with a better overall survival (hazard ratio = 0.42, 95% confidence interval 0.29-0.61; P < 0.01) and better PFS (hazard ratio 0.38, 95% confidence interval 0.27-0.53; P < 0.001). Conclusion: In this multicentre retrospective cohort study, the development of at least one irAE was associated with significantly longer mPFS and mOS; however, more severe grade 3 and 4 irAEs were associated with worse outcomes. Delayed-onset irAEs, after the 3-month timepoint, were associated with better clinical outcomes.
MeSH term(s)	Female ; Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Retrospective Studies ; Lung Neoplasms/pathology ; Nivolumab/adverse effects ; Antineoplastic Agents, Immunological/adverse effects ; Antibodies, Monoclonal, Humanized
Chemical Substances	pembrolizumab (DPT0O3T46P) ; Nivolumab (31YO63LBSN) ; Antineoplastic Agents, Immunological ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2024.01.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2774: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery.

Cetin, Miray / Pinamonti, Veronica / Schmid, Theresa / Boschert, Tamara / Mellado Fuentes, Ana / Kromer, Kristina / Lerner, Taga / Zhang, Jing / Herzig, Yonatan / Ehlert, Christopher / Hernandez-Hernandez, Miguel / Samaras, Georgios / Torres, Claudia Maldonado / Fisch, Laura / Dragan, Valeriia / Kouwenhoven, Arlette / Van Schoubroeck, Bertrand / Wils, Hans / Van Hove, Carl /

Platten, Michael / Green, Edward W / Stevenaert, Frederik / Felix, Nathan J / Lindner, John M

Science advances

2024 Volume 10, Issue 5, Page(s) eadk3060

Abstract: ... presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite ... to diagnostic and therapeutic applications, yet remain underdeveloped. Here, we present T-FINDER [T cell ... expression, T-FINDER both robustly identifies unknown peptide:HLA ligands from antigen libraries and rapidly ...

Abstract	Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA-presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applications, yet remain underdeveloped. Here, we present T-FINDER [T cell Functional Identification and (Neo)-antigen Discovery of Epitopes and Receptors], a system to rapidly deconvolute CD4 and CD8 TCRs and targets physiologically processed and presented by an individual's unmanipulated, complete human leukocyte antigen (HLA) haplotype. Combining a highly sensitive TCR signaling reporter with an antigen processing system to overcome previously undescribed limitations to target expression, T-FINDER both robustly identifies unknown peptide:HLA ligands from antigen libraries and rapidly screens and functionally validates the specificity of large TCR libraries against known or predicted targets. To demonstrate its capabilities, we apply the platform to multiple TCR-based applications, including diffuse midline glioma, celiac disease, and rheumatoid arthritis, providing unique biological insights and showcasing T-FINDER's potency and versatility.
MeSH term(s)	Humans ; Ligands ; Histocompatibility Antigens Class I ; Receptors, Antigen, T-Cell/metabolism ; HLA Antigens ; Histocompatibility Antigens Class II
Chemical Substances	Ligands ; Histocompatibility Antigens Class I ; Receptors, Antigen, T-Cell ; HLA Antigens ; Histocompatibility Antigens Class II
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adk3060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Canadian COVID-19 host genetics cohort replicates known severity associations.

PLoS genetics

2024 Volume 20, Issue 3, Page(s) e1011192

Abstract: The HostSeq initiative recruited 10,059 Canadians infected with SARS-CoV-2 between March 2020 and March 2023, obtained clinical information on their disease experience and whole genome sequenced (WGS) their DNA. We analyzed the WGS data for genetic ... ...

Abstract	The HostSeq initiative recruited 10,059 Canadians infected with SARS-CoV-2 between March 2020 and March 2023, obtained clinical information on their disease experience and whole genome sequenced (WGS) their DNA. We analyzed the WGS data for genetic contributors to severe COVID-19 (considering 3,499 hospitalized cases and 4,975 non-hospitalized after quality control). We investigated the evidence for replication of loci reported by the International Host Genetics Initiative (HGI); analyzed the X chromosome; conducted rare variant gene-based analysis and polygenic risk score testing. Population stratification was adjusted for using meta-analysis across ancestry groups. We replicated two loci identified by the HGI for COVID-19 severity: the LZTFL1/SLC6A20 locus on chromosome 3 and the FOXP4 locus on chromosome 6 (the latter with a variant significant at P < 5E-8). We found novel significant associations with MRAS and WDR89 in gene-based analyses, and constructed a polygenic risk score that explained 1.01% of the variance in severe COVID-19. This study provides independent evidence confirming the robustness of previously identified COVID-19 severity loci by the HGI and identifies novel genes for further investigation.
MeSH term(s)	Humans ; COVID-19/genetics ; SARS-CoV-2/genetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Canada/epidemiology ; Genome-Wide Association Study ; Membrane Transport Proteins ; Forkhead Transcription Factors ; North American People
Chemical Substances	SLC6A20 protein, human ; Membrane Transport Proteins ; FOXP4 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1011192
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: IncobotulinimtoxinA (Xeomin) for the treatment of adductor laryngeal dystonia: A prospective, open-label clinical trial.

Kohli, Nikita / Lerner, Michael / Rashty, Jamie / Kirke, Diana / Stewart, Thomas / Blitzer, Andrew

American journal of otolaryngology

2022 Volume 43, Issue 6, Page(s) 103613

Abstract: ... function (PNF) following treatment, and a side effect profile. Outcomes were analyzed using the paired t ...

Abstract	Objectives: Demonstrate an understanding of incobotulinumtoxinA efficacy in the treatment of adductor spasmodic dysphonia (SD). Understand that incobotulinumtoxinA can successfully be used as an alternative to onabotulinumtoxinA and for secondary non-responders. Methods: We conducted a prospective open-label trial from 2016 until 2019 regarding the use of incobotulinimtoxinA for the treatment of adductor spasmodic dysphonia. Exclusion criteria included pregnant/nursing women, botulinum toxin for other indications, known allergy, neuromuscular or systemic diseases, use of aminoglycoside antibiotics, substance abuse, litigation regarding prior therapy, or other confounding conditions. Sixty-four injection sessions with completed with sixteen patients who were enrolled in the study and underwent EMG-guided incobotulinumtoxinA injections to the thyroarytenoid (TA) muscle using a hollow monopolar Teflon-coated needle via a trans-cricothyroid membrane approach. Dosages to each TA muscle were recorded and patients completed a Voice Handicap Index-10 (VHI-10), a validated worksheet regarding their perceived percent of normal function (PNF) following treatment, and a side effect profile. Outcomes were analyzed using the paired t-test. Results: For primary transitioners to incobotulinimtoxinA, VHI-10 scores and best percent normal function did not significantly change. For non-responders, VHI-10 decreased from 32.5 on Botox to 19.5 on incobotulinimtoxinA and best PNF increased from 37.6 to 90 %, which was statistically significant. Transient side effects included breathiness. Conclusions: Our study demonstrates that incobotulinimtoxinA may be used successfully for adductor SD either as first line treatment or in secondary non-responders to onabotulinumtoxinA.
MeSH term(s)	Female ; Humans ; Aminoglycosides/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Botulinum Toxins, Type A/therapeutic use ; Dysphonia/drug therapy ; Dystonia/drug therapy ; Laryngeal Muscles ; Polytetrafluoroethylene/therapeutic use ; Prospective Studies ; Treatment Outcome
Chemical Substances	Aminoglycosides ; Anti-Bacterial Agents ; Botulinum Toxins, Type A (EC 3.4.24.69) ; incobotulinumtoxinA (EC 3.4.24.69) ; Polytetrafluoroethylene (9002-84-0)
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103613
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1637: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The evolution of plasticity at geographic range edges.

Usui, Takuji / Lerner, David / Eckert, Isaac / Angert, Amy L / Garroway, Colin J / Hargreaves, Anna / Lancaster, Lesley T / Lessard, Jean-Philippe / Riva, Federico / Schmidt, Chloé / van der Burg, Karin / Marshall, Katie E

Trends in ecology & evolution

2023 Volume 38, Issue 9, Page(s) 831–842

Abstract: Phenotypic plasticity enables rapid responses to environmental change, and could facilitate range shifts in response to climate change. What drives the evolution of plasticity at range edges, and the capacity of range-edge individuals to be plastic, ... ...

Abstract	Phenotypic plasticity enables rapid responses to environmental change, and could facilitate range shifts in response to climate change. What drives the evolution of plasticity at range edges, and the capacity of range-edge individuals to be plastic, remain unclear. Here, we propose that accurately predicting when plasticity itself evolves or mediates adaptive evolution at expanding range edges requires integrating knowledge on the demography and evolution of edge populations. Our synthesis shows that: (i) the demography of edge populations can amplify or attenuate responses to selection for plasticity through diverse pathways, and (ii) demographic effects on plasticity are modified by the stability of range edges. Our spatially explicit synthesis for plasticity has the potential to improve predictions for range shifts with climate change.
MeSH term(s)	Humans ; Adaptation, Physiological ; Climate Change ; Biological Evolution ; Phenotype
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	284965-3
ISSN	1872-8383 ; 0169-5347
ISSN (online)	1872-8383
ISSN	0169-5347
DOI	10.1016/j.tree.2023.04.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Zs Bio TEE: Show issues
Z 2005/711: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reply by Authors.

Foster, H E / Dahm, P / Kohler, T S / Lerner, L B / Parsons, J K / Wilt, T J / McVary, K T

The Journal of urology

2020 Volume 203, Issue 6, Page(s) 1219–1221

MeSH term(s)	Humans ; Lower Urinary Tract Symptoms ; Male ; Prostatic Hyperplasia
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000000802
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Catalyst-free diboration and silaboration of alkenes and alkynes using bis(9-heterofluorenyl)s.

Gilmer, Jannik / Trageser, Timo / Čaić, Luis / Virovets, Alexander / Bolte, Michael / Lerner, Hans-Wolfram / Fantuzzi, Felipe / Wagner, Matthias

Chemical science

2023 Volume 14, Issue 17, Page(s) 4589–4596

Abstract: Diboration and silaboration reactions are prominent tools to introduce valuable functional groups into organic substrates. To date, most diboranes(4) and silylboranes used for this purpose are electronically and/or kinetically stabilized and require ... ...

Abstract	Diboration and silaboration reactions are prominent tools to introduce valuable functional groups into organic substrates. To date, most diboranes(4) and silylboranes used for this purpose are electronically and/or kinetically stabilized and require activation by a catalyst. We show here that the tetraaryl (μ-hydrido)diborane(4) anion [3]
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc01395b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito