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  1. Article ; Online: Deciphering the evolutionary mechanisms of SARS-CoV-2: Absence of ORF8 protein and its potential advantage in the emergence of viral lineages.

    Velazquez-Salinas, Lauro

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e29002

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; COVID-19 ; Biological Evolution ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The complex evolutionary dynamics of SARS-CoV-2, a big challenge to control the pandemic of COVID-19.

    Velazquez-Salinas, Lauro

    Journal of medical virology

    2022  Volume 94, Issue 11, Page(s) 5082–5085

    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27979
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Assessing the Potential Role of Cats (

    Gomez-Romero, Ninnet / Basurto-Alcantara, Francisco Javier / Velazquez-Salinas, Lauro

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: Several questions regarding the evolution of SARS-CoV-2 remain poorly elucidated. One of these questions is the possible evolutionary impact of SARS-CoV-2 after the infection in domestic animals. In this study, we aimed to evaluate the potential role of ... ...

    Abstract Several questions regarding the evolution of SARS-CoV-2 remain poorly elucidated. One of these questions is the possible evolutionary impact of SARS-CoV-2 after the infection in domestic animals. In this study, we aimed to evaluate the potential role of cats as generators of relevant SARS-CoV-2 lineages during the pandemic. A total of 105 full-length genome viral sequences obtained from naturally infected cats during the pandemic were evaluated by distinct evolutionary algorithms. Analyses were enhanced, including a set of highly related SARS-CoV-2 sequences recovered from human populations. Our results showed the apparent high susceptibility of cats to the infection SARS-CoV-2 compared with other animal species. Evolutionary analyses indicated that the phylogenomic characteristics displayed by cat populations were influenced by the dominance of specific SARS-CoV-2 genetic groups affecting human populations. However, disparate dN/dS rates at some genes between populations recovered from cats and humans suggested that infection in these two species may suggest a different evolutionary constraint for SARS-CoV-2. Interestingly, the branch selection analysis showed evidence of the potential role of natural selection in the emergence of five distinct cat lineages during the pandemic. Although these lineages were apparently irrelevant to public health during the pandemic, our results suggested that additional studies are needed to understand the role of other animal species in the evolution of SARS-CoV-2 during the pandemic.
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12111361
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  4. Article: Vesicular stomatitis Indiana virus near-full-length genome sequences reveal low genetic diversity during the 2019 outbreak in Colorado, USA.

    Bertram, Miranda R / Rodgers, Case / Reed, Kirsten / Velazquez-Salinas, Lauro / Pelzel-McCluskey, Angela / Mayo, Christie / Rodriguez, Luis

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1110483

    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1110483
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  5. Article ; Online: Complete Coding Genome Sequences of Five Foot-and-Mouth Disease Viruses Belonging to Serotype O, Isolated from Cattle in Uganda in 2015 to 2016.

    Ahmed, Zaheer / Velazquez-Salinas, Lauro / Mwiine, Frank N / Vander Waal, Kimberly / Rieder, Elizabeth

    Microbiology resource announcements

    2022  Volume 11, Issue 8, Page(s) e0044522

    Abstract: Complete coding genome sequences of five foot-and-mouth disease virus (FMDV) serotype O strains that were isolated from the field between 2015 and 2016 showed five lineages within the EA-2 topotype circulating in four different regions (northern, western, ...

    Abstract Complete coding genome sequences of five foot-and-mouth disease virus (FMDV) serotype O strains that were isolated from the field between 2015 and 2016 showed five lineages within the EA-2 topotype circulating in four different regions (northern, western, eastern, and central) of Uganda. The genomic diversity may help in devising FMDV control strategies for Uganda.
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00445-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Beyond the biology

    Schafer, Elizabeth A. / Eberl, Samantha / Velazquez-Salinas, Lauro

    Evaluating the role of political, economic, and social factors associated with the incidence and mortality of SARS-CoV-2 during the first seven months of the COVID-19 pandemic

    2022  

    Abstract: Purpose: In this study we propose to identify significant economic, political, and social factors that helped contribute to the incidence and mortality of SARS-CoV-2 around the world during the first seven months of the COVID-19 pandemic. Methods: ... ...

    Abstract Purpose: In this study we propose to identify significant economic, political, and social factors that helped contribute to the incidence and mortality of SARS-CoV-2 around the world during the first seven months of the COVID-19 pandemic. Methods: Retrospective analyses were conducted using data acquired by the World Health Organization regarding the number of new cases and deaths from 76 countries from January through July 2020. Hierarchical cluster and principal component analyses were used to categorize different countries based on their ability to control the outbreak based on number of cases and deaths throughout these initial months of the pandemic. Furthermore, using non-parametrical analyses, different variables were correlated with multiple economic, political, and social indexes. Results: Multiple significant correlations were found, including the control of corruption, government effectiveness, and the human life indicator, with indexes containing the higher correlations demonstrating the capability of individual countries to help drive the course of this pandemic. Geographical hotspots were identified that required further attention to aid in outbreak control. Conclusion: Collectively, the findings in this study indicate that multiple factors beyond the biological should be considered in the implementation of measures to contain this pandemic

    Comment: 18 pages, 5 figures
    Keywords Physics - Physics and Society ; Quantitative Biology - Populations and Evolution ; Statistics - Methodology
    Subject code 360
    Publishing date 2022-04-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Deletion of the

    Ramirez-Medina, Elizabeth / Rai, Ayushi / Espinoza, Nallely / Valladares, Alyssa / Silva, Ediane / Velazquez-Salinas, Lauro / Borca, Manuel V / Gladue, Douglas P

    Viruses

    2023  Volume 15, Issue 7

    Abstract: African swine fever (ASF) is a highly contagious disease that affects wild and domestic swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia and the Caribbean region. The etiological agent of ASF is a large, highly ... ...

    Abstract African swine fever (ASF) is a highly contagious disease that affects wild and domestic swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia and the Caribbean region. The etiological agent of ASF is a large, highly complex structural virus (ASFV) harboring a double-stranded genome encoding for more than 160 proteins whose functions, in most cases, have not been experimentally characterized. We show here that deletion of the ASFV gene
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus/physiology ; Virulence/genetics ; African Swine Fever ; Gene Deletion ; Virulence Factors/genetics
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010.

    Ramirez-Medina, Elizabeth / Rai, Ayushi / Espinoza, Nallely / Spinard, Edward / Silva, Ediane / Burton, Leeanna / Clark, Jason / Meyers, Amanda / Valladares, Alyssa / Velazquez-Salinas, Lauro / Gay, Cyril G / Gladue, Douglas P / Borca, Manuel V

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces ... ...

    Abstract We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces protection, while intramuscularly (IM), administered at doses of 10
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040319
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  9. Article: A Multiplex Real-Time Reverse Transcription Polymerase Chain Reaction Assay With Enhanced Capacity to Detect Vesicular Stomatitis Viral Lineages of Central American Origin.

    Hole, Kate / Nfon, Charles / Rodriguez, Luis L / Velazquez-Salinas, Lauro

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 783198

    Abstract: Vesicular stomatitis virus (VSV) causes a disease in susceptible livestock that is clinically indistinguishable from foot-and-mouth disease. Rapid testing is therefore critical to identify VSV and rule out FMD. We previously developed and validated a ... ...

    Abstract Vesicular stomatitis virus (VSV) causes a disease in susceptible livestock that is clinically indistinguishable from foot-and-mouth disease. Rapid testing is therefore critical to identify VSV and rule out FMD. We previously developed and validated a multiplex real-time reverse transcription polymerase chain reaction assay (mRRT-PCR) for detection of both VS New Jersey virus (VSNJV) and VS Indiana virus (VSIV). However, it was subsequently apparent that this assay failed to detect some VSNJV isolates in Mexico, especially in genetic group II, lineage 2.1. In order to enhance the sensitivity of the mRRT-PCR for VSNJV, parts of the assay were redesigned and revalidated using new and improved PCR chemistries. The redesign markedly improved the assay by increasing the VSNJV detection sensitivity of lineage 2.1 and thereby allowing detection of all VSNJV clades. The new assay showed an increased capability to detect VSNJV. Specifically, the new mRRT-PCR detected VSNJV in 100% (87/87) of samples from Mexico in 2006-2007 compared to 74% for the previous mRRT-PCR. Furthermore, the analytical sensitivity of the new mRRT-PCR was enhanced for VSNJV. Importantly, the modified assay had the same sensitivity and specificity for VSIV as the previously published assay. Our results highlight the challenges the large genetic variability of VSV pose for virus detection by mRRT-PCR and show the importance of frequent re-evaluation and validation of diagnostic assays for VSV to ensure high sensitivity and specificity.
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.783198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: ASF Vaccine Candidate ASFV-G-∆I177L Does Not Exhibit Residual Virulence in Long-Term Clinical Studies.

    Borca, Manuel V / Ramirez-Medina, Elizabeth / Silva, Ediane / Rai, Ayushi / Espinoza, Nallely / Velazquez-Salinas, Lauro / Gladue, Douglas P

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: African swine fever (ASF) is an important disease in swine currently producing a pandemic affecting pig production worldwide. Except in Vietnam, where two vaccines were recently approved for controlled use in the field, no vaccine is commercially ... ...

    Abstract African swine fever (ASF) is an important disease in swine currently producing a pandemic affecting pig production worldwide. Except in Vietnam, where two vaccines were recently approved for controlled use in the field, no vaccine is commercially available for disease control. Up to now, the most effective vaccines developed are based on the use of live-attenuated viruses. Most of these promising vaccine candidates were developed by deleting virus genes involved in the process of viral pathogenesis and disease production. Therefore, these vaccine candidates were developed via the genomic modification of parental virus field strains, producing recombinant viruses and reducing or eliminating their residual virulence. In this scenario, it is critical to confirm the absence of any residual virulence in the vaccine candidate. This report describes the assessment of the presence of residual virulence in the ASFV vaccine candidate ASFV-G-∆I177L in clinical studies conducted under high virus loads and long-term observation periods. The results demonstrated that domestic pigs intramuscularly inoculated with 10
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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