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  1. Article ; Online: Post-infectious bronchiolitis obliterans in children.

    Champs, Natália Silva / Lasmar, Laura M L B F / Camargos, Paulo A M / Marguet, Christophe / Fischer, Gilberto Bueno / Mocelin, Helena Teresinha

    Jornal de pediatria

    2011  Volume 87, Issue 3, Page(s) 187–198

    Abstract: Objective: To review publications about the main features of post-infectious bronchiolitis obliterans and its history, etiology, epidemiology, risk factors, pathogenesis, histological findings, clinical presentation, complementary tests, diagnostic ... ...

    Abstract Objective: To review publications about the main features of post-infectious bronchiolitis obliterans and its history, etiology, epidemiology, risk factors, pathogenesis, histological findings, clinical presentation, complementary tests, diagnostic criteria, differential diagnosis, treatment and prognosis.
    Sources: Non-systematic review of MEDLINE and LILACS databases and selection of 66 most relevant studies.
    Summary of the findings: In the post-infectious bronchiolitis obliterans there is an insult to respiratory epithelial cells, and its clinical severity is associated with the degree of lesion and inflammation. Diagnosis is made according to clinical signs and symptoms, by exclusion of main differential diagnoses and with the aid of complementary tests. High resolution CT, particularly images obtained during inspiration and expiration, provide information for the evaluation of the small airways. Pulmonary function tests show fixed airway obstructions and marked decrease of FEF25-75%. Treatment has not been definitely established, and corticoids have been administered as pulse therapy or by inhalation of high doses of steroids. However, data about its efficacy are scarce in the literature. Long-term prognosis is variable, and there might be either clinical improvement or deterioration into respiratory insufficiency and death.
    Conclusion: Post-infectious bronchiolitis obliterans is a disease with a high morbidity rate; it should be treated by a multidisciplinary team, and patients should be followed up for a long period of time.
    MeSH term(s) Bacterial Infections/complications ; Bronchiolitis Obliterans/diagnosis ; Bronchiolitis Obliterans/drug therapy ; Bronchiolitis Obliterans/etiology ; Child ; Humans ; Prognosis ; Risk Factors ; Virus Diseases/complications
    Language Portuguese
    Publishing date 2011-05-05
    Publishing country Brazil
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.2223/JPED.2083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Avian influenza: the threat of the 21st century.

    Andrade, Cláudia Ribeiro de / Ibiapina, Cássio da Cunha / Champs, Natália Silva / Toledo Junior, Antonio Carlos Castro de / Picinin, Isabela Furtado de Mendonça

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2009  Volume 35, Issue 5, Page(s) 470–479

    Abstract: This study aimed to review the literature on infection with the H5N1 subtype of avian influenza A virus, taking into consideration the fact that, in the event of a pandemic, children might become a major risk group. Searches were limited to the past ten ... ...

    Abstract This study aimed to review the literature on infection with the H5N1 subtype of avian influenza A virus, taking into consideration the fact that, in the event of a pandemic, children might become a major risk group. Searches were limited to the past ten years and were carried out using the following electronic databases: Medline, MD Consult, HighWire and Medscape. Children and young adults account for a significant proportion of the susceptible population. We found that more than half of the individuals infected were under 20 years of age and that one quarter was under the age of 10. The incubation period ranged from 2 to 5 days. Initial clinical manifestations are nonspecific, which hinders the diagnosis. Most of the infected individuals presented severe pneumonia, which evolved to respiratory insufficiency within an average of 4 days. Chest X-rays can reveal diffuse multifocal/ interstitial infiltrates or segmental/lobar consolidation with air bronchogram. The pathogenic potential is high, with mortality rates up to 63%, indicating that the pandemic virus might present high pathogenicity and high mortality. Knowledge of the risk of a pandemic and of the measures to be taken in suspect cases constitutes an important step toward controlling a potential pandemic.
    MeSH term(s) Adolescent ; Adult ; Child ; Disease Outbreaks/prevention & control ; Humans ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza, Human/diagnosis ; Influenza, Human/prevention & control ; Influenza, Human/therapy ; Influenza, Human/virology ; Middle Aged ; Risk Factors ; Young Adult
    Keywords covid19
    Language Portuguese
    Publishing date 2009-06-21
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/s1806-37132009000500014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gripe aviária

    Cláudia Ribeiro de Andrade / Cássio da Cunha Ibiapina / Natália Silva Champs / Antonio Carlos Castro de Toledo Junior / Isabela Furtado de Mendonça Picinin

    Jornal Brasileiro de Pneumologia, Vol 35, Iss 5, Pp 470-

    a ameaça do século XXI Avian influenza: the threat of the 21st century

    2009  Volume 479

    Abstract: Este estudo teve como objetivo fazer uma revisão da literatura a respeito da infecção pelo vírus influenza A subtipo H5N1, levando em conta a possibilidade de as crianças serem um dos grupos etários mais acometidos caso ocorra uma pandemia. A revisão ... ...

    Abstract Este estudo teve como objetivo fazer uma revisão da literatura a respeito da infecção pelo vírus influenza A subtipo H5N1, levando em conta a possibilidade de as crianças serem um dos grupos etários mais acometidos caso ocorra uma pandemia. A revisão bibliográfica foi realizada nos seguintes bancos de dados, restrita aos últimos 10 anos: Medline, MD Consult, HighWire e Medscape. As crianças e os adultos jovens representam uma fração importante da população susceptível. Mais da metade dos indivíduos infectados apresentavam menos de 20 anos de idade, e um quarto era menor do que 10 anos. O período de incubação variou de 2 a 5 dias. As manifestações clínicas iniciais são não específicas, o que dificulta o diagnóstico. A maioria dos casos apresentou um quadro de pneumonia grave, que evoluiu para insuficiência respiratória em 4 dias em média. A radiografia de tórax pode mostrar infiltrado intersticial difuso ou multifocal ou consolidação lobar ou segmentar com broncograma aéreo. A infecção tem alta patogenicidade, com 63% de letalidade, o que indica que o vírus pandêmico também pode apresentar alta patogenicidade com mortalidade elevada. O conhecimento sobre os riscos da pandemia e sobre as medidas que podem ser tomadas em casos suspeitos é um importante passo para o controle de uma possível pandemia. This study aimed to review the literature on infection with the H5N1 subtype of avian influenza A virus, taking into consideration the fact that, in the event of a pandemic, children might become a major risk group. Searches were limited to the past ten years and were carried out using the following electronic databases: Medline, MD Consult, HighWire and Medscape. Children and young adults account for a significant proportion of the susceptible population. We found that more than half of the individuals infected were under 20 years of age and that one quarter was under the age of 10. The incubation period ranged from 2 to 5 days. Initial clinical manifestations are nonspecific, which hinders the diagnosis. Most of the infected individuals presented severe pneumonia, which evolved to respiratory insufficiency within an average of 4 days. Chest X-rays can reveal diffuse multifocal/ interstitial infiltrates or segmental/lobar consolidation with air bronchogram. The pathogenic potential is high, with mortality rates up to 63%, indicating that the pandemic virus might present high pathogenicity and high mortality. Knowledge of the risk of a pandemic and of the measures to be taken in suspect cases constitutes an important step toward controlling a potential pandemic.
    Keywords Vírus da influenza A ; Vetores de doenças ; Surtos de doenças ; Vírus da influenza A subtipo H5N1 ; Influenza A virus ; Disease vectors ; Disease outbreaks ; H5N1 subtype ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2009-05-01T00:00:00Z
    Publisher Sociedade Brasileira de Pneumologia e Tisiologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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