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Article: Malondialdehyde value as radical oxidative marker and endogenous antioxidant value analysis in brain tumor.

Dharmajaya, Ridha / Sari, Dina Keumala

Annals of medicine and surgery (2012)

2022 Volume 77, Page(s) 103231

Abstract: Introduction: Oxidative stress has been considered as one of many contributor in developing risk of cancer. Oxidative stress may also promote the increasing number of free radical. Malondialdehyde (MDA) is one of radical oxidative marker, while ... ...

Abstract	Introduction: Oxidative stress has been considered as one of many contributor in developing risk of cancer. Oxidative stress may also promote the increasing number of free radical. Malondialdehyde (MDA) is one of radical oxidative marker, while Superoxide Dismutase (SOD) play role as endogenous antioxidant. It has been postulated that in cancer cells there is an increase of oxidative stress compared to normal cell. Method: This study is a case controlled analytical study to find the relationship between levels of MDA and SOD in patients with brain tumours. The sample obtained was 35 people who met the inclusion and exclusion criteria. Based on this analysis, it will be determined whether there is a significant relationship between levels of MDA and SOD in each type of brain tumours. Result: There is no significant relationship from all groups brain tumour and all tumours have a low correlation (r = 0.187) in the value of superoxide dismutase level. There is also no significant relationship from all groups (p = 0.302) and a low correlation (r = 0.187) to the value of Malondialdehyde level. Discussion: There was no relationship between superoxide dismutase in any type of intracranial tumour in this study. These concluded that superoxide values could not be a risk factor for primary intracranial tumours. Levels of MDA which is an indicator of lipid peroxidation, were significantly higher in patients consisting of meningiomas and gliomas. In high grade gliomas, the MDA increases due to the progressive progression of glioma tumours due to an increase in Reactive oxygen species levels. Conclusion: This study shows no correlation between SOD as an endogenous antioxidant and MDA as radical oxidative marker in primary brain tumour.
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.103231
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Article ; Online: The Addition of Atezolizumab to Chemotherapy in Non-Small Cell Lung Cancer: A Trial-Based Review and Meta-Analysis.

Fitri, Nadya Keumala / Nainggolan, Bahagia Willibrordus Maria / Firsty, Naufal Nandita / Pradana, Andika / Sari, Dina Keumala

World journal of oncology

2023 Volume 15, Issue 1, Page(s) 72–80

Abstract: Background: Non-small cell lung cancer (NSCLC) stands as one of the most prevalent types of cancer worldwide, driving extensive research in oncologic therapeutic approaches. Atezolizumab, among the treatments under scrutiny, is undergoing evaluation as ... ...

Abstract	Background: Non-small cell lung cancer (NSCLC) stands as one of the most prevalent types of cancer worldwide, driving extensive research in oncologic therapeutic approaches. Atezolizumab, among the treatments under scrutiny, is undergoing evaluation as a potential first-line therapy for NSCLC. This review aims to assess the efficacy of atezolizumab in treating patients with NSCLC and to shed light on the ongoing quest for the most effective treatment. Methods: Multiple scientific databases, including PubMed, Cochrane, and ScienceDirect, were consulted. The literature identification utilized the strategic Boolean term method of keywords relating to "non-small cell lung cancer" and "atezolizumab" to suggest the analyzed population in our review without restricting the potential outcomes. The primary inclusion criterion is clinical studies that attempted to determine the efficacy of atezolizumab in NSCLC patients. Results: We included four trials to be analyzed in the final analysis, which we stratified into the programmed cell death-ligand 1 (PD-L1) expressivity status aside from the pooled intention-to-treat (ITT) population. We found the addition of atezolizumab may significantly improve the overall survival (OS) in the respective arm, remarkably among the high PD-L1 expression group (TC3 or IC3). The result of our meta-analysis presented the pooled OS of 0.79 (0.72, 0.87) in 95% confidence interval (CI) with a P value of < 0.05. Sub-analysis of the PD-L1's expression revealed TC3 population benefits the most (hazard ratio (HR): 0.55, 95% CI (0.42, 0.73)), compared to low (HR: 0.80, 95% CI (0.68, 0.93)) and negative expression (HR: 0.79, 95% CI (0.68, 0.93)); which is statistically meaningful (P < 0.05). Similar result was also observed in progression-free survival (PFS) analysis with the HR value of 0.63 (0.55, 0.72), with P value of < 0.05, favoring atezolizumab arm. Conclusions: Upon examination, the study reveals that the addition of atezolizumab demonstrates notable improvements in both OS and PFS among NSCLC patients. These findings present promising attributes for atezolizumab as a viable treatment for NSCLC. However, it is important to acknowledge that the future holds further revelations in this realm, and more insights are yet to be uncovered.
Language	English
Publishing date	2023-12-09
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548989-6
ISSN	1920-454X ; 1920-454X
ISSN (online)	1920-454X
ISSN	1920-454X
DOI	10.14740/wjon1701
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Article: Role and value of inflammatory markers in brain tumors: A case controlled study.

Dharmajaya, Ridha / Sari, Dina Keumala

Annals of medicine and surgery (2012)

2021 Volume 63, Page(s) 102107

Abstract: Introduction: Brain tumor is one of the most devastating diseases in the world. The Pathogenesis is vary in multiple aspect of mechanism. The tumor microenvironment contains many different noncancerous cell types in addition to cancer cells. ... ...

Abstract	Introduction: Brain tumor is one of the most devastating diseases in the world. The Pathogenesis is vary in multiple aspect of mechanism. The tumor microenvironment contains many different noncancerous cell types in addition to cancer cells. Inflammation is thought to be one of the factors that influence the oncogenesis process in brain tumors. Methods: This study is a case controlled analytical study that analyzes the relationship between levels of inflammatory markers with the type of brain tumor. Samples of 35 people were then categorized according to the variables above and analyzing to measure its significance. Results: Based on demografic study, most sample was male with age was 41-50 years It was found that high levels of procalcitonin were found in the case of glioma brain tumors. Procalcitonin level was considered a significant marker in predicting the severity of a brain tumor (p < 0.005). There was no significant value between the C-Reactive Protein and Neutrophyl-Lymphocyte ratio values for brain tumors. Discussion: Abnormal inflammation is a characteristic of malignant cancers and malignant transformation of low-grade gliomas and other brain tumor. Inflammation-induced activation of transcription factors contributes to the survival and rapid growth of glioma cells. Conclusion: As in other malignant cancers, inflammation may contribute to tumor progression. Biomarkers based on inflammation, such as the classical example of Procalcitonin and C-reactive protein, have been used to assess prognosis of glioma patients. These results should be validated and extended in larger clinical studies.
Language	English
Publishing date	2021-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.01.055
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Article ; Online: The anti-obesity properties of

Rusdiana, Rusdiana / Widyawati, Tri / Sari, Dina Keumala / Widjaja, Sry Suryani / Putra, Deddi Prima

Journal of advanced veterinary and animal research

2023 Volume 10, Issue 4, Page(s) 809–816

Abstract: Objective: Various disease complications are a risk of overweight or obesity, so losing weight can reduce the risk of diseases caused by obesity. Binahong leaf ethanol extract (: Aim: This study aims to analyze whether : Materials and methods: ... ...

Abstract	Objective: Various disease complications are a risk of overweight or obesity, so losing weight can reduce the risk of diseases caused by obesity. Binahong leaf ethanol extract ( Aim: This study aims to analyze whether Materials and methods: Animals were grouped into six groups as follows: the normal diet (K1), the negative control group (K2), the positive control group with Orlistat at a dose of 20 mg/kg BW (K3), an ethanol extract of Results: ERK levels of abdominal fat were lowered in the treatment group using the extract of Conclusion: Anredera cordifolia
Language	English
Publishing date	2023-12-31
Publishing country	Bangladesh
Document type	Journal Article
ZDB-ID	2766493-4
ISSN	2311-7710 ; 2311-7710
ISSN (online)	2311-7710
ISSN	2311-7710
DOI	10.5455/javar.2023.j737
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Article ; Online: A randomized, placebo-controlled trial of zinc supplementation during pregnancy for the prevention of stunting: analysis of maternal serum zinc, cord blood osteocalcin and neonatal birth length.

Rohmawati, Lili / Keumala Sari, Dina / Sitepu, Makmur / Rusmil, Kusnandi

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

2021 Volume 18, Issue 2, Page(s) 415–420

Abstract: Aim To investigate the influence of zinc supplementation on pregnant women for the prevention of stunting through an analysis of maternal serum zinc, cord blood osteocalcin and neonatal birth length. Methods This study was conducted with pre-test/post- ... ...

Abstract	Aim To investigate the influence of zinc supplementation on pregnant women for the prevention of stunting through an analysis of maternal serum zinc, cord blood osteocalcin and neonatal birth length. Methods This study was conducted with pre-test/post-test control groups and double-blind randomization. Patients were pregnant mothers in second or third trimester and with their newborns who met the inclusion criteria. A total of 71 pregnant mothers and their newborns completed this study. They were divided into two groups of 35 and 36 patients, the supplementation (20 mg/day) and placebo groups, respectively for 12 weeks. The parameters assessed were maternal serum zinc levels, cord blood osteocalcin and birth length measurements. Results The mean maternal serum zinc level was 54.6±8.7 µg/dL from 71 patients. The mean maternal serum zinc levels after zinc supplementation were significantly higher than those of the placebo group: 55.1±9.9 to 59.1±8.6) μg/dL (p=0.017) and 54.2±7.5 to 50±8.6 μg/dL (p=0.001), respectively. The comparison of mean cord blood osteocalcin levels and median neonatal birth lengths in the supplementation group was higher than in the placebo group: 131.8±35.3 vs 90.6±35.4 ng/ml (p=0.001) and 49.3 (46.5-51.3) vs 48.3 (46-50.8) cm (p=0.004), respectively. Maternal serum zinc levels after zinc supplementation had a positive significant correlation with cord blood osteocalcin and neonatal birth length: r=0.434 (p=0.001) and r=0.597 (p=0.001), respectively. Conclusion There was a significant correlation of maternal serum zinc with cord blood osteocalcin and neonatal birth length after zinc supplementation.
MeSH term(s)	Dietary Supplements ; Double-Blind Method ; Female ; Fetal Blood ; Growth Disorders ; Humans ; Infant, Newborn ; Osteocalcin ; Pregnancy ; Zinc
Chemical Substances	Osteocalcin (104982-03-8) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-04-19
Publishing country	Bosnia and Herzegovina
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2378942-6
ISSN	1840-2445 ; 1840-2445
ISSN (online)	1840-2445
ISSN	1840-2445
DOI	10.17392/1267-21
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Article: Need Action for No Relationship Between Emotional Intelligence on Physical Activity Among Undergraduates in Colombo District.

Wijerathne, Tharindi / Sari, Dina Keumala / Liyanage, Thanuja / Kumaranayake, Ranil / Adithya, Dilantha

Journal of multidisciplinary healthcare

2023 Volume 16, Page(s) 3933–3940

Abstract: Purpose: Participation in regular physical activity is influenced by a variety of factors, including psychological dimensions. Emotional intelligence (EI), an emerging term, has not yet been extensively researched in relation to Physical Activity (PA). ... ...

Abstract	Purpose: Participation in regular physical activity is influenced by a variety of factors, including psychological dimensions. Emotional intelligence (EI), an emerging term, has not yet been extensively researched in relation to Physical Activity (PA). Thus, the aim of the present study was to examine the relationship between EI on the PA of university undergraduates. Methods: Cross sectional design was used to conduct the study. A total of 400 Colombo district state university undergraduates were included in the sample. The participants filled out two standard questionnaires. Wong and Low questionnaire to measure EI and the International Physical Activity Questionnaire (IPAQ- Long Form) to measure physical activity. Convenience sampling has been used in order to collect the data. SPSS 25.0 software was used to process and analyze the data with Spearman's test and Mann-Whitney Results: The rate of significance is 0.061 and as it is greater than 0.05 and the test results are not significant, the null hypothesis was accepted, and the hypothesis was rejected. At the same time, there was a weak negative correlation between EI and PA, which was statistically not significant - rs = - 0.094, p = 0.061. Conclusion: It is crucial to emphasize and put into practice the need for undergraduates to engage in more PA. The findings provide a basis for research aimed at determining the relationship between EI and PA.
Language	English
Publishing date	2023-12-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S428677
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Article ; Online: Positive Correlation Between General Public Knowledge and Attitudes Regarding COVID-19 Outbreak 1 Month After First Cases Reported in Indonesia.

Sari, Dina Keumala / Amelia, Rina / Dharmajaya, Ridha / Sari, Liza Meutia / Fitri, Nadya Keumala

Journal of community health

2020 Volume 46, Issue 1, Page(s) 182–189

Abstract: The increasing number cases of coronavirus disease (COVID-19) infections in the general population in Indonesia raises questions concerning the public's knowledge and attitudes regarding this pandemic. To determine the correlation between the general ... ...

Abstract	The increasing number cases of coronavirus disease (COVID-19) infections in the general population in Indonesia raises questions concerning the public's knowledge and attitudes regarding this pandemic. To determine the correlation between the general public's knowledge and attitudes regarding the COVID-19 outbreak 1 month after the first cases were reported in Indonesia. This cross-sectional study was conducted between early March and the end of April 2020 in the general population of Indonesia, beginning with the North Sumatra region, where the spread of COVID-19 in Indonesia began. Questionnaires were randomly distributed online in the red zone in Indonesia. Data were collected by collecting people's responses to the questionnaire, which were distributed via WhatsApp (WA) application and were competed independently by the participants. A descriptive analysis was conducted to describe the demographic characteristics, knowledge, and attitudes of the general population. A total of 201 people had good knowledge (98%) and a positive attitude (96%) regarding the COVID-19 pandemic. The respondents had a negative attitude in relation to two aspects of the COVID-19 outbreak: having to always maintain a distance of 1.5 m when in crowds, and not being able to regularly exercise or eat nutritious food (78.6% and 79.1%, respectively). Most people in Indonesia have good knowledge and a positive attitude regarding the COVID-19 pandemic. However, negative attitudes were still found in this study, and as a result, transmission prevention measures cannot reach their maximum effectiveness by simply publicizing the increase in day-to-day cases to the general public.
MeSH term(s)	Adolescent ; Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Disease Outbreaks ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Indonesia/epidemiology ; Male ; Middle Aged ; Surveys and Questionnaires ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-020-00866-0
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Article: The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake.

Sari, Dina Keumala / Sari, Liza Meutia / Laksmi, Lidya Imelda / Farhat

International journal of general medicine

2021 Volume 14, Page(s) 841–850

Abstract: Purpose: The routine examination of vitamin D levels is carried out by checking serum 25(OH)D levels, while serum 1.25(OH)D levels are less frequently utilized. The proposition that testing for salivary vitamin D can show a correlation with serum levels ...

Abstract	Purpose: The routine examination of vitamin D levels is carried out by checking serum 25(OH)D levels, while serum 1.25(OH)D levels are less frequently utilized. The proposition that testing for salivary vitamin D can show a correlation with serum levels in healthy people is questionable, especially with low vitamin D intake. This study aimed to find the correlation between vitamin D levels, which were assessed as 25(OH)D and 1.25(OH)D in saliva, and serum 25(OH)D and 1.25(OH)D levels in people with low vitamin D intake. Patients and methods: This study is a cross-sectional study involving healthy men and women, aged 18-60 years, carried out from August to November, 2020, in North Sumatra Province, Indonesia. The parameters studied were the 25(OH)D and 1.25(OH)D levels in saliva and serum, and vitamin D intake. The statistical analysis used was the Spearman correlation test, performed to determine the correlation between each parameter. Results: This study involved 56 study subjects, who were rural adults (male or female) with a 78.6% deficiency in 25(OH)D found by examining saliva, and a 76.8% deficiency found by examining the serum. All of the subjects were categorized as having low vitamin D intake (less than 15 micrograms per day). The analysis showed a moderate correlation between levels of saliva 25(OH)D and serum 25(OH)D ( Conclusion: In people with low vitamin D intake, there was a moderate correlation between serum 25(OH)D and saliva, but a weak correlation was found in the 1.25(OH)D assay. The use of saliva 25(OH)D levels to detect 25(OH)D in the circulation is a possible non-invasive alternative to serum testing.
Language	English
Publishing date	2021-03-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S302912
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Article ; Online: High-fat Diet Increases Sprague-Dawley Corticosterone Blood Levels with Nominal Change in Adrenocorticotrophic hormone (ACTH) Level with Signs of Increased Mesenteric Adiposity

Khairil Azwan / Resni Mona / Jannathul Firdous / Dina Keumala Sari / Pamela Rosie David / Noorzaid Muhamad

Indonesian Biomedical Journal, Vol 14, Iss 1, Pp 29-

2022 Volume 35

Abstract: BACKGROUND: Corticosterone is a common hormone in research involving rodents as it is used to indicate and measure stress levels. It was widely reported that certain dietary habits and components induce Hypothalamic-Pituitary-Adrenal (HPA) axis activity, ...

Abstract	BACKGROUND: Corticosterone is a common hormone in research involving rodents as it is used to indicate and measure stress levels. It was widely reported that certain dietary habits and components induce Hypothalamic-Pituitary-Adrenal (HPA) axis activity, with corticosterone found in the bloodstream. Chronic corticosterone presence can portray signs and symptoms of certain endocrine. Certain food and chemicals were found to alter HPA axis activity leading to dysregulation of the HPA axis. Earlier studies have shown enhancement of the HPA axis to produce more glucocorticoids by an unbalanced diet. This study aims to shed more light on this subject. METHODS: Sprague Dawley rats were divided into five groups of seven each and were fed five respective diets (control, high-fat, high-protein, high-sugar, and high-starch), with tap water as drinking water ad libitum. After eight weeks, the rats were euthanized, blood was collected, and serum harvested and kept for analysis. Mesenteric fat was identified, harvested, and stained with hematoxylin and eosin (H&E) and set for viewing under light microscope. The hormones of interest which is adrenocorticotropic hormone (ACTH) and corticosterone was extracted from the blood, to be processed accordingly and quantified using the High-Performance Liquid Chromatography (HPLC) with photodiode array (PDA) analysis technique. RESULTS: The results showed an increase in Sprague-Dawley corticosterone blood levels with a nominal change in ACTH level. Advanced hypertrophy was observed in mesenteric adipose tissue in the high-fat diet group compared to the other diet groups. CONCLUSION: This study confirms the negative effect of a high-fat diet on health from a hormonal and adipocyte perspective. A high-fat diet was found to instigate the HPA axis and influence blood corticosterone level. KEYWORDS: adrenocorticotrophic hormone, ACTH, corticosterone, mesenteric fat, diet
Keywords	Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Secretariat of The Indonesian Biomedical Journal
Document type	Article ; Online
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Article ; Online: High-fat Diet Increases Sprague-Dawley Corticosterone Blood Levels with Nominal Change in Adrenocorticotrophic hormone (ACTH) Level with Signs of Increased Mesenteric Adiposity

Khairil Azwan / Resni Mona / Jannathul Firdous / Dina Keumala Sari / Pamela Rosie David / Noorzaid Muhamad

Indonesian Biomedical Journal, Vol 14, Iss 1, Pp 29-

2022 Volume 35

Abstract	BACKGROUND: Corticosterone is a common hormone in research involving rodents as it is used to indicate and measure stress levels. It was widely reported that certain dietary habits and components induce Hypothalamic-Pituitary-Adrenal (HPA) axis activity, with corticosterone found in the bloodstream. Chronic corticosterone presence can portray signs and symptoms of certain endocrine. Certain food and chemicals were found to alter HPA axis activity leading to dysregulation of the HPA axis. Earlier studies have shown enhancement of the HPA axis to produce more glucocorticoids by an unbalanced diet. This study aims to shed more light on this subject. METHODS: Sprague Dawley rats were divided into five groups of seven each and were fed five respective diets (control, high-fat, high-protein, high-sugar, and high-starch), with tap water as drinking water ad libitum. After eight weeks, the rats were euthanized, blood was collected, and serum harvested and kept for analysis. Mesenteric fat was identified, harvested, and stained with hematoxylin and eosin (H&E) and set for viewing under light microscope. The hormones of interest which is adrenocorticotropic hormone (ACTH) and corticosterone was extracted from the blood, to be processed accordingly and quantified using the High-Performance Liquid Chromatography (HPLC) with photodiode array (PDA) analysis technique. RESULTS: The results showed an increase in Sprague-Dawley corticosterone blood levels with a nominal change in ACTH level. Advanced hypertrophy was observed in mesenteric adipose tissue in the high-fat diet group compared to the other diet groups. CONCLUSION: This study confirms the negative effect of a high-fat diet on health from a hormonal and adipocyte perspective. A high-fat diet was found to instigate the HPA axis and influence blood corticosterone level. KEYWORDS: adrenocorticotrophic hormone, ACTH, corticosterone, mesenteric fat, diet
Keywords	Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Secretariat of The Indonesian Biomedical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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