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  1. Article ; Online: Possible application of H

    Evgen'ev, Mikhail B / Frenkel, Anton

    Cell stress & chaperones

    2020  Volume 25, Issue 5, Page(s) 713–715

    MeSH term(s) Administration, Inhalation ; Animals ; Anti-Inflammatory Agents/therapeutic use ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Hydrogen Sulfide/therapeutic use ; Injections, Intravenous ; Mice ; Pandemics ; Pneumonia, Bacterial/therapy ; Pneumonia, Viral/therapy ; Rats ; Thiosulfates/therapeutic use ; Ventilator-Induced Lung Injury/therapy
    Chemical Substances Anti-Inflammatory Agents ; Thiosulfates ; sodium thiosulfate (HX1032V43M) ; Hydrogen Sulfide (YY9FVM7NSN)
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-020-01120-1
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    Zs.A 4797: Show issues Location:
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  2. Article ; Online: Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia

    Evgen’ev, Mikhail B. / Frenkel, Anton

    Cell Stress and Chaperones

    2020  Volume 25, Issue 5, Page(s) 713–715

    Keywords Cell Biology ; Biochemistry ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-020-01120-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.

    Shaposhnikov, Mikhail V / Zakluta, Alexey S / Zemskaya, Nadezhda V / Guvatova, Zulfiya G / Shilova, Victoria Y / Yakovleva, Daria V / Gorbunova, Anastasia A / Koval, Liubov A / Ulyasheva, Natalia S / Evgen'ev, Mikhail B / Zatsepina, Olga G / Moskalev, Alexey A

    Mechanisms of ageing and development

    2022  Volume 203, Page(s) 111656

    Abstract: The gasotransmitter hydrogen sulfide ( ... ...

    Abstract The gasotransmitter hydrogen sulfide (H
    MeSH term(s) Animals ; Cystathionine ; Cystathionine beta-Synthase/genetics ; Cystathionine beta-Synthase/metabolism ; Cystathionine gamma-Lyase/genetics ; Cystathionine gamma-Lyase/metabolism ; Cysteine ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Hydrogen Sulfide/metabolism ; Longevity
    Chemical Substances Cystathionine (375YFJ481O) ; Cystathionine beta-Synthase (EC 4.2.1.22) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Cysteine (K848JZ4886) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-03-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia

    Evgen039, / ev, Mikhail B / Frenkel, Anton

    Cell Stress Chaperones

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #260151
    Database COVID19

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  5. Article ; Online: FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy.

    Funikov, Sergei Y / Rezvykh, Alexander P / Mazin, Pavel V / Morozov, Alexey V / Maltsev, Andrey V / Chicheva, Maria M / Vikhareva, Ekaterina A / Evgen'ev, Mikhail B / Ustyugov, Aleksey A

    Neurogenetics

    2018  Volume 19, Issue 3, Page(s) 189–204

    Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that leads to the eventual death of motor neurons. Described cases of familial ALS have emphasized the significance of protein misfolding and aggregation of two functionally related ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that leads to the eventual death of motor neurons. Described cases of familial ALS have emphasized the significance of protein misfolding and aggregation of two functionally related proteins, FUS (fused in sarcoma) and TDP-43, implicated in RNA metabolism. Herein, we performed a comprehensive analysis of the in vivo model of FUS-mediated proteinopathy (ΔFUS(1-359) mice). First, we used the Noldus CatWalk system and confocal microscopy to determine the time of onset of the first clinical symptoms and the appearance of FUS-positive inclusions in the cytoplasm of neuronal cells. Second, we applied RNA-seq to evaluate changes in the gene expression profile encompassing the pre-symptomatic and the symptomatic stages of disease progression in motor neurons and the surrounding microglia of the spinal cord. The resulting data show that FUS-mediated proteinopathy is virtually asymptomatic in terms of both the clinical symptoms and the molecular aspects of neurodegeneration until it reaches the terminal stage of disease progression (120 days from birth). After this time, the pathological process develops very rapidly, resulting in the formation of massive FUS-positive inclusions accompanied by a transcriptional "burst" in the spinal cord cells. Specifically, it manifests in activation of a pro-inflammatory phenotype of microglial cells and malfunction of acetylcholine synapse transmission in motor neurons. Overall, we assume that the highly reproducible course of the pathological process, as well as the described accompanying features, makes ΔFUS(1-359) mice a convenient model for testing potential therapeutics against proteinopathy-induced decay of motor neurons.
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Disease Models, Animal ; Inclusion Bodies/metabolism ; Inclusion Bodies/pathology ; Male ; Mice ; Mice, Transgenic ; Motor Neurons/physiology ; Proteostasis Deficiencies/genetics ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/pathology ; RNA-Binding Protein FUS/genetics ; Signal Transduction/genetics ; Spinal Cord/metabolism ; Spinal Cord/pathology
    Chemical Substances FUS protein, mouse ; RNA-Binding Protein FUS
    Language English
    Publishing date 2018-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339887-8
    ISSN 1364-6753 ; 1364-6745
    ISSN (online) 1364-6753
    ISSN 1364-6745
    DOI 10.1007/s10048-018-0553-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hsp70 family proteins seem to facilitate allo- and xenotransplantation in the rat brain.

    Korochkin, Leonid I / Alexandrova, Maria A / Pavlova, Galina V / Bashkirov, Viktor N / Revischin, Alexander V / Alexenko, Oxana A / Evgen'ev, Mikhail B

    Tsitologiia

    2002  Volume 44, Issue 8, Page(s) 803–806

    Abstract: Drosophila neuroectodermal embryonic cells were transplanted into the occipital brain region of adult rats. The first series of experiments used a transgenic strain expressing lacZ to detect the presence of Drosophila cells. The second series used a ... ...

    Abstract Drosophila neuroectodermal embryonic cells were transplanted into the occipital brain region of adult rats. The first series of experiments used a transgenic strain expressing lacZ to detect the presence of Drosophila cells. The second series used a strain carrying a is lethal (ts403) in the X chromosome; this mutation strongly inhibits the synthesis of heat shock proteins (hsps) and their transport into the nuclei. Immunostaining reveals a strong induction of hsp70 in the xenografts in the first series of experiments, in which no glial scar was detectable. By contrast, where the ts mutation was xenotransplanted, the condition of xenografts was worse, and a glial scar was readily evident between the xenograft and host tissue.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Transplantation ; Drosophila/embryology ; Drosophila/genetics ; Embryo, Nonmammalian/cytology ; HSP70 Heat-Shock Proteins/biosynthesis ; Immunohistochemistry ; Nerve Tissue/cytology ; Nerve Tissue/embryology ; Neuroglia/pathology ; Occipital Lobe/metabolism ; Occipital Lobe/pathology ; Occipital Lobe/surgery ; Rats ; Transplantation, Heterologous
    Chemical Substances HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2002
    Publishing country Russia (Federation)
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280565-0
    ISSN 0041-3771
    ISSN 0041-3771
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  7. Article ; Online: Exogenous mammalian extracellular HSP70 reduces endotoxin manifestations at the cellular and organism levels.

    Rozhkova, Elena / Yurinskaya, Marina / Zatsepina, Olga / Garbuz, David / Karpov, Vadim / Surkov, Sergei / Murashev, Arkady / Ostrov, Vladimir / Margulis, Boris / Evgen'ev, Mikhail / Vinokurov, Maxim

    Annals of the New York Academy of Sciences

    2010  Volume 1197, Page(s) 94–107

    Abstract: In this study, we checked whether HSP70 preparations of different origins are able to protect model animals (rats) from endotoxic shock and modify the response of myeloid cells to lipopolysaccharide (LPS) challenge. It was shown that HSP70 preparations ... ...

    Abstract In this study, we checked whether HSP70 preparations of different origins are able to protect model animals (rats) from endotoxic shock and modify the response of myeloid cells to lipopolysaccharide (LPS) challenge. It was shown that HSP70 preparations can effectively protect organisms from endotoxic shock by strongly decreasing mortality and restoring both homeostasis and various hemodynamic characteristics. At the cellular level, HSP70 preparations significantly inhibit LPS-induced reactive oxygen species production in various myeloid cells and decrease NO expression in macrophages, which is enhanced after LPS priming. In parallel, HSP70 preconditioning partially normalizes neutrophil apoptosis, which is disturbed as a result of LPS stimulation. These results suggest that the antiseptic actions of HSP70 preparations are probably realized at the level of receptor membrane complexes of myeloid cells, which represent the major target of LPS action. Taken together, our findings show that extracellular mammalian HSP70 may play an important role in innate immunity modulation and stimulation of endogenous protective mechanisms, both at the cellular and organism levels, which make this protein a promising base for the development of efficient antiseptic drugs.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; Cells/immunology ; Cells/metabolism ; Endotoxins/immunology ; HSP70 Heat-Shock Proteins/immunology ; HSP70 Heat-Shock Proteins/metabolism ; Hemodynamics/drug effects ; Immunity, Innate ; Lipopolysaccharides/immunology ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/toxicity ; Male ; Mammals/immunology ; Mammals/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/immunology ; Shock, Septic/immunology
    Chemical Substances Endotoxins ; HSP70 Heat-Shock Proteins ; Lipopolysaccharides ; Reactive Oxygen Species
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2009.05375.x
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  8. Article ; Online: RUSSIAN SOCIETY AND POWER ON THE EVE OF THE 2018 PRESIDENTIAL ELECTIONS (ROUND TABLE)

    Andrei Y. SHutov / Elena B. SHestopal / Aleksandr I. Solov'ev / Vladimir V. Petukhov / Elena S. Petrenko / Mikhail V. Mamonov / Aleksandr S. Barsenkov / Aleksei Y. Zudin / Sergei E. Zaslavskii / Boris I. Makarenko / Tat'yana A. SHtukina / Igor' I. Kuznetsov / YUliya D. Artamonova / Vasilii A. Zorin / Kirill O. Telin / Ekaterina P. Dobrynina / Maksim I. ZHestkov / Andrei L. Zverev / Tat'yana V. Evgen'eva /
    Natal'ya V. Smul'kina

    Вестник Московского государственного областного университета, Iss

    2018  Volume 1

    Abstract: In the format of the round table, which was organized on November 18, 2017, at the Department of Sociology and Psychology of Politics, Faculty of Political Science, Lomonosov Moscow State University, an expert discussion took place on the topic “Russian ... ...

    Abstract In the format of the round table, which was organized on November 18, 2017, at the Department of Sociology and Psychology of Politics, Faculty of Political Science, Lomonosov Moscow State University, an expert discussion took place on the topic “Russian society and power on the eve of 2018 presidential elections”. The main discussed issues were the psychological peculiarities of the Russian society in the context of presidential elections (the political demands of the Russians, the perception of the electoral process in the Russian society, political values) as well as the status of the elites on the eve of the 2018 presidential elections. The experts of the round table were sociologists and politologists from Lomonosov Moscow State University, Higher School of Economics, Chelyabinsk State University, Institute of Sociology of the Russian Academy of Sciences, “Public opinion” Fund, Russian Public Opinion Research Center (VCIOM), Center of Political Technology, Institute of Social-economic and Political Research, Center of Socio-political Projects and Communication. Representatives of the Council of Federation of the Federal Assembly of the Russian Federation, of the “Rossiyskaya Gazeta” and of the International News Agency “Rossiya Segodnya” also took part in the discussion.
    Keywords society ; political power ; Russian politics ; president ; the 2018 presidential elections ; political psychology ; Political science ; J
    Language Russian
    Publishing date 2018-03-01T00:00:00Z
    Publisher Moscow Region State University Editorial Office
    Document type Article ; Online
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