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  1. Article: [Treatment of hypertension complicated with renal disorders].

    Kiyomoto, Hideyasu

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2006  Volume 96, Issue 1, Page(s) 65–72

    MeSH term(s) Humans ; Hypertension/complications ; Hypertension/drug therapy ; Kidney Diseases/complications
    Language Japanese
    Publishing date 2006-06-07
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.96.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Screening of COVID-19 polymerase chain reaction tests using saliva for pregnant women and their partners in Himeji city.

    Okamura, Shinsuke / Akamatsu, Nobuo / Kitajima, Takashi / Nakabayashi, Koji / Fukumoto, Shun / Katayama, Takaaki / Mizutani, Yasushi / Kiyomoto, Hideyasu / Yamada, Hideto

    The journal of obstetrics and gynaecology research

    2020  Volume 47, Issue 4, Page(s) 1253–1255

    Abstract: A screening of coronavirus disease 2019 (COVID-19) polymerase chain reaction (PCR) tests using saliva for pregnant women and their partners was performed at all 12 maternity facilities located in Himeji city between May 29 and September 5, 2020. Pregnant ...

    Abstract A screening of coronavirus disease 2019 (COVID-19) polymerase chain reaction (PCR) tests using saliva for pregnant women and their partners was performed at all 12 maternity facilities located in Himeji city between May 29 and September 5, 2020. Pregnant women at 37 or more weeks of gestation or who experienced threatened labor and their partners who cared for an infant underwent a saliva PCR test with informed consent. As a result, all of 1475 pregnant women and 1343 partners tested negative for COVID-19 PCR. There were no cases of false positive or false negative PCR tests. This cohort study revealed for the first time that a screening of COVID-19 PCR tests using saliva may be useful to sustain perinatal medical care during the pandemic period in Japan.
    MeSH term(s) COVID-19/diagnosis ; Cohort Studies ; Diagnostic Screening Programs ; False Negative Reactions ; False Positive Reactions ; Female ; Humans ; Japan ; Male ; Perinatal Care ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; Saliva/virology ; Spouses
    Language English
    Publishing date 2020-12-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.14591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chronic blockade of the (pro)renin receptor ameliorates the kidney damage in the non-clipped kidney of Goldblatt hypertension.

    Kiyomoto, Hideyasu / Moriwaki, Kumiko

    Hypertension research : official journal of the Japanese Society of Hypertension

    2011  Volume 34, Issue 3, Page(s) 289–291

    MeSH term(s) Animals ; Female ; Humans ; Hypertension, Renovascular/drug therapy ; Hypertension, Renovascular/physiopathology ; Kidney/drug effects ; Kidney/physiopathology ; Mice ; Rats ; Receptors, Cell Surface/antagonists & inhibitors ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Treatment Outcome ; Vacuolar Proton-Translocating ATPases/antagonists & inhibitors
    Chemical Substances ATP6AP2 protein, human ; Receptors, Cell Surface ; prorenin receptor ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
    Language English
    Publishing date 2011-03
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2010.253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A rare case among hypertensive patients: how do we handle reninomas?

    Okuda, Hiroshi / Abe, Michiaki / Kiyomoto, Hideyasu

    Internal medicine (Tokyo, Japan)

    2013  Volume 52, Issue 17, Page(s) 1853

    MeSH term(s) Female ; Humans ; Juxtaglomerular Apparatus/metabolism ; Juxtaglomerular Apparatus/pathology ; Kidney Neoplasms/diagnosis ; Preoperative Care/methods ; Renal Veins ; Renin/metabolism
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2013-08-27
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.52.0973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Serious Hypocalcemia After Withdrawal of Vitamin D Analog in Bedridden Nonagenarians with Previous Thyroidectomy: A Report of Two Cases.

    Mishima, Eikan / Nishimiya, Kensuke / Fujiwara, Yasushi / Nishizawa, Masafumi / Kiyomoto, Hideyasu / Ito, Sadayoshi

    Journal of the American Geriatrics Society

    2016  Volume 64, Issue 6, Page(s) 1374–1376

    MeSH term(s) Aged, 80 and over ; Bedridden Persons ; Bone Density Conservation Agents/therapeutic use ; Female ; Humans ; Hypocalcemia/diagnosis ; Hypocalcemia/etiology ; Hypocalcemia/therapy ; Hypoparathyroidism/complications ; Thyroidectomy ; Vitamin D/analogs & derivatives ; Vitamin D/therapeutic use ; Withholding Treatment
    Chemical Substances Bone Density Conservation Agents ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.14171
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  6. Article ; Online: Angiotensin II receptor blocker is a renoprotective remedy for metabolic syndrome.

    Sofue, Tadashi / Kiyomoto, Hideyasu

    Hypertension research : official journal of the Japanese Society of Hypertension

    2009  Volume 32, Issue 9, Page(s) 735–737

    MeSH term(s) Albuminuria/prevention & control ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Diabetic Nephropathies/prevention & control ; Humans ; Kidney Diseases/etiology ; Kidney Diseases/prevention & control ; Metabolic Syndrome/complications ; Metabolic Syndrome/drug therapy ; Obesity/complications ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensin II Type 1 Receptor Blockers
    Language English
    Publishing date 2009-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2009.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis.

    Yamada, Hiroyuki / Doi, Kent / Tsukamoto, Tatsuo / Kiyomoto, Hideyasu / Yamashita, Kazuto / Yanagita, Motoko / Terada, Yoshio / Mori, Kiyoshi

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 41

    Abstract: Background: Theoretically, atrial natriuretic peptide (ANP), especially low-dose ANP, is beneficial in acute kidney injury (AKI). In this study, we examined whether low-dose ANP is effective in preventing or treating AKI by conducting an updated ... ...

    Abstract Background: Theoretically, atrial natriuretic peptide (ANP), especially low-dose ANP, is beneficial in acute kidney injury (AKI). In this study, we examined whether low-dose ANP is effective in preventing or treating AKI by conducting an updated systematic review for randomized controlled trials (RCTs).
    Method: We searched the Excerpta Medica database (EMBASE), PubMed, and Cochrane CENTRAL databases for RCTs that compare the effects of low-dose ANP (≤ 50 ng/kg/min) with a placebo or conventional therapy in at-risk patients or patients with AKI. The primary outcome was the incidence of new AKI (in prevention RCTs), while the secondary outcomes were in-hospital mortality rate, renal replacement therapy (RRT) requirement, length of hospital and intensive care unit (ICU) stay, incidence of hypotension, and peak serum creatinine levels. The risk-of-bias was evaluated using the Cochrane Collaboration risk-of-bias tool. Trial sequential analysis (TSA) was used for each outcome of interest.
    Results: A total of 18 RCTs (16 prevention and two treatment trials) fulfilled our inclusion criteria. In prevention RCTs, the incidence of new AKI was significantly low in the low-dose ANP group (relative risk [RR] = 0.51; 95% confidence interval [CI] = 0.36-0.72; P = 0.0001) compared to the control group. In addition, the low-dose ANP group showed a significantly reduced RRT requirement in both prevention (RR = 0.17; 95% CI = 0.04-0.64; P = 0.009) and treatment (RR = 0.43; 95% CI = 0.20-0.93; P = 0.03) RCTs. Among secondary outcomes, in some cases, low-dose ANP was associated with a reduction in ICU and in-hospital stay. The risk-of-bias assessment and TSA results indicated that the sample sizes and qualities of the RCTs were insufficient to conclude the efficacy of low-dose ANP.
    Conclusion: Low-dose ANP might be effective in preventing or treating AKI. However, the evidence accumulated so far is not strong enough to demonstrate ANP's beneficial effects. The next step is to elucidate the effects of low-dose ANP by conducting multicenter, high-quality, large-sample RCTs.
    Trial registration: PROSPERO registry CRD42017068568 . Registered 20 June 2017.
    MeSH term(s) Acute Kidney Injury/drug therapy ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/prevention & control ; Atrial Natriuretic Factor/pharmacology ; Atrial Natriuretic Factor/therapeutic use ; Hospital Mortality ; Humans ; Length of Stay ; Renal Replacement Therapy/methods ; Renal Replacement Therapy/standards ; Treatment Outcome
    Chemical Substances Atrial Natriuretic Factor (85637-73-6)
    Language English
    Publishing date 2019-02-11
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2330-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Do vasculature reactive oxygen species play a role in the mobilization of bone marrow endothelial progenitor cells?

    Kiyomoto, Hideyasu / Nishiyama, Akira

    Journal of hypertension

    2008  Volume 26, Issue 2, Page(s) 188–190

    MeSH term(s) Animals ; Bone Marrow Cells/physiology ; Endothelial Cells/physiology ; Hypertension/blood ; Hypertension/physiopathology ; Mice ; Reactive Oxygen Species/blood ; Reactive Oxygen Species/metabolism ; Stem Cells/physiology
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2008-02
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0b013e3282f2851a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

    Taira, Makiko / Mugikura, Shunji / Mori, Naoko / Hozawa, Atsushi / Saito, Tomo / Nakamura, Tomohiro / Kiyomoto, Hideyasu / Kobayashi, Tadao / Ogishima, Soichi / Nagami, Fuji / Uruno, Akira / Shimizu, Ritsuko / Kobayashi, Tomoko / Yasuda, Jun / Kure, Shigeo / Sakurai, Miyuki / Motoike, Ikuko N / Kumada, Kazuki / Nakaya, Naoki /
    Obara, Taku / Oba, Kentaro / Sekiguchi, Atsushi / Thyreau, Benjamin / Mutoh, Tatsushi / Takano, Yuji / Abe, Mitsunari / Maikusa, Norihide / Tatewaki, Yasuko / Taki, Yasuyuki / Yaegashi, Nobuo / Tomita, Hiroaki / Kinoshita, Kengo / Kuriyama, Shinichi / Fuse, Nobuo / Yamamoto, Masayuki

    JMA journal

    2023  Volume 6, Issue 3, Page(s) 246–264

    Abstract: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of ... ...

    Abstract The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.
    Language English
    Publishing date 2023-06-30
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2022-0220
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  10. Article: The earlier, the better.

    Kiyomoto, Hideyasu / Hitomi, Hirofumi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2007  Volume 30, Issue 1, Page(s) 1–2

    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Animals ; Blood Pressure ; Disease Progression ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Kidney Diseases/prevention & control ; Renin-Angiotensin System/drug effects ; Time Factors
    Chemical Substances Angiotensin II Type 1 Receptor Blockers
    Language English
    Publishing date 2007-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1175297-x
    ISSN 0916-9636
    ISSN 0916-9636
    DOI 10.1291/hypres.30.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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