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  1. Article ; Online: Status of Cancer Research in India

    Phulen Sarma

    Proceedings of Indian National Science Academy, Vol 84, Iss 1, Pp 141-

    2018  Volume 152

    Abstract: Status of Cancer Research in ... ...

    Abstract Status of Cancer Research in India
    Keywords Science ; Q
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A simple treatment for the removal of superficial ocular surface foreign body using disposable paper strip.

    R, Balamurugan / Sarma, Phulen / Syamala, Divya Deepthi / Nicodemus, Deepthi Slesser

    The American journal of emergency medicine

    2023  Volume 71, Page(s) 240–243

    MeSH term(s) Humans ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Eye ; Face
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.05.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic Drug Monitoring of Levetiracetam in Different Trimesters of Pregnant Women with Epilepsy in a Tertiary Care Center: A Prospective Study.

    Kumaravel, J / Sarma, Phulen / Suri, Vanita / Singh, Parampreet / Prakash, Ajay / Medhi, Bikash

    Neurology India

    2024  Volume 72, Issue 2, Page(s) 358–363

    Abstract: Background: Levetiracetam is the most commonly used antiepileptic drug in pregnant women due to its low teratogenic risk profile, favorable pharmacokinetic characteristics, and safety profile. Serum levels of levetiracetam vary in epilepsy during ... ...

    Abstract Background: Levetiracetam is the most commonly used antiepileptic drug in pregnant women due to its low teratogenic risk profile, favorable pharmacokinetic characteristics, and safety profile. Serum levels of levetiracetam vary in epilepsy during pregnancy. Therefore, the aim of the study was to evaluate the serum levels of levetiracetam during different trimesters of pregnancy by using therapeutic drug monitoring (TDM).
    Materials and methods: This was a single-center, prospective study. Pregnant women with epilepsy on levetiracetam were enrolled after getting written informed consent from them. Serum trough levels of levetiracetam were estimated at all trimesters by high-performance liquid chromatography (HPLC).
    Results: The study included 16 participants with mean ± standard deviation (SD) age of 27.75 ± 4 years. There were nine (56.2%) participants with generalized seizure disorder and seven (43.8%) participants of focal seizure disorder. Among 16 patients, 10 (62.5%) participants were on levetiracetam alone and six (37.5%) participants were on levetiracetam combined with other antiepileptic drugs. In a total of 48 trough samples, 45 sample concentrations were below the therapeutic range of 12-46 mg/l and three sample concentrations were within the therapeutic range. There was a statistically significant difference in the concentration-dose ratio (CDR) of levetiracetam between the third and first trimesters (P-value 0.018).
    Conclusion: There was a statistically significant difference in serum levetiracetam concentration between the third and first trimesters. A well-conducted, intensive pharmacokinetic sampling study in PWWE with a control group is needed in future to evaluate the whole pharmacokinetic profile of levetiracetam and to correlate the clinical outcome.
    MeSH term(s) Humans ; Levetiracetam/pharmacokinetics ; Levetiracetam/blood ; Levetiracetam/therapeutic use ; Female ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/blood ; Anticonvulsants/therapeutic use ; Pregnancy ; Drug Monitoring/methods ; Adult ; Epilepsy/drug therapy ; Epilepsy/blood ; Prospective Studies ; Tertiary Care Centers ; Young Adult ; Pregnancy Trimesters/blood ; Pregnancy Complications/drug therapy ; Pregnancy Complications/blood ; Piracetam/analogs & derivatives ; Piracetam/blood ; Piracetam/pharmacokinetics ; Piracetam/therapeutic use
    Chemical Substances Levetiracetam (44YRR34555) ; Anticonvulsants ; Piracetam (ZH516LNZ10)
    Language English
    Publishing date 2024-04-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/ni.ni_439_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Evaluation of the Efficacy and Safety of Midazolam Nasal Spray in Patients With Seizure Clusters: A Systematic Review and Meta-Analysis.

    Niraj, Niraj / Mahajan, Sonia / Prakash, Ajay / Sarma, Phulen / Medhi, Bikash

    Cureus

    2023  Volume 15, Issue 1, Page(s) e34064

    Abstract: Midazolam nasal spray (MDZ-NS) is a new emerging rescue medication that suppresses epileptic seizures. Until now, few studies, pharmacokinetic (PK) and pharmacodynamic (PD) profiles, and clinical trials have shown that midazolam nasal spray could become ... ...

    Abstract Midazolam nasal spray (MDZ-NS) is a new emerging rescue medication that suppresses epileptic seizures. Until now, few studies, pharmacokinetic (PK) and pharmacodynamic (PD) profiles, and clinical trials have shown that midazolam nasal spray could become an effective and promising alternative to conventional routes (intravenous {IV}/rectal). Therefore, we thought of conducting a systematic review and meta-analysis of midazolam (MDZ) to assess its potential outcomes. The analysis was also evaluated based on the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of midazolam nasal spray. A systematic literature search was carried out through various databases to identify studies of accounted outcomes of midazolam nasal spray (MDZ-NS). Randomized and other studies of patients (12 years or older) with seizure clusters (SCs) were included. A total of three full-text articles were considered for systematic review and meta-analysis as per the inclusion and exclusion criteria. The 5 mg MDZ-NS was observed to be equally safe as a placebo, and the risk ratio (RR) was 1.01 (95% confidence interval (CI): 0.67-1.53). After the administration of MDZ-NS, either the patients remained seizure-free for six hours or more or the seizure was terminated within 10 minutes and had no recurrence between 10 minutes and six hours. The risk ratio (RR) obtained was 1.54 (95% CI: 1.25-1.91). The result was statistically significant as a higher success rate was observed with the use of 5 mg midazolam nasal spray compared to placebo (p < 0.0001). Heterogeneity was not observed in the results of the included studies (inconsistency index {I
    Language English
    Publishing date 2023-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.34064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Paxlovid: A promising drug for the challenging treatment of SARS-COV-2 in the pandemic era.

    Niraj, Niraj / Mahajan, Sonia Shinde / Prakash, Ajay / Sarma, Phulen / Medhi, Bikash

    Indian journal of pharmacology

    2023  Volume 54, Issue 6, Page(s) 452–458

    Abstract: Coronavirus infection is a pandemic threat and the most dangerous disease of the ... ...

    Abstract Coronavirus infection is a pandemic threat and the most dangerous disease of the 21
    MeSH term(s) Humans ; SARS-CoV-2 ; Pandemics ; COVID-19 ; Antiviral Agents/adverse effects
    Chemical Substances nirmatrelvir and ritonavir drug combination ; Antiviral Agents
    Language English
    Publishing date 2023-02-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/ijp.ijp_291_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 311: Show issues

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  6. Article ; Online: Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19.

    Bhattacharyya, Anusuya / Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) 434

    MeSH term(s) Adult ; COVID-19/drug therapy ; Coronavirus Infections ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0001
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  7. Article ; Online: Role of Iron Chelators in Mucormycosis.

    Mahalmani, Vidya / Sarma, Phulen / Prakash, Ajay / Medhi, Bikash

    Indian journal of pharmacology

    2021  Volume 53, Issue 4, Page(s) 261–263

    MeSH term(s) Animals ; COVID-19/complications ; Humans ; Iron/metabolism ; Iron Chelating Agents/therapeutic use ; Mucormycosis/drug therapy ; Mucormycosis/etiology ; Mucormycosis/metabolism ; SARS-CoV-2
    Chemical Substances Iron Chelating Agents ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-08-20
    Publishing country India
    Document type Editorial
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/ijp.ijp_604_21
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  8. Article: Neuroprotective Effect of

    Ralta, Arti / Prakash, Ajay / Kumar M, Praveen / Kumar, Rohit / Sarma, Phulen / Bhatia, Alka / Medhi, Bikash / Chakrabarti, Amitava

    Basic and clinical neuroscience

    2023  Volume 14, Issue 1, Page(s) 155–166

    Abstract: Introduction: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of : Methods: PTZ kindling model was developed by daily administration of the sub-convulsive dose of PTZ 30 mg/kg for four ... ...

    Abstract Introduction: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of
    Methods: PTZ kindling model was developed by daily administration of the sub-convulsive dose of PTZ 30 mg/kg for four weeks. After four weeks of induction, the following treatment, namely sodium valproic acid (SVA) 200 mg/kg,
    Results: C. paniculatus
    Conclusion: C. paniculatus
    Language English
    Publishing date 2023-01-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652444-2
    ISSN 2228-7442 ; 2008-126X
    ISSN (online) 2228-7442
    ISSN 2008-126X
    DOI 10.32598/bcn.2021.3154.1
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  9. Article ; Online: Letter to the editor: Possible role of topical povidone iodine in case of accidental ocular exposure to SARS-CoV-2.

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2020  Volume 258, Issue 11, Page(s) 2575–2578

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Povidone ; Povidone-Iodine/adverse effects ; SARS Virus ; SARS-CoV-2
    Chemical Substances Povidone-Iodine (85H0HZU99M) ; Povidone (FZ989GH94E)
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-020-04864-9
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  10. Article ; Online: Possible prophylactic or preventive role of topical povidone iodine during accidental ocular exposure to 2019-nCoV.

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2020  Volume 258, Issue 11, Page(s) 2563–2565

    MeSH term(s) Administration, Ophthalmic ; Anti-Infective Agents, Local/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Eye Infections, Viral/prevention & control ; Eye Infections, Viral/transmission ; Humans ; Ophthalmic Solutions ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Povidone-Iodine/administration & dosage ; SARS-CoV-2
    Chemical Substances Anti-Infective Agents, Local ; Ophthalmic Solutions ; Povidone-Iodine (85H0HZU99M)
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-020-04752-2
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