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Article ; Online: Laboratory animals as potential biosensors to predict earthquakes.

Manda, Kailash

Lab animal

2023 Volume 52, Issue 5, Page(s) 97–98

MeSH term(s)	Animals ; Earthquakes ; Animals, Laboratory
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Letter
ISSN	1548-4475
ISSN (online)	1548-4475
DOI	10.1038/s41684-023-01165-6
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Article ; Online: Possible challenges in behavioral phenotyping of rodents following COVID-19 lockdown.

Manda, Kailash

Lab animal

2020 Volume 49, Issue 6, Page(s) 159

MeSH term(s)	Animal Husbandry ; Animals ; Behavior, Animal ; Brain/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Earth, Planet ; Mice ; Pandemics ; Pneumonia, Viral/epidemiology ; Vibration
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Letter
ISSN	1548-4475
ISSN (online)	1548-4475
DOI	10.1038/s41684-020-0559-4
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Article: Possible challenges in behavioral phenotyping of rodents following COVID-19 lockdown

Manda, Kailash

Lab Anim (NY)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #244488
Database	COVID19

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Article ; Online: Possible challenges in behavioral phenotyping of rodents following COVID-19 lockdown

Manda, Kailash

Lab Animal

2020 Volume 49, Issue 6, Page(s) 159–159

Keywords	Animal Science and Zoology ; General Veterinary ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ISSN	0093-7355
DOI	10.1038/s41684-020-0559-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intranasal (2R, 6R)-hydroxynorketamine for acute pain: Behavioural and neurophysiological safety analysis in mice.

Goswami, Nidhi / Aleem, Mohd / Manda, Kailash

Clinical and experimental pharmacology & physiology

2022 Volume 50, Issue 2, Page(s) 169–177

Abstract: Ketamine is known for its antinociceptive effect and is also used for treatment-resistant depression. However, the efficacy and safety of (2R, 6R)-hydroxynorketamine (HNK), a ketamine metabolite has been sparingly investigated for acute pain management. ... ...

Abstract	Ketamine is known for its antinociceptive effect and is also used for treatment-resistant depression. However, the efficacy and safety of (2R, 6R)-hydroxynorketamine (HNK), a ketamine metabolite has been sparingly investigated for acute pain management. The current study aims at investigating the antinociceptive effect of intranasal (2R, 6R)-HNK using pre-clinical models of acute pain. Additionally, the behavioural and neurophysiological safety analyses were carried out for the effective time window. Antinociceptive efficacy of (2R, 6R)-HNK was evaluated using the hot plate test and Hargreaves' plantar test. The formalin test was carried out in both the acute and tonic phases. The neurophysiological and behavioural safety analyses were carried out separately for the haemodynamic function, cortical electroencephalography (EEG), and spontaneous behavioural functions. Analgesic effect of (2R, 6R)-HNK was evident by a significant increase in paw-withdrawal latency in both Hargreaves' and hot plate tests. Additionally, the (2R, 6R)-HNK showed a significant ameliorative effect on pain-related behaviour in the second phase of the formalin test. (2R, 6R)-HNK exhibited an anxiolytic effect without causing any significant changes in locomotor activity and haemodynamic parameters. Power spectral density (PSD) analysis of electroencephalogram revealed no significant changes except a comparative increase in the gamma band range. Both the locomotor functions in the open field test and the PSD value of delta wave indicated no sedative effect at the given dose of (2R, 6R)-HNK. The results demonstrated the pain-alleviating effect of (2R, 6R)-HNK without compromising the neurophysiological and behavioural function. Therefore, intranasal (2R, 6R)-HNK is suggested as a safe candidate for further clinical study in the management of acute pain.
MeSH term(s)	Mice ; Animals ; Ketamine ; Antidepressive Agents ; Acute Pain/drug therapy ; Depression ; Analgesics/pharmacology ; Analgesics/therapeutic use
Chemical Substances	Ketamine (690G0D6V8H) ; Antidepressive Agents ; Analgesics
Language	English
Publishing date	2022-11-30
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.13737
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Zs.A 990: Show issues

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Article ; Online: Serum biomarkers based neurotrauma severity scale: a study in the mice model of fluid percussion injury.

Aleem, Mohd / Goswami, Nidhi / Manda, Kailash

Acta neurobiologiae experimentalis

2022 Volume 82, Issue 2, Page(s) 147–156

Abstract: The study aimed to investigate the significance of serum biomarkers in the severity grading of traumatic brain injury (TBI). For this purpose, mice underwent fluid percussion injury (FPI) at three discrete severity levels, mild, moderate, and severe. The ...

Abstract	The study aimed to investigate the significance of serum biomarkers in the severity grading of traumatic brain injury (TBI). For this purpose, mice underwent fluid percussion injury (FPI) at three discrete severity levels, mild, moderate, and severe. The severity of trauma was verified by the qualitative and quantitative histopathology of the brain. The serum samples were analyzed for the potential changes in ubiquitin C‑terminal hydrolase‑1 (UCHL‑1), S100β, interleukin‑6 (IL‑6), corticosterone, and β‑endorphin at 24 and 72 h post injury. A multifold increase in the values of UCHL‑1 was reported at all severity extents of FPI. However, TBI severity‑dependent increase in UCHL‑1 was reported on 72 h following FPI but not at 24 h. S100β values were significantly augmented in the mild and moderate group at both the time point but not in the severe group. Serum level of IL‑6 was significantly increased in the mild injury group at 24 h but not in the moderate and severe. At 72 h, IL‑6 showed a reverse trend. β‑endorphin and corticosterone were sensitive at an early stage only. Such unique dynamics of each biomarker enable us to propose TBI severity scale in the term of biomarkers codes to predict the extent of neurotrauma. Our preclinical study presents a predictive model for further clinical validation.
MeSH term(s)	Animals ; Biomarkers ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/pathology ; Corticosterone ; Disease Models, Animal ; Interleukin-6 ; Mice ; Percussion ; beta-Endorphin
Chemical Substances	Biomarkers ; Interleukin-6 ; beta-Endorphin (60617-12-1) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2022-07-14
Publishing country	Poland
Document type	Journal Article
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
DOI	10.55782/ane-2022-013
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Zs.B 479: Show issues

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Article: Intranasal Ketamine for Acute Pain: Behavioral and Neurophysiological Safety Analysis in Mice.

Goswami, Nidhi / Aleem, Mohd / Manda, Kailash

Current therapeutic research, clinical and experimental

2021 Volume 94, Page(s) 100627

Abstract: Background: Subanesthetic ketamine has been used for treatment-resistant depression and is popular as an opioid-sparing agent.: Objective: The present study aimed to investigate the dose-dependent antinociceptive effect of intranasal ketamine (INK) ... ...

Abstract	Background: Subanesthetic ketamine has been used for treatment-resistant depression and is popular as an opioid-sparing agent. Objective: The present study aimed to investigate the dose-dependent antinociceptive effect of intranasal ketamine (INK) along with behavioral and neurophysiological safety in mice. Methods: Antinociceptive efficacy was evaluated in the terms of thermal nociceptive response and formalin test. The safety studies were carried out separately in healthy mice using telemetry-based cortical electroencephalography, hemodynamic changes, and spontaneous behavioral functions, including anxiety, stereotypic movement, and locomotor functions. Results: INK administration significantly augmented the thermal nociceptive threshold and alleviated the pain response in the tonic phase of the formalin test. The results showed the dose-independent effectiveness of ketamine for thermal nociceptive responses because there were no significant differences among different INK dose groups. Behavioral safety analysis using the open field exploratory test revealed no significant effect of INK on anxiety-like functions in healthy mice. However, INK mice showed significantly more stereotypic movement but slower locomotor activities. The electroencephalography signal power spectrum density analysis revealed no significant changes by INK administration except a lower value in the α range. No significant changes were reported in heart rate, diastolic blood pressure, or systolic blood pressure at the higher dose equivalent used in the pain model. Conclusions: The study demonstrated the behavioral and neurophysiological safety of INK, although it had a mild sedative effect. Therefore, INK is suggested as a potentially safe candidate for the management of acute pain. (Curr Ther Res Clin Exp. 2021; 82:XXX-XXX)© 2021 Elsevier HS Journals, Inc.
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	205697-5
ISSN	1879-0313 ; 0011-393X
ISSN (online)	1879-0313
ISSN	0011-393X
DOI	10.1016/j.curtheres.2021.100627
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Zs.A 306: Show issues

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Article ; Online: Clinical relevance of chronic neuropathic pain phenotypes in mice: A comprehensive behavioral analysis.

Goswami, Nidhi / Aleem, Mohd / Manda, Kailash

Behavioural brain research

2020 Volume 400, Page(s) 113055

Abstract: Despite a large number of preclinical studies performed each year, the safe and effective therapeutic interventions for chronic pain are scant. Therefore, it appears that pre-clinical modeling requires a systematically organized behavioral test paradigm ... ...

Abstract	Despite a large number of preclinical studies performed each year, the safe and effective therapeutic interventions for chronic pain are scant. Therefore, it appears that pre-clinical modeling requires a systematically organized behavioral test paradigm to quantify the response of animals for a specific pain state. The present study, therefore, conceptualized a test battery to evaluate the behavioral changes in mice following neuropathic pain. We employed sciatic nerve chronic constriction injury (CCI) in C57BL/6 J mice to model chronic pain state. Mice were monitored for thermal hyperalgesia and grip strength for 30 days. Subsequently, mice underwent a behavioral test battery consisting of the nociceptive threshold, the affective and cognitive functions and motor coordination, and strength. Our results showed that CCI mice are insensitive to thermal stimuli. However, nerve-injured mice showed significant changes in neuromuscular coordination, basal anxiety, and hedonic state. Such impaired neuromuscular coordination is indicative of disability rather than the actual pain phenotype. While using the digital gait analysis, our study revealed rationales for the insensitivity of CCI mice to thermal stimuli. Our results suggest that the predictive validity of the CCI model necessitates a comprehensive behavioral test battery to select the clinically relevant and measurable phenotype to quantify chronic neuropathic pain.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Chronic Pain/etiology ; Chronic Pain/physiopathology ; Constriction ; Disease Models, Animal ; Female ; Hyperalgesia/etiology ; Hyperalgesia/physiopathology ; Mice ; Mice, Inbred C57BL ; Neuralgia/etiology ; Neuralgia/physiopathology ; Peripheral Nerve Injuries/complications ; Peripheral Nerve Injuries/physiopathology ; Phenotype ; Sciatic Nerve/injuries
Language	English
Publishing date	2020-12-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2020.113055
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Zs.A 1599: Show issues

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Article ; Online: Low-pressure fluid percussion minimally adds to the sham craniectomy-induced neurobehavioral changes: Implication for experimental traumatic brain injury model.

Aleem, Mohd / Goswami, Nidhi / Kumar, Mayank / Manda, Kailash

Experimental neurology

2020 Volume 329, Page(s) 113290

Abstract: Modeling experimental traumatic brain injury (TBI) in rodents is necessarily required to understand the pathophysiological and neurobehavioral consequences of neurotrauma. Numerous models have been developed to study experimental TBI. Fluid percussion ... ...

Abstract	Modeling experimental traumatic brain injury (TBI) in rodents is necessarily required to understand the pathophysiological and neurobehavioral consequences of neurotrauma. Numerous models have been developed to study experimental TBI. Fluid percussion injury (FPI) is the most extensively used model to represent clinical phenotypes. Nevertheless, the surgical 'sham' procedure (craniectomy), a prerequisite of FPI, is the impeding factor in experimental TBI. We hypothesized that if craniectomy causes substantial structural and functional changes in the brain, it might mimic the mild FPI-induced neurobehavioral dysfunctions. To understand the hypothesis, C57BL/6 mice were exposed to lateral FPI at 1.2 atm pressure and changes in the neuronal architecture, hippocampal neurogenesis, neuroinflammation, and behavioral functions were compared to the sham (craniectomy) and control mice at day 7 post-FPI. We observed that both the craniectomy and FPI significantly augmented the ipsilateral hippocampal neurogenesis as evaluated by DCX and Beta-III tubulin immunoreactivity. Similarly, a significant increase in GFAP and TMEM immunoreactivity in CA1 and CA3 regions showed that craniectomy mimics FPI-induced neuroinflammation. The additive damaging effect of craniectomy with FPI was also reported in the term of axonal and dendritic fragmentation, swelling and neuronal death using silver staining, Fluoro-jade, and MAP-2 immunoreactivity. Sham-exposed mice showed a significant functional decrease in grip strength. Our results indicate that sham craniectomy itself is enough to cause TBI like characteristics, and thus fluid percussion at mild pressure is minimally additive with craniectomy. Considering the method as a mixed (focal & diffused) injury model, the 'net neurotrauma severity' should be compared with naïve control instead of the sham as it is an outcome of cumulative damage due to fluid pressure and craniectomy. Nevertheless, to understand the long term consequences of neurotrauma, the extent of recovery in surgical sham may separately be quantified.
MeSH term(s)	Animals ; Brain Injuries, Traumatic/etiology ; Brain Injuries, Traumatic/pathology ; Brain Injuries, Traumatic/psychology ; Craniotomy/adverse effects ; Disease Models, Animal ; Hand Strength/physiology ; Locomotion/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Percussion/adverse effects
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2020.113290
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Zs.A 184: Show issues

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Article ; Online: Vitamin-D ameliorates sepsis-induced acute lung injury via augmenting miR-149-5p and downregulating ER stress.

Ahmad, Shaniya / Zaki, Almaz / Manda, Kailash / Mohan, Anant / Syed, Mansoor Ali

The Journal of nutritional biochemistry

2022 Volume 110, Page(s) 109130

Abstract: Acute lung injury is a life-threatening medical problem induced by sepsis or endotoxins and may be associated with enhanced Endoplasmic reticulum stress (ER stress). Vitamin-D (Vit-D) possesses an anti-inflammatory effect; however, this specific ... ...

Abstract	Acute lung injury is a life-threatening medical problem induced by sepsis or endotoxins and may be associated with enhanced Endoplasmic reticulum stress (ER stress). Vitamin-D (Vit-D) possesses an anti-inflammatory effect; however, this specific mechanism on acute lung injury is still unknown. Here we scrutinize the mechanism of Vit-D on Acute lung injury (ALI) models and explored the Vit-D augmented miRNA's role in regulating the ER stress pathway in ALI. Sepsis was induced by CLP, and Endotoxemia was caused by lipopolysaccharide (LPS). We found that Vit-D alleviates pulmonary edema, improves lung histoarchitecture, infiltration of neutrophils, endothelial barrier in mice, and improves ER stress markers Activating Transcription Factor 6 (ATF6) and CHOP (C/EBP Homologous Protein) expression elevated by CLP/LPS induce ALI. Vit-D decreases the nitric oxide production and ATF6 in macrophages induced by LPS. Vit-D augments miR (miR-149-5p) in LPS-induce macrophages, CLP, and LPS-induced ALI models. Vit-D enhanced miRNA-149-5p when overexpressed, inhibited ER-specific ATF6 inflammatory pathway in LPS-stimulated macrophages, and improved histoarchitecture of the lung in LPS/CLP-induced mice models. This vitro and vivo studies demonstrate that Vit-D could improve ALI induced by CLP/LPS. In this regard, miR-149-5p may play a crucial role in vitamin-D inhibiting LPS/CLP induce ALI. The mechanism might be an association of increased miR-149-5p and its regulated gene target ATF6, and downstream CHOP proteins were suppressed. Thus, these findings demonstrate that the anti-inflammatory effect of Vit-D is achieved by augmentation of miRNA-149-5p expression, which may be a key physiologic mediator in the prevention and treatment of ALI.
MeSH term(s)	Animals ; Mice ; Acute Lung Injury/drug therapy ; Acute Lung Injury/etiology ; Acute Lung Injury/prevention & control ; Anti-Inflammatory Agents ; Endoplasmic Reticulum Stress ; Lipopolysaccharides/toxicity ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Sepsis/complications ; Vitamin D ; Vitamins
Chemical Substances	Anti-Inflammatory Agents ; Lipopolysaccharides ; MicroRNAs ; Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.109130
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