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  1. Article ; Online: Comment on: Prevalence of LTBI in patients with autoimmune diseases and accuracy of IGRA in predicting TB relapse: Reply.

    Chandrashekara, S

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 4, Page(s) e148

    MeSH term(s) Humans ; Interferon-gamma Release Tests ; Prevalence ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Tuberculin Test ; Autoimmune Diseases/epidemiology
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead442
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  2. Article: Osteoporosis in Rheumatology.

    Chandrashekara, S

    Indian journal of orthopaedics

    2023  Volume 57, Issue Suppl 1, Page(s) 176–180

    Abstract: Introduction: Osteoporosis is a common diagnosis and comorbidity observed in patients with rheumatic diseases. It is frequently associated with conditions such as rheumatoid arthritis, spondyloarthropathy, systemic lupus erythematosus, and other ... ...

    Abstract Introduction: Osteoporosis is a common diagnosis and comorbidity observed in patients with rheumatic diseases. It is frequently associated with conditions such as rheumatoid arthritis, spondyloarthropathy, systemic lupus erythematosus, and other autoimmune rheumatic diseases.
    Conclusion: The incidence of osteoporosis is influenced by factors such as uncontrolled disease, prolonged and higher doses of steroid use, immobility, advanced age, and postmenopausal status. Achieving good control of the underlying disease, minimizing or avoiding the use of steroids for extended periods, and ensuring adequate supplementation of vitamin D and calcium are crucial in reducing the incidence of osteoporosis. Regular screening and appropriate management of osteoporosis can significantly decrease the associated morbidity and mortality.
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 603194-8
    ISSN 0019-5413
    ISSN 0019-5413
    DOI 10.1007/s43465-023-01024-z
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  3. Article ; Online: Photoexcited Toluidine Blue Inhibits Tau Aggregation in Alzheimer’s Disease

    Tushar Dubey / Nalini Vijay Gorantla / Kagepura Thammaiah Chandrashekara / Subashchandrabose Chinnathambi

    ACS Omega, Vol 4, Iss 20, Pp 18793-

    2019  Volume 18802

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Presentation of Ewing’s sarcoma as unilateral sacroiliitis

    Balebail Gopalakrishna Dharmanand / S Chandrashekara / Vikram Muralidhar Haridas

    Internet Journal of Rheumatology and Clinical Immunology, Vol 1, Iss

    2013  Volume 1

    Abstract: ... of Ewing’s sarcoma, which clinically presented as SI. ...

    Abstract Presence of sacroiliitis (SI) is one of the hallmarks for diagnosing seronegative spondyloarthropathy, especially ankylosing spondylitis. In certain cases, the occurrence of erosions around sacroiliac joint due to other causes can mislead the diagnosis. We are discussing here a rare case of Ewing’s sarcoma, which clinically presented as SI.
    Keywords Ewing's sarcoma ; unilateral sacroiliitis ; ankylosing spondylitis ; seronegative spondyloarthropathy ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-05-01T00:00:00Z
    Publisher ChanRe Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: An unusual presentation of Wegener’s granulomatosis during pregnancy

    Vikram Muralidhar Haridas / S Chandrashekara / Balebail Gopalakrishna Dharmanand

    Internet Journal of Rheumatology and Clinical Immunology, Vol 1, Iss

    2013  Volume 1

    Abstract: The occurrence of Wegener’s granulomatosis (WG), a multisystem autoimmune disease of unknown ...

    Abstract The occurrence of Wegener’s granulomatosis (WG), a multisystem autoimmune disease of unknown etiology, during pregnancy and postpartum is rare. We present here a rare case of a pregnant woman with corneal ulcer that occurred secondary to WG during the postpartum period.
    Keywords Wegener's granulomatosis ; marginal corneal ulcer ; arthritis ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher ChanRe Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Prevalence of LTBI in patients with autoimmune diseases and accuracy of IGRA in predicting TB relapse.

    Chandrashekara, S / Panchagnula, Renuka / Chennupati, Yogitha

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 12, Page(s) 3952–3956

    Abstract: Objectives: The current study evaluated latent tuberculosis infection (LTBI) positivity in a cohort of Indian subjects and the accuracy of IFN-gamma release assay (IGRA) in predicting tuberculosis (TB) reactivation.: Methods: This cross-sectional, ... ...

    Abstract Objectives: The current study evaluated latent tuberculosis infection (LTBI) positivity in a cohort of Indian subjects and the accuracy of IFN-gamma release assay (IGRA) in predicting tuberculosis (TB) reactivation.
    Methods: This cross-sectional, retrospective chart-based study considered patients diagnosed with autoimmune rheumatic diseases (AIRDs), especially those who received treatment with biologics or targeted synthetic (ts)DMARDs. The patients had undergone LTBI screening and IGRA test. The study excluded patients with inadequate information and those who had undergone test exclusively for diagnostic purpose. Statistical analyses were carried out for descriptive, demographic and clinical variables. Accuracy and error rate in predicting the absence of TB reactivation were calculated for IGRA test.
    Results: The study selected 943 patients who had undergone IGRA pre-screening prior to the initiation of biologics or tsDMARDs with a mean age of 42.93 ± 14.01 years and male-to-female ratio of 1:2.08. RA was the most common primary diagnosis (43.16%). The proportion of subjects who received single, double and triple or more DMARDs or immune suppressants were 54.35%, 33.33% and 7.69%, respectively. Among the selected subjects, 125 patients were LTBI positive and 816 were negative. All patients, except one who tested positive at baseline, received antitubercular prophylaxis. Accuracy of IGRA in predicting the absence of TB reactivation was 99.6%, with an error rate of 0.46.
    Conclusion: LTBI screening is beneficial in AIRDs patients prior to the prescription of biologics or tsDMARDs. IGRA is ideal for identifying patients with increased likelihood of developing TB upon receiving biologics or tsDMARDs with reasonable accuracy.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Interferon-gamma Release Tests ; Tuberculin Test ; Prevalence ; Cross-Sectional Studies ; Retrospective Studies ; Tuberculosis/drug therapy ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/epidemiology ; Antirheumatic Agents/therapeutic use ; Biological Products/therapeutic use
    Chemical Substances Antirheumatic Agents ; Biological Products
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead315
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  7. Article ; Online: Pharmacokinetic consideration of synthetic DMARDs in rheumatoid arthritis.

    Chandrashekara, S

    Expert opinion on drug metabolism & toxicology

    2013  Volume 9, Issue 8, Page(s) 969–981

    Abstract: Introduction: Current treatment strategy for rheumatoid arthritis (RA) focuses on tight disease control and remission. The present understanding of the immune-pathological process of RA, mechanism of synthetic DMARDs and the clinical experience of the ... ...

    Abstract Introduction: Current treatment strategy for rheumatoid arthritis (RA) focuses on tight disease control and remission. The present understanding of the immune-pathological process of RA, mechanism of synthetic DMARDs and the clinical experience of the drugs have raised certain concerns over their clinical use.
    Areas covered: The review summarizes latest concepts in the pathogenesis of RA, and the mechanism of action and pharmacokinetics of commonly used synthetic DMARDs. It also covers the principle of enzyme and receptor kinetics, and limitation of current knowledge on RA disease measures.
    Expert opinion: There is a need to rationalize the use of synthetic DMARDs to help improve RA treatment. One recommendation to assist the rationalization of this treatment is by the construction of suitable models of the disease process, thereby augmenting treatment options. Currently, the dosage and duration of this type of treatment is based on its overall effect and clinical outcome. Each DMARD will confer its effect on a specific component of the multilevel, multicellular, pathological process of RA. Furthermore, developing definitive biomarkers could help to better assess the disease at its various stages instead of using conventional RA measures for drug titration and to help in the rationalization of drug regimen. Integrating pharmacokinetic and pharmacodynamic properties into this model will also help in improving treatment outcomes.
    MeSH term(s) Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/chemical synthesis ; Antirheumatic Agents/pharmacokinetics ; Arthritis, Rheumatoid/drug therapy ; Biomarkers/blood ; Humans ; Models, Biological ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Biomarkers
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1517/17425255.2013.789499
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    Zs.A 6264: Show issues Location:
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  8. Article ; Online: Effect of natural farming, organic farming, and recommended package of practices on yield and economics of irrigated wheat (Triticum aestivum)

    ALOK KUMAR BEHERA / C P CHANDRASHEKARA

    The Indian Journal of Agricultural Sciences, Vol 93, Iss

    2023  Volume 1

    Abstract: An experiment was carried out on a split-plot design with two uneven controls, viz. four foliar concentrations of cow urine, and jeevamrutha under natural farming which were compared with Organic farming (OF), and Recommended package of practices (RPP) ... ...

    Abstract An experiment was carried out on a split-plot design with two uneven controls, viz. four foliar concentrations of cow urine, and jeevamrutha under natural farming which were compared with Organic farming (OF), and Recommended package of practices (RPP) given by University of Agricultural Sciences, Dharwad (UASD). The treatments were replicated thrice. The study found that the UASD RPP recorded significantly higher grain yield, straw yield, gross return, net return, and B:C ratio than OF and natural farming practices. The grain yield reduction in the best treatment (cow urine @50% + jeevamrutha @100%) was 16% lesser than RPP, and 2% higher than OF. However, the cost of cultivation in natural farming with cow urine @50% + jeevamrutha @100% was lesser to the extent of 6.91 and 30.42% than UASD RPP and OF. Hence, the study indicates that irrigated wheat can be grown under UASD RPP followed by natural farming treatment more profitably.
    Keywords Cow urine ; Jeevamrutha ; Natural farming ; Organic farming ; RPP ; Wheat ; Agriculture ; S
    Subject code 910
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Indian Council of Agricultural Research
    Document type Article ; Online
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  9. Article ; Online: Author Correction: Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.

    Dubey, Tushar / Gorantla, Nalini Vijay / Chandrashekara, Kagepura Thammaiah / Chinnathambi, Subashchandrabose

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9518

    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-12514-9
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  10. Article ; Online: The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review.

    Chandrashekara, S

    Indian journal of pharmacology

    2012  Volume 44, Issue 6, Page(s) 665–671

    Abstract: Autoimmune disease (AD) is one of the emerging noncommunicable diseases. Remission is a possibility in AD, but current treatment strategies are not able to achieve this. We have well-established protocols for infections, oncology, metabolic diseases, and ...

    Abstract Autoimmune disease (AD) is one of the emerging noncommunicable diseases. Remission is a possibility in AD, but current treatment strategies are not able to achieve this. We have well-established protocols for infections, oncology, metabolic diseases, and transplantation which are often used as models for the management of AD. Studies and observations suggest that in contrast to diseases used as a role model, AD has wide variability, different causative and pathogenic process, which is highly dynamic, making the current treatment strategies to fall short of expected complete remission. In this brief review, it is attempted to highlight the current understanding of AD and the probable gaps in the treatment strategies. Few hypothetical suggestions to modify the treatment protocols are presented.
    MeSH term(s) Animals ; Autoimmune Diseases/therapy ; Autoimmunity ; Graft Rejection ; Humans ; Immunosuppression
    Language English
    Publishing date 2012-12-16
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/0253-7613.103235
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    Zs.MO 311: Show issues

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