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  1. Article ; Online: Reply to the Letter to the Editor in response to "Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis".

    Riva, Nilo / Quattrini, Angelo

    European journal of neurology

    2022  Volume 30, Issue 1, Page(s) 283–284

    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/diagnosis ; Prognosis ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-10-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15586
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  2. Article ; Online: Hemiplegic-type ALS shows a strong correlation between upper, lower motor neuron degeneration and pTDP-43 pathology.

    Riva, Nilo / Quattrini, Angelo

    Journal of neurology, neurosurgery, and psychiatry

    2021  Volume 92, Issue 9, Page(s) 917

    MeSH term(s) Amyotrophic Lateral Sclerosis ; DNA-Binding Proteins ; Hemiplegia ; Humans ; Nerve Degeneration
    Chemical Substances DNA-Binding Proteins
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2021-326512
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  3. Article ; Online: Advancing amyotrophic lateral sclerosis disease diagnosis: A lab-on-chip electrochemical immunosensor for ultra-sensitive TDP-43 protein detection and monitoring in serum patients'.

    Turco, Antonio / Primiceri, Elisabetta / Chiriacò, Maria Serena / La Pesa, Velia / Ferrara, Francesco / Riva, Nilo / Quattrini, Angelo / Romano, Alessandro / Maruccio, Giuseppe

    Talanta

    2024  Volume 273, Page(s) 125866

    Abstract: The global increase in population aging has led to a rise in neurodegenerative diseases (NDs), posing significant challenges to public health. Developing selective and specific biomarkers for early diagnosis and drug development is crucial addressing the ...

    Abstract The global increase in population aging has led to a rise in neurodegenerative diseases (NDs), posing significant challenges to public health. Developing selective and specific biomarkers for early diagnosis and drug development is crucial addressing the growing burden of NDs. In this context, the RNA-binding protein TDP-43 has emerged as a promising biomarker for amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and TDP-43-associated proteinopathies. However, existing detection methods suffer from limitations such as cost, complexity, and operator dependence. Here, we present a novel electrochemical biosensor integrated into a lab-on-chip (LoC) platform to detect TDP-43. The sensor utilizes electrosynthesized polypyrrole derivatives with carboxylic groups for transducer functionalization, enabling targeted immobilization of TDP-43 antibodies. Differential pulsed voltammetry (DPV) is used for the indirect detection and quantification of TDP-43. The chip exhibits rapid response, good reproducibility, a linear detection range, and sensitivity from 0.01 ng/mL to 25 ng/mL of TDP-43 protein concentration with a LOD = 10 pg/mL. Furthermore, successful TDP-43 detection in complex matrices like serum of ALS patients and healthy individuals demonstrates its potential as a point-of-care diagnostic device. This electrochemical biosensor integrated into a chip offers good sensitivity, rapid response, and robust performance, providing a promising avenue for advancing neurodegenerative disease diagnostics and therapeutic development.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/metabolism ; Polymers ; Biosensing Techniques ; Neurodegenerative Diseases ; Reproducibility of Results ; Immunoassay ; Pyrroles ; DNA-Binding Proteins/metabolism ; Biomarkers/metabolism
    Chemical Substances Polymers ; Pyrroles ; DNA-Binding Proteins ; Biomarkers
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125866
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  4. Article ; Online: Primary Lateral Sclerosis Presenting With Focal Onset Spreading Through Contiguous Neuroanatomic Regions.

    Schito, Paride / Spinelli, Edoardo Gioele / Malvaso, Antonio / Russo, Tommaso / Falzone, Yuri Matteo / Agosta, Federica / Quattrini, Angelo / Filippi, Massimo / Riva, Nilo

    Neurology

    2022  Volume 98, Issue 12, Page(s) 503–504

    MeSH term(s) Amyotrophic Lateral Sclerosis ; Humans ; Motor Neurons
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200011
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  5. Article ; Online: Normal structure and pathological features in peripheral neuropathies.

    Hoke, Ahmet / Cerri, Federica / Fisgin, Aysel / Riva, Nilo / Quattrini, Angelo

    Journal of the peripheral nervous system : JPNS

    2021  Volume 26 Suppl 2, Page(s) S11–S20

    Abstract: Normal nerve architecture is basic to a complete understanding of nerve pathology. Here, normal components of the nerve are illustrated, including myelinated and non-myelinated nerve fibres, stromal elements, and vascular components. These are relevant ... ...

    Abstract Normal nerve architecture is basic to a complete understanding of nerve pathology. Here, normal components of the nerve are illustrated, including myelinated and non-myelinated nerve fibres, stromal elements, and vascular components. These are relevant because the differential diagnosis of neuropathy depends on the pathological processes affecting axon, myelin, interstitial space, and blood vessels. Thus, we present a description of the general pathological characteristics for the diagnosis of peripheral nerve disorders.
    MeSH term(s) Axons/pathology ; Humans ; Myelin Sheath/pathology ; Peripheral Nerves/pathology ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/pathology
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12462
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  6. Article ; Online: Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review.

    Napoli, Giovanni / Rubin, Martina / Cutillo, Gianni / Schito, Paride / Russo, Tommaso / Quattrini, Angelo / Filippi, Massimo / Riva, Nilo

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. We describe four new cases of Tako-Tsubo syndrome (TTS) in ALS patients with an appraisal of the literature. We present a late-stage ALS patient with prominent bulbar involvement that presented TTS during hospitalization. We then retrospectively identify three additional ALS-TTS cases reporting relevant clinical findings. TTS cardiomyopathy has been observed in different acute neurological conditions, and the co-occurrence of ALS and TTS has already been reported. Cardiovascular autonomic dysfunctions have been described in ALS, especially in the context of an advanced diseases and with bulbar involvement. Noradrenergic hyperfunction linked to sympathetic denervation and ventilatory deficits coupled in different instances with a trigger event could play a synergistic role in the development of TTS in ALS. Sympathetic hyperfunctioning and ventilatory deficits in conjunction with cardiac autonomic nerves impairment may play a role in the development of TTS in a context of ALS.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/complications ; Takotsubo Cardiomyopathy/complications ; Neurodegenerative Diseases/complications ; Retrospective Studies ; Primary Dysautonomias
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512096
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  7. Article: A novel

    Castelnovo, Veronica / Canu, Elisa / Domi, Teuta / Pozzi, Laura / Vignaroli, Francesca / Spinelli, Edoardo Gioele / Ghirelli, Alma / Tondo, Giacomo / Comi, Cristoforo / Riva, Nilo / Quattrini, Angelo / Carrera, Paola / Filippi, Massimo / Agosta, Federica

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1204504

    Abstract: Objectives: We report the clinical presentation and evolution of a case with a novel Progranulin gene (: Materials and methods: A 60 year-old, white patient was followed due to a history of language disturbances. Eighteen months after onset, the ... ...

    Abstract Objectives: We report the clinical presentation and evolution of a case with a novel Progranulin gene (
    Materials and methods: A 60 year-old, white patient was followed due to a history of language disturbances. Eighteen months after onset, the patient underwent FDG positron emission tomography (PET), and at month 24 was hospitalized to perform neuropsychological evaluation, brain 3 T MRI, lumbar puncture for cerebrospinal fluid (CSF) analysis, and genotyping. At month 31, the patient repeated the neuropsychological evaluation and brain MRI.
    Results: At onset the patient complained prominent language production difficulties, such as effortful speech and anomia. At month 18, FDG-PET showed left fronto-temporal and striatal hypometabolism. At month 24, the neuropsychological evaluation reported prevalent speech and comprehension deficits. Brain MRI reported left fronto-opercular and striatal atrophy, and left frontal periventricular white matter hyperintensities (WMHs). Increased CSF total tau level was observed. Genotyping revealed a new
    Discussion and conclusion: The new
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1204504
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  8. Article ; Online: Progression of cognitive and behavioral disturbances in motor neuron diseases assessed using standard and computer-based batteries.

    Castelnovo, Veronica / Canu, Elisa / Riva, Nilo / Poletti, Barbara / Cividini, Camilla / Fontana, Andrea / Solca, Federica / Silani, Vincenzo / Filippi, Massimo / Agosta, Federica

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2021  Volume 22, Issue 3-4, Page(s) 223–236

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Amyotrophic Lateral Sclerosis/complications ; Cognition ; Computers ; Humans ; Motor Neuron Disease/complications ; Retrospective Studies
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2020.1867179
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  9. Article ; Online: Neurofilament light chain as a biological marker for amyotrophic lateral sclerosis: a meta-analysis study.

    Sferruzza, Giacomo / Bosco, Luca / Falzone, Yuri Matteo / Russo, Tommaso / Domi, Teuta / Quattrini, Angelo / Filippi, Massimo / Riva, Nilo

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2021  Volume 23, Issue 5-6, Page(s) 446–457

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Amyotrophic Lateral Sclerosis/diagnosis ; Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Humans ; Intermediate Filaments ; Neurofilament Proteins
    Chemical Substances Biomarkers ; Neurofilament Proteins
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2021.2007952
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  10. Article ; Online: Italian reference values and brain correlates of verbal fluency index -

    Canu, Elisa / Castelnovo, Veronica / Rancoita, Paola Mv / Leocadi, Michela / Lamanuzzi, Alessandra / Spinelli, Edoardo Gioele / Basaia, Silvia / Riva, Nilo / Poletti, Barbara / Solca, Federica / Verde, Federico / Ticozzi, Nicola / Silani, Vincenzo / Abrahams, Sharon / Filippi, Massimo / Agosta, Federica

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2023  Volume 24, Issue 5-6, Page(s) 457–465

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Reference Values ; Brain/diagnostic imaging ; Cognitive Dysfunction ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/etiology ; Neuropsychological Tests
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2167606
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