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  1. Article: Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges.

    Liu, Qi / Gao, Yuan / He, Jinzhi

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth. To this end, stem cell-based ... ...

    Abstract Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth. To this end, stem cell-based regenerative endodontic treatment has been regarded as one of the most promising strategies for treating young permanent teeth with pulp and periapical infections. Endogenous stem cells residing in the apical papilla, named stem cells from the apical papilla (SCAPs), have been intensively investigated due to their critical roles in pulp regeneration and root redevelopment. The present review summarizes advances in the field of SCAPs studies and discusses the challenges that need to be further addressed.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11072047
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  2. Article: Predictive value of a nomogram model for adverse outcomes in very low birth weight infants with patent ductus arteriosus: A prospective study.

    Sun, Xuan / Chen, Ling / Gao, Jinzhi

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1131129

    Abstract: Objective: To establish a nomogram model incorporating markers of echocardiography and N-terminal pro brain natriuretic peptide (NT-proBNP) for predicting adverse outcomes of patent ductus arteriosus (PDAao) in very low birth weight infants and to ... ...

    Abstract Objective: To establish a nomogram model incorporating markers of echocardiography and N-terminal pro brain natriuretic peptide (NT-proBNP) for predicting adverse outcomes of patent ductus arteriosus (PDAao) in very low birth weight infants and to evaluate the predictive values of the model.
    Methods: A prospective study was conducted for very low birth weight infants who were admitted from May 2019 to September 2020. An echocardiogram and blood NT-proBNP test were carried out in the first 48 h after birth, and the arterial duct remained open in all patients. Other data collected included clinical symptoms and infant characteristics. A nomogram model was established to predict the risk of PDAao (including severe BPD, IVH, NEC or death). Internal verifications were performed for the nomogram, and the discrimination and calibration of the model were evaluated by the C-index and calibration curve.
    Results: Eighty-two infants were enrolled and divided into an adverse outcome (AO) group and normal outcome (NO) group with 41 patients in each group. PDA diameter, PDA maximum flow velocity, left atrium diameter/aortic diameter (LA/AO) ratio and NT-proBNP level were independent risk factors for PDAao and were included in the nomogram model. The model presented good discrimination with a C-index of 0.917 (95% CI 0.859-0.975). The calibration curves in showed high consistency and indicated good
    Conclusion: The nomogram model incorporating the PDA diameter, PDA maximum flow velocity, LA/AO ratio and NT-proBNP level in the first 48 h could early predict the later occurrence of PDAao in very low birth weight infants.
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1131129
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  3. Article ; Online: Constructing sequence-controlled heterolayered dendritic lanthanide chelates

    Yang, Zhaoxuan / Lin, Haojin / Lin, Yaying / Wang, Jinzhi / Bu, Yifan / Lin, Hongyu / Gao, Jinhao

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 41, Page(s) 6195–6198

    Abstract: The construction of sequence-controlled heterometallic lanthanide complexes is challenging despite their intriguing physical/chemical properties and enormous potential applications. Here we report a one-pot strategy that exploits orthogonal chemical ... ...

    Abstract The construction of sequence-controlled heterometallic lanthanide complexes is challenging despite their intriguing physical/chemical properties and enormous potential applications. Here we report a one-pot strategy that exploits orthogonal chemical reactions for modular assembly, which allows for rapid preparation of sequence-controlled heterolayered lanthanide-complex dendritic structures.
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc06393j
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  4. Article ; Online: Wnt family member 1 (Wnt1) overexpression-induced M2 polarization of microglia alleviates inflammation-sensitized neonatal brain injuries.

    Gao, Jinzhi / Xu, Hao / Rong, Zhihui / Chen, Ling

    Bioengineered

    2022  Volume 13, Issue 5, Page(s) 12409–12420

    Abstract: Intrauterine infection induces inflammation-mediated microglial activation and brain injury. This study aimed to explore the regulatory mechanism of Wnt family member 1 (Wnt1) in intrauterine infection-mediated microglial polarization. The cell counting ... ...

    Abstract Intrauterine infection induces inflammation-mediated microglial activation and brain injury. This study aimed to explore the regulatory mechanism of Wnt family member 1 (Wnt1) in intrauterine infection-mediated microglial polarization. The cell counting kit-8 (CCK-8) assay was used to determine the viability of microglia, and cytokine expression levels were determined using enzyme linked immunosorbent assay (ELISA) kits and real-time quantitative PCR (RT-qPCR). The number of CD206
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Animals ; Brain Injuries ; Cytokines/metabolism ; Family ; Inflammation/metabolism ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Microglia/metabolism ; Signal Transduction ; Wnt1 Protein/metabolism
    Chemical Substances Cytokines ; Lipopolysaccharides ; Wnt1 Protein ; Wnt1 protein, mouse ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2022.2074767
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  5. Article: The challenging diagnosis of food protein-induced enterocolitis syndrome: A case report series.

    Zhao, Caiyan / Chen, Ling / Gao, Jinzhi

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 913278

    Abstract: Food protein-induced enterocolitis syndrome (FPIES) is a type of non-immunoglobulin E (IgE)-mediated food allergy. However, in addition to vomiting and diarrhea, IgE-mediated skin or respiratory symptoms may be comorbidities in some patients with FPIES. ... ...

    Abstract Food protein-induced enterocolitis syndrome (FPIES) is a type of non-immunoglobulin E (IgE)-mediated food allergy. However, in addition to vomiting and diarrhea, IgE-mediated skin or respiratory symptoms may be comorbidities in some patients with FPIES. We described four unusual cases of neonates with FPIES, whose clinical presentations were variable and misleading. All patients experienced vomiting, diarrhea or other gastrointestinal symptoms, and three of them developed IgE-mediated food allergy. Case 1 was admitted to the hospital with convulsions and then developed severe sepsis and necrotizing enterocolitis (NEC)-like appearance. Case 2 was wrongly diagnosed with Stevens-Johnson syndrome due to a severe extravasation rash of the skin and mucous membranes and a systemic inflammatory response. There was unexplained cholestasis in case 3, which might be attributed to food allergy. Asymptomatic elevation of C-reactive protein was the only hint at early-stage FPIES in case 4. Moreover, there were increased serum food-specific IgG values in three of the above cases. After eliminating the offending food, all of the above clinical manifestations rapidly improved in the four cases; thus, we believe that the most correct diagnosis in the described four cases was FPIES. This case report series should further draw clinicians' attention to FPIES with variable and atypical symptoms. The usefulness of IgG levels in identifying the presence of FPIES is uncertain.
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.913278
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  6. Article: Primary Adrenocortical Insufficiency Case Series in the Neonatal Period: Genetic Etiologies Are More Common Than Expected.

    Gao, Jinzhi / Chen, Ling

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 464

    Abstract: Primary adrenocortical insufficiency (PAI) is an important cause of morbidity in neonates. The most common cause of PAI in neonates is congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). Other rarer monogenic cases, for ... ...

    Abstract Primary adrenocortical insufficiency (PAI) is an important cause of morbidity in neonates. The most common cause of PAI in neonates is congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). Other rarer monogenic cases, for example, adrenal hypoplasia congenita (AHC) or familial glucocorticoid deficiency, also simulate clinical manifestation of 21-OHD, leading to misdiagnosis. The therapies and prognosis of these monogenic cases of PAI are entirely different. This study aimed to compare the differences of clinical data and identify genetic etiologies of PAI cases in the neonatal period. All 7 neonates initially presented with hyperpigmentation, hyponatremia, hyperkalemia, and high serum adrenocorticotropic hormone levels. Only CAH patients showed hyperandrogenism and remarkably elevated serum 17-hydroxyprogesterone levels. All the pathogenic mutations found in CYP21A2 were well known, except c.1069C>T (exon 8). The male patient with AHC had a novel hemizygous deletion of exon 2 in DAX1. The other one with familial glucocorticoid deficiency type 1 had two novel heterozygous mutations in the gene coding melanocortin 2 receptor, c.701C>T (exon 2) and c.119delT (exon 2). Glucocorticoid and/or mineralocorticoid replacement therapy depends on the cause of PAI. Genetic testing can be performed as a alternative diagnostic approach to provide information about therapy, prognosis, and genetic counseling.
    Language English
    Publishing date 2020-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00464
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  7. Article ; Online: Preparation of nitrogen-doped carbon quantum dots from chelating agent and used as fluorescent probes for accurate detection of ClO

    Wang, Guiqiao / Zhang, Shurong / Cui, Jinzhi / Gao, Wensu / Rong, Xing / Lu, Yaxin / Gao, Canzhu

    Analytica chimica acta

    2022  Volume 1195, Page(s) 339478

    Abstract: In this study, a novel ionic sensor based on nitrogen-doped carbon quantum dots (N-CQDs) was developed for sensitive detection of hypochlorite ions ( ... ...

    Abstract In this study, a novel ionic sensor based on nitrogen-doped carbon quantum dots (N-CQDs) was developed for sensitive detection of hypochlorite ions (ClO
    MeSH term(s) Carbon ; Chelating Agents ; Chromium ; Fluorescent Dyes ; Nitrogen ; Quantum Dots ; Reproducibility of Results
    Chemical Substances Chelating Agents ; Fluorescent Dyes ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2022.339478
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  8. Article ; Online: Novel Approaches for the Solid-Phase Synthesis of Dihydroquinazoline-2(1

    Wang, Qiong / Pan, Ying / Luo, Hongjun / Zhang, Yanmei / Gao, Fenfei / Wang, Jinzhi / Zheng, Jinhong

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: In the design of antineoplastic drugs, quinazolinone derivatives are often used as small molecule inhibitors for kinases or receptor kinases, such as the EGFR tyrosine kinase inhibitor gefitinib, p38MAP kinase ... ...

    Abstract In the design of antineoplastic drugs, quinazolinone derivatives are often used as small molecule inhibitors for kinases or receptor kinases, such as the EGFR tyrosine kinase inhibitor gefitinib, p38MAP kinase inhibitor
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238577
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: Novel highly selective fluorescence sensing strategy for Mercury(Ⅱ) in water based on nitrogen-doped carbon quantum dots.

    Wang, Guiqiao / Zhang, Shurong / Cui, Jinzhi / Gao, Wensu / Rong, Xing / Lu, Yaxin / Gao, Canzhu

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2022  Volume 286, Page(s) 122010

    Abstract: In this work, a fluorescent signal-closing probe of nitrogen-doped carbon quantum dots (NCQDs) was developed for quantitative detection of mercury ions ( ... ...

    Abstract In this work, a fluorescent signal-closing probe of nitrogen-doped carbon quantum dots (NCQDs) was developed for quantitative detection of mercury ions (Hg
    MeSH term(s) Quantum Dots/chemistry ; Carbon/chemistry ; Nitrogen/chemistry ; Mercury ; Water ; Spectrometry, Fluorescence/methods ; Fluorescent Dyes/chemistry ; Ions
    Chemical Substances Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Mercury (FXS1BY2PGL) ; Water (059QF0KO0R) ; Fluorescent Dyes ; Ions
    Language English
    Publishing date 2022-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2022.122010
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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
    Z 1611 a: Show issues
    924/340: Show issues

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  10. Article: 18

    Chen, Jinzhi / Zhang, Xi / Ma, Linlin / Gao, Yuan / Fu, Zhanli / Liu, Meng

    Frontiers in medicine

    2023  Volume 10, Page(s) 1258310

    Abstract: Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematopoietic malignancy, which originating from precursors of plasmacytoid dendritic cells. Allogeneic hematopoietic stem cell transplantation (HSCT) is normally ... ...

    Abstract Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematopoietic malignancy, which originating from precursors of plasmacytoid dendritic cells. Allogeneic hematopoietic stem cell transplantation (HSCT) is normally considered in the treatment of BPDCN patients to acquire sustained remission. Post-transplant lymphoproliferative disorder (PTLD) is a group of conditions involving abnormal lymphoid cells proliferation in the context of extrinsic immunosuppression after solid organ transplantation (SOT) or HSCT. Herein, we report a patient with BPDCN, who suffered from PTLD after allogeneic HSCT.
    Case presentation: A 66-year-old man was diagnosed with BPDCN, confirmed by pathologic examination after splenectomy. The post-surgery
    Conclusion: When patients with BPDCN recurred new enlarged lymph nodes after allogeneic HSCT and immunosuppressive therapy, PTLD should be taken into consideration.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1258310
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