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  1. Article ; Online: Posterior Ischemic Optic Neuropathy After Extensive Spine Surgery: A Case Report and Review of the Literature.

    Levinson, Ben / Reddy, Sundara

    AANA journal

    2019  Volume 87, Issue 1, Page(s) 37–42

    Abstract: Postoperative vision loss (POVL) after spine surgery is a rare but devastating complication. Because of its rarity (incidence < 0.2%), POVL might not be considered for inclusion in an informed consent by surgeons and anesthesia providers. We present a ... ...

    Abstract Postoperative vision loss (POVL) after spine surgery is a rare but devastating complication. Because of its rarity (incidence < 0.2%), POVL might not be considered for inclusion in an informed consent by surgeons and anesthesia providers. We present a case of POVL due to posterior ischemic optic neuropathy following prone spine surgery. Posterior ischemic optic neuropathy is characterized by acute painless vison loss that is progressive and irreversible. Our case is atypical because the patient experienced moderate improvement of visual acuity. Increased awareness and understanding of risk factors associated with POVL is an important and timely patient safety topic. In this report we review different pathophysiologies and risk factors for POVL following spine surgery along with recommendations for informed consent and strategies to reduce the incidence of POVL.
    MeSH term(s) Aged ; Anesthesia/adverse effects ; Bone Neoplasms/secondary ; Carcinoma, Renal Cell/secondary ; Diagnosis, Differential ; Humans ; Kidney Neoplasms/pathology ; Lumbar Vertebrae ; Magnetic Resonance Imaging ; Male ; Neoplasm Metastasis ; Optic Neuropathy, Ischemic/chemically induced ; Optic Neuropathy, Ischemic/diagnosis ; Postoperative Complications/chemically induced ; Postoperative Complications/diagnosis ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery
    Language English
    Publishing date 2019-10-06
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603605-3
    ISSN 2162-5239 ; 0094-6354
    ISSN (online) 2162-5239
    ISSN 0094-6354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1286: Show issues Location:
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  2. Article ; Online: Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection.

    Levinson, Ruth / Elbaz, Meital / Ben-Ami, Ronen / Shasha, David / Levinson, Tal / Choshen, Guy / Petrov, Ksenia / Gadoth, Avi / Paran, Yael

    Infectious diseases (London, England)

    2020  Volume 52, Issue 8, Page(s) 600–602

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Disease Progression ; Dysgeusia ; Humans ; Olfaction Disorders ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1772992
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  3. Article ; Online: Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing.

    Gatla, Himavanth / Uth, Nicholas / Levinson, Yonatan / Navaei, Ali / Sargent, Alex / Ramaswamy, Senthil / Friedrich Ben-Nun, Inbar

    Frontiers in medical technology

    2022  Volume 4, Page(s) 850565

    Abstract: Allogeneic T cells are key immune therapeutic cells to fight cancer and other clinical indications. High T cell dose per patient and increasing patient numbers result in clinical demand for a large number of allogeneic T cells. This necessitates a ... ...

    Abstract Allogeneic T cells are key immune therapeutic cells to fight cancer and other clinical indications. High T cell dose per patient and increasing patient numbers result in clinical demand for a large number of allogeneic T cells. This necessitates a manufacturing platform that can be scaled up while retaining cell quality. Here we present a closed and scalable platform for T cell manufacturing to meet clinical demand. Upstream manufacturing steps of T cell activation and expansion are done in-vessel, in a stirred-tank bioreactor. T cell selection, which is necessary for CAR-T-based therapy, is done in the bioreactor itself, thus maintaining optimal culture conditions through the selection step. Platform's attributes of automation and performing the steps of T cell activation, expansion, and selection in-vessel, greatly contribute to enhancing process control, cell quality, and to the reduction of manual labor and contamination risk. In addition, the viability of integrating a closed, automated, downstream process of cell concentration, is demonstrated. The presented T cell manufacturing platform has scale-up capabilities while preserving key factors of cell quality and process control.
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3129
    ISSN (online) 2673-3129
    DOI 10.3389/fmedt.2022.850565
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  4. Article ; Online: Impact of tolerance to fluconazole on treatment response in Candida albicans bloodstream infection.

    Levinson, Tal / Dahan, Alon / Novikov, Anna / Paran, Yael / Berman, Judith / Ben-Ami, Ronen

    Mycoses

    2020  Volume 64, Issue 1, Page(s) 78–85

    Abstract: Background: Treatment of Candida albicans bloodstream infection with fluconazole is associated with significant mortality despite in vitro susceptibility to the drug.: Objectives: We sought to determine whether tolerance to fluconazole is predictive ... ...

    Abstract Background: Treatment of Candida albicans bloodstream infection with fluconazole is associated with significant mortality despite in vitro susceptibility to the drug.
    Objectives: We sought to determine whether tolerance to fluconazole is predictive of treatment failure.
    Methods: We reviewed patients with monomicrobial C albicans bloodstream infection who received primary monotherapy with fluconazole. Tolerance to fluconazole, defined as the fraction of growth above the MIC, was quantified using the disc diffusion assay and digital image analyses. Survival analyses were performed with host and treatment factors as predictive variables.
    Results: Among 44 patients included in the study, all-cause mortality was 29.5% at 30 days and 43.1% at 12 weeks. Forty-one isolates (93%) were susceptible to fluconazole (MIC50, 0.5 mg/L). Fluconazole tolerance was strongly associated with death for patients treated with fluconazole within 24 h of candidemia onset (33.3% vs 0%; p = .007), but not among patients whose treatment was started later. MIC did not correlate with survival, regardless of treatment delay. A Cox regression model including time to treatment, tolerance to fluconazole, fluconazole exposure and Pitt bacteraemia score provided good prediction of treatment outcome (area under the receiver-operator curve, 0.82).
    Conclusions: In patients with C albicans bloodstream infection, tolerance testing was predictive of fluconazole efficacy if the drug was started early. Further study is required to validate the utility of this metric to guide treatment choices.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antifungal Agents/therapeutic use ; Candida albicans ; Candidemia/drug therapy ; Candidiasis/drug therapy ; Candidiasis/mortality ; Cohort Studies ; Drug Resistance, Fungal ; Female ; Fluconazole/therapeutic use ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Survival Analysis ; Treatment Failure ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2020-10-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13191
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    Ud II Zs.176: Show issues Location:
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  5. Article ; Online: A network analysis of eating disorder symptoms and characteristics in an inpatient sample.

    Olatunji, Bunmi O / Levinson, Cheri / Calebs, Ben

    Psychiatry research

    2018  Volume 262, Page(s) 270–281

    Abstract: Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative ... ...

    Abstract Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable category or dimension, but rather are themselves constitutive of the disorder. In the present study, data from ED patients (n = 5193) that completed the Eating Disorders Inventory - 2 (EDI-2; Garner, 1991) before and after inpatient treatment were used to identify symptoms (i.e., body dissatisfaction) and characteristics (i.e., perfectionism) central to EDs. Results revealed that interoceptive awareness and ineffectiveness, but not body dissatisfaction and drive for thinness, were central to the ED network at admission and discharge. Although effect sizes were small, multiple regression analyses revealed that ineffectiveness at admission predicted discharge BMI (over and above interoceptive awareness and BMI at admission) and discharge depression (over and above interoceptive awareness and depression at admission), but not discharge anxiety. These findings suggest that interoceptive awareness and ineffectiveness are central symptoms of EDs that may have implications for treatment outcome. The implications of these findings for conceptualizing the nature and treatment of EDs are discussed.
    MeSH term(s) Adolescent ; Adult ; Aged ; Body Image/psychology ; Child ; Drive ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/psychology ; Female ; Humans ; Inpatients/psychology ; Interoception/physiology ; Middle Aged ; Personality ; Self Concept ; Symptom Assessment ; Young Adult
    Language English
    Publishing date 2018-02-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2018.02.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1541: Show issues Location:
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  6. Article ; Online: Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT.

    Charpak-Amikam, Yoav / Lapidus, Tom / Isaacson, Batya / Duev-Cohen, Alexandra / Levinson, Tal / Elbaz, Adi / Levi-Schaffer, Francesca / Osherov, Nir / Bachrach, Gilad / Hoyer, Lois L / Korem, Maya / Ben-Ami, Ronen / Mandelboim, Ofer

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2463

    Abstract: Candida albicans is the most common fungal pathogen and a prevalent cause of deadly bloodstream infections. Better understanding of the immune response against it, and the ways by which it evades immunity, are crucial for developing new therapeutics ... ...

    Abstract Candida albicans is the most common fungal pathogen and a prevalent cause of deadly bloodstream infections. Better understanding of the immune response against it, and the ways by which it evades immunity, are crucial for developing new therapeutics against it. Natural Killer (NK) cells are innate lymphocytes best known for their role against viruses and tumors. In recent years it became clear that NK cells also play an important role in anti-fungal immunity. Here we show that while NK cells recognize and eliminate C. albicans, the fungal cells inhibit NK cells by manipulating the immune checkpoint receptor TIGIT (T cell immunoreceptor with Ig and ITIM domains) in both humans and mice. We identify the responsible fungal ligands as members of the Als (Agglutinin-Like Sequences) protein family. Furthermore, we show that blocking this interaction using immunotherapy with a TIGIT-blocking antibody can re-establish anti-Candida immunity and serve as a potential therapeutic tool.
    MeSH term(s) Agglutinins/metabolism ; Animals ; Candida albicans/metabolism ; Immunotherapy ; Killer Cells, Natural ; Mice ; Receptors, Immunologic/metabolism
    Chemical Substances Agglutinins ; Receptors, Immunologic
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30087-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection

    Levinson, Ruth / Elbaz, Meital / Ben-Ami, Ronen / Shasha, David / Levinson, Tal / Choshen, Guy / Petrov, Ksenia / Gadoth, Avi / Paran, Yael

    Infect Dis (Lond)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #603719
    Database COVID19

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  8. Article ; Online: Anosmia and dysgeusia in patients with mild SARS-CoV-2 infection

    Levinson, Ruth / Elbaz, Meital / Ben-Ami, Ronen / Shasha, David / Levinson, Tal / Choshen, Guy / Petrov, Ksenia / Gadoth, Avi / Paran, Yael

    Abstract: In this cohort of 42 patients with mild COVID19 we describe the unique clinical feature of acute anosmia and dysgeusia in more than third of patients. Median onset of these features was 3.3 days after onset of illness (range 0-7) with rapid recovery in ... ...

    Abstract In this cohort of 42 patients with mild COVID19 we describe the unique clinical feature of acute anosmia and dysgeusia in more than third of patients. Median onset of these features was 3.3 days after onset of illness (range 0-7) with rapid recovery in most patient.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20055483
    DOI 10.1101/2020.04.11.20055483
    Database COVID19

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  9. Article ; Online: Anosmia and dysgeusia in patients with mild SARS-CoV-2 infection

    Levinson, Ruth / Elbaz, Meital / Ben-Ami, Ronen / Shasha, David / Levinson, Tal / Choshen, Guy / Petrov, Ksenia / Gadoth, Avi / Paran, Yael

    medRxiv

    Abstract: In this cohort of 42 patients with mild COVID19 we describe the unique clinical feature of acute anosmia and dysgeusia in more than third of patients. Median onset of these features was 3.3 days after onset of illness (range 0-7) with rapid recovery in ... ...

    Abstract In this cohort of 42 patients with mild COVID19 we describe the unique clinical feature of acute anosmia and dysgeusia in more than third of patients. Median onset of these features was 3.3 days after onset of illness (range 0-7) with rapid recovery in most patient.
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.11.20055483
    Database COVID19

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  10. Article ; Online: Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection

    Levinson, Ruth / Elbaz, Meital / Ben-Ami, Ronen / Shasha, David / Levinson, Tal / Choshen, Guy / Petrov, Ksenia / Gadoth, Avi / Paran, Yael

    Infectious Diseases

    2020  Volume 52, Issue 8, Page(s) 600–602

    Keywords Microbiology (medical) ; General Immunology and Microbiology ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1772992
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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