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Article ; Online: Adaptive servoventilation in a pediatric patient.

Tabone, Laurence / Amaddeo, Alessandro / Khirani, Sonia / Fauroux, Brigitte

2020 Volume 55, Issue 4, Page(s) 850–852

Language	English
Publishing date	2020-01-31
Publishing country	United States
Document type	Letter
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24672
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Article ; Online: Not All Breaths That Follow a Ventilator Cycle Are Reverse Triggering.

Levy, Michael / Tabone, Laurence / Mortamet, Guillaume / Thibault, Céline / Emeriaud, Guillaume

Annals of the American Thoracic Society

2021 Volume 18, Issue 7, Page(s) 1263–1264

MeSH term(s)	Humans ; Respiration, Artificial ; Respiratory System ; Ventilators, Mechanical
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202102-120LE
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Zs.A 5828: Show issues

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Article ; Online: Positive End-Expiratory Pressure in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Higher May Be Too High.

Tabone, Laurence / Martin, Sophie / Emeriaud, Guillaume

Critical care medicine

2020 Volume 48, Issue 12, Page(s) 1925–1927

MeSH term(s)	COVID-19 ; Humans ; Pandemics ; Positive-Pressure Respiration ; Respiratory Distress Syndrome ; SARS-CoV-2
Language	English
Publishing date	2020-12-12
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000004648
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Zs.A 1261: Show issues

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Article: Noninvasive Neurally Adjusted Ventilatory Assist in Infants With Bronchiolitis: Respiratory Outcomes in a Single-Center, Retrospective Cohort, 2016-2018.

Lepage-Farrell, Alex / Tabone, Laurence / Plante, Virginie / Kawaguchi, Atsushi / Feder, Joshua / Al Omar, Sally / Emeriaud, Guillaume

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 25, Issue 3, Page(s) 201–211

Abstract: Objectives: To describe our experience of using noninvasive neurally adjusted ventilatory assist (NIV-NAVA) in infants with bronchiolitis, its association with the evolution of respiratory effort, and PICU outcomes.: Design: Retrospective analysis of ...

Abstract	Objectives: To describe our experience of using noninvasive neurally adjusted ventilatory assist (NIV-NAVA) in infants with bronchiolitis, its association with the evolution of respiratory effort, and PICU outcomes. Design: Retrospective analysis of a prospectively curated, high-frequency electronic database. Setting: A PICU in a university-affiliated maternal-child health center in Canada. Patients: Patients younger than 2 years old who were admitted with a diagnosis of acute bronchiolitis and treated with NIV-NAVA from October 2016 to June 2018. Interventions: None. Measurements and main results: Patient characteristics, as well as respiratory and physiologic parameters, including electrical diaphragmatic activity (Edi), were extracted from the electronic database. Respiratory effort was estimated using the modified Wood Clinical Asthma Score (mWCAS) and the inspiratory Edi. A comparison in the respiratory effort data was made between the 2 hours before and 2 hours after starting NIV-NAVA. In the two seasons, 64 of 205 bronchiolitis patients were supported with NIV-NAVA. These 64 patients had a median (interquartile range [IQR]) age of 52 days (32-92 d), and there were 36 of 64 males. Treatment with NIV-NAVA was used after failure of first-tier noninvasive respiratory support; 25 of 64 patients (39%) had at least one medical comorbidity. NIV-NAVA initiation was associated with a moderate decrease in mWCAS from 3.0 (IQR, 2.5-3.5) to 2.5 (IQR, 2.0-3.0; p < 0.001). NIV-NAVA initiation was also associated with a statistically significant decrease in Edi ( p < 0.01). However, this decrease was only clinically relevant in infants with a 2-hour baseline Edi greater than 20 μV; here, the before and after Edi was 44 μV (IQR, 33-54 μV) compared with 27 μV (IQR, 21-36 μV), respectively ( p < 0.001). Overall, six of 64 patients (9%) required endotracheal intubation. Conclusions: In this single-center retrospective cohort, in infants with bronchiolitis who were considered to have failed first-tier noninvasive respiratory support, the use of NIV-NAVA was associated with a rapid decrease in respiratory effort and a 9% intubation rate.
MeSH term(s)	Infant ; Male ; Humans ; Child, Preschool ; Interactive Ventilatory Support ; Retrospective Studies ; Noninvasive Ventilation ; Bronchiolitis/therapy ; Intubation, Intratracheal
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003407
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Article ; Online: Prevention of submicron aerosolized particle dispersion: evaluation of an aerosol box using a pediatric simulation model.

Tabone, Laurence / Rivest, Dominic / Levy, Arielle / Buyck, Michael / Jouvet, Philippe / Aubin, Carl-Eric / François, Tine / Robert, Etienne / Baudin, Florent

Experimental lung research

2022 Volume 48, Issue 9-10, Page(s) 266–274

Abstract: Background and Aim: ...

Abstract	Background and Aim:
MeSH term(s)	Humans ; Child ; Aerosolized Particles and Droplets ; SARS-CoV-2 ; COVID-19/prevention & control ; Respiratory Aerosols and Droplets ; Suction
Chemical Substances	Aerosolized Particles and Droplets
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2022.2135795
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Article ; Online: Pediatric barrier enclosure for nasopharyngeal suctioning during Covid-19 pandemic: A simulation based-study.

Buyck, Michael / Levy, Arielle / Tabone, Laurence / Aubin, Carl-Eric / Jouvet, Philippe / Baudin, Florent

The American journal of emergency medicine

2020 Volume 45, Page(s) 608–610

MeSH term(s)	COVID-19/epidemiology ; Child ; Comorbidity ; Computer Simulation ; Humans ; Nasopharynx ; Pandemics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/therapy ; SARS-CoV-2 ; Suction/methods
Language	English
Publishing date	2020-12-11
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2020.11.077
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Article ; Online: Cerebral oxygenation in children with sleep-disordered breathing.

Tabone, Laurence / Khirani, Sonia / Amaddeo, Alessandro / Emeriaud, Guillaume / Fauroux, Brigitte

Paediatric respiratory reviews

2019 Volume 34, Page(s) 18–23

Abstract: Sleep-disordered breathing (SDB) is associated with neurocognitive and behavioral dysfunction, and structural brain abnormalities. Near infrared spectroscopy allows a continuous and non-invasive monitoring of brain tissue oxygenation, giving insight in ... ...

Abstract	Sleep-disordered breathing (SDB) is associated with neurocognitive and behavioral dysfunction, and structural brain abnormalities. Near infrared spectroscopy allows a continuous and non-invasive monitoring of brain tissue oxygenation, giving insight in some pathophysiological mechanisms potentially associated with SDB-related neurocognitive dysfunction. The present review summarizes the finding of studies describing brain tissue oxygenation in adults and children with SDB. Contrary to adults, mean nocturnal tissue oxygenation index (TOI) during sleep does not seem to be different in children with SDB as compared to healthy controls. During respiratory events such as apnoeas and hypopnoeas, the decrease in TOI precedes the peripheral, systemic desaturation. The decrease in TOI has been shown to be greater during apnoeas as compared to hypopnoeas, during rapid-eye movement sleep as compared to other sleep stages, in younger children as compared to their older counterparts, and in those with a high apnoea-hypopnoea index as compared with a low apnoea-hypopnoea index. Studies analyzing the association between repetitive changes in TOI and neurocognitive and behavioral dysfunction may help to decipher the pathophysiology of neurocognitive dysfunction associated with SDB in children.
MeSH term(s)	Adult ; Age Factors ; Brain/diagnostic imaging ; Brain/metabolism ; Child ; Humans ; Oxygen/metabolism ; Sleep ; Sleep Apnea Syndromes/metabolism ; Sleep Apnea Syndromes/physiopathology ; Sleep Stages/physiology ; Sleep, REM/physiology ; Spectroscopy, Near-Infrared
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-10-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147664-0
ISSN	1526-0550 ; 1526-0542
ISSN (online)	1526-0550
ISSN	1526-0542
DOI	10.1016/j.prrv.2019.10.002
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Zs.A 5919: Show issues

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Article ; Online: Determining Optimal Mean Arterial Blood Pressure Based on Cerebral Autoregulation in Children after Cardiac Surgery.

Tabone, Laurence / El-Tannoury, Jihad / Levy, Michael / Sauthier, Michael / Joram, Nicolas / Du Pont-Thibodeau, Geneviève / Bourgoin, Pierre / Al-Omar, Sally / Poirier, Nancy / Emeriaud, Guillaume / Thibault, Céline

Pediatric cardiology

2023 Volume 45, Issue 1, Page(s) 81–91

Abstract: To evaluate the feasibility of continuous determination of the optimal mean arterial blood pressure (opt-MAP) according to cerebral autoregulation and to describe the opt-MAP, the autoregulation limits, and the time spent outside these limits in children ...

Abstract	To evaluate the feasibility of continuous determination of the optimal mean arterial blood pressure (opt-MAP) according to cerebral autoregulation and to describe the opt-MAP, the autoregulation limits, and the time spent outside these limits in children within 48 h of cardiac surgery. Cerebral autoregulation was assessed using the correlation coefficient (COx) between cerebral oxygenation and MAP in children following cardiac surgery. Plots depicting the COx according to the MAP were used to determine the opt-MAP using weighted multiple time windows. For each patient, we estimated (1) the time spent with MAP outside the autoregulation limits and (2) the burden of deviation, defined as the area between the MAP curve and the autoregulation limits when the MAP was outside these limits. Fifty-one patients with a median age of 7.1 (IQR 0.7-52.0) months old were included. The opt-MAP was calculated for 94% (IQR 90-96) of the monitored time. The opt-MAP was significantly lower in neonates < 1 month old. The patients spent 24% (18-31) of the time outside of the autoregulation limits, with no significant differences between age groups. Continuous determination of the opt-MAP is feasible in children within the first 48 h following cardiac surgery.
MeSH term(s)	Child ; Infant, Newborn ; Humans ; Infant ; Child, Preschool ; Arterial Pressure/physiology ; Monitoring, Intraoperative ; Prospective Studies ; Cardiopulmonary Bypass ; Cerebrovascular Circulation/physiology ; Cardiac Surgical Procedures/adverse effects ; Homeostasis ; Blood Pressure/physiology
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-023-03326-3
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Article ; Online: ß-D-Glucan Assay in the Cerebrospinal Fluid for the Diagnosis of Non-cryptococcal Fungal Infection of the Central Nervous System: A Retrospective Multicentric Analysis and a Comprehensive Review of the Literature.

Bigot, Jeanne / Leroy, Jordan / Chouaki, Taieb / Cholley, Laurence / Bigé, Naïke / Tabone, Marie-Dominique / Brissot, Eolia / Thorez, Sophie / Maizel, Julien / Dupont, Hervé / Sendid, Boualem / Hennequin, Christophe / Guitard, Juliette

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 77, Issue 5, Page(s) 711–720

Abstract: Background: Except for cryptococcosis, fungal infection of the central nervous system (FI-CNS) is a rare but severe complication. Clinical and radiological signs are non-specific, and the value of conventional mycological diagnosis is very low. This ... ...

Abstract	Background: Except for cryptococcosis, fungal infection of the central nervous system (FI-CNS) is a rare but severe complication. Clinical and radiological signs are non-specific, and the value of conventional mycological diagnosis is very low. This study aimed to assess the value of β1,3-D-glucan (BDG) detection in the cerebrospinal fluid (CSF) of non-neonatal non-cryptococcosis patients. Methods: Cases associated with BDG assay in the CSF performed in 3 French University Hospitals over 5 years were included. Clinical, radiological, and mycological results were used to classify the episodes as proven/highly probable, probable, excluded, and unclassified FI-CNS. Sensitivity and specificity were compared to that calculated from an exhaustive review of the literature. Results: In total, 228 episodes consisting of 4, 7, 177, and 40 proven/highly probable, probable, excluded, and unclassified FI-CNS, respectively, were analysed. The sensitivity of BDG assay in CSF to diagnose proven/highly probable/probable FI-CNS ranged from 72.7% [95% confidence interval {CI}: 43.4%‒90.2%] to 100% [95% CI: 51%‒100%] in our study and was 82% in the literature. For the first time, specificity could be calculated over a large panel of pertinent controls and was found at 81.8% [95% CI: 75.3%‒86.8%]. Bacterial neurologic infections were associated with several false positive results. Conclusions: Despite its sub-optimal performance, BDG assay in the CSF should be added to the diagnostic armamentarium for FI-CNS.
MeSH term(s)	Humans ; Glucans ; Retrospective Studies ; beta-Glucans ; Sensitivity and Specificity ; Cryptococcosis/diagnosis ; Central Nervous System ; Multicenter Studies as Topic
Chemical Substances	Glucans ; beta-Glucans
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad274
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Simulation-Based Rapid Development and Implementation of a Novel Barrier Enclosure for Use in COVID-19 Patients: The SplashGuard CG.

François, Tine / Tabone, Laurence / Levy, Arielle / Seguin, Laurence Alix / Touré, Taher / Aubin, Carl Eric / Jouvet, Philippe

Critical care research and practice

2020 Volume 2020, Page(s) 3842506

Abstract: Background: The current COVID-19 pandemic has resulted in over 54,800,000 SARS-CoV-2 infections worldwide with a mortality rate of around 2.5%. As observed in other airborne viral infections such as influenza and SARS-CoV-1, healthcare workers are at ... ...

Abstract	Background: The current COVID-19 pandemic has resulted in over 54,800,000 SARS-CoV-2 infections worldwide with a mortality rate of around 2.5%. As observed in other airborne viral infections such as influenza and SARS-CoV-1, healthcare workers are at high risk for infection when performing aerosol-generating medical procedures (AGMP). Additionally, the threats of a global shortage of standard personal protective equipment (PPE) prompted many healthcare workers to explore alternative protective enclosures, such as the "aerosol box" invented by a Taiwanese anesthetist. Our study includes the design process of a protective barrier enclosure and its subsequent clinical implementation in the management of critically ill adults and children infected with SARS-CoV-2. Methods and results: The barrier enclosure was designed for use in our tertiary care facility and named "SplashGuard CG" (CG for Care Givers). The device has been adapted using a multi- and interdisciplinary approach, with collaboration between physicians, respiratory therapists, nurses, and biomechanical engineers. Computer-aided design and simulation sessions throughout the entire process facilitated the rapid and safe implementation of the SplashGuard CG in different settings (intensive care unit, emergency department, and the operating room) during AGMPs such as bag-valve-mask ventilation, nasopharyngeal suctioning, intubation and extubation, and noninvasive ventilation. Indications for use and anticipatory precautions were communicated to all healthcare workers using the SplashGuard CG. The entire process was completed within one month. Conclusion: The rapid design, development, and clinical implementation of a new barrier enclosure, the "SplashGuard CG," was feasible in this time of crisis thanks to close collaboration between medical and engineering teams and the use of recurring simulation sessions to test and improve the initial prototypes. Following this accelerated process, it is necessary to maintain team skills, monitor any undesirable effects, and evaluate and continuously improve this new device.
Language	English
Publishing date	2020-12-17
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2573849-5
ISSN	2090-1313 ; 2090-1305
ISSN (online)	2090-1313
ISSN	2090-1305
DOI	10.1155/2020/3842506
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