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Article: Urban vs Suburban: Is the Door-to-Balloon Time Affected by Geographic, Socioeconomic, or Racial Differences? A Tale of Two Campuses.

Zughaib, Marc / Ters, Patrick / Singh, Robby / Zughaib, Marcel

2020 Volume 2020, Page(s) 8367123

Abstract: Background: In 2004, the ACC/AHA released guidelines in the treatment of ST-segment elevation myocardial infarction (STEMI) within a time window from the time a patient physically enters the hospital to the time of percutaneous coronary intervention ( ... ...

Abstract	Background: In 2004, the ACC/AHA released guidelines in the treatment of ST-segment elevation myocardial infarction (STEMI) within a time window from the time a patient physically enters the hospital to the time of percutaneous coronary intervention (PCI). This time window is defined as the door-to-balloon time (DTB) and is recommended to be under 90 minutes to improve patient mortality. To add another layer of complexity, patients with varying socioeconomic status and racial differences experience large disparities in health. Our institution provides care for patients in two locations separated by approximately 30 miles within the Detroit metropolitan area. We aimed this study to investigate any differences between DTB times of our two campuses (urban versus suburban population) as well as any differences in the components that comprise DTB times. Methods: We retrospectively collected data on all patients who presented to either Campus 1 or Campus 2 with a STEMI from 2016 to 17. DTB times, demographical, temporal, and anatomical data were collected and analyzed. Our search included 169 patients who met the full inclusion criteria. Results: The combined average of the overall DTB time for both campuses was 81 minutes, 15 seconds (95% CI: 78:05, 84:25). The average DTB time in Campus 1 was 78 minutes and 41 seconds (95% CI: 73:05, 84:18) versus 82 minutes and 46 seconds (95% CI: 78:55, 86:38) for Campus 2 ( Conclusions: Our study demonstrated that we have been able to provide high-quality care to all of our patients presenting with STEMI at either campus, regardless of socioeconomic differences in the populations they serve. Additionally, each campus has demonstrated DTB well below the nationally recommended guidelines.
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2506187-2
ISSN	2090-0597 ; 2090-8016
ISSN (online)	2090-0597
ISSN	2090-8016
DOI	10.1155/2020/8367123
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Article: Death With Function and Graft Failure After Kidney Transplantation: Risk Factors at Baseline Suggest New Approaches to Management.

Transplantation direct

2022 Volume 8, Issue 2, Page(s) e1273

Abstract: Background: Improving both patient and graft survival after kidney transplantation are major unmet needs. The goal of this study was to assess risk factors for specific causes of graft loss to determine to what extent patients who develop either death ... ...

Abstract	Background: Improving both patient and graft survival after kidney transplantation are major unmet needs. The goal of this study was to assess risk factors for specific causes of graft loss to determine to what extent patients who develop either death with a functioning graft (DWFG) or graft failure (GF) have similar baseline risk factors for graft loss. Methods: We retrospectively studied all solitary renal transplants performed between January 1, 2006, and December 31, 2018, at 3 centers and determined the specific causes of DWFG and GF. We examined outcomes in different subgroups using competing risk estimates and cause-specific Cox models. Results: Of the 5752 kidney transplants, graft loss occurred in 21.6% (1244) patients, including 12.0% (691) DWFG and 9.6% (553) GF. DWFG was most commonly due to malignancy (20.0%), infection (19.7%), cardiac disease (12.6%) with risk factors of older age and pretransplant dialysis, and diabetes as the cause of renal failure. For GF, alloimmunity (38.7%), glomerular diseases (18.6%), and tubular injury (13.9%) were the major causes. Competing risk incidence models identified diabetes and older recipients with higher rates of both DWFG and nonalloimmune GF. Conclusions: These data suggest that at baseline, 2 distinct populations can be identified who are at high risk for renal allograft loss: a younger, nondiabetic patient group who develops GF due to alloimmunity and an older, more commonly diabetic population who develops DWFG and GF due to a mixture of causes-many nonalloimmune. Individualized management is needed to improve long-term renal allograft survival in the latter group.
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001273
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Article ; Online: Long-term Outcomes of Sequential Hematopoietic Stem Cell Transplantation and Kidney Transplantation: Single-center Experience.

Moreira, Carla Leal / Hasib Sidiqi, M / Buadi, Francis K / Litzow, Mark R / Gertz, Morie A / Dispenzieri, Angela / Russell, Stephen J / Ansell, Stephen M / Stegall, Mark D / Prieto, Mikel / Dean, Patrick G / Nyberg, Scott L / El Ters, Mireille / Hogan, William J / Amer, Hatem / Cosio, Fernando G / Leung, Nelson

Transplantation

2020 Volume 105, Issue 7, Page(s) 1615–1624

Abstract: Background: Experience with sequential hematopoietic stem cell transplant (HSCT) and kidney transplant (KT) is limited.: Methods: We conducted a retrospective observational study of adult patients who underwent both HSCT and KT at our center, with a ... ...

Abstract	Background: Experience with sequential hematopoietic stem cell transplant (HSCT) and kidney transplant (KT) is limited. Methods: We conducted a retrospective observational study of adult patients who underwent both HSCT and KT at our center, with a median follow-up of 11 y. Results: In our 54 patients cohort (94% autologous HSCT), 36 (67%) patients received HSCT first followed by KT, while 18 (33%) received KT before HSCT. In both groups, AL amyloidosis represented 50% of hematologic diagnosis. Only 4 patients expired due to hematologic disease relapse (2 patients in each group) and only 3 allografts were lost due to hematologic disease recurrence (HSCT first n = 1 and KT first n = 2). Overall 1, 5, and 10 y death-censored graft survival rates were 94%, 94%, and 94%, respectively, for the HSCT first group and 89%, 89%, and 75%, respectively, for the KT first group. Overall 1, 5, and 10 y patients survival rates were 100%, 97% and 90%, respectively, for the HSCT first group and 100%, 76%, and 63%, respectively, for the KT first group. Conclusions: Our study supports safety of sequential KT and HSCT, with improved overall patient survival compared to recipients of HSCT remaining on dialysis and good long-term kidney allograft outcome.
MeSH term(s)	Adult ; Female ; Graft Survival ; Hematologic Diseases/diagnosis ; Hematologic Diseases/mortality ; Hematologic Diseases/surgery ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Neoplasms/etiology ; Recurrence ; Retrospective Studies ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-10-07
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003477
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Corrigendum to Heybeli C, Bentall A, Wen J, et al. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707-715.

Heybeli, Cihan / Bentall, Andrew / Wen, Jiqiu / Alexander, Mariam Priya / Buadi, Francis K / Cosio, Fernando G / Dean, Patrick G / Dispenzieri, Angela / Dingli, David / El Ters, Mireille / Gertz, Morie A / Amer, Hatem / Kapoor, Prashant / Khamash, Hasan / Kourelis, Taxiarchis / Kumar, Shaji / Lorenz, Elizabeth C / Mai, Martin / Muchtar, Eli /

Murray, David L / Prieto, Mikel / Schinstock, Carrie A / Stegall, Mark D / Warsame, Rahma / Leung, Nelson

Kidney international

2021 Volume 100, Issue 6, Page(s) 1348–1349

Language	English
Publishing date	2021-10-09
Publishing country	United States
Document type	Published Erratum
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.10.001
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Zs.A 797: Show issues

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Article ; Online: A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis.

Heybeli, Cihan / Bentall, Andrew / Wen, Jiqiu / Alexander, Mariam Priya / Buadi, Francis K / Cosio, Fernando G / Dean, Patrick G / Dispenzieri, Angela / Dingli, David / El Ters, Mireille / Gertz, Morie A / Hatem, Amer / Kapoor, Prashant / Khamash, Hasan / Kourelis, Taxiarchis / Kumar, Shaji / Lorenz, Elizabeth C / Mai, Martin / Muchtar, Eli /

Murray, David L / Prieto, Mikel / Schinstock, Carrie A / Stegall, Mark D / Warsame, Rahma / Leung, Nelson

Kidney international

2020 Volume 99, Issue 3, Page(s) 707–715

Abstract: Longer survival using modern therapies has increased the number of patients with immunoglobulin light-chain amyloidosis receiving kidney transplantation. We evaluated 60 patients with immunoglobulin light chain amyloidosis who underwent kidney ... ...

Abstract	Longer survival using modern therapies has increased the number of patients with immunoglobulin light-chain amyloidosis receiving kidney transplantation. We evaluated 60 patients with immunoglobulin light chain amyloidosis who underwent kidney transplantation based on their hematologic response for outcomes of death, graft failure, and complications. Patient hematologic responses (light-chain in blood or urine) prior to kidney transplantation were three patients had no response, five had a partial response, six had a very good partial response, 37 had a complete response, and nine were treatment-naive patients (never treated for this disorder). After transplantation, seven of nine treatment-naive patients achieved a complete response. The median follow-up for the entire transplant cohort was 61 months. The estimated median overall survival from the time of kidney transplantation was 123 months for the entire group. Median overall survival was not reached for the very good partial response plus complete response groups, it was 47 months for no response plus partial response groups, and 117 months for the treatment-naive group (all significantly different). Median overall survival of very good partial response was 81 months, while the median was not reached in the complete response group (no significant difference). The time to amyloid recurrence was significantly longer in complete response compared to very good partial response (median 181 vs 81 months). Death-censored graft survival at one- and five-years was 98.3%, and 95.8%, respectively for all groups. Of the 60 patients, three had allograft failure, 19 died with a functioning graft, and 13 had an amyloid recurrence. Thus, outcomes after kidney transplant in patients with immunoglobulin light-chain amyloidosis seem acceptable if a very good partial response or complete response is achieved either before or after transplantation.
MeSH term(s)	Amyloidosis/diagnosis ; Amyloidosis/surgery ; Humans ; Immunoglobulin Light Chains ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/therapy ; Kidney Transplantation/adverse effects ; Neoplasm Recurrence, Local ; Treatment Outcome
Chemical Substances	Immunoglobulin Light Chains
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.06.036
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Zs.A 797: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Enhanced posttransplant management of patients with diabetes improves patient outcomes.

Keddis, Mira T / El Ters, Mireille / Rodrigo, Emilio / Dean, Patrick / Wohlfahrtova, Mariana / Kudva, Yogish C / Lorenz, Elizabeth C / Cosio, Fernando G

Kidney international

2014 Volume 86, Issue 3, Page(s) 610–618

Abstract: ... recipients with diabetes mellitus has improved markedly since 1996 likely reflecting, at least in part ...

Abstract	The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was significantly increased (hazard ratio (HR) 2.68 (1.95-3.69)) due to higher cardiovascular-, infection-, and malignancy-related deaths in those with diabetes. However, 5-year mortality in patients with diabetes significantly declined over time (HR 0.883 (0.817-0.954)), narrowing the mortality difference between patients with and those without diabetes and in more recent years largely eliminating it. Post transplant, patients with diabetes experienced a significant decline in major fatal/nonfatal cardiac events (HR 0.853 (0.782-0.930)) and infectious deaths over time. In contrast, neither cardiac events nor overall mortality declined in recipients without diabetes. The decline in mortality due to diabetes did not relate to a reduced pretransplant risk profile and was independent of posttransplant variables. The use of cardioprotective medications and glycemic control improved over time post transplant. Furthermore, graft function and serum albumin significantly improved over time and these parameters related to better survival (albumin, HR 0.365 (0.223-0.599); eGFR, HR 0.803 (0.756-0.852)). Thus, survival of kidney recipients with diabetes mellitus has improved markedly since 1996 likely reflecting, at least in part, enhanced posttransplant management and outcomes.
MeSH term(s)	Adult ; Aged ; Cardiovascular Diseases/mortality ; Comorbidity ; Diabetes Mellitus/mortality ; Diabetes Mellitus/therapy ; Female ; Glomerular Filtration Rate ; Graft Survival ; Humans ; Infection/mortality ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Mortality/trends ; Neoplasms/mortality ; Postoperative Period ; Risk Factors ; Serum Albumin/metabolism ; Survival Rate
Chemical Substances	Serum Albumin
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2014.70
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance (MGRS)-Associated Lesions: A Case Series.

Heybeli, Cihan / Alexander, Mariam Priya / Bentall, Andrew J / Amer, Hatem / Buadi, Francis K / Dean, Patrick G / Dingli, David / Dispenzieri, Angela / El Ters, Mireille / Gertz, Morie A / Issa, Naim S / Kapoor, Prashant / Kourelis, Taxiarchis / Kukla, Aleksandra / Kumar, Shaji / Lacy, Martha Q / Lorenz, Elizabeth C / Muchtar, Eli / Murray, David L /

Nasr, Samih H / Prieto, Mikel / Rajkumar, S Vincent / Schinstock, Carrie A / Stegall, Mark D / Warsame, Rahma / Leung, Nelson

American journal of kidney diseases : the official journal of the National Kidney Foundation

2021 Volume 79, Issue 2, Page(s) 202–216

Abstract: Rationale & objective: Data on kidney transplantation outcomes among patients with monoclonal gammopathy of renal significance (MGRS) are lacking.: Study design: Case series of patients with MGRS, some of whom received clone-directed therapies before ...

Abstract	Rationale & objective: Data on kidney transplantation outcomes among patients with monoclonal gammopathy of renal significance (MGRS) are lacking. Study design: Case series of patients with MGRS, some of whom received clone-directed therapies before kidney transplantation. Setting & participants: 28 patients who underwent kidney transplantation from 1987 through 2016 after diagnosis with MGRS-associated lesions including light-chain deposition disease (LCDD), C3 glomerulopathy with monoclonal gammopathy (C3G-MG), and light-chain proximal tubulopathy (LCPT). Findings: Of the 19 patients with LCDD, 10 were treated before kidney transplantation and 9 were treatment-naive. Among the treated patients with LCDD, 3 (30%) experienced histologic recurrence, 2 (20%) grafts failed, and 2 (20%) died during a median follow-up of 70 (range, 3-162) months after transplant. In the treatment-naive LCDD group, 8 (89%) had histologic recurrence, 6 (67%) grafts failed, and 4 (44%) patients died during a median follow-up of 60 (range, 35-117) months. Of the 5 patients who had a complete response before transplant, none died, and only 1 experienced graft failure, 162 months after transplant. Of 5 patients with C3G-MG, 3 were treatment-naive before transplant. Both patients who were treated before transplant had histologic recurrence, and 1 experienced graft failure and died. Among the 3 patients with treatment-naive C3G-MG, histologic recurrence occurred in all, and graft loss and death were observed in 2 and 1, respectively. In the LCPT group (n=4), histologic recurrence was observed in all 3 patients who did not receive clone-directed therapies before transplant, and 2 of these patients died, 1 with a functioning kidney. The 1 patient with LCPT who received therapy before transplant did not have histologic recurrence or graft loss and survived. Limitations: Small sample size, nonstandardized clinical management, retrospective design. Conclusions: Recurrence is very common in all MGRS-associated lesions after kidney transplant. Achieving a complete hematologic response may reduce the risks of recurrence, graft loss, and death. More studies are needed to determine the effects of hematologic response on outcomes for each MGRS-associated lesion.
MeSH term(s)	Humans ; Kidney ; Kidney Diseases ; Kidney Transplantation/adverse effects ; Monoclonal Gammopathy of Undetermined Significance ; Paraproteinemias/complications ; Retrospective Studies
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2021.04.015
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article ; Online: Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring.

Abend, Nicholas / Adams, Eleri / Al Balushi, Asim / Alburaki, Wissam / Appendino, Juan / Barbosa, Vargas Stephanie / Birca, Ala / Bonifacio, Sonia / Branagan, Aoife / Chang, Taeun / Chowdhury, Rasheda / Christou, Helen / Chu, Catherine / Cilio, M Roberta / Comani, Silvia / Corsi-Cabrera, María / Croce, Pierpaolo / Cubero-Rego, Lourdes / Dawoud, Fady /

de Vries, Linda / Dehaes, Mathieu / Devane, Declan / Duncan, Aubrey / El Ters, Nathalie / El-Dib, Mohamed / Elshibiny, Hoda / Esser, Michael / Fairchild, Karen / Finucane, Elaine / Franceschini, Maria Angela / Gallagher, Anne / Ghosh, Anirban / Glass, Hannah / Venkata, Sujith Kumar Reddy Gurram / Baillet, Thalía Harmony / Herzberg, Emily / Hildrey, Emily / Hurley, Tim / Inder, Terrie / Jacobs, Elke / Jefferies, Kimberley / Jermendy, Agnes / Khazaei, Mohammad / Kilmartin, Keira / King, Graham / Lauronen, Leena / Lee, Sarah / Leijser, Lara / Lind, Janice / Llaguno, Nathalie Sales / Machie, Michelle / Magalhães, Maurício / Mahdi, Zamzam / Maluomi, Julie / Marandyuk, Bohdana / Massey, Shavonne / McCulloch, Charles / Metsäranta, Marjo / Mikkonen, Kirsi / Mohammad, Khorshid / Molloy, Eleanor / Momin, Sarfaraz / Munster, Chelsea / Murthy, Prashanth / Netto, Alexandre / Nevalainen, Päivi / Nguyen, Jennifer / Nieves, Maria / Nyman, Jenna / Oliver, Norma / Peeters, Cacha / Pietrobom, Rafaela Fabri Rodrigues / Pijpers, Judith / Pinchefksy, Elana / Ping, Yee Billie / Quirke, Fiona / Raeisi, Khadijeh / Ricardo-Garcell, Josefina / Robinson, Jill / Rodrigues, Daniela Pereira / Rosati, Justin / Scott, James / Scringer-Wilkes, Maxine / Shellhaas, Renée / Smit, Liesbeth / Soul, Janet / Srivastava, Ankur / Steggerda, Sylke / Sunwoo, John / Szakmar, Eniko / Tamburro, Gabriella / Thomas, Sumesh / Toiviainen-Salo, Sanna / Toma, Adrian Ioan / Vanhatalo, Sampsa / Variane, Gabriel Fernando Todeschi / Vein, Alla / Vesoulis, Zachary / Vilan, Ana / Volpe, Joseph / Weeke, Lauren / Wintermark, Pia / Wusthoff, Courtney / Zappasodi, Filippo / Zein, Hussein / Zempel, John

Journal of neonatal-perinatal medicine

2021 Volume 15, Issue 2, Page(s) 467–485

MeSH term(s)	Brain ; Electroencephalography ; Humans ; Infant, Newborn ; Monitoring, Physiologic ; Seizures/therapy
Language	English
Publishing date	2021-03-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2435387-5
ISSN	1878-4429 ; 1934-5798
ISSN (online)	1878-4429
ISSN	1934-5798
DOI	10.3233/NPM-229006
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Article: Urban vs Suburban: Is the Door-to-Balloon Time Affected by Geographic, Socioeconomic, or Racial Differences? A Tale of Two Campuses.

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Article: Death With Function and Graft Failure After Kidney Transplantation: Risk Factors at Baseline Suggest New Approaches to Management.

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Article ; Online: Long-term Outcomes of Sequential Hematopoietic Stem Cell Transplantation and Kidney Transplantation: Single-center Experience.

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Article ; Online: Corrigendum to Heybeli C, Bentall A, Wen J, et al. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707-715.

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Article ; Online: A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis.

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Article ; Online: Enhanced posttransplant management of patients with diabetes improves patient outcomes.

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Article ; Online: Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance (MGRS)-Associated Lesions: A Case Series.

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Article ; Online: Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring.

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