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  1. Article ; Online: Genome Sequences of Three SARS-CoV-2 ORF7a Deletion Variants Obtained from Patients in Hong Kong.

    Tse, Herman / Wong, Sally Cheuk-Ying / Ip, Ka-Fai / Cheng, Vincent Chi-Chung / To, Kelvin Kai-Wang / Lung, David Christopher / Choi, Garnet Kwan-Yue

    Microbiology resource announcements

    2021  Volume 10, Issue 15

    Abstract: We report the genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains from the clinical samples of three coronavirus disease 2019 (COVID-19) patients in Hong Kong. All the genome sequences showed a 370-nucleotide deletion ...

    Abstract We report the genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains from the clinical samples of three coronavirus disease 2019 (COVID-19) patients in Hong Kong. All the genome sequences showed a 370-nucleotide deletion resulting in the complete loss of ORF7a.
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00251-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ebola virus disease in nonendemic countries

    Samson Sai-Yin Wong / Sally Cheuk-Ying Wong

    Journal of the Formosan Medical Association, Vol 114, Iss 5, Pp 384-

    2015  Volume 398

    Abstract: The 2014 West African outbreak of Ebola virus disease was unprecedented in its scale and has resulted in transmissions outside endemic countries. Clinicians in nonendemic countries will most likely face the disease in returning travelers, either among ... ...

    Abstract The 2014 West African outbreak of Ebola virus disease was unprecedented in its scale and has resulted in transmissions outside endemic countries. Clinicians in nonendemic countries will most likely face the disease in returning travelers, either among healthcare workers, expatriates, or visiting friends and relatives. Clinical suspicion for the disease must be heightened for travelers or contacts presenting with compatible clinical syndromes, and strict infection control measures must be promptly implemented to minimize the risk of secondary transmission within healthcare settings or in the community. We present a concise review on human filoviral disease with an emphasis on issues that are pertinent to clinicians practicing in nonendemic countries.
    Keywords Ebola ; filovirus ; hemorrhagic fever ; nosocomial ; travel medicine ; Medicine (General) ; R5-920
    Language English
    Publishing date 2015-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Ebola virus disease in nonendemic countries.

    Wong, Samson Sai-Yin / Wong, Sally Cheuk-Ying

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2015  Volume 114, Issue 5, Page(s) 384–398

    Abstract: The 2014 West African outbreak of Ebola virus disease was unprecedented in its scale and has resulted in transmissions outside endemic countries. Clinicians in nonendemic countries will most likely face the disease in returning travelers, either among ... ...

    Abstract The 2014 West African outbreak of Ebola virus disease was unprecedented in its scale and has resulted in transmissions outside endemic countries. Clinicians in nonendemic countries will most likely face the disease in returning travelers, either among healthcare workers, expatriates, or visiting friends and relatives. Clinical suspicion for the disease must be heightened for travelers or contacts presenting with compatible clinical syndromes, and strict infection control measures must be promptly implemented to minimize the risk of secondary transmission within healthcare settings or in the community. We present a concise review on human filoviral disease with an emphasis on issues that are pertinent to clinicians practicing in nonendemic countries.
    MeSH term(s) Clinical Trials as Topic ; Disease Outbreaks/history ; Filoviridae/pathogenicity ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/transmission ; History, 20th Century ; History, 21st Century ; Humans ; Travel ; Travel Medicine ; Vaccines, DNA/immunology
    Chemical Substances Vaccines, DNA
    Keywords covid19
    Language English
    Publishing date 2015-04-13
    Publishing country Singapore
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2015.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: High attack rate in a Tong Lau house outbreak of COVID-19 with subdivided units in Hong Kong.

    Wang, Qun / Lung, David Christopher / Chan, Pak-To / Jia, Wei / Dung, Chung-Hin / Miao, Te / Huang, Jianxiang / Chen, Wenzhao / Wang, Zixuan / Leung, Kai-Ming / Xu, Pengcheng / Lin, Zhang / Wong, Daniel / Tse, Herman / Ying Wong, Sally Cheuk / Choi, Garnet Kwan-Yue / To, Kelvin Kai-Wang / Cheng, Vincent Chi-Chung / Yuen, Kwok-Yung /
    Li, Yuguo

    Interface focus

    2022  Volume 12, Issue 2, Page(s) 20210063

    Abstract: Poor housing conditions are known to be associated with infectious diseases such as high Coronavirus disease 2019 (COVID-19) incidences. Transmission causes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in poor housing conditions can be ...

    Abstract Poor housing conditions are known to be associated with infectious diseases such as high Coronavirus disease 2019 (COVID-19) incidences. Transmission causes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in poor housing conditions can be complex. An understanding of the exact mechanism of transmission can help to pinpoint contributing environmental issues. Here, we investigated a Hong Kong COVID-19 outbreak in early 2021 in four traditional Tong Lau houses with subdivided units. There are more than 80 subdivided units of less than 20 m
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2021.0063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Posterior Oropharyngeal Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

    Wong, Sally Cheuk Ying / Tse, Herman / Siu, Hon Kei / Kwong, Tsz Shan / Chu, Man Yee / Yau, Felix Yat Sun / Cheung, Ingrid Yu Ying / Tse, Cindy Wing Sze / Poon, Kin Chiu / Cheung, Kwok Chi / Wu, Tak Chiu / Chan, Johnny Wai Man / Cheuk, Wah / Lung, David Christopher

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 11, Page(s) 2939–2946

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on the healthcare system worldwide. Diagnostic testing remained one of the limiting factors for early identification and isolation of infected patients. This study ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on the healthcare system worldwide. Diagnostic testing remained one of the limiting factors for early identification and isolation of infected patients. This study aimed to evaluate posterior oropharyngeal saliva (POPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection among patients with confirmed or suspected COVID-19.
    Methods: The laboratory information system was searched retrospectively for all respiratory specimens and POPS requested for SARS-CoV-2 RNA detection between 1 February 2020 and 15 April 2020. The agreement and diagnostic performance of POPS against NPsp were evaluated.
    Results: A total of 13772 specimens were identified during the study period, including 2130 POPS and 8438 nasopharyngeal specimens (NPsp). Two hundred and twenty-nine same-day POPS-NPsp paired were identified with POPS and NPsp positivity of 61.5% (95% confidence interval [CI] 55.1-67.6%) and 53.3% (95% CI 46.8-59.6%). The overall, negative and positive percent agreement were 76.0% (95% CI 70.2-80.9%), 65.4% (95% CI 55.5-74.2%), 85.2% (95% CI 77.4-90.8%). Better positive percent agreement was observed in POPS-NPsp obtained within 7 days (96.6%, 95% CI 87.3-99.4%) compared with after 7 days of symptom onset (75.0%, 95% CI 61.4-85.2%). Among the 104 positive pairs, the mean difference in Cp value was 0.26 (range: 12.63 to -14.74), with an overall higher Cp value in NPsp (Pearson coefficient 0.579). No significant temporal variation was noted between the 2 specimen types.
    Conclusions: POPS is an acceptable alternative specimen to nasopharyngeal specimen for the detection of SARS-CoV-2.
    MeSH term(s) COVID-19 ; Clinical Laboratory Techniques ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Saliva
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong.

    Tse, Herman / Lung, David Christopher / Wong, Sally Cheuk-Ying / Ip, Ka-Fai / Wu, Tak-Chiu / To, Kelvin Kai-Wang / Kok, Kin-Hang / Yuen, Kwok-Yung / Choi, Garnet Kwan-Yue

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 9, Page(s) 1696–1699

    Abstract: Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a ...

    Abstract Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5'-untranslated region (UTR) duplication and transposition.
    MeSH term(s) COVID-19 ; Genomics ; Hong Kong/epidemiology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Zika virus infection-the next wave after dengue?

    Wong, Samson Sai-Yin / Poon, Rosana Wing-Shan / Wong, Sally Cheuk-Ying

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2016  Volume 115, Issue 4, Page(s) 226–242

    Abstract: Zika virus was initially discovered in east Africa about 70 years ago and remained a neglected arboviral disease in Africa and Southeast Asia. The virus first came into the limelight in 2007 when it caused an outbreak in Micronesia. In the ensuing decade, ...

    Abstract Zika virus was initially discovered in east Africa about 70 years ago and remained a neglected arboviral disease in Africa and Southeast Asia. The virus first came into the limelight in 2007 when it caused an outbreak in Micronesia. In the ensuing decade, it spread widely in other Pacific islands, after which its incursion into Brazil in 2015 led to a widespread epidemic in Latin America. In most infected patients the disease is relatively benign. Serious complications include Guillain-Barré syndrome and congenital infection which may lead to microcephaly and maculopathy. Aedes mosquitoes are the main vectors, in particular, Ae. aegypti. Ae. albopictus is another potential vector. Since the competent mosquito vectors are highly prevalent in most tropical and subtropical countries, introduction of the virus to these areas could readily result in endemic transmission of the disease. The priorities of control include reinforcing education of travellers to and residents of endemic areas, preventing further local transmission by vectors, and an integrated vector management programme. The container habitats of Ae. aegypti and Ae. albopictus means engagement of the community and citizens is of utmost importance to the success of vector control.
    MeSH term(s) Aedes/virology ; Animals ; Disease Outbreaks/history ; Guillain-Barre Syndrome/etiology ; History, 20th Century ; History, 21st Century ; Humans ; Infant, Newborn ; Macular Degeneration/etiology ; Microcephaly/etiology ; Travel Medicine ; Zika Virus ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology ; Zika Virus Infection/transmission
    Language English
    Publishing date 2016-03-07
    Publishing country Singapore
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2016.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spread of SARS-CoV-2 aerosols via two connected drainage stacks in a high-rise housing outbreak of COVID-19.

    Wang, Qun / Lin, Zhang / Niu, Jianlei / Choi, Garnet Kwan-Yue / Fung, Jimmy C H / Lau, Alexis K H / Louie, Peter / Leung, Kenneth K M / Huang, Jianxiang / Cheng, Pan / Zhao, Pengcheng / Chen, Wenzhao / Zhang, Sheng / Fu, Liye / Chan, P W / Wong, Ann Han / Tse, Herman / Wong, Sally Cheuk Ying / Lai, Raymond Wai Man /
    Hui, David Sc / Yuen, Kwok-Yung / Lung, David Christopher / Li, Yuguo

    Journal of hazardous materials

    2022  Volume 430, Page(s) 128475

    Abstract: Vertical transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) along a vertical column of flats has been documented in several outbreaks of coronavirus disease 2019 (COVID-19) in Guangdong and Hong Kong. We describe an outbreak in ... ...

    Abstract Vertical transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) along a vertical column of flats has been documented in several outbreaks of coronavirus disease 2019 (COVID-19) in Guangdong and Hong Kong. We describe an outbreak in Luk Chuen House, involving two vertical columns of flats associated with an unusually connected two-stack drainage system, in which nine individuals from seven households were infected. The index case resided in Flat 812 (8th floor, Unit 12), two flats (813, 817) on its opposite side reported one case each (i.e., a horizontal sub-cluster). All other flats with infected residents were vertically associated, forming a vertical sub-cluster. We injected tracer gas (SF
    MeSH term(s) Aerosols ; COVID-19/epidemiology ; Disease Outbreaks ; Housing ; Humans ; Phylogeny ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-02-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong.

    Cao, Huiluo / Wong, Sally Cheuk-Ying / Yam, Wing-Cheong / Liu, Melissa Chun-Jiao / Chow, Kin-Hung / Wu, Alan Ka-Lun / Ho, Pak-Leung

    International journal of medical microbiology : IJMM

    2019  Volume 309, Issue 5, Page(s) 270–273

    Abstract: In 2017, we identified a Clostridium difficile strain HKCD4 that caused community-acquired fulminant colitis in a previously healthy child. Phylogenetically, it belonged to clade 2, sequence type 67 and was resistant to fluoroquinolone and tetracycline. ... ...

    Abstract In 2017, we identified a Clostridium difficile strain HKCD4 that caused community-acquired fulminant colitis in a previously healthy child. Phylogenetically, it belonged to clade 2, sequence type 67 and was resistant to fluoroquinolone and tetracycline. The strain was pathogenicity locus and binary toxin positive. It has a mutation in the trehalose repressor treR leading to the L172I substitution that was previously reported in the epidemic ribotype 027 lineage. HKCD4 has a tcdB sequence that shared very high identities with 3 highly virulent reference strains. It has a CpG depleted genome that is characteristic of hypervirulent C. difficile. The emergence of ST67 lineage with molecular feature of hypervirulence in the community is concerning and emphasizes the need for full characterization of strains causing severe disease in patients without classical risk factors.
    MeSH term(s) Bacterial Proteins/genetics ; Child ; Clostridium Infections/diagnosis ; Clostridium Infections/microbiology ; Clostridium difficile/genetics ; Clostridium difficile/pathogenicity ; Colitis/microbiology ; Colon/diagnostic imaging ; Colon/microbiology ; Cross Infection/microbiology ; Female ; Genome, Bacterial ; Genomics ; Hong Kong ; Humans ; Ribotyping ; Tomography, X-Ray Computed ; Virulence
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2019-05-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2019.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Zika virus infection—the next wave after dengue?

    Samson Sai-Yin Wong / Rosana Wing-Shan Poon / Sally Cheuk-Ying Wong

    Journal of the Formosan Medical Association, Vol 115, Iss 4, Pp 226-

    2016  Volume 242

    Abstract: Zika virus was initially discovered in east Africa about 70 years ago and remained a neglected arboviral disease in Africa and Southeast Asia. The virus first came into the limelight in 2007 when it caused an outbreak in Micronesia. In the ensuing decade, ...

    Abstract Zika virus was initially discovered in east Africa about 70 years ago and remained a neglected arboviral disease in Africa and Southeast Asia. The virus first came into the limelight in 2007 when it caused an outbreak in Micronesia. In the ensuing decade, it spread widely in other Pacific islands, after which its incursion into Brazil in 2015 led to a widespread epidemic in Latin America. In most infected patients the disease is relatively benign. Serious complications include Guillain–Barré syndrome and congenital infection which may lead to microcephaly and maculopathy. Aedes mosquitoes are the main vectors, in particular, Ae. aegypti. Ae. albopictus is another potential vector. Since the competent mosquito vectors are highly prevalent in most tropical and subtropical countries, introduction of the virus to these areas could readily result in endemic transmission of the disease. The priorities of control include reinforcing education of travellers to and residents of endemic areas, preventing further local transmission by vectors, and an integrated vector management programme. The container habitats of Ae. aegypti and Ae. albopictus means engagement of the community and citizens is of utmost importance to the success of vector control.
    Keywords Zika virus ; Flavivirus ; Aedes ; travel medicine ; congenital abnormalities ; Medicine (General) ; R5-920
    Subject code 390
    Language English
    Publishing date 2016-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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