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Book: Xi tong yu jin hua zhi wu xue zhong de fen zi biao ji

Zou, Yuping / Ge, Song / Wang, Xiaodong

(Sheng ming ke xue zhuan lun)

2001

Author's details	Zou Yuping, Ge Song, Wang Xiaodong bian zhu
Series title	Sheng ming ke xue zhuan lun
Keywords	DNA fingerprinting of plants. ; Genetic polymorphisms. ; Plant molecular genetics.
Language	Chinese
Size	vi, 266 :, ill. ;, 27 cm.
Edition	Di 1 ban.
Publisher	Ke xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	7030087119 ; 9787030087119
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer.

Ge, Li-Ping / Jin, Xi / Ma, Ding / Wang, Zi-Yu / Liu, Cheng-Lin / Zhou, Chao-Zheng / Zhao, Shen / Yu, Tian-Jian / Liu, Xi-Yu / Di, Gen-Hong / Shao, Zhi-Ming / Jiang, Yi-Zhou

Cell research

2024 Volume 34, Issue 1, Page(s) 58–75

Abstract: Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical relevance and key determinant of ITH in TNBC are poorly understood. Here, ... ...

Abstract	Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical relevance and key determinant of ITH in TNBC are poorly understood. Here, we comprehensively characterized ITH levels using multi-omics data across our center's cohort (n = 260), The Cancer Genome Atlas cohort (n = 134), and four immunotherapy-treated cohorts (n = 109). Our results revealed that high ITH was associated with poor patient survival and immunotherapy resistance. Importantly, we identified zinc finger protein 689 (ZNF689) deficiency as a crucial determinant of ITH formation. Mechanistically, the ZNF689-TRIM28 complex was found to directly bind to the promoter of long interspersed element-1 (LINE-1), inducing H3K9me3-mediated transcriptional silencing. ZNF689 deficiency reactivated LINE-1 retrotransposition to exacerbate genomic instability, which fostered ITH. Single-cell RNA sequencing, spatially resolved transcriptomics and flow cytometry analysis confirmed that ZNF689 deficiency-induced ITH inhibited antigen presentation and T-cell activation, conferring immunotherapy resistance. Pharmacological inhibition of LINE-1 significantly reduced ITH, enhanced antitumor immunity, and eventually sensitized ZNF689-deficient tumors to immunotherapy in vivo. Consistently, ZNF689 expression positively correlated with favorable prognosis and immunotherapy response in clinical samples. Altogether, our study uncovers a previously unrecognized mechanism underlying ZNF689 deficiency-induced ITH and suggests LINE-1 inhibition combined with immunotherapy as a novel treatment strategy for TNBC.
MeSH term(s)	Humans ; Immunotherapy ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/therapy ; Transcription Factors/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Drug Resistance, Neoplasm/genetics
Chemical Substances	ZNF689 protein, human ; Transcription Factors ; Apoptosis Regulatory Proteins
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-023-00909-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5283: Show issues

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Article: [Critical Review on Environmental Occurrence and Photochemical Behavior of Substituted Polycyclic Aromatic Hydrocarbons].

Ge, Lin-Ke / Wang, Zi-Yu / Cao, Sheng-Kai / Che, Xiao-Jia / Zhu, Chao / Zhang, Peng / Ma, Hong-Rui

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 7, Page(s) 3957–3969

Abstract: Substituted polycyclic aromatic hydrocarbons (SPAHs) are a type of emerging pollutant that widely exist in the environment, which also exhibit carcinogenicity, mutagenicity, and teratogenicity. These pollutants belong to toxic pollutants because of their ...

Abstract	Substituted polycyclic aromatic hydrocarbons (SPAHs) are a type of emerging pollutant that widely exist in the environment, which also exhibit carcinogenicity, mutagenicity, and teratogenicity. These pollutants belong to toxic pollutants because of their similar structures to polycyclic aromatic hydrocarbons (PAHs). Their environmental behavior and ecological risk have attracted increasing attention. Based on a literature review, we found a new breakthrough in the source, distribution, behavior, and risk of SPAHs with comparison to traditional pollutants PAHs. This paper reviewed the current research progress on the environmental occurrence and photochemical behavior of SPAHs. Their sources, formation mechanisms, and distribution characteristics in the multimedia environment were highlighted, and the photochemical transformation kinetics, pathways, and affecting factors of SPAHs in water, ice, and other media were discussed. Furthermore, the research prospects about the environmental behavior and risk of SPAHs were proposed.
Language	Chinese
Publishing date	2023-07-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202207277
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Article ; Online: Synthesis and superconductivity in yttrium-cerium hydrides at high pressures.

Chen, Liu-Cheng / Luo, Tao / Cao, Zi-Yu / Dalladay-Simpson, Philip / Huang, Ge / Peng, Di / Zhang, Li-Li / Gorelli, Federico Aiace / Zhong, Guo-Hua / Lin, Hai-Qing / Chen, Xiao-Jia

Nature communications

2024 Volume 15, Issue 1, Page(s) 1809

Abstract: Further increasing the critical temperature and/or decreasing the stabilized pressure are the general hopes for the hydride superconductors. Inspired by the low stabilized pressure associated with Ce 4f electrons in superconducting cerium superhydride ... ...

Abstract	Further increasing the critical temperature and/or decreasing the stabilized pressure are the general hopes for the hydride superconductors. Inspired by the low stabilized pressure associated with Ce 4f electrons in superconducting cerium superhydride and the high critical temperature in yttrium superhydride, we carry out seven independent runs to synthesize yttrium-cerium alloy hydrides. The synthetic process is examined by the Raman scattering and X-ray diffraction measurements. The superconductivity is obtained from the observed zero-resistance state with the detected onset critical temperatures in the range of 97-141 K. The upper critical field towards 0 K at pressure of 124 GPa is determined to be between 56 and 78 T by extrapolation of the results of the electrical transport measurements at applied magnetic fields. The analysis of the structural data and theoretical calculations suggest that the phase of Y
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46133-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The self-medication behaviors of residents and the factors related to the consideration of drug efficacy and safety-A cross-sectional study in China.

Ge, Pu / Zhang, Zi-Wei / Zhang, Jin-Zi / Lyu, Ke / Niu, Yu-Yao / Tong, Yu-Ting / Xiong, Ping / Ling, Rong / Li, Qi-Yu / Yu, Wen-Li / Min, He-Wei / Deng, Yu-Qian / Wang, Yu-Jia / Sun, Xiao-Nan / Sun, Xin-Ying / Yu, Lian / Wu, Yi-Bo

Frontiers in pharmacology

2023 Volume 14, Page(s) 1072917

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1072917
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The mechanism of Bai He Gu Jin Tang against non-small cell lung cancer revealed by network pharmacology and molecular docking.

Xie, Rui-Fei / Song, Zi-Yu / Xu-Shao, Lu-Yao / Huang, Jin-Ge / Zhao, Ting / Yang, Zi

Medicine

2022 Volume 101, Issue 52, Page(s) e32555

Abstract: Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related burden and deaths, thus effective treatment strategies with lower side effects for NSCLC are urgently needed. To systematically analyze the mechanism of Bai He Gu Jin ... ...

Abstract	Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related burden and deaths, thus effective treatment strategies with lower side effects for NSCLC are urgently needed. To systematically analyze the mechanism of Bai He Gu Jin Tang (BHGJT) against NSCLC by network pharmacology and molecular docking. Methods: The active compounds of BHGJT were obtained by searching the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine and Encyclopaedia of Traditional Chinese Medicine. Search tool for interactions of chemicals was used for acquiring the targets of BHGJT. The component-target network was mapped by Cytoscape. NSCLC-related genes were obtained by searching Genecards, DrugBank and Therapeutic Target Database. The protein-protein interaction network of intersection targets was established based on Search Tool for Recurring Instances of Neighboring Genes (STRING), and further, the therapeutic core targets were selected by topological parameters. The hub targets were transmitted to Database for Annotation, Visualization and Integrated Discovery for gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Finally, AutoDock Vina and MglTools were employed for molecular docking validation. Results: Two hundred fifty-six compounds and 237 putative targets of BHGJT-related active compounds as well as 1721potential targets of NSCLC were retrieved. Network analysis showed that 8 active compounds of BHGJT including kaempferol, quercetin, luteolin, isorhamnetin, beta-sitosterol, stigmasterol, mairin and liquiritigenin as well as 15 hub targets such as AKR1B10 and AKR1C2 contribute to the treatment of BHGJT against NSCLC. GO functional enrichment analysis shows that BHGJT could regulate many biological processes, such as apoptotic process. Three modules of the endocrine related pathways including the inflammation, hypoxia related pathways as well as the other cancer related pathways based on Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis might explain the biological mechanisms of BHGJT in treating BHGJT. The results of molecular docking verified that AKR1B10 and AKR1C2 had the strongest binding activity with the 8 key compounds of NSCLC. Conclusion: Our study reveals the mechanism of BHGJT in treating NSCLC involving multiple components, multiple targets and multiple pathways. The present study laid an initial foundation for the subsequent research and clinical application of BHGJT and its active compounds against NSCLC.
MeSH term(s)	Male ; Humans ; Molecular Docking Simulation ; Network Pharmacology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Neoplasm Recurrence, Local ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032555
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Autotransplantation of third molars with completely formed roots to replace compromised molars with the computer-aided rapid prototyping.

Xia, Jia-Jia / Ge, Zi-Yu / Fu, Xiao-Hui / Zhang, Yan-Zhen

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.

2020 Volume 32, Issue 3, Page(s) 265–271

Abstract: Objective: To describe a method to fabricate donor tooth replica to assist surgeons in preparation of recipient socket during tooth autotransplantation.: Materials and methods: A total of 28 compromised molars in 27 patients were transplanted with ... ...

Abstract	Objective: To describe a method to fabricate donor tooth replica to assist surgeons in preparation of recipient socket during tooth autotransplantation. Materials and methods: A total of 28 compromised molars in 27 patients were transplanted with third molars using computer-aided rapid prototyping (CARP) technique. Surgery time and extra-alveolar time were documented. Postoperatively, the distance between cervix of transplanted tooth and the alveolar wall was measured. The degree of postoperative pain experienced was assessed with visual analog scale at day 1, 3, and 7. Results: From 28 clinical cases, the average extra-alveolar time and surgery time were 2.5 minutes (±1.3) and 44 minutes (±6.8), respectively. Postoperatively, the average distance between cervix of transplanted tooth and the alveolar wall was 0.87 mm (±0.15) at the mesial-cervix, 0.95 mm (±0.17) at the distal-cervix, 0.88 mm (±0.18) at the buccal-cervix, and 0.95 mm (±0.13) at the lingual-cervix. The value of visual analog scale score significantly decreased from day 1 to day 3. Conclusions: CARP is a reliable technique for fabrication of tooth like surgical replicas in conventional autotransplantation. Clinical significance: CARP technique minimized extra-oral time, reduced iatrogenic damage, and consequently increased the survival rate of tooth autotransplantation.
MeSH term(s)	Cone-Beam Computed Tomography ; Female ; Humans ; Molar ; Molar, Third ; Surgery, Computer-Assisted ; Tooth ; Transplantation, Autologous
Language	English
Publishing date	2020-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2043146-6
ISSN	1708-8240 ; 1496-4155
ISSN (online)	1708-8240
ISSN	1496-4155
DOI	10.1111/jerd.12573
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3314: Show issues

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Article ; Online: Synthesis of superconducting phase of La

Huang, Ge / Peng, Di / Luo, Tao / Chen, Liu-Cheng / Dalladay-Simpson, Philip / Cao, Zi-Yu / Gorelli, Federico A / Zhong, Guo-Hua / Lin, Hai-Qing / Chen, Xiao-Jia

Journal of physics. Condensed matter : an Institute of Physics journal

2023 Volume 36, Issue 7

Abstract: Clathrate hydrideFm3-m- ... ...

Abstract	Clathrate hydrideFm3-m-LaH
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ad0915
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibition of hippocampal cyclin-dependent kinase 5 activity ameliorates learning and memory dysfunction in a mouse model of bronchopulmonary dysplasia.

Tao, Fang-Fei / Wang, Zi-Yu / Wang, Ying / Lv, Qian-Ru / Cai, Peng-Peng / Min, Hai-Wen / Ge, Jian-Wei / Yin, Chun-Yu / Cheng, Rui

CNS neuroscience & therapeutics

2023 Volume 29, Issue 8, Page(s) 2339–2354

Abstract: Aims: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), which is the independent risk factor for neurodevelopment deficits in premature infants. However, the effect of hippocampal cyclin-dependent kinase 5 (CDK5) ... ...

Abstract	Aims: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), which is the independent risk factor for neurodevelopment deficits in premature infants. However, the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. Methods: Mice were placed in a hyperoxia chamber from postnatal Day 1 to Day 7. Hematoxylin and eosin staining was used to evaluate the lung histomorphological characteristics. Learning and memory functions of mice were detected by Morris water maze. TUNEL staining was applied to measure the number of apoptotic cells. The expression of CDK5, apoptosis-related protein, and neuroplasticity-related proteins were analyzed by Western blot. Golgi staining was used to assess the structure of dendritic spines. Results: Hyperoxia-induced BPD mice showed a long-term learning and memory dysfunction, more severe neuronal apoptosis, and a decline of synaptic plasticity. Inhibition of CDK5 overactivation ameliorated cognitive deficits, neuronal apoptosis, and synaptic plasticity disorders in BPD mice. Conclusions: This study first found a vital role of CDK5 in BPD-associated neurodevelopmental disorders. Inhibition of CDK5 overexpression could effectively improve cognitive dysfunctions in BPD mice, which indicated that hippocampal CDK5 may be a new target for prevention and treatment in learning and memory dysfunction of BPD.
MeSH term(s)	Animals ; Mice ; Bronchopulmonary Dysplasia/drug therapy ; Bronchopulmonary Dysplasia/complications ; Cyclin-Dependent Kinase 5/metabolism ; Disease Models, Animal ; Hippocampus/metabolism ; Hyperoxia/complications ; Hyperoxia/metabolism ; Learning ; Memory Disorders
Chemical Substances	Cyclin-Dependent Kinase 5 (EC 2.7.11.1) ; Cdk5 protein, mouse (EC 2.7.11.22)
Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4537: Show issues

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Article ; Online: Establishment of Indirect Competitive Enzyme-linked Immunosorbent Assay (ic-ELISA) for Copper ion (Cu

Fu, Xian-Shu / Li, Chao-Feng / Ji, Qing-Ge / Yu, Xiao-Ping / Ye, Zi-Hong / Zhang, Ming-Zhou / Zhang, Biao / Qiu, Yu-Lou

Journal of food protection

2024 Volume 87, Issue 5, Page(s) 100262

Abstract: Adding an appropriate amount of copper to feed can promote the growth and development of livestock; however, a large amount of heavy metal copper can accumulate in livestock through the enrichment effect, which poses a serious threat to human health. ... ...

Abstract	Adding an appropriate amount of copper to feed can promote the growth and development of livestock; however, a large amount of heavy metal copper can accumulate in livestock through the enrichment effect, which poses a serious threat to human health. Traditional Cu
MeSH term(s)	Copper ; Enzyme-Linked Immunosorbent Assay/methods ; Animals ; Meat Products/analysis ; Mice ; Food Contamination/analysis ; Humans ; Swine
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.1016/j.jfp.2024.100262
Database	MEDical Literature Analysis and Retrieval System OnLINE

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