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  1. Article ; Online: MRCG: A MRI Retrieval Framework With Convolutional and Graph Neural Networks for Secure and Private IoMT.

    Tang, Zhiri / Sun, Zhao-Hui / Wu, Edmond Q / Wei, Chuan-Feng / Ming, Dong / Chen, Sheng-Di

    IEEE journal of biomedical and health informatics

    2023  Volume 27, Issue 2, Page(s) 814–822

    Abstract: In the context of Industry 4.0, the medical industry is horizontally integrating the medical resources of the entire industry through the Internet of Things (IoT) and digital interconnection technologies. Speeding up the establishment of the public ... ...

    Abstract In the context of Industry 4.0, the medical industry is horizontally integrating the medical resources of the entire industry through the Internet of Things (IoT) and digital interconnection technologies. Speeding up the establishment of the public retrieval database of diagnosis-related historical data is a common call for the entire industry. Among them, the Magnetic Resonance Imaging (MRI) retrieval system, which is one of the key tools for secure and private the Internet of Medical Things (IoMT), is significant for patients to check their conditions and doctors to make clinical diagnoses securely and privately. Hence, this paper proposes a framework named MRCG that integrates Convolutional Neural Network (CNN) and Graph Neural Network (GNN) by incorporating the relationship between multiple gallery images in the graph structure. First, we adopt a Vgg16-based triplet network jointly trained for similarity learning and classification task. Next, a graph is constructed from the extracted features of triplet CNN where each node feature encodes a query-gallery image pair. The edge weight between nodes represents the similarity between two gallery images. Finally, a GNN with skip connections is adopted to learn on the constructed graph and predict the similarity score of each query-gallery image pair. Besides, Focal loss is also adopted while training GNN to tackle the class imbalance of the nodes. Experimental results on some benchmark datasets, including the CE-MRI dataset and a public MRI dataset from the Kaggle platform, show that the proposed MRCG can achieve 88.64% mAP and 86.59% mAP, respectively. Compared with some other state-of-the-art models, the MRCG can also outperform all the baseline models.
    MeSH term(s) Humans ; Internet of Things ; Neural Networks, Computer ; Magnetic Resonance Imaging ; Databases, Factual
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2021.3130028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Efficacy and safety of low-dose esketamine for painless gastrointestinal endoscopy in adults: a systematic evaluation and meta-analysis.

    Deng, Juan / Yu, Yun-Feng / Tang, Zheng-Guo / Lei, Hua-Juan / Tan, Chuan-Chuan

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1364546

    Abstract: Object: ...

    Abstract Object:
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1364546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel UHPLC‒MS/MS method for quantitative analysis of zanubrutinib in rat plasma: application to an in vivo interaction study between zanubrutinib and triazole antifungal.

    Tang, Peng-Fei / Bao, Su-Su / Xiao, Zhong-Xiang / Xie, Wei-Fei / Wu, Xue-Meng / Ge, Hong-Lei / Shao, Chuan-Feng

    BMC chemistry

    2023  Volume 17, Issue 1, Page(s) 107

    Abstract: Background: This study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and isavuconazole in rats.: Methods: A protein precipitation method using acetonitrile was used to prepare plasma ... ...

    Abstract Background: This study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and isavuconazole in rats.
    Methods: A protein precipitation method using acetonitrile was used to prepare plasma samples using ibrutinib as an internal standard. Chromatographic separation and mass spectrometric detection of the analytes and internal standards were performed on a Shimadzu 8040 UHPLC‒MS/MS equipped with a Shim-pack velox C18 column (2.1 × 50 mm, 2.7 µm). Methanol and 0.1% formic acid-water were used as mobile phases. Intraday and interday precision and accuracy, extraction recoveries, and matrix effects of this method were determined. The linearity and sample stability of the method were assessed. Eighteen male Sprague‒Dawley (SD) rats were randomly divided into three groups with zanubrutinib (30 mg/kg) alone, zanubrutinib in combination with fluconazole (20 mg/kg) or zanubrutinib in combination with isavuconazole (20 mg/kg). Blood samples (200 µL) were collected at designated time points (ten evenly distributed time points within 12 h). The concentration of zanubrutinib was determined using the UHPLC‒MS/MS method developed in this study.
    Results: The typical fragment ions were m/z 472.15 → 290.00 for zanubrutinib and m/z 441.20 → 138.10 for ibrutinib (IS). The range of the standard curve was 1-1000 ng/mL with a regressive coefficient (R
    Conclusion: This study provides information to understand the metabolism of zanubrutinib with concurrent use with isavuconazole or fluconazole, and further clinical trials are needed to validate the results in animals.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-023-01017-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Review of dietary patterns and gastric cancer risk: epidemiology and biological evidence.

    Pu, Ke / Feng, Yang / Tang, Qian / Yang, Guodong / Xu, Chuan

    Frontiers in oncology

    2024  Volume 14, Page(s) 1333623

    Abstract: Due to rapid research expansion on dietary factors and development of cancer prevention guidelines, the field of dietary pattern and its relationship to cancer risk has gained more focus. Numerous epidemiology studies have reported associations between ... ...

    Abstract Due to rapid research expansion on dietary factors and development of cancer prevention guidelines, the field of dietary pattern and its relationship to cancer risk has gained more focus. Numerous epidemiology studies have reported associations between Gastric Cancer (GC) and both data-driven posteriori dietary pattern and priori dietary pattern defined by predetermined dietary indexes. As dietary patterns have evolved, a series of patterns based on biological markers has advanced, offering deeper insights into the relationship between diet and the risk of cancer. Although researches on dietary patterns and cancer risk are booming, there is limited body of literature focusing specifically on GC. In this study, we compare the similarities and differences among the specific components of dietary patterns and indices, summarize current state of knowledge regarding dietary patterns related to GC and illustrate their potential mechanisms for GC prevention. In conclusion, we offer suggestions for future research based on the emerging themes within this rapidly evolving field.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1333623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Efficient Experimental Verification of Quantum Gates with Local Operations.

    Zhang, Rui-Qi / Hou, Zhibo / Tang, Jun-Feng / Shang, Jiangwei / Zhu, Huangjun / Xiang, Guo-Yong / Li, Chuan-Feng / Guo, Guang-Can

    Physical review letters

    2022  Volume 128, Issue 2, Page(s) 20502

    Abstract: Verifying the correct functioning of quantum gates is a crucial step toward reliable quantum information processing, but it becomes an overwhelming challenge as the system size grows due to the dimensionality curse. Recent theoretical breakthroughs show ... ...

    Abstract Verifying the correct functioning of quantum gates is a crucial step toward reliable quantum information processing, but it becomes an overwhelming challenge as the system size grows due to the dimensionality curse. Recent theoretical breakthroughs show that it is possible to verify various important quantum gates with the optimal sample complexity of O(1/ε) using local operations only, where ε is the estimation precision. In this Letter, we propose a variant of quantum gate verification (QGV) that is robust to practical gate imperfections and experimentally realize efficient QGV on a 2-qubit controlled-not gate and a 3-qubit Toffoli gate using only local state preparations and measurements. The experimental results show that, by using only 1600 and 2600 measurements on average, we can verify with 95% confidence level that the implemented controlled-not gate and Toffoli gate have fidelities of at least 99% and 97%, respectively. Demonstrating the superior low sample complexity and experimental feasibility of QGV, our work promises a solution to the dimensionality curse in verifying large quantum devices in the quantum era.
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.020502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage.

    Tang, Chuan-Feng / Wang, Cong-Ying / Wang, Jun-Han / Wang, Qiao-Na / Li, Shen-Jie / Wang, Hai-Ou / Zhou, Feng / Li, Jian-Mei

    Nutrients

    2022  Volume 14, Issue 9

    Abstract: Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, ... ...

    Abstract Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood-brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression.
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Depression/etiology ; Fatty Acids, Volatile/metabolism ; Fructose/adverse effects ; Fructose/metabolism ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Neurogenesis
    Chemical Substances Fatty Acids, Volatile ; Fructose (30237-26-4)
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14091882
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  7. Article: Development and Validation of a UHPLC-MS/MS Method for Quantitation of Almonertinib in Rat Plasma: Application to an

    Tang, Peng-Fei / Bao, Su-Su / Gao, Nan-Yong / Shao, Chuan-Feng / Xie, Wei-Fei / Wu, Xue-Meng / Zhao, Le-Ping / Xiao, Zhong-Xiang

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 960311

    Abstract: Almonertinib was approved for the first-line treatment of advanced NSCLC patients with EGFR-TKI-sensitive genetic mutations by National Medical Products Administration (NMPA) in 2021.The purpose of this study was to establish and validate a fast, ... ...

    Abstract Almonertinib was approved for the first-line treatment of advanced NSCLC patients with EGFR-TKI-sensitive genetic mutations by National Medical Products Administration (NMPA) in 2021.The purpose of this study was to establish and validate a fast, accurate, stable and facile ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of almonertinib in rat plasma, it was employed to explore the effect of Paxlovid on the pharmacokinetics of almonertinib in rats. Zanubrutinib was used as an internal standard (IS), and the plasma samples were prepared by the protein precipitation method using acetonitrile. Chromatographic separation was carried out on a Shimadzu LC-20AT ultra-performance liquid chromatography system using a Shim-pack velox C18 (2.1× 50 mm, 2.7 μM) column. The mobile phase consisted of methanol and 0.1% formic acid-water. Mass spectrum analysis was executed using Shimadzu 8040 Triple quadrupole mass spectrometry. The precursor and product ions of the analyte and internal standard were detected in multiple reaction monitoring (MRM) mode. The typical fragment ions were
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.960311
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  8. Article ; Online: Plasmonic-Enhanced Bright Single Spin Defects in Silicon Carbide Membranes.

    Zhou, Ji-Yang / Li, Qiang / Hao, Zhi-He / Lin, Wu-Xi / He, Zhen-Xuan / Liang, Rui-Jian / Guo, Liping / Li, Hao / You, Lixing / Tang, Jian-Shun / Xu, Jin-Shi / Li, Chuan-Feng / Guo, Guang-Can

    Nano letters

    2023  Volume 23, Issue 10, Page(s) 4334–4343

    Abstract: Optically addressable spin defects in silicon carbide (SiC) have emerged as attractable platforms for various quantum technologies. However, the low photon count rate significantly limits their applications. We strongly enhanced the brightness by 7 times ...

    Abstract Optically addressable spin defects in silicon carbide (SiC) have emerged as attractable platforms for various quantum technologies. However, the low photon count rate significantly limits their applications. We strongly enhanced the brightness by 7 times and spin-control strength by 14 times of single divacancy defects in 4H-SiC membranes using a surface plasmon generated by gold film coplanar waveguides. The mechanism of the plasmonic-enhanced effect is further studied by tuning the distance between single defects and the surface of the gold film. A three-energy-level model is used to determine the corresponding transition rates consistent with the enhanced brightness of single defects. Lifetime measurements also verified the coupling between defects and surface plasmons. Our scheme is low-cost, without complicated microfabrication and delicate structures, which is applicable for other spin defects in different materials. This work would promote developing spin-defect-based quantum applications in mature SiC materials.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c00568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reflective dielectric cavity enhanced emission from hexagonal boron nitride spin defect arrays.

    Zeng, Xiao-Dong / Yang, Yuan-Ze / Guo, Nai-Jie / Li, Zhi-Peng / Wang, Zhao-An / Xie, Lin-Ke / Yu, Shang / Meng, Yu / Li, Qiang / Xu, Jin-Shi / Liu, Wei / Wang, Yi-Tao / Tang, Jian-Shun / Li, Chuan-Feng / Guo, Guang-Can

    Nanoscale

    2023  Volume 15, Issue 36, Page(s) 15000–15007

    Abstract: Among the various kinds of spin defects in hexagonal boron nitride (hBN), the negatively charged boron vacancy ( ... ...

    Abstract Among the various kinds of spin defects in hexagonal boron nitride (hBN), the negatively charged boron vacancy (V
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03486k
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  10. Article ; Online: Zero-trade-off multiparameter quantum estimation via simultaneously saturating multiple Heisenberg uncertainty relations.

    Hou, Zhibo / Tang, Jun-Feng / Chen, Hongzhen / Yuan, Haidong / Xiang, Guo-Yong / Li, Chuan-Feng / Guo, Guang-Can

    Science advances

    2021  Volume 7, Issue 1

    Abstract: Quantum estimation of a single parameter has been studied extensively. Practical applications, however, typically involve multiple parameters, for which the ultimate precision is much less understood. Here, by relating the precision limit directly to the ...

    Abstract Quantum estimation of a single parameter has been studied extensively. Practical applications, however, typically involve multiple parameters, for which the ultimate precision is much less understood. Here, by relating the precision limit directly to the Heisenberg uncertainty relation, we show that to achieve the highest precisions for multiple parameters at the same time requires the saturation of multiple Heisenberg uncertainty relations simultaneously. Guided by this insight, we experimentally demonstrate an optimally controlled multipass scheme, which saturates three Heisenberg uncertainty relations simultaneously and achieves the highest precisions for the estimation of all three parameters in SU(2) operators. With eight controls, we achieve a 13.27-dB improvement in terms of the variance (6.63 dB for the SD) over the classical scheme with the same loss. As an experiment demonstrating the simultaneous achievement of the ultimate precisions for multiple parameters, our work marks an important step in multiparameter quantum metrology with wide implications.
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abd2986
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