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Article ; Online: Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA.

Salemi, Michele / Mogavero, Maria Paola / Lanza, Giuseppe / Mongioì, Laura M / Calogero, Aldo E / Ferri, Raffaele

2022 Volume 11, Issue 12

Abstract: Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer's dementia is the most common, while Parkinson's disease (PD) is ... ...

Abstract	Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer's dementia is the most common, while Parkinson's disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease-even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.
MeSH term(s)	Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Comorbidity ; Humans ; Neoplasms/epidemiology ; Neoplasms/genetics ; Neoplasms/pathology ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/genetics ; Parkinson Disease/pathology ; RNA, Untranslated/genetics
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11121930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antioxidants for male infertility: therapeutic scheme and indications. A retrospective single-center real-life study.

Cannarella, Rossella / Crafa, Andrea / Sawaid Kaiyal, Raneen / Kuroda, Shinnosuke / Barbagallo, Federica / Alamo, Angela / Mongioì, Laura M / Sapienza, Sabrina / Condorelli, Rosita A / LA Vignera, Sandro / Calogero, Aldo E

Minerva endocrinology

2024

Abstract: Background: This single-center real-life study was conducted to evaluate the most effective combination of nutraceuticals and the most appropriate indications for the treatment of male infertile patients.: Methods: Infertile patients aged 20-55 years ...

Abstract	Background: This single-center real-life study was conducted to evaluate the most effective combination of nutraceuticals and the most appropriate indications for the treatment of male infertile patients. Methods: Infertile patients aged 20-55 years were treated with a combination of antioxidants (Androlen Results: Forty-three patients were enrolled. In the overall analysis, only progressive motility significantly improved after therapy. Subgroup analysis showed a significant increase in progressive motility, total motile sperm count (TMSC), and in the percentage of alive spermatozoa after treatment in the group A. Progressive motility improved significantly in patients with varicocele, while the TMSC in patients with varicocele and those with idiopathic infertility. The percentage of alive spermatozoa increased in patients with testicular hypotrophy. Conclusions: Treatment with antioxidants increased progressive sperm motility, especially in patients with varicocele or idiopathic infertility.
Language	English
Publishing date	2024-01-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.23.04080-0
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Article: DNA Methylation in Offspring Conceived after Assisted Reproductive Techniques: A Systematic Review and Meta-Analysis.

Cannarella, Rossella / Crafa, Andrea / Mongioì, Laura M / Leggio, Loredana / Iraci, Nunzio / La Vignera, Sandro / Condorelli, Rosita A / Calogero, Aldo E

Journal of clinical medicine

2022 Volume 11, Issue 17

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-08-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11175056
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Article ; Online: Lifestyle and sexual habits of students in a Southern Italian region.

Cimino, Laura / Crafa, Andrea / Cannarella, Rossella / Barbagallo, Federica / Mongioì, Laura M / Aversa, Antonio / LA Vignera, Sandro / Condorelli, Rosita A / Calogero, Aldo E

Minerva endocrinology

2023

Abstract: Background: Incorrect or harmful lifestyle during youth may impact negatively gonadal function later in life. To reduce the development of risky behaviors a series of health prevention and intervention campaigns have been conducted in Italy. The present ...

Abstract	Background: Incorrect or harmful lifestyle during youth may impact negatively gonadal function later in life. To reduce the development of risky behaviors a series of health prevention and intervention campaigns have been conducted in Italy. The present study is part of a Sicily Region (Italy) health surveillance program that was carried out on a sample of late adolescents. Methods: Between March 2022 to December 2022, we enrolled 718 adolescents (15-26 years old) attending the last two years of high school (278 males and 440 females) in the districts of Syracuse, Ragusa, Catania, and Agrigento (Sicily, Italy). All adolescents were invited to complete a questionnaire that explored their lifestyles and the student's knowledge of sexually transmitted diseases (STDs) and the main andrological diseases. Results: Our analysis revealed that 43% of students smoke cigarettes, with a similar gender distribution; one-third of the students use illicit drugs, with a higher prevalence of males than females. More than two-thirds of youngsters reported drinking alcohol with a statistically significant difference between genders. 68.2% of students do not have sexual difficulties and males have a greater tendency to sexual promiscuity than females and only about half of them use condoms. 92% of students surf the Internet every day; boys tend to visit pornographic sites more often than girls. Conclusions: This survey revealed statistically significant differences between the two genders in terms of lifestyle and sexual habits. In particular, the survey shows that the prevalence of risky behaviour is still extremely high among late adolescents and young adults and that much still needs to be done in terms of prevention and information. Adequate prevention campaigns, to be proposed in the early years of adolescence, should be initiated in order to provide youngsters with adequate preparation in terms of healthy lifestyle habits.
Language	English
Publishing date	2023-09-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.23.03998-2
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Article: The Use of Ellagic Acid and Annona Muricata Improves Semen Quality in Men with High-Risk Papillomavirus Infection.

La Vignera, Sandro / Basile, Livia / Aversa, Antonio / Calogero, Aldo E / Grillo, Agata / Cannarella, Rossella / Mongioì, Laura M / Condorelli, Rosita A

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Background: Few data are currently available on the treatment of patients with HPV infection. In particular, there is no agreement on the use of antioxidants in these patients. Ellagic acid and annona muricata appear to improve HPV clearance in infected ... ...

Abstract	Background: Few data are currently available on the treatment of patients with HPV infection. In particular, there is no agreement on the use of antioxidants in these patients. Ellagic acid and annona muricata appear to improve HPV clearance in infected women. However, it is presently unknown whether they could enhance the clearance of HPV infection in infertile male patients. Aim: To evaluate the effects of a commercially available combined compound containing ellagic acid and annona muricata on semen quality in patients with documented papillomavirus (HPV) infection, and on the frequency of HPV DNA detection in seminal fluid after treatment. In addition, anti-sperm antibodies and the percentage of spermatozoa with fragmented DNA were evaluated. Materials and methods: This was a retrospective case-control study including patients attending our center for infertility. Fifty selected patients who were positive for high risk (HR)-HPV with available semen analysis results were consecutively enrolled. Patients were classified into two groups, according to the clinician’s decision to either administer ellagic acid 100 mg and annona muricata 100 mg (combined tablet formulation) for a period of three months (Group A; 25 patients), or to re-evaluate HPV DNA after a period of active surveillance only (protected sexual intercourse) (Group B; 25 patients). Results: Group A patients had a mean age of 31.0 ± 11.0 years, while Group B was 33.0 ± 8.0 years old (p > 0.05). After three months of treatment with ellagic acid and annona muricata, all conventional seminal parameters improved more significantly in Group A than in Group B patients: sperm concentration = 45 mil/mL vs. 20 mil/mL (p < 0.05); sperm progressive motility = 45% vs. 18% (p < 0.05); and normal sperm morphology = 18% vs. 6% (p < 0.05). After the treatment, the frequency of persistence of HPV DNA in the seminal fluid was significantly lower in Group A patients compared to those in Group B (12/25 = 48% vs. 22/25 = 88%; p < 0.05). Finally, after 3 months, Group A showed a significant reduction in anti-sperm antibodies and in the percentage of spermatozoa with fragmented DNA. Conclusion: The results of this study demonstrate, for the first time, the effects of a commercially available combined compound containing ellagic acid and annona muricata on semen quality in patients with HR-HPV infection, and that this therapy is also associated with a significant reduction in the persistence of HPV DNA in the seminal fluid.
Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164691
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Article ; Online: The Role of Resveratrol Administration in Human Obesity.

Mongioì, Laura M / La Vignera, Sandro / Cannarella, Rossella / Cimino, Laura / Compagnone, Michele / Condorelli, Rosita A / Calogero, Aldo E

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: Obesity is a widespread disease that is associated with numerous and serious comorbidities. These include metabolic syndrome, diabetes mellitus, cardiovascular-cerebrovascular disease, hypertension, obstructive sleep apnea syndrome, cancer, and sexual ... ...

Abstract	Obesity is a widespread disease that is associated with numerous and serious comorbidities. These include metabolic syndrome, diabetes mellitus, cardiovascular-cerebrovascular disease, hypertension, obstructive sleep apnea syndrome, cancer, and sexual and hormonal disorders. The treatment of obesity has therefore become a goal of great clinical and social relevance. Among the therapeutic strategies against obesity, resveratrol has aroused great interest. This polyphenol has anticancer and antioxidant properties and cytoprotective and anti-inflammatory effects. Other favorable effects attributed to resveratrol are anti-lipid, anti-aging, anti-bacterial, anti-viral, and neuroprotective actions. Administration of resveratrol appears to improve the metabolic profile in obese and/or insulin-resistant patients. This article aims to review the main results of clinical studies evaluating the effects of administering resveratrol alone in overweight/obese patients.
MeSH term(s)	Anti-Obesity Agents/therapeutic use ; Antioxidants/therapeutic use ; Humans ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/pathology ; Resveratrol/therapeutic use
Chemical Substances	Anti-Obesity Agents ; Antioxidants ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094362
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Article ; Online: Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity.

Mongioì, Laura M / Cimino, Laura / Greco, Emanuela / Cannarella, Rossella / Condorelli, Rosita A / La Vignera, Sandro / Calogero, Aldo E

Current opinion in pharmacology

2021 Volume 60, Page(s) 72–82

Abstract: Obesity and metabolic diseases have become a worrying reality, especially in more developed societies. They are associated with the development of many comorbidities, such as type 2 diabetes mellitus, hypogonadism, hypertension, cerebrovascular and ... ...

Abstract	Obesity and metabolic diseases have become a worrying reality, especially in more developed societies. They are associated with the development of many comorbidities, such as type 2 diabetes mellitus, hypogonadism, hypertension, cerebrovascular and cardiovascular diseases, neoplasia, obstructive sleep apnea, and non-alcoholic fatty liver disease. Therefore, weight loss is of paramount importance. A promising therapeutic option to achieve this goal is the very-low-calorie ketogenic diet. This review aims to summarize the main effects of very-low-calorie-ketogenic diet on the glycometabolic and gonadal profiles of men with overweight/obesity.
MeSH term(s)	Diabetes Mellitus, Type 2 ; Diet, Ketogenic ; Humans ; Male ; Obesity ; Overweight ; Weight Loss
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2021.06.013
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Article ; Online: Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation.

Condorelli, Rosita A / Aversa, Antonio / Basile, Livia / Cannarella, Rossella / Mongioì, Laura M / Cimino, Laura / Perelli, Sarah / Caprio, Massimiliano / Cimino, Sebastiano / Calogero, Aldo E / La Vignera, Sandro

Nutrients

2022 Volume 14, Issue 5

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Diet, Ketogenic ; Humans ; Inflammation ; Male ; Obesity ; Overweight ; Quality of Life
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051081
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Article ; Online: Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility.

Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / La Vignera, Sandro / Calogero, Aldo E

International journal of molecular sciences

2020 Volume 21, Issue 5

Abstract: Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, ... ...

Abstract	Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, current evidence suggest that a relevant number of sperm transcripts and proteins are involved in acrosome reactions, sperm‒oocyte fusion and, once released into the oocyte, embryo growth and development. The aim of this review is to provide updated and comprehensive insight into the molecular biology of spermatogenesis, including evidence on spermatogenetic failure and underlining the role of the sperm-carried molecular factors involved in oocyte fertilization and embryo growth. This represents the first step in the identification of new possible diagnostic and, possibly, therapeutic markers in the field of apparently idiopathic male infertility.
MeSH term(s)	DNA Fragmentation ; Female ; Humans ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Male ; Oocytes/metabolism ; Oocytes/physiology ; Spermatogenesis/genetics ; Spermatogenesis/physiology ; Spermatozoa/metabolism ; Spermatozoa/physiology
Language	English
Publishing date	2020-03-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21051728
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Article ; Online: Corrigendum to: Influence of 25‑hydroxy-cholecalciferol levels on SARS-CoV-2 infection and COVID-19 severity: A systematic review and meta-analysis [EClinicalMedicine 37 (2021) 100,967].

Crafa, Andrea / Cannarella, Rossella / Condorelli, Rosita A / Mongioì, Laura M / Barbagallo, Federica / Aversa, Antonio / La Vignera, Sandro / Calogero, Aldo E

EClinicalMedicine

2021 Volume 41, Page(s) 101168

Abstract: This corrects the article DOI: 10.1016/j.eclinm.2021.100967.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.eclinm.2021.100967.].
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Published Erratum
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.101168
Database	MEDical Literature Analysis and Retrieval System OnLINE

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