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Article ; Online: Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study.

Nishimura, Goshi / Sano, Daisuke / Arai, Yasuhiro / Takahashi, Hideaki / Hatano, Takashi / Kitani, Yosuke / Takada, Kentaro / Wada, Takashi / Hiiragi, Yohei / Oridate, Nobuhiko

International journal of clinical oncology

2021 Volume 26, Issue 11, Page(s) 1995–2003

Abstract: ... of early T-stage head and neck cancer by transoral surgery (TOS): (1) tumor thickness > 7 mm on enhanced ...

Abstract	Background: We had previously identified the following risk factors for insufficient control of early T-stage head and neck cancer by transoral surgery (TOS): (1) tumor thickness > 7 mm on enhanced computed tomography (CT), and (2) poor differentiation in pathological examination. We subsequently used a different patient cohort to validate the usefulness of these factors in determining the need for adaptation of TOS. Study setting: A prospective observational study METHODS: Patients who received TOS as a definitive treatment between April 1, 2016 and September 30, 2020 were included. Primary control rates (by single TOS and TOS alone) in relation to the above-mentioned risk factors were calculated. Overall (O), recurrence-free (RF), and disease-free (DF) survival (S) outcomes were evaluated. A combination analysis based on the number of risk factors was also performed. Results: Patients with tumor thickness > 7 mm had a 2.88-fold [95% confidence interval (CI) 1.01-8.51] higher risk of incomplete primary resection by single TOS, while patients who showed poor differentiation on pathological assessments had a 13.14-fold (95% CI 3.66-47.14) higher risk of insufficient primary control by TOS alone. The 3 year OS, RFS, and DFS rates were 99%, 83%, and 63%, respectively. Patients with both risk factors had a 93.00-fold (95% CI 4.99-1732.00) higher risk of incomplete primary control by TOS alone. Conclusions: Among patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma, primary control by TOS alone may not be achieved in patients with both risk factors, that is, tumor thickness > 7 mm as measured by enhanced CT and poor differentiation on pathological examination.
MeSH term(s)	Carcinoma, Squamous Cell/surgery ; Head and Neck Neoplasms ; Humans ; Neoplasm Recurrence, Local ; Oropharyngeal Neoplasms/surgery ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck/surgery
Language	English
Publishing date	2021-07-21
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-021-01992-y
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Zs.A 4828: Show issues

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Article: Immortalization and Characterization of Porcine Macrophages That Had Been Transduced with Lentiviral Vectors Encoding the SV40 Large T Antigen and Porcine Telomerase Reverse Transcriptase.

Takenouchi, Takato / Kitani, Hiroshi / Suzuki, Shunichi / Nakai, Michiko / Fuchimoto, Dai-Ichiro / Tsukimoto, Mitsutoshi / Shinkai, Hiroki / Sato, Mitsuru / Uenishi, Hirohide

Frontiers in veterinary science

2017 Volume 4, Page(s) 132

Abstract: The domestic pig is an important agricultural animal, and thus, infectious diseases that affect pigs can cause severe economic losses in the global swine industry. Various porcine pathogens target macrophages, which are classical innate immune cells. ... ...

Abstract	The domestic pig is an important agricultural animal, and thus, infectious diseases that affect pigs can cause severe economic losses in the global swine industry. Various porcine pathogens target macrophages, which are classical innate immune cells. Although macrophages basically protect the host from pathogens, they also seem to contribute to infectious processes. Therefore, cultured macrophages can be used to develop
Keywords	covid19
Language	English
Publishing date	2017-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2017.00132
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Article ; Online: Establishment of SV40 large T antigen-immortalized bovine liver sinusoidal cell lines and their immunological responses to deoxynivalenol and lipopolysaccharide.

Yoshioka, Miyako / Takenouchi, Takato / Kitani, Hiroshi / Okada, Hiroyuki / Yamanaka, Noriko

Cell biology international

2016 Volume 40, Issue 12, Page(s) 1372–1379

Abstract: ... with SV40 large T antigen. The pro-inflammatory cytokine responses in these cell lines to deoxynivalenol ...

Abstract	Immortalized bovine sinusoidal cell lines provide useful tools to study the immunological responses in the liver to the gastrointestinal tract-derived toxic substances, which may cause systemic symptoms in the affected livestock. Here, we established two immortalized bovine liver sinusoidal cell lines, endothelial-like B46, and myofibroblast-like A26, from primary cultures of bovine liver cells by the transfection with SV40 large T antigen. The pro-inflammatory cytokine responses in these cell lines to deoxynivalenol (DON) and lipopolysaccharide (LPS) were then compared to those in the primary bovine Kupffer cells (BKC). BKC were highly responsive to LPS, showing increased levels of IL-1α, IL-1β, IL-6, and TNF-α mRNA 3 h after stimulation. DON induced similar pro-inflammatory cytokine responses in BKC, except for IL-6. The endothelial B46 cells exhibited upregulation of IL-1α, IL-1β, and IL-6 3 h after stimulation by LPS. In contrast to the stimulation by LPS, B46 had relatively low pro-inflammatory cytokine responses to DON, except for IL-1α, which was moderately induced at 3 h and increased at 24 h after stimulation. The myofibroblast-like A26 cells exhibited low responses in the induction of pro-inflammatory cytokines to LPS or DON; however, the expression of IL-6 was significantly observed 3 h after DON stimulation. Our results suggest that bovine liver sinusoidal cells have distinctive pro-inflammatory cytokine responses against harmful substances, and these immune responses might determine the consequence of systemic inflammations in the diseased animal.
MeSH term(s)	Animals ; Antigens, Viral, Tumor/metabolism ; Cattle ; Cell Line, Transformed ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Immunohistochemistry ; Kupffer Cells/drug effects ; Kupffer Cells/metabolism ; Lipopolysaccharides/pharmacology ; Liver/cytology ; Liver/drug effects ; Liver/immunology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Trichothecenes/pharmacology
Chemical Substances	Antigens, Viral, Tumor ; Cytokines ; Lipopolysaccharides ; RNA, Messenger ; Trichothecenes ; deoxynivalenol (JT37HYP23V)
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.10682
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Zs.A 1451: Show issues

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Article ; Online: Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells.

Sato, Mitsuru / Sawahata, Ryoko / Takenouchi, Takato / Kitani, Hiroshi

International immunology

2011 Volume 23, Issue 8, Page(s) 493–502

Abstract: ... T cells. However, it largely remains unknown that how this domain transduces TCR signaling. Here ... the interaction was uncovered by screening a λgt11 cDNA expression library obtained from the mouse T-cell line KKF ... EVH1 scFv intrabodies in gene-transfected NIH3T3 cells and T cells derived from these Tg mice. WASP ...

Abstract	Wiskott-Aldrich syndrome protein (WASP) plays important roles in TCR signaling. In transgenic (Tg) mice, over-expression of the WASP N-terminal region (exons 1-5) including the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain and anti-WASP-EVH1 single-chain variable fragment (scFv) intracellular expressed antibodies (intrabodies) impairs IL-2 production in activated T cells. However, it largely remains unknown that how this domain transduces TCR signaling. Here, we demonstrate for the first time that the WASP N-terminal domain specifically associates with the Fyn SH3 domain; the interaction was uncovered by screening a λgt11 cDNA expression library obtained from the mouse T-cell line KKF. The interaction between Fyn and WASP was inhibited by over-expression of the WASP N-terminal domain and anti-WASP-EVH1 scFv intrabodies in gene-transfected NIH3T3 cells and T cells derived from these Tg mice. WASP-interacting protein binding to the EVH1 domain of WASP was also inhibited in these Tg mice T cells. Furthermore, tyrosine phosphorylation of WASP and nuclear translocation of nuclear factor of activated T cells following TCR stimulation was severely inhibited by over-expression of the WASP N-terminal domain. These observations strongly suggest that the WASP N-terminal domain plays a pivotal role in the TCR signaling cascade by binding to Fyn.
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Gene Expression ; Gene Expression Regulation/immunology ; Interleukin-2/biosynthesis ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism ; Multiprotein Complexes/metabolism ; NFATC Transcription Factors/metabolism ; NIH 3T3 Cells ; Phosphorylation/genetics ; Phosphorylation/immunology ; Protein Binding/physiology ; Proto-Oncogene Proteins c-fyn/genetics ; Proto-Oncogene Proteins c-fyn/metabolism ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Signal Transduction/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Tyrosine/metabolism ; Wiskott-Aldrich Syndrome Protein/genetics ; Wiskott-Aldrich Syndrome Protein/immunology ; Wiskott-Aldrich Syndrome Protein/metabolism
Chemical Substances	Carrier Proteins ; Interleukin-2 ; Multiprotein Complexes ; NFATC Transcription Factors ; Receptors, Antigen, T-Cell ; Recombinant Fusion Proteins ; Waspip protein, mouse ; Wiskott-Aldrich Syndrome Protein ; Tyrosine (42HK56048U) ; Fyn protein, mouse (EC 2.7.10.2) ; Proto-Oncogene Proteins c-fyn (EC 2.7.10.2) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2011-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxr042
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Single domain intrabodies against WASP inhibit TCR-induced immune responses in transgenic mice T cells.

Sato, Mitsuru / Sawahata, Ryoko / Sakuma, Chisato / Takenouchi, Takato / Kitani, Hiroshi

Scientific reports

2013 Volume 3, Page(s) 3003

Abstract: ... in immune cells. In T cells from anti-WASP V(H) and V(L) single domain Tg mice, interleukin-2 production induced ... by T cell receptor (TCR) stimulation were impaired, and specific interaction between the WASP N ...

Abstract	Intrabody technology provides a novel approach to decipher the molecular mechanisms of protein function in cells. Single domains composed of only the variable regions (V(H) or V(L)) of antibodies are the smallest recombinant antibody fragments to be constructed thus far. In this study, we developed transgenic (Tg) mice expressing the V(H) or V(L) single domains derived from a monoclonal antibody raised against the N-terminal domain of Wiskott-Aldrich syndrome protein (WASP), which is an adaptor molecule in immune cells. In T cells from anti-WASP V(H) and V(L) single domain Tg mice, interleukin-2 production induced by T cell receptor (TCR) stimulation were impaired, and specific interaction between the WASP N-terminal domain and the Fyn SH3 domain was strongly inhibited by masking the binding sites in WASP. These results strongly suggest that the V(H)/VL single domain intrabodies are sufficient to knockdown the domain function of target proteins in the cytosol.
MeSH term(s)	Animals ; Antibody Specificity/immunology ; Female ; Gene Expression ; Immunization ; Interleukin-2/biosynthesis ; Intracellular Space ; Lymphocyte Activation/immunology ; Mice ; Mice, Transgenic ; NFATC Transcription Factors/metabolism ; Ovalbumin/immunology ; Phosphorylation ; Protein Binding/immunology ; Protein Interaction Domains and Motifs ; Protein Transport ; Proto-Oncogene Proteins c-fyn/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Single-Domain Antibodies/genetics ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Transfection ; Wiskott-Aldrich Syndrome Protein/chemistry ; Wiskott-Aldrich Syndrome Protein/immunology ; Wiskott-Aldrich Syndrome Protein/metabolism
Chemical Substances	Interleukin-2 ; NFATC Transcription Factors ; Receptors, Antigen, T-Cell ; Single-Domain Antibodies ; Wiskott-Aldrich Syndrome Protein ; Ovalbumin (9006-59-1) ; Proto-Oncogene Proteins c-fyn (EC 2.7.10.2)
Language	English
Publishing date	2013-10-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep03003
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Article: Notch1 signaling and regulatory T cell function.

Asano, Naoki / Watanabe, Tomohiro / Kitani, Atsushi / Fuss, Ivan J / Strober, Warren

Journal of immunology (Baltimore, Md. : 1950)

2007 Volume 180, Issue 5, Page(s) 2796–2804

Abstract: ... enforcing. Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-beta ...

Abstract	Previous studies have shown that the Notch1 and TGF-beta signaling pathways are mutually re-enforcing. Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-beta signaling, we investigated whether Notch1 signaling also participated in Treg effector function. Initial studies showed that Notch1 ligands, particularly Jagged1, are present on Tregs and that, indeed, blockade of Notch1 signaling with an anti-Jagged1 or a blocking anti-Notch1 Ab inhibits Treg suppressor function in vitro. We then showed that a signaling component generated by Notch1 activation (Notch1 intracellular domain) of dendritic cells physically interacts with a signaling component generated by TGF-beta signaling (pSmad3). Furthermore, this interaction has functional downstream effects because over-expression of Notch1 intracellular domain facilitates pSmad3 translocation to the nucleus and enhances pSmad3 transcriptional activity of a Smad-sensitive promoter linked to a luciferase reporter. Finally, we showed that blockade of TGF-beta signaling and Notch signaling did not have additive inhibitory effects on Treg suppressor function. These results are consistent with the conclusion that Notch1 signaling facilitates TGF-beta-mediated effector function of Tregs.
MeSH term(s)	Animals ; Calcium-Binding Proteins/biosynthesis ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Coculture Techniques ; Female ; Growth Inhibitors/antagonists & inhibitors ; Growth Inhibitors/biosynthesis ; Growth Inhibitors/immunology ; Growth Inhibitors/physiology ; HT29 Cells ; Humans ; Immune Sera/pharmacology ; Intercellular Signaling Peptides and Proteins/biosynthesis ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Interleukin-2 Receptor alpha Subunit/biosynthesis ; Interleukin-2 Receptor alpha Subunit/metabolism ; Jagged-1 Protein ; Jurkat Cells ; Ligands ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mink ; Receptor, Notch1/antagonists & inhibitors ; Receptor, Notch1/biosynthesis ; Receptor, Notch1/immunology ; Receptor, Notch1/physiology ; Serrate-Jagged Proteins ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/antagonists & inhibitors ; Transforming Growth Factor beta/physiology
Chemical Substances	Calcium-Binding Proteins ; Growth Inhibitors ; Immune Sera ; Intercellular Signaling Peptides and Proteins ; Interleukin-2 Receptor alpha Subunit ; JAG1 protein, human ; Jag1 protein, mouse ; Jagged-1 Protein ; Ligands ; Membrane Proteins ; Receptor, Notch1 ; Serrate-Jagged Proteins ; Transforming Growth Factor beta
Language	English
Publishing date	2007-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.180.5.2796
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large T antigen-immortalized rat liver cell lines.

Takenouchi, Takato / Yoshioka, Miyako / Yamanaka, Noriko / Kitani, Hiroshi

Cell biology international reports

2010 Volume 17, Issue 1, Page(s) e00001

Abstract: ... molecular basis of EMT, we established two phenotypically different SV40 large T antigen-immortalized ...

Abstract	EMT (epithelial-mesenchymal transition) is a key process in the development of liver fibrosis. This process is also essential for liver morphogenesis in embryonic development. To study the cellular and molecular basis of EMT, we established two phenotypically different SV40 large T antigen-immortalized cell lines from rat hepatocytes. The first cell line, which had an epithelial morphology and was established in DMEM (Dulbecco's modified Eagle's medium)/Ham's F-12 (DF)-based medium (RL/DF cells), expressed CK18 (cytokeratin 18), a marker of parenchymal hepatocytes. The other, a mesenchymal-like cell line established in DMEM-based medium (RL/DMEM cells), expressed αSMA (α-smooth muscle actin), a marker of hepatic myofibroblasts. Epithelial RL/DF cells underwent phenotypic changes, such as increased expression of αSMA, when the culture medium was switched to DMEM-based medium. In contrast, mesenchymal RL/DMEM cells were induced to express the epithelial marker CK18 with a concomitant decrease in αSMA expression when the culture medium was replaced with DF-based medium. These cell lines may provide novel in vitro models for the study of the conversion between epithelial and mesenchymal phenotypes during EMT in liver fibrosis and morphogenesis.
Language	English
Publishing date	2010-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2575357-5
ISSN	2041-5346
ISSN	2041-5346
DOI	10.1042/CBR20100001
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Article ; Online: Regulatory T cells and the induction of IL-17.

Kitani, A / Xu, L

Mucosal immunology

2008 Volume 1 Suppl 1, Page(s) S43–6

Abstract: T helper (Th)17 cells have been shown to play a role in the pathogenesis of inflammatory and ... that although transforming growth factor (TGF)-beta alone induces FoxP3(+) regulatory T (Treg) cells, TGF-beta and interleukin (IL)-6 ... acting in concert, induce differentiation of mouse naive T cells into Th17. As we previously showed ...

Abstract	T helper (Th)17 cells have been shown to play a role in the pathogenesis of inflammatory and autoimmune diseases including inflammatory bowel diseases (IBD). It is now well established that although transforming growth factor (TGF)-beta alone induces FoxP3(+) regulatory T (Treg) cells, TGF-beta and interleukin (IL)-6, acting in concert, induce differentiation of mouse naive T cells into Th17. As we previously showed that CD4(+)CD25(+)Foxp3(+) "natural" Treg cells express cell surface or secrete TGF-beta, we examined whether Treg cells serve to induce Th17 differentiation. We found that upon activation, Treg cells induce CD4(+)CD25(-) naive T cells or Treg cells themselves to differentiate into Th17 in the presence of IL-6 alone without exogenous addition of TGF-beta. We also found that TGF-â is also produced by dendritic cells that are in contact with Treg cells. Although Treg cells are effectively recruited at inflamed mucosa in patients with IBD, it is possible that Treg cells may have undesirable effects through their ability to differentiate into pathogenic Th17 in the presence of IL-6 and/or IL-23 at sites of inflammation. Further study of the relationship between Treg cells and Th17 cells in the inflamed tissue in IBD is important for possible Treg cell-mediated therapeutic applications.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Forkhead Transcription Factors/immunology ; Humans ; Interleukin-17/biosynthesis ; Interleukin-17/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/immunology
Chemical Substances	Forkhead Transcription Factors ; Interleukin-17 ; Interleukin-2 Receptor alpha Subunit ; Transforming Growth Factor beta
Language	English
Publishing date	2008-10-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/mi.2008.51
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Zs.A 6796: Show issues

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Article ; Online: Extracapsular extension of prostate cancer: diagnostic value of combined multiparametric magnetic resonance imaging and isovoxel 3-dimensional T2-weighted imaging at 1.5 T.

Itatani, Ryo / Namimoto, Tomohiro / Takaoka, Hiroko / Katahira, Kazuhiro / Morishita, Syoji / Kitani, Kosuke / Hamada, Yasuyuki / Kitaoka, Mitsuhiko / Nakaura, Takeshi / Yamashita, Yasuyuki

Journal of computer assisted tomography

2015 Volume 39, Issue 1, Page(s) 37–43

Abstract: Objective: The objective of this study was to assess whether adding isovoxel 3-dimensional T2-weighted imaging (volume isotropic T2-weighted acquisition [VISTA]) to multiparametric magnetic resonance imaging (mp-MRI) improves the ability to diagnose the ...

Abstract	Objective: The objective of this study was to assess whether adding isovoxel 3-dimensional T2-weighted imaging (volume isotropic T2-weighted acquisition [VISTA]) to multiparametric magnetic resonance imaging (mp-MRI) improves the ability to diagnose the extracapsular extension (ECE) of prostate cancer. Methods: Two radiologists independently evaluated ECE on images acquired with mp-MRI only (method A) and mp-MRI plus VISTA (method B) in 50 men who had undergone prostatectomy. We also compared the signal-to-noise ratio of the tumor on T2WI and VISTA scans. Results: Sensitivity, specificity, and accuracy were higher with method B. For both readers, specificity, accuracy, and the area under the receiver operating characteristic curve of method B were significantly higher than those of method A (reader 1: P = 0.028, 0.025, and 0.006; reader 2: P = 0.017, 0.0071, and 0.018). The signal-to-noise ratio was significantly higher on T2-weighted imaging than VISTA images (9.21 [SD, 2.46] vs 7.30 [SD, 1.87], P < 0.01). Conclusions: The addition of VISTA to mp-MRI improves the diagnostic value for ECE significantly.
MeSH term(s)	Aged ; Aged, 80 and over ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Multimodal Imaging/methods ; Observer Variation ; Prostatic Neoplasms/pathology ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000000172
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Zs.A 1388: Show issues

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Article ; Online: A novel Foley catheter made of high-intensity near-infrared fluorescent silicone rubber for image-guided surgery of lower rectal cancer.

Sato, Takayuki / Kitani, Ichiro

Photodiagnosis and photodynamic therapy

2024 Volume 45, Page(s) 103976

Abstract: Background: Urethral injury occurs in 1-6 % of male cases during minimally invasive surgery of lower rectal cancer. A Foley catheter emitting near-infrared (NIR) fluorescence of sufficient intensity has been expected to locate the urethra during image- ... ...

Abstract	Background: Urethral injury occurs in 1-6 % of male cases during minimally invasive surgery of lower rectal cancer. A Foley catheter emitting near-infrared (NIR) fluorescence of sufficient intensity has been expected to locate the urethra during image-guided surgery. Although it has been difficult to impart NIR fluorescent properties to biocompatible thermosetting polymers, we have recently succeeded in developing a NIR fluorescent compound for silicone rubber and a NIR fluorescent Foley catheter (HICARL). Here, we evaluated its NIR fluorescence properties and visibility performance using porcine anorectal isolation specimens. Methods: The HICARL catheter was made of a mixture of solid silicone rubber and a NIR fluorescent compound that emits fluorescence with a wavelength of 820-880 nm, while a conventional transparent Foley catheter was made of solid silicone rubber only. As a standard for comparison of the intensity of NIR fluorescence, a transparent Foley catheter the lumen of which was filled with a mixture of indocyanine green (ICG) and human plasma was used. As a comparison to assess the visibility performance of the HICARL catheter, a transparent Foley catheter into which a commercially available NIR fluorescent polyurethane ureteral catheter (NIRC) was placed was used. Results: A NIR fluorescence quantitative imaging analysis revealed that the Foley-NIRC catheter and the HICARL catheter emitted 3.42 ± 0.42 and 6.43 ± 0.07 times more fluorescence than the Foley-ICG catheter, respectively. The location of the HICARL catheter placed in the anorectum with a wall thickness of 3.8 ± 0.1 mm was clearly delineated in its entirety by NIR fluorescence, while that of the Foley-NIRC catheter was faintly or only partially visible. Conclusions: The HICARL catheter emitting NIR fluorescence of sufficient intensity is a promising and easy-to-use tool for urethral visualization during image-guided surgery of lower rectal cancer.
MeSH term(s)	Humans ; Male ; Animals ; Swine ; Silicone Elastomers ; Photochemotherapy/methods ; Photosensitizing Agents ; Coloring Agents ; Indocyanine Green/pharmacology ; Surgery, Computer-Assisted ; Catheters ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery
Chemical Substances	Silicone Elastomers ; Photosensitizing Agents ; Coloring Agents ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2024.103976
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