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  1. Article: Constrained Mixture Models of Soft Tissue Growth and Remodeling - Twenty Years After.

    Humphrey, J D

    Journal Of Elasticity

    2021  Volume 145, Issue 1-2, Page(s) 49–75

    Abstract: Soft biological tissues compromise diverse cell types and extracellular matrix constituents, each of which can possess individual natural configurations, material properties, and rates of turnover. For this reason, mixture-based models of growth (changes ...

    Abstract Soft biological tissues compromise diverse cell types and extracellular matrix constituents, each of which can possess individual natural configurations, material properties, and rates of turnover. For this reason, mixture-based models of growth (changes in mass) and remodeling (change in microstructure) are well-suited for studying tissue adaptations, disease progression, and responses to injury or clinical intervention. Such approaches also can be used to design improved tissue engineered constructs to repair, replace, or regenerate tissues. Focusing on blood vessels as archetypes of soft tissues, this paper reviews a constrained mixture theory introduced twenty years ago and explores its usage since by contrasting simulations of diverse vascular conditions. The discussion is framed within the concept of mechanical homeostasis, with consideration of solid-fluid interactions, inflammation, and cell signaling highlighting both past accomplishments and future opportunities as we seek to understand better the evolving composition, geometry, and material behaviors of soft tissues under complex conditions.
    Language English
    Publishing date 2021-01-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2015283-8
    ISSN 1573-2681 ; 0374-3535
    ISSN (online) 1573-2681
    ISSN 0374-3535
    DOI 10.1007/s10659-020-09809-1
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  2. Article ; Online: New computational approach to shunt design in congenital heart palliation.

    Ban, E / Humphrey, J D

    Journal of biomechanics

    2023  Volume 152, Page(s) 111568

    Abstract: Shunts are commonly used to redirect blood to pulmonary arteries in procedures that palliate congenital cardiovascular defects. Previous clinical studies and hemodynamic simulations reveal a critical role of shunt diameter in balancing flow to pulmonary ... ...

    Abstract Shunts are commonly used to redirect blood to pulmonary arteries in procedures that palliate congenital cardiovascular defects. Previous clinical studies and hemodynamic simulations reveal a critical role of shunt diameter in balancing flow to pulmonary versus systemic vessels, but the biomechanical process of creating the requisite anastomosis between the shunt and host vessel has received little attention. Here, we report a new Lagrange multiplier-based finite element approach that represents the shunt and host vessels as individual structures and predicts the anastomosis geometry and attachment force that result when the shunt is sutured at an incision in the host, followed by pressurization. Simulations suggest that anastomosis orifice opening increases markedly with increasing length of the host incision and moderately with increasing blood pressure. The host artery is further predicted to conform to common stiff synthetic shunts, whereas more compliant umbilical vessel shunts should conform to the host, with orifice area transitioning between these two extremes via a Hill-type function of shunt stiffness. Moreover, a direct relationship is expected between attachment forces and shunt stiffness. This new computational approach promises to aid in surgical planning for diverse vascular shunts by predicting in vivo pressurized geometries.
    MeSH term(s) Humans ; Infant ; Heart Defects, Congenital/surgery ; Heart ; Anastomosis, Surgical/methods ; Blood Vessel Prosthesis ; Pulmonary Artery/surgery
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2023.111568
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    Zs.A 700: Show issues Location:
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  3. Article ; Online: Guest Editors' Introduction.

    Kriet, J David / Humphrey, Clinton D

    Facial plastic surgery : FPS

    2022  Volume 38, Issue 4, Page(s) 323

    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/s-0042-1757811
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  4. Book ; Online: Social susceptibility to multiple air pollutants in cardiovascular disease

    Clougherty, Jane E. / Humphrey, Jamie L. / Kinnee, Ellen J. / Robinson, Lucy F. / McClure, Lesly A. / Kubzansky, Laura D. / Reid, Colleen E.

    with a critique by the HEI Review Committee

    (Research report / Health Effects Institute ; 206)

    2021  

    Author's details Jane E. Clougherty, Jamie L. Humphrey, Ellen J. Kinnee, Lucy F. Robinson, Leslie A. McClure, Laura D. Kubzansky, and Colleen E. Reid
    Series title Research report / Health Effects Institute ; 206
    Collection
    Language English
    Size 1 Online-Ressource (ix, 74 Seiten), Illustrationen, Diagramme
    Publisher Health Effects Institut
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT021262259
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Comment on "Tensional homeostasis at different length scales" by D. Stamenović and M. L. Smith,

    Humphrey, Jay D / Cyron, Christian J

    Soft matter

    2022  Volume 18, Issue 3, Page(s) 675–679

    Abstract: Many cell-types that reside within load bearing tissues appear to exhibit mechanical homeostasis, that is, a tendency to regulate particular mechanical quantities near a preferred value, often called a set-point. It is suggested here that assessing ... ...

    Abstract Many cell-types that reside within load bearing tissues appear to exhibit mechanical homeostasis, that is, a tendency to regulate particular mechanical quantities near a preferred value, often called a set-point. It is suggested here that assessing potential mechanical homeostasis requires careful attention to derivations and definitions, that is, appropriate solutions to the initial-boundary value problems that define the biophysical situation of interest and appropriate definitions of what is meant by homeostasis. Noting that this term was coined carefully, with
    MeSH term(s) Homeostasis
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d1sm01151k
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  6. Article ; Online: Ex vivo biomechanical characterization of umbilical vessels: Possible shunts in congenital heart palliation.

    Murtada, S-I / Ramachandra, A B / Humphrey, J D

    Journal of biomechanics

    2023  Volume 151, Page(s) 111518

    Abstract: Children born with congenital heart defects typically undergo staged palliative surgeries to reconstruct the circulation to improve transport of deoxygenated blood to the lungs. As part of the first surgery, a temporary shunt (Blalock-Thomas-Taussig) is ... ...

    Abstract Children born with congenital heart defects typically undergo staged palliative surgeries to reconstruct the circulation to improve transport of deoxygenated blood to the lungs. As part of the first surgery, a temporary shunt (Blalock-Thomas-Taussig) is often created in neonates to connect a systemic and a pulmonary artery. Standard-of-care shunts are synthetic, which can lead to thrombosis, and much stiffer than the two host vessels, which can cause adverse mechanobiological responses. Moreover, the neonatal vasculature can undergo significant changes in size and structure over a short period, thus constraining the use of a non-growing synthetic shunt. Recent studies suggest that autologous umbilical vessels could serve as improved shunts, but there has not been a detailed biomechanical characterization of the four primary vessels - subclavian artery, pulmonary artery, umbilical vein, and umbilical artery. Herein, we biomechanically phenotype umbilical veins and arteries from prenatal mice (E18.5) and compare them to subclavian and pulmonary arteries harvested at two critical postnatal developmental ages (P10, P21). Comparisons include age-specific physiological conditions and simulated 'surgical-like' shunt conditions. Results suggest that the intact umbilical vein is a better choice as a shunt than the umbilical artery due to concerns with lumen closure and constriction related intramural damage in the latter. Yet, decellularization of umbilical arteries may be a viable alternative, with the possibility of host cellular infiltration and subsequent remodeling. Given recent efforts using autologous umbilical vessels as Blalock-Thomas-Taussig shunts in a clinical trial, our findings highlight aspects of the associated biomechanics that deserve further investigation.
    MeSH term(s) Animals ; Mice ; Heart Defects, Congenital/surgery ; Pulmonary Artery/surgery ; Subclavian Artery/surgery ; Constriction, Pathologic ; Prostheses and Implants
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2023.111518
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  7. Article ; Online: Managing Craniomaxillofacial Injuries in Athletes.

    Kriet, J David / Humphrey, Clinton D

    Facial plastic surgery clinics of North America

    2021  Volume 30, Issue 1, Page(s) xiii–xiv

    MeSH term(s) Athletes ; Facial Injuries ; Humans ; Skull Fractures
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1315178-2
    ISSN 1558-1926 ; 1064-7406
    ISSN (online) 1558-1926
    ISSN 1064-7406
    DOI 10.1016/j.fsc.2021.09.001
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  8. Article ; Online: Where will pediatric praziquantel be needed in Tanzania? Geographical variation in prevalence, and risk factors of

    Mazigo, Humphrey D / Ambrose, Emmanuela E / Mwingira, Upendo J

    Parasite epidemiology and control

    2024  Volume 24, Page(s) e00337

    Abstract: Background: Pediatric schistosomiasis has been recognized as a public health concern in schistosomiasis endemic areas of sub-Saharan Africa, including Tanzania. However, there is limited epidemiological information relating to pediatric schistosomiasis ... ...

    Abstract Background: Pediatric schistosomiasis has been recognized as a public health concern in schistosomiasis endemic areas of sub-Saharan Africa, including Tanzania. However, there is limited epidemiological information relating to pediatric schistosomiasis in Tanzania. Therefore, this current focused on assessing the geographical prevalence of
    Methods: A total of 1585 PreSAC aged 1-6 years were enrolled in a cross-sectional study. A single urine and stool sample were obtained from each child and processed using point-of-care circulating cathodic (POC-CCA) antigen and Kato Katz (K-K) technique. The overall prevalence of
    Conclusion: Schistosoma mansoni
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-6731
    ISSN (online) 2405-6731
    DOI 10.1016/j.parepi.2024.e00337
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  9. Article ; Online: Journal of Biomechanical Engineering: Legacy Paper 2017.

    Humphrey, J D

    Journal of biomechanical engineering

    2017  Volume 140, Issue 2

    MeSH term(s) Biomechanical Phenomena ; Engineering ; Mechanical Phenomena ; Periodicals as Topic
    Language English
    Publishing date 2017-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4038593
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  10. Article ; Online: Medical School Rankings-Bad for the Health of the Profession and the Public.

    Humphrey, Holly J / Levinson, Dana / Carter, Keme

    JAMA

    2023  Volume 329, Issue 16, Page(s) 1343–1344

    MeSH term(s) Humans ; Schools, Medical/classification ; Schools, Medical/standards ; Schools, Medical/statistics & numerical data ; Students, Medical/statistics & numerical data ; Medicine/standards ; Medicine/statistics & numerical data
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.2815
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