LIVIVO - Search results -

Search results

Result 1 - 10 of total 2439

Search options

Article ; Online: Effects of dietary vitamin K

Bai, Hanako / Arai, Hikoji / Ikuta, Kentarou / Ishikawa, Sho / Ohtani, Yoshihisa / Iwashita, Kunihiro / Okada, Nao / Shirakawa, Hitoshi / Komai, Michio / Terada, Fuminori / Obara, Yoshiaki

Animal science journal = Nihon chikusan Gakkaiho

2021 Volume 93, Issue 1, Page(s) e13680

Abstract: The effect of dietary vitamin K ...

Abstract	The effect of dietary vitamin K
MeSH term(s)	Animal Feed/analysis ; Animals ; Cattle ; Diet/veterinary ; Dietary Supplements/analysis ; Digestion ; Female ; Fermentation ; Lactation ; Milk ; Rumen/metabolism ; Vitamin K 1/metabolism ; Vitamin K 2/metabolism ; Vitamin K 2/pharmacology ; Vitamin K 3/metabolism
Chemical Substances	Vitamin K 2 (11032-49-8) ; Vitamin K 3 (723JX6CXY5) ; Vitamin K 1 (84-80-0)
Language	English
Publishing date	2021-12-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13680
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article: Effect of a cathepsin K inhibitor on arthritis and bone mineral density in ovariectomized rats with collagen-induced arthritis.

Yamashita, Takahiro / Hagino, Hiroshi / Hayashi, Ikuta / Hayashibara, Masako / Tanida, Atsushi / Nagira, Keita / Fukui, Ryohei / Nagashima, Hideki

Bone reports

2018 Volume 9, Page(s) 1–10

Abstract: Objectives: Cathepsin K is expressed by osteoclasts and synovial fibroblasts and degrades key ... components of bone and cartilage. Inhibition of cathepsin K protease activity may be beneficial ... We investigated the effect of ONO-KK1-300-01, a cathepsin K inhibitor (CKI), on arthritis and bone mineral density ...

Abstract	Objectives: Cathepsin K is expressed by osteoclasts and synovial fibroblasts and degrades key components of bone and cartilage. Inhibition of cathepsin K protease activity may be beneficial for the prevention of bone erosion and cartilage degradation in rheumatoid arthritis (RA). The collagen-induced arthritis (CIA) rat model is well established for studying the pathology and treatment of RA. We investigated the effect of ONO-KK1-300-01, a cathepsin K inhibitor (CKI), on arthritis and bone mineral density (BMD) in rats with CIA. Methods: Seven-month-old female Sprague Dawley rats were divided into 5 groups: rats without CIA (CNT); CIA rats that underwent ovariectomy (OVX) and were treated with CKI; CIA rats that underwent OVX and were treated with vehicle (Veh); CIA rats that underwent sham surgery and were treated with CKI; and CIA rats that underwent sham surgery and were treated with Veh. CKI was orally administered at a dose of 15 mg/kg, thus initiating collagen sensitization, until death at 4 weeks. We evaluated hind paw thickness and the arthritis score every week until death. Radiographs of the resected left foot were obtained with a soft X-ray apparatus. Destruction of bone and cartilage was classified and scored as previously described by Engelhardt et al. BMD was measured by bone densitometry at the halfway point between the distal metaphysis and the diaphysis of the resected right femur. We also performed histomorphometry of the proximal left tibia, histological evaluation of arthritis, and a bone strength test. Results: CKI administration significantly reduced hind paw thickness and the arthritis score, and prevented a decrease in BMD. The radiographic score was significantly lower in the CKI group than in the Veh group. In the histomorphometric analysis, bone-resorption parameters were significantly lower in the CKI groups than in the Veh groups. CKI significantly inhibited synovial proliferation in the CIA rats. In the bone strength test, the ultimate stress was significantly higher in the CKI groups than in the Veh groups. Conclusion: Our findings indicate that cathepsin K inhibitors may inhibit systemic and local bone loss, ameliorate arthritis, and attenuate the decrease of bone strength in an animal model of arthritis.
Language	English
Publishing date	2018-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2018.05.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Iron deficiency anemia and newly available iron preparations].

Ikuta, Katsuya

Rinsho ketsueki] The Japanese journal of clinical hematology

2022 Volume 63, Issue 9, Page(s) 1026–1034

Abstract: The body does not possess an active export system for iron. Therefore, the amount of iron uptake is usually small; iron metabolism in the body should be considered a "semi-closed system." However, iron needed for erythropoiesis can be lacking in the case ...

Abstract	The body does not possess an active export system for iron. Therefore, the amount of iron uptake is usually small; iron metabolism in the body should be considered a "semi-closed system." However, iron needed for erythropoiesis can be lacking in the case of continuous bleeding, and thus, iron deficiency anemia (IDA) would occur. IDA is the most common form of anemia; approximately 70% of anemia is IDA. Therefore, upper and lower endoscopies or gynecological procedures should be used to treat bleeding sites; in addition, the small intestine can now be widely observed and treated by double-balloon and capsule endoscopies. Iron replacement therapy for IDA is also important; however, oral iron administration frequently causes adverse events in the gastrointestinal tract, such as nausea and vomiting, making long-term oral iron administration difficult. Newly approved ferric citrate hydrate causes fewer adverse events for the gastrointestinal tract. For a long time, concerning intravenous (IV) iron formulation, saccharated ferric iron oxide has been the only available IV iron formulation in Japan. However, ferric carboxymaltose was recently approved, and administration at a dose of 500 mg/day can achieve a certain iron replacement with less administration. Thus, more effective treatment for patients with IDA might be achieved by these new procedures as well as oral and IV iron preparations.
MeSH term(s)	Administration, Intravenous ; Administration, Oral ; Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/etiology ; Humans ; Iron/therapeutic use ; Iron Deficiencies
Chemical Substances	Iron (E1UOL152H7)
Language	Japanese
Publishing date	2022-08-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.63.1026
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1175: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 535: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [The newest information for iron metabolism: ferric carboxymaltose, a recently available treatment option for iron-deficiency anemia].

Ikuta, Katsuya

Rinsho ketsueki] The Japanese journal of clinical hematology

2021 Volume 62, Issue 5, Page(s) 388–396

Abstract: Iron-deficiency anemia (IDA) is the most common form of anemia. It is treated through iron replacement therapy, with oral iron administration as the recommended first-line treatment. However, intravenous (IV) iron formulation is at timed used owing to ... ...

Abstract	Iron-deficiency anemia (IDA) is the most common form of anemia. It is treated through iron replacement therapy, with oral iron administration as the recommended first-line treatment. However, intravenous (IV) iron formulation is at timed used owing to adverse effects of oral iron administration such as gastrointestinal symptoms. Although saccharated ferric iron oxide had been the only available IV iron formulation in Japan for a long time, ferric carboxymaltose (FCM) has recently been approved. In this review, the characteristics, efficacy, and safety of FCM will be discussed mainly by introducing the results of three clinical trials for FCM conducted in Japan. More effective treatment for patients with IDA might be achieved through the introduction of FCM administration in clinical settings.
MeSH term(s)	Anemia, Iron-Deficiency/drug therapy ; Ferric Compounds ; Humans ; Iron ; Japan ; Maltose/analogs & derivatives ; Treatment Outcome
Chemical Substances	Ferric Compounds ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; Iron (E1UOL152H7)
Language	Japanese
Publishing date	2021-06-09
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.62.388
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1175: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 535: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels.

Doi, Kosuke / Kawakami, Kouki / Ikuta, Tatsuya / Inoue, Asuka

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9453

Abstract: Arginine-vasopressin (AVP), a cyclic peptide hormone composed of nine amino acids, regulates water reabsorption by increasing intracellular cyclic adenosine monophosphate (cAMP) concentrations via the vasopressin V2 receptor (V2R). Plasma AVP is a ... ...

Abstract	Arginine-vasopressin (AVP), a cyclic peptide hormone composed of nine amino acids, regulates water reabsorption by increasing intracellular cyclic adenosine monophosphate (cAMP) concentrations via the vasopressin V2 receptor (V2R). Plasma AVP is a valuable biomarker for the diagnosis of central diabetes insipidus (CDI) and is commonly measured using radioimmunoassay (RIA). However, RIA has several drawbacks, including a long hands-on time, complex procedures, and handling of radioisotopes with special equipment and facilities. In this study, we developed a bioassay to measure plasma AVP levels using HEK293 cells expressing an engineered V2R and a cAMP biosensor. To achieve high sensitivity, we screened V2R orthologs from 11 various mammalian species and found that the platypus V2R (pV2R) responded to AVP with approximately six-fold higher sensitivity than that observed by the human V2R. Furthermore, to reduce cross-reactivity with desmopressin (DDAVP), a V2R agonist used for CDI treatment, we introduced a previously described point mutation into pV2R, yielding an approximately 20-fold reduction of responsiveness to DDAVP while maintaining responsiveness to AVP. Finally, a comparison of plasma samples from 12 healthy individuals demonstrated a strong correlation (Pearson's correlation value: 0.90) between our bioassay and RIA. Overall, our assay offers a more rapid and convenient method for quantifying plasma AVP concentrations than existing techniques.
MeSH term(s)	Humans ; Arginine Vasopressin/blood ; HEK293 Cells ; Cyclic AMP/blood ; Cyclic AMP/metabolism ; Receptors, Vasopressin/genetics ; Biosensing Techniques/methods ; Deamino Arginine Vasopressin/pharmacology ; Animals ; Biological Assay/methods
Chemical Substances	Arginine Vasopressin (113-79-1) ; Cyclic AMP (E0399OZS9N) ; Receptors, Vasopressin ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60035-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues.

Cui, Guangwei / Abe, Shinya / Kato, Ryoma / Ikuta, Koichi

Frontiers in immunology

2024 Volume 15, Page(s) 1349184

Abstract: Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T lymphocytes. They are characterized by semi-invariant T cell receptors (TCRs) that recognize both self and foreign lipid antigens presented by CD1d, a non-polymorphic ... ...

Abstract	Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T lymphocytes. They are characterized by semi-invariant T cell receptors (TCRs) that recognize both self and foreign lipid antigens presented by CD1d, a non-polymorphic MHC class I-like molecule. iNKT cells play a critical role in stimulating innate and adaptive immune responses, providing an effective defense against infections and cancers, while also contributing to chronic inflammation. The functions of iNKT cells are specific to their location, ranging from lymphoid to non-lymphoid tissues, such as the thymus, lung, liver, intestine, and adipose tissue. This review aims to provide insights into the heterogeneity of development and function in iNKT cells. First, we will review the expression of master transcription factors that define subsets of iNKT cells and their production of effector molecules such as cytokines and granzymes. In this article, we describe the gene expression profiles contributing to the kinetics, distribution, and cytotoxicity of iNKT cells across different tissue types. We also review the impact of cytokine production in distinct immune microenvironments on iNKT cell heterogeneity, highlighting a recently identified circulating iNKT cell subset. Additionally, we explore the potential of exploiting iNKT cell heterogeneity to create potent immunotherapies for human cancers in the future.
MeSH term(s)	Humans ; Natural Killer T-Cells ; Cues ; Adipose Tissue ; Cell Membrane ; Neoplasms ; Tumor Microenvironment
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1349184
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.

Ikuta, Koichi / Asahi, Takuma / Cui, Guangwei / Abe, Shinya / Takami, Daichi

Advances in experimental medicine and biology

2024 Volume 1444, Page(s) 111–127

Abstract: Recently, considerable attention has been directed toward innate-like T cells (ITCs) and innate lymphoid cells (ILCs) owing to their indispensable contributions to immune responses, tissue homeostasis, and inflammation. Innate-like T cells include NKT ... ...

Abstract	Recently, considerable attention has been directed toward innate-like T cells (ITCs) and innate lymphoid cells (ILCs) owing to their indispensable contributions to immune responses, tissue homeostasis, and inflammation. Innate-like T cells include NKT cells, MAIT cells, and γδ T cells, whereas ILCs include NK cells, type 1 ILCs (ILC1s), type 2 ILCs (ILC2s), and type 3 ILCs (ILC3s). Many of these ITCs and ILCs are distributed to specific tissues and remain tissue-resident, while others, such as NK cells and some γδ T cells, circulate through the bloodstream. Nevertheless, recent research has shed light on novel subsets of innate immune cells that exhibit characteristics intermediate between tissue-resident and circulating states under normal and pathological conditions. The local microenvironment frequently influences the development, distribution, and function of these innate immune cells. This review aims to consolidate the current knowledge on the functional heterogeneity of ITCs and ILCs, shaped by local environmental cues, with particular emphasis on IL-15, which governs the activities of the innate immune cells involved in type 1 immune responses.
MeSH term(s)	Humans ; Lymphocytes ; Immunity, Innate ; Killer Cells, Natural ; Inflammation
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-981-99-9781-7_8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Effective Use of Image Correction Color Chart for Image Recognition.

Ikuta, Kento / Fukuoka, Kohei / Suyama, Yoshiko / Yagi, Shunjiro

Plastic and reconstructive surgery. Global open

2023 Volume 11, Issue 1, Page(s) e4795

Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004795
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7091: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations.

Ikuta, Shotaro / Nakagawa, Hidetoshi / Kai, Toshiya / Sugano, Kiyohiko

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Volume 192, Page(s) 106622

Abstract: This study aimed to develop a dissolution test that can predict the bioequivalence (BE) of enteric-coated pellet formulations. The original duloxetine hydrochloride capsule (reference formulation (RF); Cymbalta® 30 mg capsule) and four generic test ... ...

Abstract	This study aimed to develop a dissolution test that can predict the bioequivalence (BE) of enteric-coated pellet formulations. The original duloxetine hydrochloride capsule (reference formulation (RF); Cymbalta® 30 mg capsule) and four generic test formulations (two capsules (CP) and two orally disintegrating tablets (OD)) were used as model formulations. Clinical BE studies were conducted on 24-47 healthy male subjects under fasting conditions. Dissolution tests were performed using a compendial paddle method (PD) (paddle speed: 50 rpm) and a flow-through cell method (FTC) (flow rate: 4 mL/min). For a further test, cotton balls were added to the vessel to apply gentle mechanistic stress to the formulations, and paddle speed was reduced to 10 rpm (paddle with cotton ball method (PDCB)).All the dissolution tests were conducted with 0.01 M HCl (pH 2.0) for 0.5 h followed by 10 mM bicarbonate buffer solutions (pH 6.5) for 4 h. One each of the two CP and two OD showed BE with RF. PDCB was able to discriminate between BE and non-BE formulations, while this was not possible with PD and FTC. In PDCB, the cotton balls intermittently moved the pellets near the vessel bottom. PDCB is useful for predicting BE during formulation development.
MeSH term(s)	Male ; Humans ; Bicarbonates ; Therapeutic Equivalency ; Tablets, Enteric-Coated ; Tablets ; Duloxetine Hydrochloride ; Solubility
Chemical Substances	Bicarbonates ; Tablets, Enteric-Coated ; Tablets ; Duloxetine Hydrochloride (9044SC542W)
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106622
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3705: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluation of driving fitness using driving simulators in patients with right-hemisphere damage: an unmatched case-control study.

Sotokawa, Tasuku / Nasu, Satonori / Ikuta, Junichi / Sonohara, Kazuki

Topics in stroke rehabilitation

2023 Volume 31, Issue 2, Page(s) 167–177

Abstract: Background: Patients with right hemisphere damage (RHD) may exhibit mild unilateral spatial neglect (USN), which is difficult to detect in general assessments performed during driving rehabilitation.: Objectives: We compared driving simulator ... ...

Abstract	Background: Patients with right hemisphere damage (RHD) may exhibit mild unilateral spatial neglect (USN), which is difficult to detect in general assessments performed during driving rehabilitation. Objectives: We compared driving simulator performance, practical driving performance, and neuropsychological test results between patients with RHD who were able and unable to return to driving to predict driving fitness based on driving simulator performance. Methods: This unmatched case-control study included 29 patients with RHD who were able (return-to-driving group, Results: The non-return-to-driving group had a significantly lower reaction rate than the return-to-driving group ( Conclusions: Decreases in reaction rates during simulated driving assessments are associated with an inability to resume driving in patients with RHD. Such assessments may aid in predicting fitness for driving in these patients.
MeSH term(s)	Humans ; Case-Control Studies ; Stroke ; Reaction Time ; ROC Curve ; Attention ; Neuropsychological Tests ; Automobile Driving
Language	English
Publishing date	2023-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1213112-x
ISSN	1945-5119 ; 1074-9357
ISSN (online)	1945-5119
ISSN	1074-9357
DOI	10.1080/10749357.2023.2235797
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4139: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 454: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito