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  1. Article: Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer's Disease.

    Herholz, Karl

    Brain sciences

    2022  Volume 12, Issue 2

    Abstract: Alzheimer's disease (AD) does not present uniform symptoms or a uniform rate of progression in all cases. The classification of subtypes can be based on clinical symptoms or patterns of pathological brain alterations. Imaging techniques may allow for the ...

    Abstract Alzheimer's disease (AD) does not present uniform symptoms or a uniform rate of progression in all cases. The classification of subtypes can be based on clinical symptoms or patterns of pathological brain alterations. Imaging techniques may allow for the identification of AD subtypes and their differentiation from other neurodegenerative diseases already at an early stage. In this review, the strengths and weaknesses of current clinical imaging methods are described. These include positron emission tomography (PET) to image cerebral glucose metabolism and pathological amyloid or tau deposits. Magnetic resonance imaging (MRI) is more widely available than PET. It provides information on structural or functional changes in brain networks and their relation to AD subtypes. Amyloid PET provides a very early marker of AD but does not distinguish between AD subtypes. Regional patterns of pathology related to AD subtypes are observed with tau and glucose PET, and eventually as atrophy patterns on MRI. Structural and functional network changes occur early in AD but have not yet provided diagnostic specificity.
    Language English
    Publishing date 2022-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12020146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: The dementias

    Herholz, Karl

    early diagnosis and evaluation

    2006  

    Author's details ed. by Karl Herholz
    Keywords Dementia / diagnosis ; Dementia / etiology ; Neuropsychological Tests ; Biological Markers ; Diagnostic Imaging / methods ; Early Diagnosis
    Language English
    Size XV, 455, [8] S. : Ill., graph. Darst.
    Publisher Taylor & Francis
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014815407
    ISBN 0-8247-2897-1 ; 978-0-8247-2897-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 4626 order for loan Magazin

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  3. Article ; Online: Hide-and-seek for radiotracers and neurodegenerative pathology.

    Herholz, Karl

    European journal of nuclear medicine and molecular imaging

    2020  Volume 47, Issue 8, Page(s) 1791–1792

    MeSH term(s) Aphasia, Primary Progressive ; Brain ; Carbolines ; Humans ; Semantics
    Chemical Substances Carbolines ; 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (J09QS3Z3WB)
    Language English
    Publishing date 2020-01-02
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-019-04661-5
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Book: Alzheimer's disease

    Herholz, Karl / Zanzonico, Pat

    a brief review

    2010  

    Author's details Karl Herholz ; Pat Zanzonico
    Language English
    Size 41 S. : Ill., graph. Darst., 19 cm
    Edition 1. Aufl.
    Publisher ABW Wiss.-Verl
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT016325818
    ISBN 978-3-940615-02-2 ; 3-940615-02-1
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Spread of tau deposits: can we trust in vivo findings?

    Herholz, Karl

    Brain : a journal of neurology

    2018  Volume 141, Issue 1, Page(s) 10–12

    MeSH term(s) Aging ; Alzheimer Disease ; Brain ; Humans ; tau Proteins
    Chemical Substances tau Proteins
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awx340
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  6. Article ; Online: Brain Tumors: An Update on Clinical PET Research in Gliomas.

    Herholz, Karl

    Seminars in nuclear medicine

    2017  Volume 47, Issue 1, Page(s) 5–17

    Abstract: A previous review published in 2012 demonstrated the role of clinical PET for diagnosis and management of brain tumors using mainly FDG, amino acid tracers, ... ...

    Abstract A previous review published in 2012 demonstrated the role of clinical PET for diagnosis and management of brain tumors using mainly FDG, amino acid tracers, and
    MeSH term(s) Biomarkers, Tumor/metabolism ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Proliferation ; Fluorodeoxyglucose F18 ; Glioma/diagnostic imaging ; Glioma/metabolism ; Glioma/pathology ; Humans ; Positron-Emission Tomography/methods
    Chemical Substances Biomarkers, Tumor ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2016.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 763: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Tau PET and tauopathies.

    Herholz, Karl

    European journal of nuclear medicine and molecular imaging

    2016  Volume 43, Issue 9, Page(s) 1684–1685

    MeSH term(s) Aged ; Diagnosis, Differential ; Humans ; Middle Aged ; Positron-Emission Tomography ; Tauopathies/diagnostic imaging ; Tauopathies/metabolism ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2016-08
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-016-3406-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Guidance for reading FDG PET scans in dementia patients.

    Herholz, K

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

    2014  Volume 58, Issue 4, Page(s) 332–343

    Abstract: 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is a powerful method for detection of disease-related impairment of cerebral glucose metabolism in neurodegenerative diseases. It is of particular interest for early and differential ...

    Abstract 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is a powerful method for detection of disease-related impairment of cerebral glucose metabolism in neurodegenerative diseases. It is of particular interest for early and differential diagnosis of dementia. Reading FDG PET scans requires training to recognise deviations from normal functional brain anatomy and its variations. This paper provides guidance for displaying FDG PET brain scans in a reproducible manner that allows reliable recognition of characteristic disease-related metabolic changes. It also describes typical findings in Alzheimer's disease, Frontotemporal Dementia and Dementia with Lewy Bodies and possible confounding factors, such as vascular changes and brain atrophy. It provides a brief overview on findings in other neurodegenerative diseases and addresses the potential and limitations of software packages for comparison of individual scans with reference data.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Brain/pathology ; Dementia/diagnosis ; Dementia/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Image Processing, Computer-Assisted/methods ; Nuclear Medicine/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Reference Values ; Software
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2014-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1281687-5
    ISSN 1827-1936 ; 1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661
    ISSN (online) 1827-1936
    ISSN 1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 18: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Book: NeuroPET

    Herholz, Karl / Herscovitch, Peter / Heiss, Wolf-Dieter

    positron emission tomography in neuroscience and clinical neurology ; with 11 tables

    2004  

    Author's details K. Herholz ; P. Herscovitch ; W.-D. Heiss
    Keywords Nervensystem ; Krankheit ; Positronen-Emissions-Tomografie ; Psychische Störung
    Subject Seelische Störung ; Mental disorder ; Psychische Krankheit ; Seelische Krankheit ; Psychiatrische Krankheit ; Psychische Erkrankung ; Psychische Störungen ; Positronen-Emissions-Tomographie ; PET ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS
    Language English
    Size XV, 297 S. : zahlr. Ill.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note System requirements: Microsoft Windows (XP/2000/NT/ME/98). MacOS X, Linux/Unix. Visualization software Vinci Lite requires Windows XP/2000/NT; videoclips (.mpg, .avi), and volume data may require additional software
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT014066014
    ISBN 3-540-00691-5 ; 978-3-540-00691-6
    Database Catalogue ZB MED Medicine, Health

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    2004 A 2692 order for loan Magazin
    2004 MO 354 <<[Begleitmaterial]>> order for loan Magazin
    2006 A 3895 order for loan Magazin
    2006 MO 776 <<[Begleitmaterial]>> order for loan Magazin

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  10. Article ; Online: Use of FDG PET as an imaging biomarker in clinical trials of Alzheimer's disease.

    Herholz, Karl

    Biomarkers in medicine

    2012  Volume 6, Issue 4, Page(s) 431–439

    Abstract: PET with the glucose analog FDG as a tracer is a mature and increasingly available clinical imaging technique that can improve the diagnostic accuracy for Alzheimer's disease, which is of particular value at an early stage of the disease when clinical ... ...

    Abstract PET with the glucose analog FDG as a tracer is a mature and increasingly available clinical imaging technique that can improve the diagnostic accuracy for Alzheimer's disease, which is of particular value at an early stage of the disease when clinical symptoms are still mild and nonspecific. It can also monitor progression of Alzheimer's disease, and the findings are closely related to clinical symptoms. FDG PET, therefore, could also potentially be used as an imaging biomarker for selection of patients and assessment of outcome in clinical trials. Several published intervention studies indicate a good correspondence between clinical outcome and FDG PET findings, but study designs and methods used for data analysis vary widely. Recent developments towards standardization of largely user-independent methods for quantification of regional metabolic impairment on FDG PET scans will allow a new generation of studies that could provide the required evidence for full qualification of FDG PET as an imaging biomarker in clinical trials.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Biomarkers/metabolism ; Clinical Trials as Topic ; Fluorodeoxyglucose F18/chemistry ; Glucose/metabolism ; Humans ; Positron-Emission Tomography
    Chemical Substances Biomarkers ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2012-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.12.51
    Database MEDical Literature Analysis and Retrieval System OnLINE

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