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  1. Article: A novel approach for the quantification of paclitaxel loaded in ethyl cellulose/kollicoat and ethylcellulose/eudragit colloidal particles by UPLC-PDA.

    Ansari, Mahvash / Ranjha, Nazar Mohammad / Hanif, Muhammad / Un Nisa, Muqadus / Ali, Hassan / M Alqahtani, Ali / Alqahtani, Taha / A Khan, Barkat

    Pakistan journal of pharmaceutical sciences

    2023  Volume 35, Issue 6(Special), Page(s) 1713–1718

    Abstract: An optimized rapid reversed phase ultra-performance liquid chromatography (UPLC-PDA) method has been developed and validated for precise and accurate quantification of paclitaxel in drug delivery systems. The chromatographic separation was attained on L1 ...

    Abstract An optimized rapid reversed phase ultra-performance liquid chromatography (UPLC-PDA) method has been developed and validated for precise and accurate quantification of paclitaxel in drug delivery systems. The chromatographic separation was attained on L1 (USP) column (2.1 ×50 mm, 1.7µm) with an isocratic mobile phase comprised of acetonitrile and water (1:1; flow rate 0.6 mL/min) and detection was executed at 227 nm by PDA detector. The proposed UPLC-PDA method is found to be rapid with retention time of 1.37 min, selective with homogenous peaks and sensitive with Limit of Detection (LOD) of 0.08µg/mL and Limit of Quantification (LOQ) of 2.6µg/mL. The method showed excellent linearity (R
    MeSH term(s) Chromatography, Liquid ; Cellulose ; Paclitaxel
    Chemical Substances ethyl cellulose (7Z8S9VYZ4B) ; methylmethacrylate-methacrylic acid copolymer (25086-15-1) ; Cellulose (9004-34-6) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2023-02-27
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Willingness to Pay For Sustainable Green Clothing

    Mahnoor Mansoor Khan / Fajar Fatima / Malaika Tariq Ranjha / Sana Akhtar

    Indonesian Journal of Social and Environmental Issues, Vol 3, Iss 2, Pp 167-

    2022  Volume 178

    Abstract: The study of green sustainable clothing examined willingness to pay for green sustainable clothing. As everything is evolving around us, so does our ecosystem. Our planet earth and climate are disrupted at a very high er rate and their impacts are ... ...

    Abstract The study of green sustainable clothing examined willingness to pay for green sustainable clothing. As everything is evolving around us, so does our ecosystem. Our planet earth and climate are disrupted at a very high er rate and their impacts are becoming more serious and harmful with increasing time. The present study was conducted in Punjab Pakistan to determine the willingness to pay for green-sustainable clothing through a questionnaire survey. It was found that the majority of people are showing their willingness to pay for sustainable clothing. According to the questionnaire survey majority of the respondent who belongs to higher income are willing to pay extra Rs 500 for sustainable clothing to improve and promote sustainability. Government must start awareness campaigns for the general public to emphasize the causes and adverse impacts and various impact on socio-economic impacts due to different anthropogenic activities.
    Keywords environment-friendly ; sustainable green clothing ; willingness to pay ; Social Sciences ; H
    Subject code 710
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher CV. Literasi Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence

    Ranjha Khan / Xiaohua Jiang / Uzma Hameed / Qinghua Shi

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession ... ...

    Abstract It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession of lipids during oocyte development. Generally, lipids are mainly stored in the form of lipid droplets and are an important source of energy metabolism. Similarly, lipids are also essential signaling molecules involved in various biological cascades of oocyte maturation, growth and oocyte competence acquisition. To understand the role of lipids in controlling the oocyte development, we have comprehensively and concisely reviewed the literature and described the role of lipid metabolism in oocyte quality and maturation. Moreover, we have also presented a simplified model of fatty acid metabolism along with its implication on determining the oocyte quality and cryopreservation for fertilization.
    Keywords lipid metabolism ; oocyte development ; oocyte maturation ; fertilization ; obesity ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence.

    Khan, Ranjha / Jiang, Xiaohua / Hameed, Uzma / Shi, Qinghua

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 639704

    Abstract: It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession ... ...

    Abstract It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession of lipids during oocyte development. Generally, lipids are mainly stored in the form of lipid droplets and are an important source of energy metabolism. Similarly, lipids are also essential signaling molecules involved in various biological cascades of oocyte maturation, growth and oocyte competence acquisition. To understand the role of lipids in controlling the oocyte development, we have comprehensively and concisely reviewed the literature and described the role of lipid metabolism in oocyte quality and maturation. Moreover, we have also presented a simplified model of fatty acid metabolism along with its implication on determining the oocyte quality and cryopreservation for fertilization.
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.639704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Advances in the application of functional nanomaterial and cold plasma for the fresh-keeping active packaging of meat.

    Umair, Muhammad / Sultana, Tayyaba / Xun, Song / Jabbar, Saqib / Riaz Rajoka, Muhammad Shahid / Albahi, Amgad / Abid, Muhammad / Ranjha, Muhammad Modassar Ali Nawaz / El-Seedi, Hesham R / Xie, Fengwei / Khan, Kashif Ur Rehman / Liqing, Zhao / Zhendan, He

    Food science & nutrition

    2023  Volume 11, Issue 10, Page(s) 5753–5772

    Abstract: The most recent advancements in food science and technology include cold sterilization of food and fresh-keeping packaging. Active packaging technology has received much interest due to the photocatalytic activity (PCA) of functional nanoparticles, ... ...

    Abstract The most recent advancements in food science and technology include cold sterilization of food and fresh-keeping packaging. Active packaging technology has received much interest due to the photocatalytic activity (PCA) of functional nanoparticles, including titanium dioxide (TiO
    Language English
    Publishing date 2023-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome.

    Khan, Ranjha / Oskouian, Babak / Lee, Joanna Y / Hodgin, Jeffrey B / Yang, Yingbao / Tassew, Gizachew / Saba, Julie D

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is an inborn error of metabolism caused by inactivating mutations ... ...

    Abstract Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is an inborn error of metabolism caused by inactivating mutations in
    MeSH term(s) Animals ; Humans ; Mice ; Aldehyde-Lyases/genetics ; Aldehyde-Lyases/metabolism ; Dependovirus/genetics ; Dependovirus/metabolism ; Lysophospholipids/metabolism ; Mice, Knockout ; Parvovirinae/metabolism ; Phosphates ; Sphingosine/metabolism ; Genetic Therapy
    Chemical Substances Aldehyde-Lyases (EC 4.1.2.-) ; Lysophospholipids ; Phosphates ; Sphingosine (NGZ37HRE42) ; sphingosine 1-phosphate lyase (aldolase) (EC 4.1.2.27)
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A novel approach for the quantification of paclitaxel loaded in ethyl cellulose/kollicoat and ethylcellulose/eudragit colloidal particles by UPLC-PDA.

    Ansari, Mahvash / Ranjha, Nazar Mohammad / Hanif, Muhammad / Nisa, Muqadus Un / Ali, Hassan / Alqahtani, Ali M / Alqahtani, Taha / Khan, Barkat A

    Pakistan journal of pharmaceutical sciences

    2022  Volume 35, Issue 4(Special), Page(s) 1275–1280

    Abstract: An optimized rapid reversed phase ultra-performance liquid chromatography (UPLC-PDA) method has been developed and validated for precise and accurate quantification of paclitaxel in drug delivery systems. The chromatographic separation was attained on L1 ...

    Abstract An optimized rapid reversed phase ultra-performance liquid chromatography (UPLC-PDA) method has been developed and validated for precise and accurate quantification of paclitaxel in drug delivery systems. The chromatographic separation was attained on L1 (USP) column (2.1 ×50 mm, 1.7µm) with an isocratic mobile phase comprised of acetonitrile and water (1:1; flow rate 0.6 mL/min) and detection was executed at 227 nm by PDA detector. The proposed UPLC-PDA method is found to be rapid with retention time of 1.37 min, selective with homogenous peaks and sensitive with Limit of Detection (LOD) of 0.08µg/mL and Limit of Quantification (LOQ) of 2.6µg/mL. The method showed excellent linearity (R
    MeSH term(s) Acetonitriles ; Cellulose/analogs & derivatives ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Excipients/analysis ; Paclitaxel ; Pharmaceutical Preparations ; Polymethacrylic Acids ; Water
    Chemical Substances Acetonitriles ; Excipients ; Pharmaceutical Preparations ; Polymethacrylic Acids ; Water (059QF0KO0R) ; methylmethacrylate-methacrylic acid copolymer (25086-15-1) ; ethyl cellulose (7Z8S9VYZ4B) ; Cellulose (9004-34-6) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-09-19
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Identification of Frameshift Variants in

    Zamani, Ghazala Y / Khan, Ranjha / Karim, Noreen / Ahmed, Zubair M / Naeem, Muhammad

    Genes

    2022  Volume 13, Issue 3

    Abstract: Xeroderma pigmentosum (XP) is a rare autosomal recessive genetic disorder characterized by severe sensitivity of skin to sunlight and an increased risk of skin cancer. XP variant (XPV), a milder subtype, is caused by variants in ... ...

    Abstract Xeroderma pigmentosum (XP) is a rare autosomal recessive genetic disorder characterized by severe sensitivity of skin to sunlight and an increased risk of skin cancer. XP variant (XPV), a milder subtype, is caused by variants in the
    MeSH term(s) Adult ; Consanguinity ; DNA Repair ; DNA-Binding Proteins/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; HEK293 Cells ; Humans ; Pakistan ; Xeroderma Pigmentosum/genetics ; Xeroderma Pigmentosum/pathology
    Chemical Substances DNA-Binding Proteins ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; REV3L protein, human (EC 2.7.7.7) ; Rad30 protein (EC 2.7.7.7)
    Language English
    Publishing date 2022-03-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13030543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identification and Functional Investigation of Novel Heterozygous

    Murtaza, Ghulam / Yang, Li / Khan, Ihsan / Unar, Ahsanullah / Khan, Mazhar / Huan, Zhang / Khan, Ranjha / Shi, Qinghua

    Genetic testing and molecular biomarkers

    2021  Volume 25, Issue 10, Page(s) 654–659

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2021.0104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neurotransmission cognitive theory: A novel approach for non-invasive brain stimulation using mechanical vibrations for the rehabilitation of neurological patients.

    Khan, Aliya A / Ranjha, Shahbaz K / Akram, Muhammad U / Khawaja, Sajid G / Shaukat, Arslan

    Medical hypotheses

    2020  Volume 143, Page(s) 110078

    Abstract: Patients suffering from neurological disorders require not only the treatment but also the rehabilitation to have their productive role in society. With the advent of modern technology and neuroscience techniques, different treatments are proposed and ... ...

    Abstract Patients suffering from neurological disorders require not only the treatment but also the rehabilitation to have their productive role in society. With the advent of modern technology and neuroscience techniques, different treatments are proposed and tested clinically. We propose a therapeutic and interventional noninvasive brain stimulation method that applies mechanical vibrations to different nerve points of the body to activate the stimuli. These stimuli reach and activate dead parts of the brain which will eventually help in neurorehabilitation of such patients. We get the theoretical basis of the procedure from the concept of neurotransmission cognitive theory which is also presented in the paper. For the pilot results of the theory and its procedure, we have applied the theory/therapy to three of the patients, suffering from dysarthria and cerebral palsy and results are quite promising. More detailed clinical studies are still required to have a strong evidential basis for the procedure.
    MeSH term(s) Brain ; Cognition ; Humans ; Neurological Rehabilitation ; Synaptic Transmission ; Vibration
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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