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  1. Article: Post-infarction Left Ventricular Free Wall Rupture Diagnosed by Contrast-Enhanced Computed Tomography: A Case Report.

    Morimoto, Yuya / Tamura, Shinobu / Kawashima, Shuji / Inoue, Shigeaki

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52127

    Abstract: A 70-year-old Japanese woman with hypertension, dyslipidemia, and diabetes mellitus complained of abdominal discomfort and vomiting and was brought to our emergency department by ambulance two days later with impaired consciousness. Her vital signs ... ...

    Abstract A 70-year-old Japanese woman with hypertension, dyslipidemia, and diabetes mellitus complained of abdominal discomfort and vomiting and was brought to our emergency department by ambulance two days later with impaired consciousness. Her vital signs suggested shock with a heart rate of 120 bpm. Electrocardiogram and initial transthoracic echocardiography suggested an inferior wall ST-elevation myocardial infarction, but the altered consciousness was inconsistent. Contrast-enhanced computed tomography was urgently performed to further clarify the cause. It revealed pericardial effusion and apparent extravasation from the left ventricular wall, confirming the early definitive diagnosis of left ventricular free wall rupture. The patient underwent successful emergent surgical repair without sequelae. Differential diagnosis of left ventricular free wall rupture is important in patients with ST-elevation myocardial infarction and impaired consciousness. Contrast-enhanced computed tomography allows early diagnosis and treatment of this life-threatening complication.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Post-Intensive Care Syndrome-10 Years after Its Proposal and Future Directions.

    Inoue, Shigeaki / Nakanishi, Nobuto / Nakamura, Kensuke

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: With the development of intensive care medicine and the standardization of various therapeutic guidelines and education systems, mortality rates in critically ill patients have improved markedly [ ... ]. ...

    Abstract With the development of intensive care medicine and the standardization of various therapeutic guidelines and education systems, mortality rates in critically ill patients have improved markedly [...].
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sex Disparities in Applied Force on Maxillary Incisors Among Novices During Laryngoscopy Using a High-Fidelity Simulator: A Prospective Observational Study.

    Ono, Yuko / Shinohara, Kazuaki / Shimada, Jiro / Sugiyama, Jun / Inoue, Shigeaki / Kotani, Joji

    The Kobe journal of medical sciences

    2024  Volume 69, Issue 4, Page(s) E151–E158

    Abstract: Endotracheal intubation (ETI) is a common and crucial intervention. Whether the performance of ETI differs according to the sex of the laryngoscopist remains unclear. The aim of this study was to assess sex disparities in markers of ETI performance among ...

    Abstract Endotracheal intubation (ETI) is a common and crucial intervention. Whether the performance of ETI differs according to the sex of the laryngoscopist remains unclear. The aim of this study was to assess sex disparities in markers of ETI performance among novices using a high-fidelity simulator. This prospective observational study was conducted from April 2017 to March 2019 in a public medical university. In total, 209 medical students (4th and 5th grade) without clinical ETI experience were recruited. Of the 209 students, 64 (30.6%) were female. The participants used either a Macintosh direct laryngoscope or C-MAC video laryngoscope in combination with a stylet or gum-elastic bougie to perform ETI on a high-fidelity simulator. The primary endpoint was the maximum force applied on the maxillary incisors during laryngoscopy. The secondary endpoint was the time to ETI. The implanted sensors in the simulator automatically quantified the force and time to ETI. The maximum force applied on the maxillary incisors was approximately 30% lower in the male than female group for all laryngoscopes and intubation aids examined (all P < 0.001). Similarly, the time to ETI was approximately 10% faster in the male than female group regardless of the types of laryngoscopes and intubation aids used (all P < 0.05). In this study, male sex was associated with a lower maximum force applied on the maxillary incisors during both direct and indirect laryngoscopy performed by novices. A clinical study focusing on sex differences in ETI performance is needed to validate our findings.
    MeSH term(s) Humans ; Male ; Female ; Laryngoscopy ; Incisor ; Laryngoscopes ; Intubation, Intratracheal ; Prospective Studies
    Language English
    Publishing date 2024-02-29
    Publishing country Japan
    Document type Observational Study ; Journal Article
    ZDB-ID 840671-6
    ISSN 1883-0498 ; 0023-2513
    ISSN (online) 1883-0498
    ISSN 0023-2513
    DOI 10.24546/0100486397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Post-Intensive Care Syndrome—10 Years after Its Proposal and Future Directions

    Shigeaki Inoue / Nobuto Nakanishi / Kensuke Nakamura

    Journal of Clinical Medicine, Vol 11, Iss 15, p

    2022  Volume 4381

    Abstract: With the development of intensive care medicine and the standardization of various therapeutic guidelines and education systems, mortality rates in critically ill patients have improved markedly [.] ...

    Abstract With the development of intensive care medicine and the standardization of various therapeutic guidelines and education systems, mortality rates in critically ill patients have improved markedly [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Postintensive care syndrome family: A comprehensive review.

    Shirasaki, Kasumi / Hifumi, Toru / Nakanishi, Nobuto / Nosaka, Nobuyuki / Miyamoto, Kyohei / Komachi, Miyuki H / Haruna, Junpei / Inoue, Shigeaki / Otani, Norio

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e939

    Abstract: Families of critically ill patients are predisposed to tremendous burdens when their relatives are admitted to the intensive care unit (ICU). Postintensive care syndrome family (PICS-F) can be described as a devastated life, encompassing psychological, ... ...

    Abstract Families of critically ill patients are predisposed to tremendous burdens when their relatives are admitted to the intensive care unit (ICU). Postintensive care syndrome family (PICS-F) can be described as a devastated life, encompassing psychological, physical, and socioeconomical burdens that begin with the emotional impact experienced by the family when the patient is admitted to the ICU. PICS-F was primarily proposed as a clinically significant psychological impairment, but it needs to be extended beyond the psychological impairment of the family to include physical and socioeconomical impairments in the future. The prevalence of physiological problems including depression, anxiety and post-traumatic syndrome is 20-40%, and that of non-physiological problems including fatigue is 15% at 6 months after the ICU stay. Assessment of PICS-F was frequently conducted at 3- or 6-month points, although the beginning of the evaluation was based on different assessment points among each of the studies. Families of ICU patients need to be given and understand accurate information, such as the patient's diagnosis, planned care, and prognosis. Prevention of PICS-F requires a continuous bundle of multifaceted and/or multidisciplinary interventions including providing a family information leaflet, ICU diary, communication facilitators, supportive grief care, and follow-up, for the patient and families from during the ICU stay to after discharge from the ICU. This is the first comprehensive review of PICS-F to address the concept, risk factors, assessment tools, prevalence, and management to prevent PICS-F to facilitate acute care physicians' understanding of PICS-F.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.939
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  6. Article: Reply to the comment.

    Okada, Yohei / Unoki, Takeshi / Matsuishi, Yujiro / Egawa, Yuko / Hayashida, Kei / Inoue, Shigeaki

    Journal of intensive care

    2020  Volume 8, Page(s) 22

    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-020-00438-3
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  7. Article ; Online: Novel Peritoneal Sclerosis Rat Model Developed by Administration of Bleomycin and Lansoprazole.

    Kunitatsu, Kosei / Yamamoto, Yuta / Nasu, Shota / Taniji, Akira / Kawashima, Shuji / Yamagishi, Naoko / Ito, Takao / Inoue, Shigeaki / Kanai, Yoshimitsu

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: In our preliminary experiment, peritoneal sclerosis likely induced by peritoneal dialysis was unexpectedly observed in the livers of rats given bleomycin and lansoprazole. We examined whether this peritoneal thickening around the liver was time- ... ...

    Abstract In our preliminary experiment, peritoneal sclerosis likely induced by peritoneal dialysis was unexpectedly observed in the livers of rats given bleomycin and lansoprazole. We examined whether this peritoneal thickening around the liver was time-dependently induced by administration of both drugs. Male Wistar rats were injected with bleomycin and/or lansoprazole for 2 or 4 weeks. The 3YB-1 cell line derived from rat fibroblasts was treated by bleomycin and/or lansoprazole for 24 h. The administration of both drugs together, but not individually, thickened the peritoneal tissue around the liver. There was accumulation of collagen fibers, macrophages, and eosinophils under mesothelial cells. Expressions of
    MeSH term(s) Rats ; Male ; Animals ; Peritoneal Fibrosis/chemically induced ; Peritoneal Fibrosis/genetics ; Bleomycin/adverse effects ; Rats, Wistar ; Lansoprazole/adverse effects ; Lansoprazole/metabolism ; Epithelial Cells/metabolism ; Peritoneum/pathology
    Chemical Substances Bleomycin (11056-06-7) ; Lansoprazole (0K5C5T2QPG)
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216108
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  8. Article ; Online: Ultrasound-based upper limb muscle thickness is useful for screening low muscularity during intensive care unit admission: A retrospective study.

    Nakanishi, Nobuto / Inoue, Shigeaki / Ono, Yuko / Sugiyama, Jun / Takayama, Kazushi / Arai, Yuta / Nakamura, Kensuke / Oto, Jun / Kotani, Joji

    Clinical nutrition ESPEN

    2023  Volume 57, Page(s) 569–574

    Abstract: Background & aims: Malnutrition is associated with poor outcomes. Muscle mass is an important malnutrition indicator included in Global Leadership Initiative on Malnutrition (GLIM) criteria. Although bioelectrical impedance analysis and dual-energy X- ... ...

    Abstract Background & aims: Malnutrition is associated with poor outcomes. Muscle mass is an important malnutrition indicator included in Global Leadership Initiative on Malnutrition (GLIM) criteria. Although bioelectrical impedance analysis and dual-energy X-ray absorptiometry are common muscle mass assessment methods, they are unreliable during intensive care unit (ICU) admission due to the influence of dynamic fluid changes. We hypothesized that ultrasound-based upper limb muscle assessment would be useful for assessing muscularity at ICU admission.
    Methods: We retrospectively analyzed prospectively obtained ultrasound data from patients admitted to an ICU. We excluded patients without computed tomography (CT) imaging of the third lumbar vertebra within 2 days of ICU admission. Primary outcomes were the diagnostic utility of ultrasound-based upper limb muscle thickness for assessing low muscularity by CT. Low muscularity was defined as a skeletal muscle index of 36.0 cm
    Results: Among 64 patients assessed by ultrasound, 52 had CT examination records and were included in the analysis. The mean age was 70 ± 13 years, and the mean body mass index was 23.3 ± 4.2 kg/m
    Conclusions: Ultrasound-based upper limb muscle thickness assessments can screen for low muscularity upon ICU admission.
    MeSH term(s) Female ; Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Retrospective Studies ; Upper Extremity ; Muscle, Skeletal/diagnostic imaging ; Intensive Care Units ; Malnutrition
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2023.07.089
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  9. Article ; Online: Gender Disparities in First Authorship at Three Medical Universities in an Area Affected by the Great East Japan Earthquake.

    Ono, Yuko / Saito, Masafumi / Shimomura, Kenju / Shinohara, Kazuaki / Yamada, Naoto / Iwasaki, Yudai / Inoue, Shigeaki / Kotani, Joji

    The Kobe journal of medical sciences

    2023  Volume 69, Issue 2, Page(s) E64–E78

    Abstract: The Great East Japan Earthquake that occurred on March 11, 2011, was one of the largest natural disasters in modern times. Publication in medical journals is important aspects of the academic promotion process, and is thus important for all scientists. ... ...

    Abstract The Great East Japan Earthquake that occurred on March 11, 2011, was one of the largest natural disasters in modern times. Publication in medical journals is important aspects of the academic promotion process, and is thus important for all scientists. However, little is known about whether and how substantial natural disasters affect gender disparities in academic productivity in disaster-affected areas. We hypothesized that the Great East Japan Earthquake widened the existing disparities in scientific publishing between male and female researchers. To test this hypothesis, this retrospective observational study using existing databases was conducted. We extracted from the MEDLINE database all types of biomedical articles published from March 11, 2007, to March 11, 2015, by three medical universities in a disaster-affected area of Japan. Differences in the proportion of female first authorship during the 4 years before and after the Great East Japan Earthquake were compared. A total of 5,873 papers were analyzed. The proportion of female first authors significantly declined after the Great East Japan Earthquake (20.5% vs. 14.1%; odds ratio 0.64; 95% confidence interval 0.56-0.73). A similar trend was identified across all prespecified subgroups, including clinical department; original article; public medical university; and prestigious journal with impact factor >6. Reference data from two medical universities minimally affected by the Great East Japan Earthquake showed the opposite trend. These results collectively suggest that large natural disasters can reinforce existing gender disparities in first authorship in biomedicine.
    MeSH term(s) Female ; Male ; Humans ; Earthquakes ; Universities ; Authorship ; Japan
    Language English
    Publishing date 2023-08-31
    Publishing country Japan
    Document type Observational Study ; Journal Article
    ZDB-ID 840671-6
    ISSN 1883-0498 ; 0023-2513
    ISSN (online) 1883-0498
    ISSN 0023-2513
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    Zs.A 193: Show issues Location:
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  10. Article ; Online: High-Velocity Nasal Insufflation Increases Nasopharyngeal Pressure with Flow-Dependent Manner Compared with High Flow Nasal Cannula in Adult Volunteers - A Single-Center Prospective Observational Study.

    Miyazaki, Yusuke / Inoue, Shigeaki / Hirose, Hajime / Kooguchi, Kunihiko / Kotani, Joji

    The Kobe journal of medical sciences

    2021  Volume 67, Issue 3, Page(s) E92–E97

    Abstract: Background: High flow nasal cannula (HFNC) can produce positive airway pressure, and the pressure increases in proportion to the gas flow. Recently, high-velocity nasal insufflation (HiVNI) was developed as a new system of HFNC. However, it is still ... ...

    Abstract Background: High flow nasal cannula (HFNC) can produce positive airway pressure, and the pressure increases in proportion to the gas flow. Recently, high-velocity nasal insufflation (HiVNI) was developed as a new system of HFNC. However, it is still unclear whether HiVNI can increase the airway pressure. The purpose of our study was to evaluate whether the HiVNI can increase the airway pressure compared to HFNC, under various gas flows.
    Methods: This single-center prospective observational study recorded nasopharyngeal pressures in fifteen healthy volunteers who received both normal HFNC and HiVNI. After a 10 Fr catheter was inserted via the nose, the catheter was connected to the manometer and high flow oxygen therapy was performed using both systems. The measurements were carried out at flows of 20, 30, and 40 L/min, and the pressures were recorded at 50 Hz. The measurements were repeated with the mouth in the open and closed positions for each high-flow system.
    Results: With the mouth open, the mean nasopharyngeal pressure was low in both systems, and the difference between the two systems was not significant. However, with the mouth closed, a significantly higher nasopharyngeal pressure was recorded with the HiVNI system compared to the HFNC system at all flows (P < .01). Furthermore, the difference between HiVNI and HFNC at each flow became significantly greater with the increase of flow (P < .01).
    Conclusion: In healthy volunteers, HiVNI can produce higher nasopharyngeal pressure than normal HFNC in a flow-dependent manner.
    MeSH term(s) Adult ; Cannula ; Continuous Positive Airway Pressure ; Humans ; Insufflation ; Oxygen Inhalation Therapy ; Volunteers
    Language English
    Publishing date 2021-12-01
    Publishing country Japan
    Document type Journal Article ; Observational Study
    ZDB-ID 840671-6
    ISSN 1883-0498 ; 0023-2513
    ISSN (online) 1883-0498
    ISSN 0023-2513
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