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Article ; Online: Letter to editor in response to 'Tian K, Ye J, Zhong Y, Jia Z, Xu W, Gao S, Cao S, Li K, Wu L. Autologous i-PRF promotes healing of radiation-induced skin injury. Wound Repair Regen. 2023;31:454-463'.

Sampoornam Pape Reddy, Saravanan / Francis, Delfin Lovelina / Harish, Ruchi / Manohar, Balaji / Chopra, Sukhbir Singh

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2023 Volume 31, Issue 6, Page(s) 729–730

MeSH term(s)	Humans ; Wound Healing ; Skin ; Skin Diseases ; Radiation Injuries/therapy
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Letter
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.13125
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Zs.A 3890: Show issues

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Article ; Online: Detection of cardiac myosin heavy chain-α-specific CD4 cells by using MHC class II/IA(k) tetramers in A/J mice.

Massilamany, Chandirasegaran / Gangaplara, Arunakumar / Chapman, Nora / Rose, Noel / Reddy, Jay

Journal of immunological methods

2011 Volume 372, Issue 1-2, Page(s) 107–118

Abstract: A/J mice bearing the H-2 allele IA(k) are highly susceptible to autoimmune myocarditis induced ... with cardiac myosin heavy chain (Myhc)-α 334-352, whereas B10.A mice carrying a similar allele IA(k) are relatively ... background. To enumerate the precursor frequencies of Myhc-α-specific CD4 T cells, we sought to create IA(k ...

Abstract	A/J mice bearing the H-2 allele IA(k) are highly susceptible to autoimmune myocarditis induced with cardiac myosin heavy chain (Myhc)-α 334-352, whereas B10.A mice carrying a similar allele IA(k) are relatively resistant, suggesting that the generation of Myhc-α-reactive T cell repertoires is influenced by genetic background. To enumerate the precursor frequencies of Myhc-α-specific CD4 T cells, we sought to create IA(k) tetramers for Myhc-α 334-352. Tetramers were created using approaches that involve covalent tethering of individual peptide sequences or exogenous loading of peptides into empty IA(k) molecules by peptide-exchange reaction. Using ribonuclease 43-56 tetramers as controls, we demonstrated that by flow cytometry (FC), Myhc-α 334-352 tetramers specifically bind myosin-reactive T cells. CD4 cells isolated from A/J mice immunized with Myhc-α 334-352 were used to optimize conditions for tetramer staining, and neuraminidase treatment prior to tetramer staining permitted the detection of Myhc-α-specific cells ex vivo. The reagents are useful tools for monitoring the frequency of Myhc-α-reactive CD4 cells and to determine their pathogenic potential at a single cell level by FC.
MeSH term(s)	Alleles ; Animals ; Blotting, Western ; CD4-Positive T-Lymphocytes/immunology ; Female ; Flow Cytometry ; Histocompatibility Antigens Class II/immunology ; Mice ; Mice, Inbred A ; Myocarditis/genetics ; Myocarditis/immunology ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/immunology
Chemical Substances	Histocompatibility Antigens Class II ; Myosin Heavy Chains (EC 3.6.4.1)
Language	English
Publishing date	2011-09-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2011.07.004
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Zs.A 795: Show issues

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Article ; Online: Re: Sequential bacillus Calmette-Guérin/Electromotive Drug Administration of Mitomycin C as the Standard Intravesical Regimen in High Risk Nonmuscle Invasive Bladder Cancer: 2-Year Outcomes: C. Gan, S. Amery, K. Chatterton, M. S. Khan, K. Thomas and T. O'Brien J Urol 2016; 195: 1697-1703.

Shenoy, Sunil P / Marla, Prashanth K / Sharma, Pritam / Batchu, Chandu Krishna / Reddy, Vijayanand R / Pai, Vivek Mangalore

The Journal of urology

2016 Volume 197, Issue 4, Page(s) 1173–1174

MeSH term(s)	Administration, Intravesical ; BCG Vaccine ; Humans ; Mitomycin ; Mycobacterium bovis ; Urinary Bladder Neoplasms
Chemical Substances	BCG Vaccine ; Mitomycin (50SG953SK6)
Language	English
Publishing date	2016-12-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2016.12.007
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Anomalous pancreatico-biliary junction and gall bladder cancer in response to Matsumoto M, Maruta M, Maeda K, Utsumi T, Sugioka A, Kuroda M (2002) Epithelial cyst of the gallbladder associated with adenocarcinoma. J Hepatobiliary Pancreat Surg 9:389-392.

Toufeeq Khan, Taqi F / Reddy, Kunam S / Johnston, Thomas D / Ranjan, Dinesh

Journal of hepato-biliary-pancreatic surgery

2003 Volume 10, Issue 6, Page(s) 455–6; author reply 456

MeSH term(s)	Adenocarcinoma/etiology ; Bile Ducts, Extrahepatic/abnormalities ; Cysts/complications ; Gallbladder Diseases/complications ; Gallbladder Neoplasms/etiology ; Humans ; Pancreas/abnormalities
Language	English
Publishing date	2003
Publishing country	Japan
Document type	Comment ; Letter
ZDB-ID	1181222-9
ISSN	1436-0691 ; 0944-1166
ISSN (online)	1436-0691
ISSN	0944-1166
DOI	10.1007/s00534-003-0857-4
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Zs.A 4024: Show issues

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Article ; Online: A third-line antiretroviral therapy register to track patient clinical and virological outcomes.

Naidoo, K / Ramruthan, J / Reddy, M / Lancaster, R

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

2022 Volume 112, Issue 8, Page(s) 511

Abstract: In 2021, South Africa (SA) had an estimated 7.8 million people living with HIV, of whom 5.6 million were receiving antiretroviral therapy (ART),[1] with 3.4 million on first-line ART, 145 000 on second-line ART (SLART) and >700 on third-line ART (TLART). ...

Abstract	In 2021, South Africa (SA) had an estimated 7.8 million people living with HIV, of whom 5.6 million were receiving antiretroviral therapy (ART),[1] with 3.4 million on first-line ART, 145 000 on second-line ART (SLART) and >700 on third-line ART (TLART).
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; HIV Infections/drug therapy ; Humans ; South Africa/epidemiology ; Viral Load
Chemical Substances	Anti-HIV Agents ; Anti-Retroviral Agents
Language	English
Publishing date	2022-08-02
Publishing country	South Africa
Document type	Editorial
ZDB-ID	390968-2
ISSN	2078-5135 ; 0038-2469 ; 0256-9574
ISSN (online)	2078-5135
ISSN	0038-2469 ; 0256-9574
DOI	10.7196.SAMJ.v112i8.16695
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Ua VI Zs.406: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 645: Show issues

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Article ; Online: The knowns and unknowns of cardiac autoimmunity in viral myocarditis.

Mone, Kiruthiga / Reddy, Jay

Reviews in medical virology

2023 Volume 33, Issue 6, Page(s) e2478

Abstract: Myocarditis can result from various infectious and non-infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate ... ...

Abstract	Myocarditis can result from various infectious and non-infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the viruses would have damaged the tissues and be cleared by the immune system. Therefore, viral signatures such as viral nucleic acids and virus-reactive antibodies may be the only readouts pointing to viruses as potential primary triggers of DCM. Thus, it becomes hard to explain persistent inflammatory infiltrates that might occur in individuals affected with chronic myocarditis/DCM manifesting myocardial dysfunctions. In these circumstances, autoimmunity is suspected, and antibodies to various autoantigens have been demonstrated, suggesting that immune therapies to suppress the autoimmune responses may be necessary. From this perspective, we endeavoured to determine whether or not the known viral causes are associated with development of autoimmune responses to cardiac antigens that include both cardiotropic and non-cardiotropic viruses. If so, what their nature and significance are in developing chronic myocarditis resulting from viruses as primary triggers.
MeSH term(s)	Humans ; Myocarditis ; Autoimmunity ; Cardiomyopathy, Dilated/complications ; Heart Failure ; Virus Diseases
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.2478
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Zs.A 3308: Show issues

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Article ; Online: A third-line antiretroviral therapy register to track patient clinical and virological outcomes.

Naidoo, K / Ramruthan, J / Reddy, M / Lancaster, R

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

2022 Volume 112, Issue 8, Page(s) 511–512

MeSH term(s)	Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; HIV Infections/drug therapy ; Humans ; South Africa ; Treatment Outcome ; Viral Load
Chemical Substances	Anti-HIV Agents ; Anti-Retroviral Agents
Language	English
Publishing date	2022-08-01
Publishing country	South Africa
Document type	Editorial
ZDB-ID	390968-2
ISSN	2078-5135 ; 0038-2469 ; 0256-9574
ISSN (online)	2078-5135
ISSN	0038-2469 ; 0256-9574
DOI	10.7196/SAMJ.2022.v112i8.16695
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Ua VI Zs.406: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 645: Show issues

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Article ; Online: Mitigation of lens opacification by a functional food in a diabetic rodent model.

Kalahasti, Krishna K / Kumar, Ch Uday / Nagaraju, Marka / Petrash, J Mark / Reddy, S Sreenivasa / Reddy, G Bhanuprakash

Chemico-biological interactions

2024 Volume 390, Page(s) 110889

Abstract: The current study was designed to test a functional food (FF) mixture containing aldose reductase inhibitors and antiglycation bioactive compounds for suppressing the onset and progression of cataracts in a diabetic rat model. Two-month-old Sprague ... ...

Abstract	The current study was designed to test a functional food (FF) mixture containing aldose reductase inhibitors and antiglycation bioactive compounds for suppressing the onset and progression of cataracts in a diabetic rat model. Two-month-old Sprague Dawley rats were grouped as control (C), diabetes untreated (D), and diabetic rats treated with FF at two doses (FF1 = 1.35 g and FF2 = 6.25 g/100g of diet). Diabetes was induced by a single injection of streptozotocin. The FF is a mixture of amla, turmeric, black pepper, cinnamon, ginger, and fenugreek added to the rodent diet. The status of cataracts was monitored weekly by a slit lamp examination for 20 weeks, after which animals were sacrificed to collect eye lenses. Feeding FF1 and FF2 to diabetic rats yielded a significant anti-hyperglycaemic effect and marginally prevented body weight loss. FF delayed cataract progression, and FF2 showed better efficacy than FF1. FF prevented the loss of lens crystallins and their insolubilization in diabetic rats. The antioxidant potential of FF was evident with the lowered protein carbonyls, lipid peroxidation, and prevention of altered antioxidant enzyme activities induced by diabetes. These studies demonstrate the efficacy of plant-derived dietary supplements against the onset and progression of cataracts in a well-established rat model of diabetic eye disease.
MeSH term(s)	Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Rodentia/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Rats, Sprague-Dawley ; Functional Food ; Lens, Crystalline ; Cataract/drug therapy ; Cataract/prevention & control ; Aldehyde Reductase/metabolism
Chemical Substances	Antioxidants ; Aldehyde Reductase (EC 1.1.1.21)
Language	English
Publishing date	2024-01-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2024.110889
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Zs.A 686: Show issues

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Article ; Online: Diagnostic Utility of QuantiFERON-Gold Testing in Patients with Ocular Inflammation in a Low-Endemic Tuberculosis Region.

Xia, Julia / Palestine, Alan G / Reddy, Amit K

American journal of ophthalmology

2024 Volume 264, Page(s) 1–7

Abstract: Purpose: To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area.: Design: Diagnostic utility analysis.: Methods: A review was performed for all uveitis patients who ... ...

Abstract	Purpose: To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. Design: Diagnostic utility analysis. Methods: A review was performed for all uveitis patients who underwent QFT-G testing at the University of Colorado Eye Center from 2009 to 2022. Records were reviewed to assess QFT-G positivity rate and to identify which patients were tested for diagnostic purposes, defined as meeting the Standardization of Uveitis Nomenclature (SUN) criteria for tubercular uveitis (TBU): anterior uveitis with iris nodules, serpiginous-like choroiditis, choroidal nodule resembling a tuberculoma, multifocal choroiditis, or occlusive retinal vasculitis. Results: A total of 388 patients with uveitis underwent QFT-G testing, of which 17 (4.38%) were positive. Only one (5.88%) patient had true TBU with anterior uveitis with iris nodules. The remaining 16 (94.1%) patients did not meet SUN criteria for TBU and were incidentally found to be QFT-G positive during laboratory work-up prior to immunosuppression. The positive predictive value was 100% when QFT-G testing was performed in patients who met SUN criteria for TBU, whereas the positive predictive value was 0% for QFT-G testing performed in patients who did not meet SUN criteria for TBU. Conclusion: In low prevalence areas, the majority of QFT-G positive tests in uveitis patients are coincidental and unrelated to their uveitic disease process. The diagnostic value of a TB test is likely to be minimal unless the SUN clinical criteria for tubercular uveitis are met.
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.03.010
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Article ; Online: Necrotizing Scleritis Secondary to Exposed Polypropylene Suture.

Mehta, Nihaal / Taravella, Michael J / Reddy, Amit K

Ophthalmology

2022 Volume 130, Issue 7, Page(s) 691

MeSH term(s)	Humans ; Scleritis/diagnosis ; Scleritis/drug therapy ; Scleritis/etiology ; Polypropylenes/adverse effects ; Sutures/adverse effects
Chemical Substances	Polypropylenes
Language	English
Publishing date	2022-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2022.08.008
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Zs.MO 533: Show issues

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