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Article ; Online: Evaluation of the hematological and immunological markers after the first and second doses of BNT162b2 mRNA vaccine.

Rafeeq, M / Jabir, M S / Al-Kuraishy, H M / Jeddoa, Z M A / Jawad, S F / Najm, M A A / Almulla, A F / Elekhnawy, E / Tayyeb, J Z / Turkistani, A / Alsfouk, B A / Batiha, G E

European review for medical and pharmacological sciences

2024 Volume 28, Issue 6, Page(s) 2605–2614

Abstract: ... granulocyte colony stimulating factor (G-CSF), interferon gamma-induced protein 10 (IP-10/CXCL10), and macrophage inflammatory protein-1 ...

Abstract	Objective: Both humoral and cellular immunity can be significantly influenced by the immunological responses to vaccination, and both responses are essential. Vaccination is the most consistent, safe, and cost-efficient practice for controlling the COVID-19 pandemic. Patients and methods: Blood samples were collected from participants who received two vaccine doses of COVID-19 Pfizer/BioNTech (BNT162b2) before and on days 7 and 10 after the first and second immunization. We evaluated some hematological and immunological markers responses to the 1st and 2nd doses of the BNT162b2 mRNA (Pfizer/BioNtech) vaccine. Results: In healthy subjects' neutrophil and WBC counts significantly increased compared to those after the first dose. The results of all first-group participant categories demonstrated no discernible variations in lymphocyte counts. There was no change in IgM or IgG in all second-group cohorts, except for a considerable rise in IgG levels in people with a history of coronavirus infection following the second dosage compared to baseline. After the second dose, CD4+ T-cell and CD8+ T-cell levels rose in all groups compared to before the immunization and after the first dosage. Data demonstrated a substantial rise in neutrophil-lymphocyte ratio (NLR) after the second dose of the vaccine. Individuals who had previously had COVID-19 disease experienced a considerable increase in C3 and C4 levels after the first and second dosages compared to baseline. Additionally, compared to their levels after the first dosage, C4 levels increased significantly following the second dosage. Interleukin (IL)-6, IL-15, macrophage colony-stimulating factor (M-CSF), granulocyte colony stimulating factor (G-CSF), interferon gamma-induced protein 10 (IP-10/CXCL10), and macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) levels were increased after boost correlated with Spike antibody levels, supporting their utility as indicators of successful humoral immunity development in response to vaccination. Conclusions: We can conclude that the Pfizer/BioNTech vaccine produced a more potent T-cell response than humoral ones.
MeSH term(s)	Humans ; mRNA Vaccines ; BNT162 Vaccine ; Pandemics ; Vaccination ; COVID-19/prevention & control ; Granulocyte Colony-Stimulating Factor ; Immunoglobulin G
Chemical Substances	mRNA Vaccines ; BNT162 Vaccine ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Immunoglobulin G
Language	English
Publishing date	2024-04-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202403_35766
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Article ; Online: Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.

Al-Kuraishy, H M / Abd Hasan, R R / Al-Gareeb, A I A / Aggad, S S / Aljohani, A S M / El-Ashmawy, I M / Elekhnawy, E / Mostafa, S A / Negm, W A / Batiha, G E

European review for medical and pharmacological sciences

2023 Volume 27, Issue 6, Page(s) 2277–2287

Abstract: Objective: Although methotrexate (MTX) is used to treat several malignancies and chronic inflammatory diseases, its clinical use is constrained because of its negative side effects, the most prevalent of which are hepatotoxicity and nephrotoxicity. So, ... ...

Abstract	Objective: Although methotrexate (MTX) is used to treat several malignancies and chronic inflammatory diseases, its clinical use is constrained because of its negative side effects, the most prevalent of which are hepatotoxicity and nephrotoxicity. So, this study aims to determine whether α-lipoic acid (ALA) and vitamin C can protect mice against the liver damage that methotrexate causes. Materials and methods: A total of 49 male mice were divided into seven groups at random. Group I received sodium bicarbonate, while groups II to VII received an intraperitoneal injection of MTX (20 mg/kg) on the tenth day, following ten days of pretreatment with ALA (60 mg/Kg), ALA (120 mg/Kg), vitamin C (100 mg/Kg), vitamin C (200 mg/Kg), ALA (60 mg/Kg), and vitamin C (100 mg/kg). Results: When compared to mice in group I, mice in group II (the control group) had significantly higher levels of the enzymes malondialdehyde (MDA), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and significantly lower (p <0.05) levels of the enzymes superoxide dismutase (SOD) and glutathione (GSH). As compared to the control group, pretreatment groups with ALA and vitamin C showed a dose-dependent substantial rise (p <0.05) in GSH and SOD levels, a dose-dependent notable decrease (p <0.05) in MDA, ALT, ALP, and LDH levels, and better liver histological architecture. In order to increase the antioxidant capacity, pretreatment with ALA and vitamin C may be able to prevent MTX-induced hepatotoxicity. Conclusions: These results imply that ALA and vitamin C are useful in the treatment of MTX-induced liver damage.
MeSH term(s)	Rats ; Male ; Mice ; Animals ; Thioctic Acid/pharmacology ; Thioctic Acid/therapeutic use ; Methotrexate/toxicity ; Ascorbic Acid/pharmacology ; Rats, Wistar ; Antioxidants/metabolism ; Vitamins/pharmacology ; Glutathione/metabolism ; Liver/pathology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Superoxide Dismutase/metabolism ; Oxidative Stress
Chemical Substances	Thioctic Acid (73Y7P0K73Y) ; Methotrexate (YL5FZ2Y5U1) ; Ascorbic Acid (PQ6CK8PD0R) ; Antioxidants ; Vitamins ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-05-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202303_31761
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Article ; Online: The potential therapeutic effect of metformin in type 2 diabetic patients with severe COVID-19.

Al-Kuraishy, H M / Al-Gareeb, A I / El Kholy, A A / El-Khateeb, E / Alexiou, A / Papadakis, M / Elekhnawy, E / Alsubaie, N / Hamad, R S / Batiha, G E

European review for medical and pharmacological sciences

2023 Volume 27, Issue 23, Page(s) 11445–11456

Abstract: Objective: Type 2 diabetes mellitus (T2DM) is regarded as a chief risk factor for(coronavirus disease 2019 (COVID-19) owing to dysregulation of the expression of angiotensin-converting enzyme 2 (ACE2) and chronic low-grade inflammatory disorders. ... ...

Abstract	Objective: Type 2 diabetes mellitus (T2DM) is regarded as a chief risk factor for(coronavirus disease 2019 (COVID-19) owing to dysregulation of the expression of angiotensin-converting enzyme 2 (ACE2) and chronic low-grade inflammatory disorders. Metformin, an insulin-sensitizing agent for managing T2DM, has pleiotropic anti-inflammatory and oxidant potentials, which may lessen the risk of diabetic complications. So, we aimed to reveal the potential role of metformin monotherapy in treating T2DM patients with COVID-19. Patients and methods: In this prospective cohort study, 60 hospitalized T2DM patients with COVID-19 on metformin plus standard anti-COVID-19 treatments compared to 40 hospitalized T2DM patients with COVID-19 on other diabetic pharmacotherapy like insulin and sulfonylurea, were recruited. Inflammatory and oxidative stress biomarkers and radiological and clinical outcomes were assessed at admission time and at the time of discharge. Results: The results of this study illustrated that metformin treatment in T2DM patients with COVID-19 was more effective in reducing inflammatory and oxidative stress biomarkers with significant amelioration of radiological scores and clinical outcomes compared to T2DM patients with COVID-19 on another diabetic pharmacotherapy. Conclusions: Our findings highlighted that metformin efficiently managed T2DM patients with COVID-19 by reducing inflammatory and oxidative stress with mitigating effects on the radiological scores and clinical outcomes.
MeSH term(s)	Humans ; Metformin ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Hypoglycemic Agents/therapeutic use ; Prospective Studies ; COVID-19/complications ; Insulin/therapeutic use ; Biomarkers
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents ; Insulin ; Biomarkers
Language	English
Publishing date	2023-12-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202312_34583
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Article ; Online: CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA genes expression in colorectal cancer patients: novel diagnostic biomarkers.

El Nakib, A M / Elsaeed, M / Abdelsalam, R A / Wafi, K / Elekhnawy, E / Alrouji, M / Alsaleem, M / Aljarba, N H / Batiha, G E / Negm, W A / Mostafa, S A

European review for medical and pharmacological sciences

2023 Volume 27, Issue 17, Page(s) 7946–7955

Abstract: ... expression in the blood of colorectal cancer patients in Egypt. This was performed to elucidate if there's ...

Abstract	Objective: This study aimed to investigate the CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA mRNA expression in the blood of colorectal cancer patients in Egypt. This was performed to elucidate if there's a link between this gene expression and other clinicopathological characteristics of the tumor. Patients and methods: A case-control study including 50 colorectal cancer patients and 50 healthy controls was conducted. Real-time polymerase chain reaction (rt-PCR) was utilized to assess the expression of CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA mRNA in blood samples. Results: Patients with colorectal cancer had significantly higher levels of mRNA for the genes CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA (p<0.001, p=0.021, p<0.001, and p<0.001, respectively) compared to controls. Remarkedly, the gene expression of AHR, TRIP13, and PIK3CA genes did not exhibit a significant correlation with the tumor stages (p=0.379, p=0.095, and p=0.526, respectively). However, there was a strong correlation between CYP24A1 and CPEB4 gene expression and tumor stages (p<0.001 and p=0.002, respectively). Conclusions: Therefore, we can conclude that increased mRNA levels of CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA in blood samples withdrawn from colorectal cancer patients could be a biomarker for the disease.
MeSH term(s)	Humans ; Vitamin D3 24-Hydroxylase ; Case-Control Studies ; Class I Phosphatidylinositol 3-Kinases/genetics ; RNA, Messenger/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; RNA-Binding Proteins ; ATPases Associated with Diverse Cellular Activities ; Cell Cycle Proteins
Chemical Substances	Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; RNA, Messenger ; PIK3CA protein, human (EC 2.7.1.137) ; CPEB4 protein, human ; RNA-Binding Proteins ; TRIP13 protein, human (EC 3.6.4.-) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Cell Cycle Proteins ; CYP24A1 protein, human (EC 1.14.15.16)
Language	English
Publishing date	2023-09-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202309_33554
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Article ; Online: Possible mechanistic insights into iron homeostasis role of the action of 4-aminoquinolines (chloroquine/hydroxychloroquine) on COVID-19 (SARS-CoV-2) infection.

Batiha, G E-S / Shaheen, H M / Al-Kuraishy, H M / Teibo, J O / Akinfe, O A / Al-Garbee, A I / Teibo, T K A / Kabrah, S M

European review for medical and pharmacological sciences

2021 Volume 25, Issue 23, Page(s) 7565–7584

Abstract: Objective: With the recent direction in drug repurposing, many approved drugs have been evaluated to assess their effect on the coronavirus or SARS-CoV-2 infection (COVID-19). Driving this path, chloroquine (CQ) has been used in the treatment of malaria ...

Abstract	Objective: With the recent direction in drug repurposing, many approved drugs have been evaluated to assess their effect on the coronavirus or SARS-CoV-2 infection (COVID-19). Driving this path, chloroquine (CQ) has been used in the treatment of malaria and hydroxychloroquine (HCQ) in immunomodulatory and anti-thrombotic action, playing a leading role in initial management of the viral infection. Materials and methods: Literature search was done using Google Scholar, PubMed and Scopus database using keywords "chloroquine" "SARS-CoV-2" "COVID-19" "mechanism of action" and articles of interest were selected providing evidence of the possible role of CQ in viral infection. Results: In a bid to understand how and if CQ and HCQ would exert their anti-viral property, mechanistic exegesis was done to review various proposed mechanisms of action. This revealed the inhibition of viral attachment and entry, inhibition of enveloped glycoprotein, inhibition of the development and proliferation of new viral particles as the way they perform their action. There is an interplay between iron metabolism and homeostasis with COVID-19 infection and viral reproduction. Conclusions: This study aims to show the functional role of CQ and HCQ, as well as to provide possible mechanistic insight on the role of iron on viral infection, iron starvation and its downstream cellular pathways involving hepcidin and proinflammatory cytokines. The overall aim of providing possible mode of action of CQ and HCQ in the management of COVID-19 infection is exhibited via its anti-viral, anti-inflammatory and anti-thrombotic activities.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/metabolism ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Drug Repositioning ; Homeostasis ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Iron/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Virus Attachment/drug effects
Chemical Substances	Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-12-17
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202112_27456
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Article ; Online: Protective effects of Zizyphus oxyphyla on liver and kidney related serum biomarkers in (CCl4) intoxicate rabbits.

Ahmad, B / Ilahi, I / Yousafzai, A M / Attaullah, M / Rahim, A / Naz, D / Hazrat, A / Batiha, G E-S / Nassan, M A / Khalil, A A K

Brazilian journal of biology = Revista brasleira de biologia

2021 Volume 83, Page(s) e246980

Abstract: ... in each. These were: group NC (normal control), group, TC (toxic control) and group ST i.e. silymarine administered ...

Abstract	The study was aimed to evaluate the therapeutic effects of Zizyphus oxyphyla leaves methanolic (ZOX-LME), on serum liver, kidney and hematology along with other serum parameters in Carbon tetrachloride (CCl4) intoxicated rabbits. Experimental animals were divided into five groups, six rabbits in each. These were: group NC (normal control), group, TC (toxic control) and group ST i.e. silymarine administered group at dose rate (50) mg/kg body weight (BW). Group ET1 and group ET2 treated with (ZOX-LME) at dose 200 mg/kg BW and 400 mg/kg BW. CCl4 administration caused significant (P> 0.05) impairment in serum liver enzymes, blood factors and other serum indices. Treatment with (ZOX-LME) significantly (P<0.05) reduced and normalized the levels of serum alanine transaminase (ALT) aspartate transaminase (AST) and alkaline phosphatase (ALP) and hematological indices. Also significant (P< 0.05) reduction was observed in creatinine, urea, uric acid, blood urea nitrogen (BUN), and albumin and glucose concentrations. The altered levels of lipid profile and serum electrolytes (Ca, Mg, Cl, Na, K, and P) were significantly (P<0.05) change toward normal levels with (ZOX-LME) feeding. In addition (ZOX-LME) ingestion caused significant improvement in GSH, GST and CAT levels, while reducing the TBARS levels, exhibited antioxidant capacity. Also (ZOX-LME) showed increase inhibition against percent scavenging of 2, 2-diphenile-1-picrylehydrazyle (DPPH) free radical. Significant (P<0.05) normalizing effects were observed with high dose 400 mg/kg BW of (ZOX-LME and were equivalent to silymarine administered groups. The histological study of liver supported the hepatoprotective and renal curative activity of (ZOX-LME).
MeSH term(s)	Animals ; Antioxidants ; Biomarkers ; Chemical and Drug Induced Liver Injury ; Kidney ; Plant Extracts/pharmacology ; Rabbits ; Ziziphus
Chemical Substances	Antioxidants ; Biomarkers ; Plant Extracts
Language	English
Publishing date	2021-08-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.246980
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Article ; Online: Sequencing analysis and efficient biodiesel production by lipase from Pseudomonas aeruginosa.

Al-Kadmy, Israa M S / Aziz, Sarah Naji / Hussein, Nadheema Hammood / El-Shafeiy, Samah N / Hamzah, Israa Hussein / Suhail, Ahmed / Alhomaidi, Eman / Algammal, Abdelazeem M / El-Saber Batiha, Gaber / ElBadre, Hala M / Hetta, Helal F

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 323

Abstract: ... as it is considered a potential alternative clean-fuel source. The current study's objective is ...

Abstract	Background: Recently, lipase processing for biodiesel production has shown a global increase as it is considered a potential alternative clean-fuel source. The current study's objective is to investigate of lipolytic activity of lipase produced from different strains of Pseudomonas aeruginosa (P. aeruginosa) in biodiesel production using edible plant oils. The goal is to develop an efficient and cost-effective method for producing inexpensive and environmentally friendly biodiesel. Methods and results: Four P. aeruginosa isolates were obtained from different environmental sources (soil), phenotypically identified, and it was confirmed by the PCR detection of the 16SrRNA gene. The isolated P. aeruginosa strains were screened for lipase production, and the recovered lipase was purified. Besides, the lipase (lip) gene was detected by PCR, and the purified PCR products were sequenced and analyzed. The production of biofuel was conducted using gas chromatography among tested oils. It was found that castor oil was the best one that enhances lipase production in-vitro.
MeSH term(s)	Humans ; Biofuels ; Pseudomonas aeruginosa/metabolism ; Lipase/metabolism ; Oils ; Base Sequence ; Pseudomonas Infections ; Plant Oils/chemistry
Chemical Substances	Biofuels ; Lipase (EC 3.1.1.3) ; Oils ; Plant Oils
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-09156-z
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Article ; Online: Protective effects of Zizyphus oxyphyla on liver and kidney related serum biomarkers in (CCl4) intoxicate rabbits

B. Ahmad / I. Ilahi / A. M. Yousafzai / M. Attaullah / A. Rahim / D. Naz / A. Hazrat / G. E-S. Batiha / M. A. Nassan / A. A. K. Khalil

Brazilian Journal of Biology, Vol

2021 Volume 83

Abstract: ... in each. These were: group NC (normal control), group, TC (toxic control) and group ST i.e. silymarine administered ...

Abstract	Abstract The study was aimed to evaluate the therapeutic effects of Zizyphus oxyphyla leaves methanolic (ZOX-LME), on serum liver, kidney and hematology along with other serum parameters in Carbon tetrachloride (CCl4) intoxicated rabbits. Experimental animals were divided into five groups, six rabbits in each. These were: group NC (normal control), group, TC (toxic control) and group ST i.e. silymarine administered group at dose rate (50) mg/kg body weight (BW). Group ET1 and group ET2 treated with (ZOX-LME) at dose 200 mg/kg BW and 400 mg/kg BW. CCl4 administration caused significant (P> 0.05) impairment in serum liver enzymes, blood factors and other serum indices. Treatment with (ZOX-LME) significantly (P<0.05) reduced and normalized the levels of serum alanine transaminase (ALT) aspartate transaminase (AST) and alkaline phosphatase (ALP) and hematological indices. Also significant (P< 0.05) reduction was observed in creatinine, urea, uric acid, blood urea nitrogen (BUN), and albumin and glucose concentrations. The altered levels of lipid profile and serum electrolytes (Ca, Mg, Cl, Na, K, and P) were significantly (P<0.05) change toward normal levels with (ZOX-LME) feeding. In addition (ZOX-LME) ingestion caused significant improvement in GSH, GST and CAT levels, while reducing the TBARS levels, exhibited antioxidant capacity. Also (ZOX-LME) showed increase inhibition against percent scavenging of 2, 2-diphenile-1-picrylehydrazyle (DPPH) free radical. Significant (P<0.05) normalizing effects were observed with high dose 400 mg/kg BW of (ZOX-LME and were equivalent to silymarine administered groups. The histological study of liver supported the hepatoprotective and renal curative activity of (ZOX-LME).
Keywords	methanol extract ; hematological parameters ; serum levels ; 2 ; 2-diphenile-1-picrylehydrazyle (DPPH) ; hepatoprotective ; (ZOX-LME) ; Science ; Q ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991 ; Botany ; QK1-989
Subject code	630
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Instituto Internacional de Ecologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology.

Yaqoob, M U / El-Hack, M E Abd / Hassan, F / El-Saadony, M T / Khafaga, A F / Batiha, G E / Yehia, N / Elnesr, S S / Alagawany, M / El-Tarabily, K A / Wang, M

Poultry science

2021 Volume 100, Issue 7, Page(s) 101143

Abstract: ... physiological structure are discussed, emphasizing the poultry's growth performance. The current review ...

Abstract	Prebiotics may modify the biological processes in the chickens' gastrointestinal tract to improve poultry performance and health. Prebiotics are natural feed additives that offer many economic advantages by decreasing mortality rates, increasing growth rates, and improving birds' feed efficiency. Prebiotic action potentially affects the degradation of indigestible dietary compounds, the synthesis of nitrogen components and vitamins, and simplifies the removal of undesirable elements in the diet. Prebiotics could also induce desirable gut microbiome modifications and affect host metabolism and immune health. It is worth mentioning that gut bacteria metabolize the prebiotic compounds into organic compounds that the host can subsequently use. It is important to limit the concept of prebiotics to compounds that influence the metabolism of resident microorganisms. Any medicinal component or feed ingredient beneficial to the intestinal microecosystem can be considered a prebiotic. In this review, the impacts of prebiotics on the gut microbiome and physiological structure are discussed, emphasizing the poultry's growth performance. The current review will highlight the knowledge gaps in this area and future research directions.
MeSH term(s)	Animals ; Chickens ; Gastrointestinal Microbiome ; Gastrointestinal Tract/chemistry ; Poultry ; Prebiotics/analysis
Chemical Substances	Prebiotics
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2021.101143
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Article ; Online: Eugenia sonderiana O. Berg leaves: Phytochemical characterization, evaluation of in vitro and in vivo antidiabetic effects, and structure-activity correlation.

Bastos, Renan G / Rodrigues, Sarah de O / Marques, Larissa A / Oliveira, Carla M de / Salles, Bruno C C / Zanatta, Ana C / Rocha, Fabíola D / Vilegas, Wagner / Pagnossa, Jorge P / de A Paula, Fernanda B / da Silva, Geraldo A / Batiha, Gaber E / Aggad, Sarah S / Alotaibi, Badriyah S / Yousef, Fatimah M / da Silva, Marcelo A

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115126

Abstract: ... extract of E. sonderiana leaves using high-performance liquid chromatography coupled ... within normal ranges, protecting the cell membranes against oxidative damage. Thus, the extract of E. sonderiana leaves ...

Abstract	Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications of diabetes mellitus. In this context, plants of the Myrtaceae family popularly used in Brazil for the treatment of diabetes mellitus, including Eugenia sonderiana, have shown beneficial effects due to the presence of phenolic compounds and saponins in their chemical constitution. Thus, the present work aimed to perform the phytochemical characterization of the hydroethanolic extract of E. sonderiana leaves using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), along with in vitro and in vivo studies of antidiabetic activity. The chemical characterization revealed the presence of phenolic compounds, flavonoids, neolignans, tannins, and saponins. In addition, the extract exhibited minimum inhibitory concentrations of alpha-amylase and alpha-glycosidase higher than the acarbose in the in vitro tests. Also, the in vivo tests revealed a slight increase in body mass in diabetic rats, as well as a significant decrease in water and feed consumption provided by the extract. Regarding serum biochemical parameters, the extract showed significant activity in decreasing the levels of glucose, hepatic enzymes, and triglycerides, in addition to maintaining HDL cholesterol levels within normal ranges, protecting the cell membranes against oxidative damage. Thus, the extract of E. sonderiana leaves was considered promising pharmaceutical ingredient in the production of a phytotherapy medication.
MeSH term(s)	Rats ; Animals ; Hypoglycemic Agents/therapeutic use ; Plant Extracts/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Phytochemicals/therapeutic use ; Phenols/pharmacology ; Plant Leaves/chemistry ; Saponins/therapeutic use ; Eugenia
Chemical Substances	Hypoglycemic Agents ; Plant Extracts ; Phytochemicals ; Phenols ; Saponins
Language	English
Publishing date	2023-07-24
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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