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  1. Article ; Online: Possibly critical role of wearing masks in general population in controlling COVID-19.

    Han, Guangshu / Zhou, Yi-Hua

    Journal of medical virology

    2020  Volume 92, Issue 10, Page(s) 1779–1781

    MeSH term(s) COVID-19/prevention & control ; COVID-19/virology ; Humans ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Thinking more about therapy with convalescent plasma for COVID-19 patients.

    Han, Guangshu / Zhou, Yi-Hua

    Human vaccines & immunotherapeutics

    2020  Volume 16, Issue 11, Page(s) 2601–2603

    MeSH term(s) Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; COVID-19/therapy ; Humans ; Immunization, Passive/methods ; SARS-CoV-2/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1787073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6967: Show issues Location:
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  5. Article ; Online: Thinking more about therapy with convalescent plasma for COVID-19 patients

    Han, Guangshu / Zhou, Yi-Hua

    Human Vaccines & Immunotherapeutics ; ISSN 2164-5515 2164-554X

    2020  

    Keywords Immunology ; Immunology and Allergy ; Pharmacology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    DOI 10.1080/21645515.2020.1787073
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Possibly critical role of wearing masks in general population in controlling COVID‐19

    Han, Guangshu / Zhou, Yi‐Hua

    Journal of Medical Virology

    2020  Volume 92, Issue 10, Page(s) 1779–1781

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25886
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.

    Han, Chunyong / Li, Xuebiao / Fan, Qian / Liu, Guangshu / Yin, Jian

    Aging

    2019  Volume 11, Issue 14, Page(s) 4858–4875

    Abstract: Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of the lncRNA CCAT1 in triple-negative breast cancer (TNBC). CCAT1 expression was higher in TNBC cells than normal breast epithelial cells. ... ...

    Abstract Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of the lncRNA CCAT1 in triple-negative breast cancer (TNBC). CCAT1 expression was higher in TNBC cells than normal breast epithelial cells. Additionally, CCAT1 expression was higher in TNBC patient tumor tissue than adjacent normal breast tissue. Silencing CCAT1 inhibited TNBC cell proliferation, migration, and invasion
    MeSH term(s) Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; Signal Transduction/physiology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
    Chemical Substances CCAT1 long noncoding RNA, human ; Kruppel-Like Transcription Factors ; MIRN218 microRNA, human ; MicroRNAs ; RNA, Long Noncoding ; zinc finger protein, X-linked
    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Importance of timely management of patients in reducing fatality rate of coronavirus disease 2019

    Yuzhu Peng / Biyun Xu / Beicheng Sun / Guangshu Han / Yi-Hua Zhou

    Journal of Infection and Public Health, Vol 13, Iss 6, Pp 890-

    2020  Volume 892

    Abstract: The outbreak of coronavirus disease 2019 (COVID-19) characterized with pneumonia, firstly occurred in Wuhan city, China, in December 2019 has so far spread in over 200 countries and territories in the world. One of the important goals in facing outbreaks ...

    Abstract The outbreak of coronavirus disease 2019 (COVID-19) characterized with pneumonia, firstly occurred in Wuhan city, China, in December 2019 has so far spread in over 200 countries and territories in the world. One of the important goals in facing outbreaks of COVID-19 is to reduce the case fatality rate. We reported here that the fatality rate of COVID-19 in other provinces of mainland China was 0.82% (121/14,708), significantly lower than 6.62% (4512/68,128) in Hubei province (p < 0.0001). The main reason for the lower fatality rate was likely due to the timely management of the patients in other provinces, highlighting the importance of timely management of patients in reducing the fatality rate of COVID-19.
    Keywords Coronavirus disease 2019 (COVID-19) ; Fatality rate ; Timely management ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Importance of timely management of patients in reducing fatality rate of coronavirus disease 2019.

    Peng, Yuzhu / Xu, Biyun / Sun, Beicheng / Han, Guangshu / Zhou, Yi-Hua

    Journal of infection and public health

    2020  Volume 13, Issue 6, Page(s) 890–892

    Abstract: The outbreak of coronavirus disease 2019 (COVID-19) characterized with pneumonia, firstly occurred in Wuhan city, China, in December 2019 has so far spread in over 200 countries and territories in the world. One of the important goals in facing outbreaks ...

    Abstract The outbreak of coronavirus disease 2019 (COVID-19) characterized with pneumonia, firstly occurred in Wuhan city, China, in December 2019 has so far spread in over 200 countries and territories in the world. One of the important goals in facing outbreaks of COVID-19 is to reduce the case fatality rate. We reported here that the fatality rate of COVID-19 in other provinces of mainland China was 0.82% (121/14,708), significantly lower than 6.62% (4512/68,128) in Hubei province (p<0.0001). The main reason for the lower fatality rate was likely due to the timely management of the patients in other provinces, highlighting the importance of timely management of patients in reducing the fatality rate of COVID-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Cities/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Disease Management ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Retrospective Studies ; SARS-CoV-2 ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country England
    Document type Journal Article
    ISSN 1876-035X
    ISSN (online) 1876-035X
    DOI 10.1016/j.jiph.2020.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cx32 reverses epithelial-mesenchymal transition in doxorubicin-resistant hepatocellular carcinoma.

    Yu, Meiling / Han, Guangshu / Qi, Benquan / Wu, Xiaoxiang

    Oncology reports

    2017  Volume 37, Issue 4, Page(s) 2121–2128

    Abstract: Recently, epithelial-mesenchymal transition (EMT) has been reported to be an important mechanism of drug resistance in numerous types of cancer cells, including hepatocellular carcinoma (HCC). However, the underlying mechanisms remain to be fully ... ...

    Abstract Recently, epithelial-mesenchymal transition (EMT) has been reported to be an important mechanism of drug resistance in numerous types of cancer cells, including hepatocellular carcinoma (HCC). However, the underlying mechanisms remain to be fully elucidated. Connexin (Cx)32 plays a crucial role in hepatocarcinogenesis. The present study investigated the role of Cx32 in the regulation of chemotherapy-induced EMT in HCC. We found that the expression levels of Cx32 and E-cadherin were clearly decreased in HCC tissues compared with the corresponding paracancerous tissues, while the expression level of vimentin was significantly enhanced in HCC tissues. The expression of Cx32 had a strong correlation with the expression of E-cadherin and vimentin. In an in vitro study, a doxorubicin (DOX)-resistant liver cell line HepG2/DOX was established from parental HepG2 cells. The results showed that HepG2/DOX cells acquired EMT characteristics, with a decreased expression level of E-cadherin and an enhanced expression level of vimentin, and possessed high migratory abilities and invasiveness. Meanwhile, Cx32 was significantly decreased in the HepG2/DOX cells. Knockdown of Cx32 by shRNA in HepG2 cells induced EMT, while overexpression of Cx32 converted EMT to mesenchymal-epithelial transition (MET) in the HepG2/DOX cells. These results suggest that Cx32 is an important regulator of DOX-induced EMT in HCC. Cx32 could be considered as a novel target to reverse DOX resistance in HCC.
    MeSH term(s) Cadherins/biosynthesis ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Movement/genetics ; Cell Proliferation/genetics ; Connexins/biosynthesis ; Connexins/genetics ; Doxorubicin/administration & dosage ; Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Neoplasm Invasiveness/genetics ; Vimentin/biosynthesis ; Gap Junction beta-1 Protein
    Chemical Substances Cadherins ; Connexins ; Vimentin ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2017-02-17
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2017.5462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4213: Show issues Location:
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