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  1. Article ; Online: Characteristic volatile components analysis of

    Li, Feifei / Liu, Yuqing / Zhu, Jie / Li, Zhining / Zhang, Lixian / Ma, Yanni / Yu, Liqin

    Natural product research

    2024  , Page(s) 1–5

    Abstract: ... Camelina ... ...

    Abstract Camelina sativa
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2334876
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  2. Article ; Online: Multienzyme-Mediated Dual-Channel Magnetic Relaxation Switching Taste Biosensor (D-MRSTB) for Simultaneous Detection of Umami Compounds and Synergistic Enhancement in Food.

    Kong, Liqin / Dong, Yongzhen / Shu, Guoqiang / Feng, Yaoze / Zhu, Ming

    ACS sensors

    2024  Volume 9, Issue 4, Page(s) 1820–1830

    Abstract: Umami substances play a significant role in the evaluation of food quality, and their synergistic enhancement is of great importance in improving and intensifying food flavors and tastes. Current biosensors available for umami detection still confront ... ...

    Abstract Umami substances play a significant role in the evaluation of food quality, and their synergistic enhancement is of great importance in improving and intensifying food flavors and tastes. Current biosensors available for umami detection still confront challenges in simultaneous quantification of multiple umami substances and umami intensities. In this study, an innovative dual-channel magnetic relaxation switching taste biosensor (D-MRSTB) was developed for the quantitative detection of representative umami substances. The multienzyme signal of D-MRSTB specifically catalyzes the umami substances of interest to generate hydrogen peroxide (H
    MeSH term(s) Biosensing Techniques/methods ; Sodium Glutamate/chemistry ; Taste ; Inosine Monophosphate/analysis ; Inosine Monophosphate/chemistry ; Limit of Detection ; Food Analysis/methods ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/analysis ; Magnetic Phenomena ; Flavoring Agents/analysis ; Flavoring Agents/chemistry
    Chemical Substances Sodium Glutamate (W81N5U6R6U) ; Inosine Monophosphate (131-99-7) ; Hydrogen Peroxide (BBX060AN9V) ; Flavoring Agents
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c02366
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  3. Article ; Online: Active pullulan-based coatings incorporated with

    An, Zhaoxiang / Yuan, Meng / Xu, Xian / Huang, Zhanwang / Zhu, Liqin / Cai, Zhipeng / Shen, Yonggen

    Food science and biotechnology

    2023  Volume 33, Issue 5, Page(s) 1147–1161

    Abstract: In the present study, ...

    Abstract In the present study,
    Language English
    Publishing date 2023-09-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-023-01420-z
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    Z 7438: Show issues

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  4. Article ; Online: The effect of SGLT2i on the GH/IGF1 axis in newly diagnosed male T2D patients - a prospective, randomized case-control study.

    Lin, Jing / Zhan, Liqin / Chen, Zheng / Lin, Xiaying / Zhu, Rongfeng

    Endocrine

    2024  Volume 84, Issue 1, Page(s) 203–212

    Abstract: Purpose: To investigate the effect of SGLT2i on the GH/IGF1 axis in male patients with newly diagnosed type 2 diabetes (T2D).: Methods: Sixty male patients with newly diagnosed T2D were recruited, and randomly assigned to Metformin+SGLT2i group or ... ...

    Abstract Purpose: To investigate the effect of SGLT2i on the GH/IGF1 axis in male patients with newly diagnosed type 2 diabetes (T2D).
    Methods: Sixty male patients with newly diagnosed T2D were recruited, and randomly assigned to Metformin+SGLT2i group or Metformin group after baseline assessment. All patients received standard lifestyle interventions, and blood indices were obtained before and after 12 weeks of treatment.
    Results: After 12 weeks of treatment with Metformin+SGLT2i, there were noteworthy improvements in patients' FPG (Fasting plasma glucose), HBA1c, HOMA-IR, HOMA-β, TyG (Triglyceride-glucose) index and UACR (P < 0.05). Both IGF1 (P = 0.01) and the IGF1/IGFBP3 ratio (P < 0.01) considerably increased, while GH and IGFBP3 did not show significant changes. When comparing Metformin+SGLT2i group to Metformin group, SGLT2i significantly improved HOMA-IR [P = 0.04], and elevated IGF1/IGFBP3 ratio [P = 0.04], SGLT2i showed a tendency of increasing IGF1 (P = 0.10), but this was not statistically meaningful. There was no effect on GH and IGFBP3. Correlation analysis showed that blood IGF1 was negatively correlated with FPG, HBA1c, HOMA-IR, TyG index and positively correlated with IGFBP3. Regression analysis indicated that FPG and testosterone had a negative effect on blood IGF1 level, while HOMA-IR had no obvious effect.
    Conclusion: In male patients with newly diagnosed T2D, SGLT2i can increase IGF1/IGFBP3 ratio, alleviate insulin resistance, but has no significant effect on GH and IGF1 levels. Additionally, our study showed that Metformin+SGLT2i treatment resulted in an increase in blood IGF1 levels and improved insulin resistance, suggesting a potentially beneficial role of IGF1 in newly diagnosed T2D.
    MeSH term(s) Humans ; Male ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Insulin Resistance ; Glycated Hemoglobin ; Case-Control Studies ; Prospective Studies ; Blood Glucose/analysis ; Metformin/therapeutic use ; Insulin-Like Growth Factor I
    Chemical Substances Hypoglycemic Agents ; Glycated Hemoglobin ; Blood Glucose ; Metformin (9100L32L2N) ; IGF1 protein, human ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03652-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Identification of Sex-Specific Markers and Candidate Genes Using WGS Sequencing Reveals a ZW-Type Sex-Determination System in the Chinese Soft-Shell Turtle (

    Zhu, Junxian / Wang, Yongchang / Chen, Chen / Ji, Liqin / Hong, Xiaoyou / Liu, Xiaoli / Chen, Haigang / Wei, Chengqing / Zhu, Xinping / Li, Wei

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Male and female Chinese soft-shelled turtles ( ...

    Abstract Male and female Chinese soft-shelled turtles (
    MeSH term(s) Female ; Male ; Animals ; Turtles/genetics ; Reptiles
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020819
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  6. Article ; Online: The state and consideration for skin test of β-lactam antibiotics in pediatrics.

    Gao, Chunhui / Ma, Bowen / Liu, Wei / Zhu, Liqin

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1147976

    Abstract: β-lactam antibiotics are the most frequently used drugs and the most common drugs that cause allergic reactions in pediatrics. The occurrence of some allergic reactions can be predicted by skin testing, especially severe adverse reactions such as ... ...

    Abstract β-lactam antibiotics are the most frequently used drugs and the most common drugs that cause allergic reactions in pediatrics. The occurrence of some allergic reactions can be predicted by skin testing, especially severe adverse reactions such as anaphylactic shock. Thus, penicillin and cephalosporin skin tests are widely used to predict allergic reactions before medication in pediatrics. However, false-positive results from skin tests were more often encountered in pediatrics than in adults. In fact, many children labeled as allergic to β-lactam are not allergic to the antibiotic, leading to the use of alternative antibiotics, which are less effective and more toxic, and the increase of antibiotic resistance. There has been controversy over whether β-lactam antibiotics should be tested for skin allergies before application in children. Based on the great controversy in the implementation of β-lactam antibiotic skin tests, especially the controversial cephalosporin skin tests in pediatrics, the mechanism and reasons of anaphylaxis to β-lactam antibiotics, the significance of β-lactam antibiotic skin tests, the current state of β-lactam antibiotic skin tests at home and abroad, and the problems of domestic and international skin tests were analyzed to determine a unified standard of β-lactam antibiotic skin tests in pediatrics to prevent and decrease adverse drug reactions, avoid waste of drugs, and a large amount of manpower and material resource consumption.
    MeSH term(s) Adult ; Child ; Humans ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Skin Tests ; Anti-Bacterial Agents/adverse effects ; beta-Lactams/adverse effects ; Penicillins/adverse effects ; Monobactams ; Cephalosporins/adverse effects ; Anaphylaxis ; Pediatrics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; Penicillins ; Monobactams ; Cephalosporins
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1147976
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  7. Article: Latamoxef dosing regimen adjustments and pharmaceutical care in pediatrics.

    Zhang, Ailin / Zuo, Meiling / Sun, Yuxuan / Chen, Jingtao / Zhu, Liqin / Liu, Wei

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1302087

    Abstract: Latamoxef is a semi-synthetic, broad-spectrum oxacephem antibiotic used primarily to treat infectious diseases, but the adverse drug reactions, such as the risk of fatal bleeding, once caused physicians to use it less frequently. However, with the rise ... ...

    Abstract Latamoxef is a semi-synthetic, broad-spectrum oxacephem antibiotic used primarily to treat infectious diseases, but the adverse drug reactions, such as the risk of fatal bleeding, once caused physicians to use it less frequently. However, with the rise of antibiotic-resistant bacterial strains, latamoxef is being used again to treat infectious diseases, especially in pediatrics. The pharmacokinetic parameters of latamoxef are highly variable, given the changes in body composition, organ maturation, and development that occurs in pediatrics. Therefore, an appropriate dosing regimen is essential. Latamoxef dosing optimization in pediatrics should adequately account for current body weight, postnatal age, postmenstrual age, and different minimum inhibitory concentration (MIC) values. In addition, attention should also be paid to some of the adverse reactions associated with latamoxef, such as coagulation disorders and bleeding risks, disulfiram-like reactions, as well as hypersensitivity and anaphylactic shock. This review summarizes the dosing regimens and some key points of pharmaceutical care for latamoxef in pediatrics in order to provide a better reference for its application in clinical practice.
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1302087
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  8. Article ; Online: Sustainable all-weather CO

    Shi, Xianjin / Huang, Yu / Long, Ran / Wang, Zhenyu / Wang, Liqin / Cao, Junji / Zhu, Gangqiang / Xiong, Yujie

    National science review

    2023  Volume 11, Issue 2, Page(s) nwad275

    Abstract: Solar-driven ... ...

    Abstract Solar-driven CO
    Language English
    Publishing date 2023-10-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwad275
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  9. Article ; Online: Acute and subchronic oral toxicity study of Camelina sativa oil in Wistar rats

    Ying Xia / Jie Zhu / Min Qu / Wenxiang Yang / Shaohua Fu / Liqin Yu / Bolin Fan

    Heliyon, Vol 10, Iss 1, Pp e23654- (2024)

    1481  

    Abstract: Objective: The aim of these studies was to ascertain if Camelina sativa oil is harmful in both the acute and subchronic states. Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral Camelina sativa ... ...

    Abstract Objective: The aim of these studies was to ascertain if Camelina sativa oil is harmful in both the acute and subchronic states. Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral Camelina sativa oil was greater than 27.6 g/kg bw. Rats were gavaged with Camelina sativa oil at dosages of 0.00, 0.92, 1.84, and 3.68 g/kg bw per day for 90 days. In addition, satellite groups were established in the control and high-dose groups for a 28-day recovery period. The following factors were assessed: mortality, clinical anomalies, body weight, food intake, hematological, serum biochemistry, urine, gross necropsy, and histology. Results: There were no observable toxicity-related changes in any of the three dosage groups. There is no toxicological relevance to the change in the high-dose hematological indicator PLT at the conclusion of the recovery period because it was within the usual range for this strain in our laboratory. The test material did not result in any pathological alterations, according to a pathological examination. Conclusion: Since the results of the current study, the no-observed-adverse-effect-level (NOAEL) for Camelina sativa oil in rats has been determined to be greater than 3.68 g/kg bw.
    Keywords Camelina sativa oil ; α-linolenic acid ; Subchronic toxicity ; No observed adverse effect level ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 630
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Foxq1 Promotes Alveolar Epithelial Cell Death through Tle1-mediated Inhibition of the NFκB Signaling Pathway.

    Zhu, Xi / Hua, Ershi / Tu, Qifeng / Liu, Mei / Xu, Liqin / Feng, Jian

    American journal of respiratory cell and molecular biology

    2024  

    Abstract: Acute lung injury is a common respiratory disease characterized by diffuse alveolar injury and interstitial edema, as well as a hyperinflammatory response, lung cell damage and oxidative stress. Foxq1, a member of the FOX family of transcription factors, ...

    Abstract Acute lung injury is a common respiratory disease characterized by diffuse alveolar injury and interstitial edema, as well as a hyperinflammatory response, lung cell damage and oxidative stress. Foxq1, a member of the FOX family of transcription factors, is expressed in various tissues, such as the lungs, liver, and kidneys, and contributes to various biological processes, such as stress, metabolism, cell cycle arrest, and aging-related apoptosis. However, the role of Foxq1 in acute lung injury is unknown. We constructed ex vivo and in vivo acute lung injury models by lipopolysaccharide tracheal perfusion of ICR mice and conditioned medium stimulation of injured MLE-12 cells. Foxq1 expression was increased, and its localization was altered in our acute lung injury model. In normal or injured MLE-12 cells, knockdown of Foxq1 promoted cell survival, and overexpression had the opposite effect. This regulatory effect was likely mediated by Tle1 and the NFκB/Bcl2/Bax signaling pathway. These data suggest a potential link between Foxq1 and acute lung injury, indicating that Foxq1 can be used as a biomarker for the diagnosis of acute lung injury. Targeted inhibition of Foxq1 expression could promote alveolar epithelial cell survival and may provide a strategy for mitigating acute lung injury.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0317OC
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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