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  1. Article: Possible Consequences of a Shortage of Hydroxychloroquine for Patients with Systemic Lupus Erythematosus amid the COVID-19 Pandemic.

    Peschken, Christine A

    The Journal of rheumatology

    2020  Volume 47, Issue 6, Page(s) 787–790

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Female ; Humans ; Hydroxychloroquine/supply & distribution ; Hydroxychloroquine/therapeutic use ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Risk Assessment ; SARS-CoV-2 ; United States
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Canada
    Document type Editorial ; Review
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.200395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Health Disparities in Systemic Lupus Erythematosus.

    Peschken, Christine A

    Rheumatic diseases clinics of North America

    2020  Volume 46, Issue 4, Page(s) 673–683

    Abstract: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by autoantibody production and diverse clinical manifestations. The many complex, overlapping, and closely associated factors that influence SLE susceptibility ... ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by autoantibody production and diverse clinical manifestations. The many complex, overlapping, and closely associated factors that influence SLE susceptibility and outcomes include ethnic disparities, low adherence to medications, and poverty, and geography. Epigenetic mechanisms may provide the link between these environmental exposures and behaviors and the disproportionate burden of SLE seen in ethnic minorities. Attention to these modifiable social determinants of health would not only improve outcomes for vulnerable patients with SLE but likely reduce susceptibility to SLE as well through epigenetic changes.
    MeSH term(s) Ethnic Groups ; Health Status Disparities ; Humans ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/etiology ; Poverty ; Social Determinants of Health ; Vulnerable Populations/ethnology
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2020.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Disparities in rheumatoid arthritis outcomes for North American Indigenous populations.

    Hitchon, Carol A / ONeil, Liam / Peschken, Christine A / Robinson, David B / Fowler-Woods, Amanda / El-Gabalawy, Hani S

    International journal of circumpolar health

    2023  Volume 82, Issue 1, Page(s) 2166447

    Abstract: Advances in rheumatoid arthritis (RA) management have significantly improved clinical outcomes of this disease; however, some Indigenous North Americans (INA) with RA have not achieved the high rates of treatment success observed in other populations. We ...

    Abstract Advances in rheumatoid arthritis (RA) management have significantly improved clinical outcomes of this disease; however, some Indigenous North Americans (INA) with RA have not achieved the high rates of treatment success observed in other populations. We review factors contributing to poor long-term outcomes for INA with RA. We conducted a narrative review of studies evaluating RA in INA supplemented with regional administrative health and clinical cohort data on clinical outcomes and health care utilisation. We discuss factors related to conducting research in INA populations including studies of RA prevention. NA with RA have a high burden of genetic and environmental predisposing risk factors that may impact disease phenotype, delayed or limited access to rheumatology care and advanced therapy. These factors may contribute to the observed increased rates of persistent synovitis, premature end-stage joint damage and mortality. Novel models of care delivery that are culturally sensitive and address challenges associated with providing speciality care to patients residing in remote communities with limited accessibility are needed. Progress in establishing respectful research partnerships with INA communities has created a foundation for ongoing initiatives to address care gaps including those aimed at RA prevention. This review highlights some of the challenges of diagnosing, treating, and ultimately perhaps preventing, RA in INA populations.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Longitudinal Studies ; Population Groups ; Indigenous Peoples ; North America
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1386707-6
    ISSN 2242-3982 ; 1239-9736
    ISSN (online) 2242-3982
    ISSN 1239-9736
    DOI 10.1080/22423982.2023.2166447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Do Patterns of Early Disease Severity Predict Grade 12 Academic Achievement in Youths With Childhood-Onset Chronic Rheumatic Diseases?

    Lim, Lily S H / Ekuma, Okechukwu / Marrie, Ruth A / Brownell, Marni / Peschken, Christine A / Hitchon, Carol A / Gerhold, Kerstin / Lix, Lisa M

    The Journal of rheumatology

    2023  Volume 50, Issue 9, Page(s) 1165–1172

    Abstract: Objective: To test the association of early disease severity with grade 12 standards test performance in individuals with childhood-onset chronic rheumatic diseases (ChildCRDs), including juvenile arthritis and systemic autoimmune rheumatic diseases.: ...

    Abstract Objective: To test the association of early disease severity with grade 12 standards test performance in individuals with childhood-onset chronic rheumatic diseases (ChildCRDs), including juvenile arthritis and systemic autoimmune rheumatic diseases.
    Methods: We used linked provincial administrative data to identify patients with ChildCRDs born between 1979 and 1998 in Manitoba, Canada. Primary outcomes were Language and Arts Achievement Index (LAI) scores and Math Achievement Index (MAI) scores from grade 12 standards test results as well as enrollment data. The secondary outcome was enrollment in grade 12 by 17 years of age. Latent class trajectory analysis identified disease severity groups using physician visits following diagnosis. Multivariable linear regression tested the association of disease severity groups with LAI and MAI scores, and logistic regression tested the association of disease severity with age-appropriate enrollment, after adjusting for sociodemographic factors and psychiatric morbidities.
    Results: The study cohort included 541 patients, 70.1% of whom were female. A 3-class trajectory model provided the best fit; it classified 9.7% of patients as having severe disease, 54.5% as having moderate disease, and 35.8% as having mild disease. After covariate adjustment, severe disease was associated with poorer LAI and MAI scores but not with age-appropriate enrollment.
    Conclusion: Among patients with ChildCRDs, those with severe disease performed more poorly on grade 12 standards tests, independent of sociodemographic and psychiatric risk factors. Clinicians should work with educators and policy makers to advocate for supports to improve educational outcomes of patients with ChildCRDs.
    MeSH term(s) Humans ; Child ; Female ; Adolescent ; Male ; Academic Success ; Rheumatic Diseases/epidemiology ; Morbidity ; Achievement ; Patient Acuity
    Language English
    Publishing date 2023-02-01
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.220656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Severe Sensory Neuronopathy in Primary Sjögren Syndrome Resulting in Charcot Arthropathy.

    Nguyen, Mai / Peschken, Christine A

    The Journal of rheumatology

    2016  Volume 43, Issue 7, Page(s) 1449–1451

    Language English
    Publishing date 2016-07
    Publishing country Canada
    Document type Letter
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.160137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Disparities in rheumatoid arthritis outcomes for North American Indigenous populations

    Carol A Hitchon / Liam ONeil / Christine A Peschken / David B Robinson / Amanda Fowler-Woods / Hani S El-Gabalawy

    International Journal of Circumpolar Health, Vol 82, Iss

    2023  Volume 1

    Abstract: ABSTRACTAdvances in rheumatoid arthritis (RA) management have significantly improved clinical outcomes of this disease; however, some Indigenous North Americans (INA) with RA have not achieved the high rates of treatment success observed in other ... ...

    Abstract ABSTRACTAdvances in rheumatoid arthritis (RA) management have significantly improved clinical outcomes of this disease; however, some Indigenous North Americans (INA) with RA have not achieved the high rates of treatment success observed in other populations. We review factors contributing to poor long-term outcomes for INA with RA. We conducted a narrative review of studies evaluating RA in INA supplemented with regional administrative health and clinical cohort data on clinical outcomes and health care utilisation. We discuss factors related to conducting research in INA populations including studies of RA prevention. NA with RA have a high burden of genetic and environmental predisposing risk factors that may impact disease phenotype, delayed or limited access to rheumatology care and advanced therapy. These factors may contribute to the observed increased rates of persistent synovitis, premature end-stage joint damage and mortality. Novel models of care delivery that are culturally sensitive and address challenges associated with providing speciality care to patients residing in remote communities with limited accessibility are needed. Progress in establishing respectful research partnerships with INA communities has created a foundation for ongoing initiatives to address care gaps including those aimed at RA prevention. This review highlights some of the challenges of diagnosing, treating, and ultimately perhaps preventing, RA in INA populations.
    Keywords Rheumatoid arthritis ; indigenous ; disparities ; phenotype ; outcomes ; prevention ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Anxiety and Mood Disorders in Systemic Lupus Erythematosus: Current Insights and Future Directions.

    Tisseverasinghe, Annaliese / Peschken, Christine / Hitchon, Carol

    Current rheumatology reports

    2018  Volume 20, Issue 12, Page(s) 85

    Abstract: Purpose of review: Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically ...

    Abstract Purpose of review: Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE, focusing on their etiology, assessment, and management.
    Recent findings: Along with psychosocial factors, there is growing evidence for a bidirectional interaction between inflammatory pathways and SLE-associated anxiety and mood disorders. Direct immune-mediated mechanisms via autoantibodies may also play a role in some cases. With a growing number of tools used in SLE for the assessment of these conditions, the search continues for the ideal instrument to use in all future investigations to allow comparisons across studies. There is data supporting psychological interventions, but a dearth of literature on pharmacotherapy for the treatment of anxiety and mood disorders in SLE. There is a clear need for further research in anxiety and mood disorders in SLE, particularly with respect to diagnostic tools and medications, which could inform much-needed updates to current guidelines.
    MeSH term(s) Anxiety Disorders/complications ; Depressive Disorder/complications ; Disease Management ; Humans ; Lupus Erythematosus, Systemic/complications
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-018-0797-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Polypharmacy and Potentially Inappropriate Medication Use in Older Adults With Systemic Lupus Erythematosus.

    Séguin, Dale Jean-Guy / Peschken, Christine A / Dolovich, Cassandra / Grymonpre, Ruby E / St John, Philip D / Tisseverasinghe, Annaliese

    Arthritis care & research

    2022  Volume 75, Issue 2, Page(s) 356–364

    Abstract: Objective: To assess the prevalence and potential risk factors for polypharmacy and prescribing of the potentially inappropriate medications, opioids and benzodiazepines/Z-drugs, in older adults with systemic lupus erythematosus (SLE).: Methods: The ... ...

    Abstract Objective: To assess the prevalence and potential risk factors for polypharmacy and prescribing of the potentially inappropriate medications, opioids and benzodiazepines/Z-drugs, in older adults with systemic lupus erythematosus (SLE).
    Methods: The study population comprised adults age ≥50 years meeting American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria followed at a tertiary care rheumatology clinic. Information on prescriptions filled in the 4 months preceding chart review was obtained from the Manitoba Drug Program Information Network. Clinical data, including age, sex, Charlson Comorbidity Index (CCI) score, Systemic Lupus Erythematosus Disease Activity Index 2000 score, prednisone use, SLE duration, and rural residence were abstracted from electronic medical records. Logistic regression analyses were performed to assess any association between polypharmacy (using 2 definitions: ≥5 and ≥10 medications), potentially inappropriate medication use, and clinical features.
    Results: A total of 206 patients (mean age 62 years, 91% female, 36% rural) were included: 148 (72%) filled ≥5 medications, 71 (35%) filled ≥10 medications, 63 (31%) used benzodiazepines/Z-drugs, and 50 (24%) used opioids. Among the 77 patients age ≥65 years, 57 (74%) filled ≥5 medications, and 26 (34%) filled ≥10 medications, compared to 30% and 4%, respectively, of Manitobans age ≥65 years (National Prescription Drug Utilization Information System, 2016). The odds of polypharmacy were greater with prednisone use (adjusted odds ratio [OR] 3.70 [95% confidence interval (95% CI) 1.40-9.79] for ≥5 medications), CCI score (adjusted OR 1.62 [95% CI 1.20-2.17]), and rural residence (adjusted OR 2.05 [95% CI 1.01-4.18]). Odds of benzodiazepine/Z-drug use were increased with polypharmacy (adjusted OR 4.35 [95% CI 1.69-11.22]), and odds of opioid use were increased with polypharmacy (adjusted OR 6.75 [95% CI 1.93-23.69]) and CCI score (adjusted OR 1.29 [95% CI 1.08-1.54]).
    Conclusion: The prevalence of polypharmacy in this SLE cohort was higher than in the general Manitoban population. Polypharmacy is a strong marker for use of prescription benzodiazepines/Z-drugs and opioids.
    MeSH term(s) Humans ; Female ; Aged ; Middle Aged ; Male ; Potentially Inappropriate Medication List ; Polypharmacy ; Prednisone ; Analgesics, Opioid/adverse effects ; Benzodiazepines/adverse effects ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology
    Chemical Substances Prednisone (VB0R961HZT) ; Analgesics, Opioid ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.24766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The value of studying clinical and serologic phenotypes in north american native populations with autoimmune disease.

    Peschken, Christine

    The Journal of rheumatology

    2013  Volume 40, Issue 7, Page(s) 1031–1033

    MeSH term(s) Female ; Humans ; Male ; Scleroderma, Systemic/ethnology
    Language English
    Publishing date 2013-07
    Publishing country Canada
    Document type Comment ; Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.130561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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