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Article ; Online: Collaboration on antimicrobial stewardship practices amongst university health systems, Veterans Affairs medical centers, and other affiliates: opportunities for greater harmony.

Hitchcock, Matthew M / Markley, J Daniel / Tassone, Daniel / Kamath, Meghan / Lee, Kimberly B / Greenfield, Adam / Rittmann, Barry / Sastry, Sangeeta

Antimicrobial stewardship & healthcare epidemiology : ASHE

2023 Volume 3, Issue 1, Page(s) e220

Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Editorial
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2023.495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Collaboration on antimicrobial stewardship practices amongst university health systems, Veterans Affairs medical centers, and other affiliates

Matthew M. Hitchcock / J. Daniel Markley / Daniel Tassone / Meghan Kamath / Kimberly B. Lee / Adam Greenfield / Barry Rittmann / Sangeeta Sastry

Antimicrobial Stewardship & Healthcare Epidemiology, Vol

opportunities for greater harmony

2023 Volume 3

Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Active Surveillance Cultures and Procalcitonin in Combination With Clinical Data to Guide Empirical Antimicrobial Therapy in Hospitalized Medical Patients With Sepsis.

Spoto, Silvia / Daniel Markley, John / Valeriani, Emanuele / Abbate, Antonio / Argemi, Josepmaria / Markley, Roshanak / Fogolari, Marta / Locorriere, Luciana / Anguissola, Giuseppina Beretta / Battifoglia, Giulia / Costantino, Sebastiano / Ciccozzi, Massimo / Bustos Guillén, César / Angeletti, Silvia

Frontiers in microbiology

2022 Volume 13, Page(s) 797932

Abstract: Objective: The prevalence of colonization with multidrug-resistant organisms (MDRO) has increased over the last decade, reaching levels as high as 23% in certain patient populations. Active surveillance cultures (ASC) represent a valuable tool to ... ...

Abstract	Objective: The prevalence of colonization with multidrug-resistant organisms (MDRO) has increased over the last decade, reaching levels as high as 23% in certain patient populations. Active surveillance cultures (ASC) represent a valuable tool to identify patients colonized with MDRO to apply preventive measures, reduce transmission, and guide empiric antimicrobial therapy. There is a paucity of data evaluating the impact of admission ASCs to predict future infection. The aim of this study was to evaluate the concordance between ASCs results and the development of clinical infection by the same microorganism identified in the surveillance swab ("swab-related infection"), in hospitalized septic patients, and to evaluate the presence of specific risk factors associated with the development of a swab-related infection. Methods: All adults admitted to the Diagnostic and Therapeutic Medicine Department of the University Hospital Campus Bio-Medico of Rome with a diagnosis of infection or any other medical reason with admission surveillance swabs (rectal or nasal) between January 2018 and February 2021 were included in the study. A retrospective chart review was conducted to identify patients that developed infections with concordant MDROs identified on ASC, and the risk factors for swab-related infection. Secondary outcomes were need of intensive care unit transfer, length of stay, sepsis or septic shock development, and all-cause mortality. Results: A total of 528 patients were included in the study, of which 97 (18.3%) had a positive surveillance swab. Among patients with positive surveillance swabs, 18 (18.5%) developed an infection with the same microorganism recovered from the swab, 57 (58.8%) developed an infection with a different microorganism than that recovered from the surveillance swab, and 22 (22.7%) did not develop an infection during hospitalization. The number of colonized sites, an interventional procedure within the previous 3 months, a Systemic Inflammatory Response Syndrome (SIRS) score ≥ 2, and a quick Sequential Organ Failure Assessment (q-SOFA) score ≥ 2 were associated with a significantly higher risk of developing a swab-related infection. SIRS and q-SOFA scores ≥ 2 and procalcitonin ≥ 0.43 ng/ml help for identifying patients with a swab-related infection. Conclusion: Patients with positive surveillance swabs were at increased risk for development of infections by the same MDRO identified in surveillance swabs (swab-related infection). This study is the first to show that the positivity of surveillance swabs, in combination with anamnestic data, PCT values, and SIRS or q-SOFA scores, serves as a valuable tool to help clinicians predict patients at higher risk for swab-related infection development and guide the administration of appropriate empiric antimicrobial therapy in septic patients.
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.797932
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Article: The Current State of Antimicrobial Stewardship: Challenges, Successes, and Future Directions.

Emberger, Jennifer / Tassone, Dan / Stevens, Michael P / Markley, J Daniel

Current infectious disease reports

2018 Volume 20, Issue 9, Page(s) 31

Abstract: Purpose of review: The aim of this study is to examine the current state of the field of antimicrobial stewardship (AS) by highlighting key challenges and successes, as well as exciting future directions.: Recent findings: AS mandates from the ... ...

Abstract	Purpose of review: The aim of this study is to examine the current state of the field of antimicrobial stewardship (AS) by highlighting key challenges and successes, as well as exciting future directions. Recent findings: AS mandates from the Centers for Medicare and Medicaid (CMS) and the Joint Commission (TJC) will stimulate increased compliance with current AS standards, but overall compliance is currently poor. Key challenges to progress in the field of AS include insufficient workforce and monetary resources, poorly defined AS metrics, and much needed expansion beyond the inpatient hospital setting. Despite these challenges, massive progress has been made in the last two and a half decades since the field of AS emerged. AS metrics are rapidly evolving and transforming the way antimicrobial stewardship programs (ASPs) measure success. Rapid diagnostics and diagnostic test stewardship are proving to be extremely effective when coupled with an ASP. Telehealth may improve access to ASP expertise in resource poor settings, and the role of bedside nurses as ASP team members has the potential to greatly augment ASP efforts. Allergy testing as an ASP strategy remains largely underutilized. ASPs have made significant gains in the battle against antimicrobial resistance (AR), but considerable advancement is still needed. Awareness of current challenges is critical to ensure progress in the field. The field of AS is expanding and transforming rapidly through integration, technology, and improved processes.
Language	English
Publishing date	2018-06-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-018-0637-6
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Article: De-escalating Antibiotic Use in the Inpatient Setting: Strategies, Controversies, and Challenges.

Daniel Markley, J / Bernard, Shaina / Bearman, Gonzalo / Stevens, Michael P

Current infectious disease reports

2017 Volume 19, Issue 4, Page(s) 17

Abstract: Purpose of review: Antibiotic de-escalation (ADE) is widely accepted as an integral strategy to curtail the global antibiotic resistance crisis. However, there is significant uncertainty regarding the ideal ADE strategy and its true impact on antibiotic ...

Abstract	Purpose of review: Antibiotic de-escalation (ADE) is widely accepted as an integral strategy to curtail the global antibiotic resistance crisis. However, there is significant uncertainty regarding the ideal ADE strategy and its true impact on antibiotic resistance. Rapid diagnostic testing has the potential to enhance ADE strategies. Herein, we aim to discuss the current strategies, controversies, and challenges of ADE in the inpatient setting. Recent findings: A consensus definition of ADE remains elusive at this time. Preliminary studies utilizing rapid diagnostic tests including matrix-assisted laser desorption/ionization time of flight (MALDI-TOF), procalcitonin, and other molecular techniques have demonstrated the potential to support ADE strategies. In the absence of evidence-based, highly specific ADE protocols, the likelihood that individual providers will make consistent, often challenging, decisions to de-escalate antibiotic therapy is low. Antimicrobial stewardship programs should support local physicians with ADE and develop innovative ways to integrate ADE into the broader construct of antimicrobial stewardship programs. The evolving field of rapid diagnostics has significant potential to improve ADE strategies, but more research is needed to fully realize this goal.
Language	English
Publishing date	2017-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-017-0575-8
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Article ; Online: Placenta Accreta Spectrum Disorders: Knowledge Gaps in Anesthesia Care.

Warrick, Christine M / Markley, John C / Farber, Michaela K / Balki, Mrinalini / Katz, Daniel / Hess, Philip E / Padilla, Cesar / Waters, Jonathan H / Weiniger, Carolyn F / Butwick, Alexander J

Anesthesia and analgesia

2022 Volume 135, Issue 1, Page(s) 191–197

Abstract: Placenta accreta spectrum (PAS) disorder is a potentially life-threatening condition that can occur during pregnancy. PAS puts pregnant individuals at a very high risk of major blood loss, hysterectomy, and intensive care unit admission. These patients ... ...

Abstract	Placenta accreta spectrum (PAS) disorder is a potentially life-threatening condition that can occur during pregnancy. PAS puts pregnant individuals at a very high risk of major blood loss, hysterectomy, and intensive care unit admission. These patients should receive care in a center with multidisciplinary experience and expertise in managing PAS disorder. Obstetric anesthesiologists play vital roles in the peripartum care of pregnant patients with suspected PAS. As well as providing high-quality anesthesia care, obstetric anesthesiologists coordinate peridelivery care, drive transfusion-related decision making, and oversee postpartum analgesia. However, there are a number of key knowledge gaps related to the anesthesia care of these patients. For example, limited data are available describing optimal anesthesia staffing models for scheduled and unscheduled delivery. Evidence and consensus are lacking on the ideal surgical location for delivery; primary mode of anesthesia for cesarean delivery; preoperative blood ordering; use of pharmacological adjuncts for hemorrhage management, such as tranexamic acid and fibrinogen concentrate; neuraxial blocks and abdominal wall blocks for postoperative analgesia; and the preferred location for postpartum care. It is also unclear how anesthesia-related decision making and interventions impact physical and mental health outcomes. High-quality international multicenter studies are needed to fill these knowledge gaps and advance the anesthesia care of patients with PAS.
MeSH term(s)	Anesthesia/adverse effects ; Blood Transfusion ; Cesarean Section ; Female ; Humans ; Hysterectomy ; Placenta Accreta/diagnosis ; Placenta Accreta/surgery ; Postpartum Hemorrhage ; Pregnancy ; Retrospective Studies
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000005862
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Article ; Online: Forced expiratory time: a composite of airway narrowing and airway closure.

Skloot, Gwen S / O'Connor-Chapman, Kieley L / Schechter, Clyde B / Markley, Daniel J / Bates, Jason H T

Journal of applied physiology (Bethesda, Md. : 1985)

2020 Volume 130, Issue 1, Page(s) 80–86

Abstract: Forced expiratory time (FET) is a spirometrically derived variable thought to reflect lung function, but its physiological basis remains poorly understood. We developed a mathematical theory of FET assuming a linear forced expiratory flow-volume profile ... ...

Abstract	Forced expiratory time (FET) is a spirometrically derived variable thought to reflect lung function, but its physiological basis remains poorly understood. We developed a mathematical theory of FET assuming a linear forced expiratory flow-volume profile that terminates when expiratory flow falls below a defined detection threshold. FET is predicted to correlate negatively with both FEV
MeSH term(s)	Forced Expiratory Volume ; Humans ; Lung ; Respiratory Function Tests ; Retrospective Studies ; Spirometry ; Vital Capacity
Language	English
Publishing date	2020-10-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00556.2020
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Article ; Online: Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional ciliary motility in Trypanosoma brucei.

Godar, Subash / Oristian, James / Hinsch, Valerie / Wentworth, Katherine / Lopez, Ethan / Amlashi, Parastoo / Enverso, Gerald / Markley, Samantha / Alper, Joshua Daniel

PLoS pathogens

2022 Volume 18, Issue 9, Page(s) e1009984

Abstract: Flagellar motility is essential for the cell morphology, viability, and virulence of pathogenic kinetoplastids. Trypanosoma brucei flagella beat with a bending wave that propagates from the flagellum's tip to its base, rather than base-to-tip as in other ...

Abstract	Flagellar motility is essential for the cell morphology, viability, and virulence of pathogenic kinetoplastids. Trypanosoma brucei flagella beat with a bending wave that propagates from the flagellum's tip to its base, rather than base-to-tip as in other eukaryotes. Thousands of dynein motor proteins coordinate their activity to drive ciliary bending wave propagation. Dynein-associated light and intermediate chains regulate the biophysical mechanisms of axonemal dynein. Tctex-type outer arm dynein light chain 2 (LC2) regulates flagellar bending wave propagation direction, amplitude, and frequency in Chlamydomonas reinhardtii. However, the role of Tctex-type light chains in regulating T. brucei motility is unknown. Here, we used a combination of bioinformatics, in-situ molecular tagging, and immunofluorescence microscopy to identify a Tctex-type light chain in the procyclic form of T. brucei (TbLC2). We knocked down TbLC2 expression using RNAi in both wild-type and FLAM3, a flagellar attachment zone protein, knockdown cells and quantified TbLC2's effects on trypanosome cell biology and biophysics. We found that TbLC2 knockdown reduced the directional persistence of trypanosome cell swimming, induced an asymmetric ciliary bending waveform, modulated the bias between the base-to-tip and tip-to-base beating modes, and increased the beating frequency. Together, our findings are consistent with a model of TbLC2 as a down-regulator of axonemal dynein activity that stabilizes the forward tip-to-base beating ciliary waveform characteristic of trypanosome cells. Our work sheds light on axonemal dynein regulation mechanisms that contribute to pathogenic kinetoplastids' unique tip-to-base ciliary beating nature and how those mechanisms underlie dynein-driven ciliary motility more generally.
MeSH term(s)	Axonemal Dyneins/genetics ; Axonemal Dyneins/metabolism ; Cell Movement ; Flagella/metabolism ; RNA Interference ; Trypanosoma brucei brucei/metabolism
Chemical Substances	Axonemal Dyneins (EC 3.6.4.2)
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1009984
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Article ; Online: Variation in a novel antipseudomonal antimicrobial consumption metric across hospital inpatient units at a Veterans Affairs hospital: A retrospective cohort study.

Vissichelli, Nicole C / Bailey, Pamela / Sabo, Roy T / Tassone, Daniel / Vaughan, Leroy / Stevens, Michael P / Markley, J Daniel

American journal of infection control

2019 Volume 47, Issue 10, Page(s) 1263–1264

Abstract: A novel antimicrobial consumption metric designed to identify the proportion of carbapenem consumption (PoCC) among broad-spectrum antipseudomonal antimicrobials has been shown to vary significantly by US Census Bureau region. This retrospective ... ...

Abstract	A novel antimicrobial consumption metric designed to identify the proportion of carbapenem consumption (PoCC) among broad-spectrum antipseudomonal antimicrobials has been shown to vary significantly by US Census Bureau region. This retrospective surveillance study identified significant total PoCC variability (27%; P = .001) across 8 inpatient units from January 2017 through June 2018. This metric may be useful in identifying and comparing inpatient units that may be overusing antipseudomonal carbapenems.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship/methods ; Carbapenems/therapeutic use ; Drug Utilization ; Hospital Units ; Hospitals ; Humans ; Inpatients ; Microbial Sensitivity Tests/methods ; Pseudomonas aeruginosa/drug effects ; Retrospective Studies ; Veterans
Chemical Substances	Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2019-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2019.04.170
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Article ; Online: Synergistic Steric and Electronic Effects on the Photoredox Catalysis by a Multivariate Library of Titania Metal-Organic Frameworks.

Bryant, Jacob T / Logan, Matthew W / Chen, Zhihengyu / Djokic, Marcus / Cairnie, Daniel R / Vazquez-Molina, Demetrius A / Nijamudheen, A / Langlois, Kyle R / Markley, Michael J / Pombar, Gisselle / Holland, Ashley A / Caranto, Jonathan D / Harper, James K / Morris, Amanda J / Mendoza-Cortes, Jose L / Jurca, Titel / Chapman, Karena W / Uribe-Romo, Fernando J

Journal of the American Chemical Society

2023 Volume 145, Issue 8, Page(s) 4589–4600

Abstract: Metal-organic frameworks (MOFs) that display photoredox activity are attractive materials for sustainable photocatalysis. The ability to tune both their pore sizes and electronic structures based solely on the choice of the building blocks makes them ... ...

Abstract	Metal-organic frameworks (MOFs) that display photoredox activity are attractive materials for sustainable photocatalysis. The ability to tune both their pore sizes and electronic structures based solely on the choice of the building blocks makes them amenable for systematic studies based on physical organic and reticular chemistry principles with high degrees of synthetic control. Here, we present a library of eleven isoreticular and multivariate (MTV) photoredox-active MOFs, UCFMOF-
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c12147
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