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Article ; Online: Post-treatment with propofol inhibits inflammatory response in LPS-induced alveolar type II epithelial cells.

Yang, Xilun / Ma, Ling

2022 Volume 23, Issue 4, Page(s) 249

Abstract: Over-inflammation and severe lung injury are major causes of morbidity and mortality in patients with coronavirus disease 2019 (COVID-19). With the COVID-19 pandemic, an increasing number of patients with preexisting lung injury and inflammation are ... ...

Abstract	Over-inflammation and severe lung injury are major causes of morbidity and mortality in patients with coronavirus disease 2019 (COVID-19). With the COVID-19 pandemic, an increasing number of patients with preexisting lung injury and inflammation are undergoing surgery or artificial ventilation under sedation in intensive care units, where 2,6-diisopropylphenol (propofol) is a commonly used drug for sedation. The aim of the present study was to investigate whether post-inflammation treatment with propofol protects epithelial type II cells against inflammation in an
Language	English
Publishing date	2022-01-31
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11174
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional MRI Changes in Patients after Thyroidectomy under General Anesthesia

Xilun Yang / Bing Yu / Ling Ma

BioMed Research International, Vol

2022 Volume 2022

Abstract: Cognitive changes affecting elderly patients following surgery under anesthesia have drawn significant attention and have been investigated in considerable depth. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to assess changes ...

Abstract	Cognitive changes affecting elderly patients following surgery under anesthesia have drawn significant attention and have been investigated in considerable depth. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to assess changes in brain functional connectivity (FC) associated with postoperative changes in cognition, a common complication in seniors undergoing surgery. In this study, we recruited 20 patients over 55 of age and scheduled an elective thyroidectomy under general anesthesia to assess perioperative changes in brain FC density (FCD) in patients undergoing thyroidectomy under general anesthesia using rs-fMRI. All 20 patients underwent a series of clinical, quantitative, neurological, and neuropsychological tests and fMRI examinations on the day before surgery (Day 0) and 7 days after surgery (Day 7). The following tests were conducted on all patients: the Minimental State Examination (MMSE), the digit symbol substitution test (DSST), the trail making test (part A), the verbal fluency test, and Warrington’s recognition memory test (WRMT). FMRI data were acquired using a 3T MR system; the FCD values were calculated using the REST software package. We used paired t-tests to compare the FCD between Day 7 and Day 0. A value of p<0.05 was considered to reflect statistical significance. The postoperative FCD was significantly reduced in the supplementary motor area (SMA). Analyses of the percentage changes of errors in the WRMT revealed a significant and negative correlation with the mean percentage change of FCD in the SMA (Spearman’s r=−0.54, 95% CI: (-0.80, -0.12), p=0.014). Postoperative changes in FCD in the SMA may be associated with the perioperative neurocognitive changes in patients undergoing partial thyroidectomy under general anesthesia.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Functional MRI Changes in Patients after Thyroidectomy under General Anesthesia.

Yang, Xilun / Yu, Bing / Ma, Ling

BioMed research international

2022 Volume 2022, Page(s) 1935125

Abstract	Cognitive changes affecting elderly patients following surgery under anesthesia have drawn significant attention and have been investigated in considerable depth. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to assess changes in brain functional connectivity (FC) associated with postoperative changes in cognition, a common complication in seniors undergoing surgery. In this study, we recruited 20 patients over 55 of age and scheduled an elective thyroidectomy under general anesthesia to assess perioperative changes in brain FC density (FCD) in patients undergoing thyroidectomy under general anesthesia using rs-fMRI. All 20 patients underwent a series of clinical, quantitative, neurological, and neuropsychological tests and fMRI examinations on the day before surgery (Day 0) and 7 days after surgery (Day 7). The following tests were conducted on all patients: the Minimental State Examination (MMSE), the digit symbol substitution test (DSST), the trail making test (part A), the verbal fluency test, and Warrington's recognition memory test (WRMT). FMRI data were acquired using a 3T MR system; the FCD values were calculated using the REST software package. We used paired
MeSH term(s)	Aged ; Anesthesia, General/adverse effects ; Brain/diagnostic imaging ; Brain Mapping ; Cognition ; Humans ; Magnetic Resonance Imaging/methods ; Thyroidectomy/adverse effects
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/1935125
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Article ; Online: Biodegradable-Glass-Fiber Reinforced Hydrogel Composite with Enhanced Mechanical Performance and Cell Proliferation for Potential Cartilage Repair

Chenkai Zhu / Changyong Huang / Wuxiang Zhang / Xilun Ding / Yang Yang

International Journal of Molecular Sciences, Vol 23, Iss 15, p

2022 Volume 8717

Abstract: Polyvinyl alcohol (PVA) hydrogels are promising implants due to the similarity of their low-friction behavior to that of cartilage tissue, and also due to their non-cytotoxicity. However, their poor mechanical resistance and insufficient durability ... ...

Abstract	Polyvinyl alcohol (PVA) hydrogels are promising implants due to the similarity of their low-friction behavior to that of cartilage tissue, and also due to their non-cytotoxicity. However, their poor mechanical resistance and insufficient durability restricts their application in this area. With the development of biodegradable glass fibers (BGF), which show desirable mechanical performance and bioactivity for orthopedic engineering, we designed a novel PVA hydrogel composite reinforced with biodegradable glass fibers, intended for use in artificial cartilage repair with its excellent cytocompatibility and long-term mechanical stability. Using structure characterization and thermal properties analysis, we found hydrogen bonding occurred among PVA molecular networks as well as in the PVA–BGF interface, which explained the increase in crystallinity and glass transition temperature, and was the reason for the improved mechanical performance and better anti-fatigue behavior of the composites in comparison with PVA. The compressive strength and modulus for the PBGF-15 composite reached 3.05 and 3.97 MPa, respectively, equaling the mechanical properties of human articular cartilage. Moreover, the increase in BGF content was found to support the proliferation of chondrocytes in vitro, whilst the PVA hydrogel matrix was able to control the ion concentration by adjusting the ions released from the BGF. Therefore, this novel biodegradable-glass-fiber-reinforced hydrogel composite possesses excellent properties for cartilage repair with potential in medical application.
Keywords	biodegradable glass fiber ; poly(vinyl alcohol) hydrogel ; composites ; mechanical performance ; degradation behavior ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Flexible calorimetric flow sensor with unprecedented sensitivity and directional resolution for multiple flight parameter detection.

Gong, Zheng / Di, Weicheng / Jiang, Yonggang / Dong, Zihao / Yang, Zhen / Ye, Hong / Zhang, Hengrui / Liu, Haoji / Wei, Zixing / Tu, Zhan / Li, Daochun / Xiang, Jinwu / Ding, Xilun / Zhang, Deyuan / Chen, Huawei

Nature communications

2024 Volume 15, Issue 1, Page(s) 3091

Abstract: The accurate perception of multiple flight parameters, such as the angle of attack, angle of sideslip, and airflow velocity, is essential for the flight control of micro air vehicles, which conventionally rely on arrays of pressure or airflow velocity ... ...

Abstract	The accurate perception of multiple flight parameters, such as the angle of attack, angle of sideslip, and airflow velocity, is essential for the flight control of micro air vehicles, which conventionally rely on arrays of pressure or airflow velocity sensors. Here, we present the estimation of multiple flight parameters using a single flexible calorimetric flow sensor featuring a sophisticated structural design with a suspended array of highly sensitive vanadium oxide thermistors. The proposed sensor achieves an unprecedented velocity resolution of 0.11 mm·s
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47284-7
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Article ; Online: Biodegradable-Glass-Fiber Reinforced Hydrogel Composite with Enhanced Mechanical Performance and Cell Proliferation for Potential Cartilage Repair.

Zhu, Chenkai / Huang, Changyong / Zhang, Wuxiang / Ding, Xilun / Yang, Yang

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract	Polyvinyl alcohol (PVA) hydrogels are promising implants due to the similarity of their low-friction behavior to that of cartilage tissue, and also due to their non-cytotoxicity. However, their poor mechanical resistance and insufficient durability restricts their application in this area. With the development of biodegradable glass fibers (BGF), which show desirable mechanical performance and bioactivity for orthopedic engineering, we designed a novel PVA hydrogel composite reinforced with biodegradable glass fibers, intended for use in artificial cartilage repair with its excellent cytocompatibility and long-term mechanical stability. Using structure characterization and thermal properties analysis, we found hydrogen bonding occurred among PVA molecular networks as well as in the PVA-BGF interface, which explained the increase in crystallinity and glass transition temperature, and was the reason for the improved mechanical performance and better anti-fatigue behavior of the composites in comparison with PVA. The compressive strength and modulus for the PBGF-15 composite reached 3.05 and 3.97 MPa, respectively, equaling the mechanical properties of human articular cartilage. Moreover, the increase in BGF content was found to support the proliferation of chondrocytes in vitro, whilst the PVA hydrogel matrix was able to control the ion concentration by adjusting the ions released from the BGF. Therefore, this novel biodegradable-glass-fiber-reinforced hydrogel composite possesses excellent properties for cartilage repair with potential in medical application.
MeSH term(s)	Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cartilage, Articular ; Cell Proliferation ; Glass ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Polyvinyl Alcohol/chemistry
Chemical Substances	Biocompatible Materials ; Hydrogels ; fiberglass ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158717
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design optimization and experimental study of a novel mechanism for a hover-able bionic flapping-wing micro air vehicle.

Deng, Huichao / Xiao, Shengjie / Huang, Binxiao / Yang, Lili / Xiang, Xinyi / Ding, Xilun

Bioinspiration & biomimetics

2020 Volume 16, Issue 2

Abstract: Allomyrina ... ...

Abstract	Allomyrina dichotoma
MeSH term(s)	Animals ; Biomechanical Phenomena ; Bionics ; Equipment Design ; Flight, Animal ; Models, Biological ; Wings, Animal
Language	English
Publishing date	2020-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2235670-8
ISSN	1748-3190 ; 1748-3182
ISSN (online)	1748-3190
ISSN	1748-3182
DOI	10.1088/1748-3190/abc292
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Article: Deprivation of Dietary Fiber Enhances Susceptibility of Piglets to Lung Immune Stress.

Yang, Yi / Jiang, Xuemei / Cai, Xuelin / Zhang, Lijia / Li, Wentao / Che, Lianqiang / Fang, Zhengfeng / Feng, Bin / Lin, Yan / Xu, Shengyu / Li, Jian / Zhao, Xilun / Wu, De / Zhuo, Yong

Frontiers in nutrition

2022 Volume 9, Page(s) 827509

Abstract: Growing evidence suggests that dietary fiber enhances short-chain fatty acid (SCFA) producing gut microbes, improving lung immunity against invading ... ...

Abstract	Growing evidence suggests that dietary fiber enhances short-chain fatty acid (SCFA) producing gut microbes, improving lung immunity against invading pathogens
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.827509
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Application of PETCT imaging information combined with tumor markers in etiological screening of infectious and non-infectious ascites

Xilun Gan / Jianbo Yang / Li Wang / Beibei Tan / Lisha Wang

Journal of Infection and Public Health, Vol 13, Iss 12, Pp 1997-

2020 Volume 2000

Abstract: In order to study the application value of PETCT image information combined with tumor markers in etiological screening of infectious and non-infectious ascites, ascites patients with unexplained etiological factors from the The Affiliated Hospital, ... ...

Abstract	In order to study the application value of PETCT image information combined with tumor markers in etiological screening of infectious and non-infectious ascites, ascites patients with unexplained etiological factors from the The Affiliated Hospital, Southwest Medical University were selected as the research objects, who were submitted to PET/CT scans and CT morphological scans for the semi-quantitative analysis of ascitic focus; in addition, the research objects were also submitted to chemiluminescence for the detection of concentrations of tumor markers in ascitic fluid, including carcinoembryonic antigen (CEA), alpha fetal protein (AFP), cancer antigen 125 (CA125), and carbohydrate antigen 19-9 (CA19-9). The results have shown that among the tumor markers CEA, AFP, CA125, and CA19-9, the tumor markers CEA, AFP, and CA19-9 had diagnostic reliability; in addition, compared with pure PET/CT imaging and ascites tumor marker detection, the combination of PET/CT imaging and tumor marker detection has more diagnostic value in infectious and non-infectious ascites etiology screening. Despite the deficiencies in the research process, it has provided a certain basis and ideas for subsequent research.
Keywords	PET/CT image ; Tumor marker ; Ascites ; Infectious ; Non-infectious ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combination of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Provides Potential Biomarkers for Early-Stage Parkinson's Disease.

Rong, Yunjie / Xu, Zhifeng / Zhu, Ye / Zhang, Xianhai / Lai, Lingfeng / Sun, Shuyi / Gao, Mingyong / Guo, Pi / Zhang, Guohua / Geng, Yiqun / Ma, Xilun / Wu, Shuohua / Yang, Lin / Shen, Zhiwei / Guan, Jitian

ACS chemical neuroscience

2022 Volume 13, Issue 18, Page(s) 2699–2708

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Biomarkers ; Diffusion Tensor Imaging/methods ; Humans ; Iron ; Magnetic Resonance Imaging/methods ; Parkinson Disease/diagnostic imaging ; Substantia Nigra/diagnostic imaging
Chemical Substances	Biomarkers ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.2c00321
Database	MEDical Literature Analysis and Retrieval System OnLINE

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