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  1. Article ; Online: Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'.

    Vehar, Susan / Boushra, Marina / Ntiamoah, Prince / Biehl, Michelle

    Cleveland Clinic journal of medicine

    2021  

    Abstract: An estimated 10% of COVID-19 survivors continue to experience symptoms several weeks to months after the appearance of initial symptoms, a condition termed post-acute sequelae of SARS-CoV-2 infection (PASC). These patients, also called "long-haulers," ... ...

    Abstract An estimated 10% of COVID-19 survivors continue to experience symptoms several weeks to months after the appearance of initial symptoms, a condition termed post-acute sequelae of SARS-CoV-2 infection (PASC). These patients, also called "long-haulers," most commonly report protracted symptoms of fatigue, cough, dyspnea, chest tightness, difficulty concentrating, arthralgia, olfactory dysfunction, and headache. While age, comorbid medical conditions, and COVID-19 severity are suspected risk factors for PASC, young and previously healthy individuals with mild COVID-19 are also at risk. Recognition of symptoms, evaluation, supportive treatment, and attention to medical comorbidities are the cornerstones of medical management.
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.88a.21010-up
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'.

    Vehar, Susan / Boushra, Marina / Ntiamoah, Prince / Biehl, Michelle

    Cleveland Clinic journal of medicine

    2021  Volume 88, Issue 5, Page(s) 267–272

    Abstract: An estimated 10% of COVID-19 survivors continue to experience symptoms several weeks to months after the appearance of initial symptoms, a condition termed post-acute sequelae of SARS-CoV-2 infection (PASC). These patients, also called "long-haulers," ... ...

    Abstract An estimated 10% of COVID-19 survivors continue to experience symptoms several weeks to months after the appearance of initial symptoms, a condition termed post-acute sequelae of SARS-CoV-2 infection (PASC). These patients, also called "long-haulers," most commonly report protracted symptoms of fatigue, cough, dyspnea, chest tightness, difficulty concentrating, arthralgia, olfactory dysfunction, and headache. While age, comorbid medical conditions, and COVID-19 severity are risk factors, young and previously healthy individuals with mild COVID-19 are also at risk. Recognition of symptoms, evaluation, supportive treatment, and attention to medical comorbidities are the cornerstones of medical management.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/etiology ; COVID-19/physiopathology ; COVID-19/therapy ; Chronic Disease ; Disease Progression ; Humans ; Risk Factors
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.88a.21010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CD1a Staining in Bronchoalveolar Lavage in Pulmonary Langerhans Cell Histiocytosis: "Barking Up the Wrong Tree!"

    Vehar, Susan J / Ribeiro Neto, Manuel L / Culver, Daniel A / Mehta, Atul C

    Journal of bronchology & interventional pulmonology

    2022  Volume 29, Issue 3, Page(s) e33–e35

    MeSH term(s) Antigens, CD1 ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; Histiocytosis, Langerhans-Cell/diagnostic imaging ; Humans ; Staining and Labeling
    Chemical Substances Antigens, CD1
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Smoking-Related Interstitial Fibrosis (SRIF) in Patients Presenting With Diffuse Parenchymal Lung Disease.

    Vehar, Susan J / Yadav, Ruchi / Mukhopadhyay, Sanjay / Nathani, Avantika / Tolle, Leslie B

    American journal of clinical pathology

    2022  Volume 159, Issue 2, Page(s) 146–157

    Abstract: Objectives: To describe the clinical, radiologic, and pathologic findings in cases where smoking-related interstitial fibrosis (SRIF) was diagnosed in surgical lung biopsy specimens from patients with clinical and imaging features of diffuse parenchymal ...

    Abstract Objectives: To describe the clinical, radiologic, and pathologic findings in cases where smoking-related interstitial fibrosis (SRIF) was diagnosed in surgical lung biopsy specimens from patients with clinical and imaging features of diffuse parenchymal lung disease (DPLD).
    Methods: Cases were included in this study if patients had clinical and imaging evidence of DPLD and surgical lung biopsy specimens revealed SRIF. A dedicated multidisciplinary conference was held to correlate clinical, radiologic, and pathologic findings.
    Results: Six cases met inclusion criteria; all six (five women/one man, aged 42-57 years, mean age 47 years) were either current smokers (five of six) or ex-smokers (one of six) and were evaluated for respiratory symptoms and abnormal pulmonary function tests, most commonly reduced forced vital capacity (n = 3) and diffusing capacity for carbon monoxide (n = 6). The most common imaging abnormalities were bilateral ground-glass opacities, which correlated with histopathologic SRIF. Follow-up of up to 10 years showed stable or improved clinical symptoms, pulmonary function tests, and radiologic findings with smoking cessation (three patients) or a decrease in smoking (three patients). No specific treatments were given, and those treated with empiric corticosteroid tapers did not show discernible responses.
    Conclusions: SRIF can present as clinically meaningful diffuse parenchymal lung disease in relatively young heavy smokers, characterized by bilateral ground-glass opacities and a stable clinical course.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Lung/diagnostic imaging ; Lung/pathology ; Bronchiolitis/pathology ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/pathology ; Smoking/adverse effects ; Fibrosis
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqac144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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