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  1. Article ; Online: Possible synergistic effects of hydroxychloroquine and steroids in COVID-19, time for a nuanced approach. Comment on Arshad et al.

    Wiseman, David M

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 99, Page(s) 344–345

    MeSH term(s) Azithromycin ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.07.064
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  3. Article ; Online: Possible synergistic effects of hydroxychloroquine and steroids in COVID-19, time for a nuanced approach. Comment on Arshad et al.

    Wiseman, David M.

    International Journal of Infectious Diseases

    2020  Volume 99, Page(s) 344–345

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.07.064
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Complete Genomic Assembly of Mauritian Cynomolgus Macaque Killer Ig-like Receptor and Natural Killer Group 2 Haplotypes.

    Prall, Trent M / Karl, Julie A / Varghese, Joshua M / Baker, David A / Minor, Nicholas R / Raveendran, Muthuswamy / Harris, R Alan / Rogers, Jeffery / Wiseman, Roger W / O'Connor, David H

    Journal of immunology (Baltimore, Md. : 1950)

    2024  

    Abstract: Mauritian-origin cynomolgus macaques (MCMs) serve as a powerful nonhuman primate model in biomedical research due to their unique genetic homogeneity, which simplifies experimental designs. Despite their extensive use, a comprehensive understanding of ... ...

    Abstract Mauritian-origin cynomolgus macaques (MCMs) serve as a powerful nonhuman primate model in biomedical research due to their unique genetic homogeneity, which simplifies experimental designs. Despite their extensive use, a comprehensive understanding of crucial immune-regulating gene families, particularly killer Ig-like receptors (KIR) and NK group 2 (NKG2), has been hindered by the lack of detailed genomic reference assemblies. In this study, we employ advanced long-read sequencing techniques to completely assemble eight KIR and seven NKG2 genomic haplotypes, providing an extensive insight into the structural and allelic diversity of these immunoregulatory gene clusters. Leveraging these genomic resources, we prototype a strategy for genotyping KIR and NKG2 using short-read, whole-exome capture data, illustrating the potential for cost-effective multilocus genotyping at colony scale. These results mark a significant enhancement for biomedical research in MCMs and underscore the feasibility of broad-scale genetic investigations.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300856
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  5. Article ; Online: Complete sequencing of a cynomolgus macaque major histocompatibility complex haplotype.

    Karl, Julie A / Prall, Trent M / Bussan, Hailey E / Varghese, Joshua M / Pal, Aparna / Wiseman, Roger W / O'Connor, David H

    Genome research

    2023  Volume 33, Issue 3, Page(s) 448–462

    Abstract: Macaques provide the most widely used nonhuman primate models for studying the immunology and pathogenesis of human diseases. Although the macaque major histocompatibility complex (MHC) region shares most features with the human leukocyte antigen (HLA) ... ...

    Abstract Macaques provide the most widely used nonhuman primate models for studying the immunology and pathogenesis of human diseases. Although the macaque major histocompatibility complex (MHC) region shares most features with the human leukocyte antigen (HLA) region, macaques have an expanded repertoire of MHC class I genes. Although a chimera of two rhesus macaque MHC haplotypes was first published in 2004, the structural diversity of MHC genomic organization in macaques remains poorly understood owing to a lack of adequate genomic reference sequences. We used ultralong Oxford Nanopore and high-accuracy Pacific Biosciences (PacBio) HiFi sequences to fully assemble the ∼5.2-Mb M3 haplotype of an MHC-homozygous, Mauritian-origin cynomolgus macaque (
    MeSH term(s) Animals ; Humans ; Macaca fascicularis/genetics ; Haplotypes ; Macaca mulatta/genetics ; Major Histocompatibility Complex/genetics ; Sequence Analysis, DNA/methods ; Alleles
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1284872-4
    ISSN 1549-5469 ; 1088-9051 ; 1054-9803
    ISSN (online) 1549-5469
    ISSN 1088-9051 ; 1054-9803
    DOI 10.1101/gr.277429.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation.

    Tiedemann, Rochelle L / Hrit, Joel / Du, Qian / Wiseman, Ashley K / Eden, Hope E / Dickson, Bradley M / Kong, Xiangqian / Chomiak, Alison A / Vaughan, Robert M / Hebert, Jakob M / David, Yael / Zhou, Wanding / Baylin, Stephen B / Jones, Peter A / Clark, Susan J / Rothbart, Scott B

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. Nucleosomal engagement through histone and DNA interactions directs UHRF1 ubiquitin ligase activity toward lysines on histone H3 tails, creating binding sites ... ...

    Abstract The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. Nucleosomal engagement through histone and DNA interactions directs UHRF1 ubiquitin ligase activity toward lysines on histone H3 tails, creating binding sites for DNMT1 through ubiquitin interacting motifs (UIM1 and UIM2). Here, we profile contributions of UHRF1 and DNMT1 to genome-wide DNA methylation inheritance and dissect specific roles for ubiquitin signaling in this process. We reveal DNA methylation maintenance at low-density CpGs is vulnerable to disruption of UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity through UIM1. Hypomethylation of low-density CpGs in this manner induces formation of partially methylated domains (PMD), a methylation signature observed across human cancers. Furthermore, disrupting DNMT1 UIM2 function abolishes DNA methylation maintenance. Collectively, we show DNMT1-dependent DNA methylation inheritance is a ubiquitin-regulated process and suggest a disrupted UHRF1-DNMT1 ubiquitin signaling axis contributes to the development of PMDs in human cancers.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.13.580169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Possible synergistic effects of hydroxychloroquine and steroids in COVID-19, time for a nuanced approach. Comment on Arshad et al.

    David M. Wiseman, PhD MRPharmS

    International Journal of Infectious Diseases, Vol 99, Iss , Pp 344-

    2020  Volume 345

    Keywords Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Automated referral to community paramedicine during 9-1-1 fall calls for resource activation.

    Quatman, Carmen E / Wiseman, Jessica M / Sheridan, Elizabeth / Caterino, Jeffrey M / Weade, Mark / Wisner, David / Leyshon, Christine / Quatman-Yates, Catherine

    Journal of the American Geriatrics Society

    2022  Volume 70, Issue 12, Page(s) 3578–3584

    Abstract: Background: We sought to improve the referral process to a community paramedicine (CP) program following a 9-1-1 encounter.: Methods: An electronic health record (EHR) for CP records with the ability to link to emergency EHR was identified and ... ...

    Abstract Background: We sought to improve the referral process to a community paramedicine (CP) program following a 9-1-1 encounter.
    Methods: An electronic health record (EHR) for CP records with the ability to link to emergency EHR was identified and implemented with a single-click referral to the CP program. Referrals were tracked for 15 months before and after implementation.
    Results: Referral capacity increased from an average of 14.2 referrals per month to 44.9 referrals per month.
    Conclusion: The results of this study suggest an EHR is a useful investment for CP programs and may be integral to efficient program operations.
    MeSH term(s) Humans ; Emergency Medical Services ; Paramedicine ; Referral and Consultation ; Accidental Falls/prevention & control ; Electronic Health Records
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18011
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  9. Article ; Online: What Do Adolescents and Young Adults Think a Cigarillo Is? Implications for Health Communication.

    Cornacchione Ross, Jennifer / Reboussin, David M / Noar, Seth M / Wiseman, Kimberly D / Sutfin, Erin L

    International journal of environmental research and public health

    2021  Volume 18, Issue 6

    Abstract: Cigarillo use has increased among adolescents and young adults and has remained high. Public education efforts are needed to communicate with these populations about cigarillo use risks, but little is known about the implications of using the term " ... ...

    Abstract Cigarillo use has increased among adolescents and young adults and has remained high. Public education efforts are needed to communicate with these populations about cigarillo use risks, but little is known about the implications of using the term "cigarillo" in such efforts. The study goal was to assess adolescent and young adult perceptions of the term "cigarillo". We conducted a nationally representative online survey of 3517 adolescents and young adults (ages 13-25). We asked participants "what is a cigarillo?" with several response options. Participants were 49.6% female, 69.8% white, 5.2% reported past 30-day cigarillo use, and 11.6% reported lifetime cigarillo use. The most common response to the question "what is a cigarillo" was "I don't know" (51% of participants), followed by "a thinner and smaller version of a traditional cigar" (30.1% of participants), which was chosen by 19.4% of adolescents and 36.8% of young adults. Among past 30-day cigarillo users, the most common response was "I don't know" (54.9%) followed by "a thinner and smaller version of a traditional cigar" (45.1%). Cigarillo users were more likely to select the "a thinner and smaller version of a traditional cigar" response than nonusers. Findings suggest that many adolescents and young adults have varied understandings of the term "cigarillo". Researchers and practitioners need to ensure that terminology used in health communication campaigns is clearly understood by the target audience to maximize effectiveness.
    MeSH term(s) Adolescent ; Adult ; Ethnicity ; Female ; Health Communication ; Humans ; Male ; Surveys and Questionnaires ; Tobacco Products ; Young Adult
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18063311
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  10. Article ; Online: Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians.

    Wiseman, Alexander / Alhamad, Tarek / Alloway, Rita R / Concepcion, Beatrice P / Cooper, Matthew / Formica, Richard / Klein, Christina L / Kumar, Vineeta / Leca, Nicolae / Shihab, Fuad / Taber, David J / Mulnick, Sarah / Bushnell, Donald M / Hadi, Monica / Bunnapradist, Suphamai

    Annals of transplantation

    2024  Volume 29, Page(s) e943498

    Abstract: BACKGROUND LCPT (Envarsus XR®) is a common once-daily, extended-release oral tacrolimus formulation used in kidney transplantation. However, there are minimal evidence-based recommendations regarding optimal dosing and treatment in the de novo and ... ...

    Abstract BACKGROUND LCPT (Envarsus XR®) is a common once-daily, extended-release oral tacrolimus formulation used in kidney transplantation. However, there are minimal evidence-based recommendations regarding optimal dosing and treatment in the de novo and conversion settings. MATERIAL AND METHODS Using Delphi methodology, 12 kidney transplantation experts with LCPT experience reviewed available data to determine potential consensus topics. Key statements regarding LCPT use were generated and disseminated to the panel in an online Delphi survey. Statements were either accepted, revised, or rejected based on the level of consensus, perceived strength of evidence, and alignment with clinical practice. Consensus was defined a priori as ≥75% agreement. RESULTS Twenty-three statements were generated: 14 focused on de novo LCPT use and 9 on general administration or LCPT conversion use. After 2 rounds, consensus was achieved for 11/14 of the former and 7/9 of the latter statements. In a de novo setting, LCPT was recognized as a first-line option based on its safety and efficacy compared to immediate-release tacrolimus. In particular, African Americans and rapid metabolizer populations were identified as preferred for first-line LCPT therapy. In a conversion setting, full consensus was achieved for converting to LCPT to address neurological adverse effects related to immediate-release tacrolimus and for the time required (approximately 7 days) for steady-state LCPT trough levels to be reached. CONCLUSIONS When randomized clinical trials do not replicate current utilization patterns, the Delphi process can successfully generate consensus statements by expert clinicians to inform clinical decision-making for the use of LCPT in kidney transplant recipients.
    MeSH term(s) Humans ; Delphi Technique ; Kidney Transplantation ; Tacrolimus/therapeutic use ; Black or African American ; Clinical Decision-Making
    Chemical Substances Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.943498
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