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  1. Article: Psychostimulant Misuse Among American Indian, Alaskan Native, or Native Hawaiian College Students in the U.S. From 2015 to 2019.

    Qeadan, Fares / Ross, Sydney / Barbeau, William A / Madden, Erin F / Venner, Kamilla L / English, Kevin

    Substance abuse : research and treatment

    2023  Volume 17, Page(s) 11782218231209667

    Abstract: Introduction: This study examines factors associated with psychostimulant misuse, including polysubstance use and social factors, among the understudied American Indian/Alaska Native/Native Hawaiian (AI/AN/NH) college student population.: Methods: ... ...

    Abstract Introduction: This study examines factors associated with psychostimulant misuse, including polysubstance use and social factors, among the understudied American Indian/Alaska Native/Native Hawaiian (AI/AN/NH) college student population.
    Methods: Data were from the 2015 to 2019 American College Health Association-National College Health Assessment IIc (ACHA-NCHA IIc) survey. Multivariable logistic regression models and odds ratios were used to estimate associations between psychostimulant misuse and potential risk and protective factors among AI/AN/NH college students, including licit and illicit substance use, social support, relationship factors, exposure to violence or abuse, mental health symptoms, drug and alcohol education, and sample demographics.
    Results: Opioid misuse among AI/AN/NH college students significantly increased the odds of using psychostimulants. Specifically, for cocaine use, the adjusted odds ratio (aOR) was 3.17 with a 95% confidence interval (C.I.) of 2.17 to 4.63; for methamphetamine use, the aOR was 38.87 (95% C.I. 19.24-78.52). For amphetamine misuse among non-Tobacco users, the aOR was 5.47 (95% C.I. 3.49-8.55), while among Tobacco users, the aOR was 2.65 (95% C.I. 2.07-3.41). For cocaine and other stimulant misuse, the aOR was 3.64 (95% C.I. 2.30-5.67). Additionally, the use of other types of licit and illicit substances was associated with greater odds of psychostimulant use and misuse. Conversely, factors such as age, living on campus, and residing in parental/guardian housing were linked with lower odds of psychostimulant use and misuse.
    Conclusion: Substance use prevention and treatment interventions targeting AI/AN/NH college students should address polysubstance use, including the combined use of opioids and psychostimulants. Substance use interventions should not be siloed to focus narrowly on single substances but rather should leverage potential protective factors against substance use, such as promoting supportive campus and family living conditions and other social support networks, in broad efforts to reduce multiple forms of substance use among AI/AN/NH students.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 1178-2218 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 1178-2218 ; 0889-7077
    DOI 10.1177/11782218231209667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy.

    Juraska, Michal / Early, Angela M / Li, Li / Schaffner, Stephen F / Lievens, Marc / Khorgade, Akanksha / Simpkins, Brian / Hejazi, Nima S / Benkeser, David A / Wang, Qi / Mercer, Laina D / Adjei, Samuel / Agbenyega, Tsiri / Anderson, Scott / Ansong, Daniel / Bii, Dennis K / Buabeng, Patrick B Y / English, Sean / Fitzgerald, Nicholas /
    Grimsby, Jonna / Kariuki, Simon K / Otieno, Kephas / Roman, François / Samuels, Aaron M / Westercamp, Nelli / Ockenhouse, Christian F / Ofori-Anyinam, Opokua / Lee, Cynthia K / MacInnis, Bronwyn L / Wirth, Dyann F / Gilbert, Peter B / Neafsey, Daniel E

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: The only licensed malaria vaccine, RTS,S/AS01 : Methods: 1,500 children aged 5-17 ... months were randomized to receive four different RTS,S/AS01 : Results: We observed significant and ... comparable VE (25-43%, 95% CI union 9-53%) against first new infection for all four RTS,S/AS01 ...

    Abstract Background: The only licensed malaria vaccine, RTS,S/AS01
    Methods: 1,500 children aged 5-17 months were randomized to receive four different RTS,S/AS01
    Results: We observed significant and comparable VE (25-43%, 95% CI union 9-53%) against first new infection for all four RTS,S/AS01
    Conclusions: All tested dosing regimens blocked some infections to a similar degree. Improved VE in participants infected during vaccination could suggest new strategies for highly efficacious malaria vaccine development and implementation. ( ClinicalTrials.gov number, NCT03276962 ).
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.22.23298907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Systemic White supremacy: U.S. state policy, policing, discrimination, and suicidality across race and sexual identity.

    English, Devin / Oshin, Linda A / Lopez, Felix Gabriel / Smith, Justin C / Busby, Danielle R / Anestis, Michael D

    Journal of psychopathology and clinical science

    2024  

    Abstract: ... we examined associations between U.S. state-level racist and heterosexist criminal legal policies and policing ...

    Abstract Although suicide rates are stable or decreasing among White communities, rates are increasing among Black communities, a trend that appears to be disproportionately affecting Black lesbian, gay, bisexual, and queer (LGBQ) people. To understand the structural drivers and mechanisms of these trends, we examined associations between U.S. state-level racist and heterosexist criminal legal policies and policing, discrimination, and suicidality among White and Black, heterosexual and LGBQ, communities. We recruited 5,064 participants in 2021 using online census-driven quota sampling. Structural equation modeling estimated associations from objective indicators of racist and heterosexist criminal legal policies to self-reported police stops, discrimination, and suicidal ideation and behavior. For White heterosexual participants, racist (β = -.22,
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3121059-4
    ISSN 2769-755X
    ISSN (online) 2769-755X
    DOI 10.1037/abn0000891
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  4. Article ; Online: Mental health impact on healthcare workers due to the COVID-19 pandemic: a U.S. cross-sectional survey study.

    Biber, Joshua / Ranes, Bethany / Lawrence, Shanieek / Malpani, Vishal / Trinh, Trong Tony / Cyders, Andrew / English, Steven / Staub, Charles L / McCausland, Kristen L / Kosinski, Mark / Baranwal, Nishtha / Berg, Daniel / Pop, Rodica

    Journal of patient-reported outcomes

    2022  Volume 6, Issue 1, Page(s) 63

    Abstract: Background: The COVID-19 pandemic has impacted the mental health and well-being of health care workers (HCWs). This study examined mental health outcomes and COVID-related stress impacts among a diverse sample of ambulatory HCWs, including clinicians ... ...

    Abstract Background: The COVID-19 pandemic has impacted the mental health and well-being of health care workers (HCWs). This study examined mental health outcomes and COVID-related stress impacts among a diverse sample of ambulatory HCWs, including clinicians and support staff, as well as the associations between mental health outcomes and work impairments in this population. Detailing these results can help in designing interventions to alleviate this burden.
    Methods: "The Health Care Worker Stress Survey" was administered to ambulatory care providers and support staff at three multispecialty care delivery organizations as part of an online, cross-sectional study conducted between June 8, 2020, and July 13, 2020.
    Results: The greatest stress impact reported by HCWs was the uncertainty regarding when the COVID-19 outbreak would be under control, while the least reported concern was about self-dying from COVID-19. Differences in COVID-19 stress impacts were observed by age, gender, and occupational risk factors. Approximately 50% of participants reported more than a minimal level of anxiety, including 22.5% who indicated moderate to severe levels of anxiety. Higher levels of anxiety were observed with younger ages and female gender, while occupational roles with increased exposure risk did not report higher levels of anxiety. Roughly two-thirds of the sample reported less than good sleep quality and one-third to one-half of the sample reported other sleep related problems that differed by age and gender. Role limitations due to emotional health correlated with COVID-19 related stress, anxiety and sleep problems.
    Conclusions: Using established, validated measures, we quantified mental health outcomes within a diverse sample of ambulatory care HCWs during the pandemic. Younger and female HCWs reported greater anxiety burden; HCWs with higher occupational risk of COVID exposure did not report higher levels of anxiety. Notable proportions of HCWs reported sleep and work impairments. Due to the cross-sectional nature of the study, it is difficult to attribute these patterns to the pandemic. These results underscore the depth and extent of mental health outcomes in HCWs in ambulatory settings and raise important questions on new interventions to relieve that burden. Further research is needed to study specific interventions to support the mental health and wellbeing of HCWs.
    Language English
    Publishing date 2022-06-13
    Publishing country Germany
    Document type Journal Article
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-022-00467-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring the Association Between Opioid Use Disorder and Alzheimer's Disease and Dementia Among a National Sample of the U.S. Population.

    Qeadan, Fares / McCunn, Ashlie / Tingey, Benjamin / Price, Ron / Bobay, Kathleen L / English, Kevin / Madden, Erin F

    Journal of Alzheimer's disease : JAD

    2023  Volume 96, Issue 1, Page(s) 229–244

    Abstract: Background: Past research suggests associations between heavy alcohol use and later life dementia. However, little is known about whether opioid use disorder (OUD) and dementia share this association, especially among age groups younger than 65 years ... ...

    Abstract Background: Past research suggests associations between heavy alcohol use and later life dementia. However, little is known about whether opioid use disorder (OUD) and dementia share this association, especially among age groups younger than 65 years old.
    Objective: Examine the association between OUD and Alzheimer's disease (AD) and dementia.
    Methods: Electronic health records between 2000 and 2021 for patients age 12 or older were identified in the Cerner Real-World database™. Patients with a prior diagnosis of dementia were excluded. Patients were followed for 1-10 years (grouped by one, three, five, and ten-year follow-up periods) in a matched retrospective cohort study. Cox proportional hazards regressions were used to estimate adjusted hazard ratios (aHRs) of incident AD/dementia stratified by age and follow-up group.
    Results: A sample of 627,810 individuals with OUD were compared to 646,340 without OUD. Individuals with OUD exhibited 88% higher risk for developing AD/dementia compared to those without OUD (aHR = 1.88, 95% CI 1.74, 2.03) within 1 year follow-up and 211% (aHR = 3.11, 95% CI 2.63, 3.69) within 10 years follow-up. When stratifying by age, younger patients (age 12-44) had a greater disparity in odds of AD/dementia between OUD and non-OUD groups compared with patients older than 65 years.
    Conclusions: Additional research is needed to understand why an association exists between OUD and AD/dementia, especially among younger populations. The results suggest that cognitive functioning screening programs for younger people diagnosed with OUD may be useful for targeting early identification and intervention for AD/dementia in particularly high risk and marginalized populations.
    MeSH term(s) Humans ; Alzheimer Disease/epidemiology ; Alzheimer Disease/diagnosis ; Retrospective Studies ; Opioid-Related Disorders/epidemiology ; Risk Assessment ; Cognition
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between long-term exposure to particulate air pollution with SARS-CoV-2 infections and COVID-19 deaths in California, U.S.A.

    English, Paul B / Von Behren, Julie / Balmes, John R / Boscardin, John / Carpenter, Catherine / Goldberg, Debbie E / Horiuchi, Sophia / Richardson, Maxwell / Solomon, Gina / Valle, Jhaqueline / Reynolds, Peggy

    Environmental advances

    2022  Volume 9, Page(s) 100270

    Abstract: Previous studies have reported associations between air pollution and COVID-19 morbidity and mortality, but most have limited their exposure assessment to a large area, have not used individual-level variables, nor studied infections. We examined 3.1 ... ...

    Abstract Previous studies have reported associations between air pollution and COVID-19 morbidity and mortality, but most have limited their exposure assessment to a large area, have not used individual-level variables, nor studied infections. We examined 3.1 million SARS-CoV-2 infections and 49,691 COVID-19 deaths that occurred in California from February 2020 to February 2021 to evaluate risks associated with long-term neighborhood concentrations of particulate matter less than 2.5 μm in diameter (PM
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ISSN 2666-7657
    ISSN (online) 2666-7657
    DOI 10.1016/j.envadv.2022.100270
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  7. Article: Grover’s Disease Treated With Total Skin Electron Beam Radiotherapy

    Renz, Paul / Hasan, Shaakir / English, Joseph C. / Wegner, Rodney E. / Jedrych, Jaroslaw / Ho, Jonhan / Colonias, Athanasios

    Journal of drugs in dermatology : JDD

    2019  Volume 18, Issue 4, Page(s) 392–393

    MeSH term(s) Acantholysis/pathology ; Acantholysis/radiotherapy ; Electrons ; Female ; Humans ; Ichthyosis/pathology ; Ichthyosis/radiotherapy ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households - Four U.S. Jurisdictions, November 2021-February 2022.

    Baker, Julia M / Nakayama, Jasmine Y / O'Hegarty, Michelle / McGowan, Andrea / Teran, Richard A / Bart, Stephen M / Mosack, Katie / Roberts, Nicole / Campos, Brooke / Paegle, Alina / McGee, John / Herrera, Robert / English, Kayla / Barrios, Carla / Davis, Alexandria / Roloff, Christine / Sosa, Lynn E / Brockmeyer, Jessica / Page, Lindsey /
    Bauer, Amy / Weiner, Joshua J / Khubbar, Manjeet / Bhattacharyya, Sanjib / Kirking, Hannah L / Tate, Jacqueline E

    MMWR. Morbidity and mortality weekly report

    2022  Volume 71, Issue 9, Page(s) 341–346

    Abstract: ... S. infections with SARS-CoV-2, the virus that causes COVID-19, during December 2021-January 2022 (1 ... To investigate the effectiveness of prevention strategies in household settings, CDC partnered with four U.S ...

    Abstract The B.1.1.529 (Omicron) variant, first detected in November 2021, was responsible for a surge in U.S. infections with SARS-CoV-2, the virus that causes COVID-19, during December 2021-January 2022 (1). To investigate the effectiveness of prevention strategies in household settings, CDC partnered with four U.S. jurisdictions to describe Omicron household transmission during November 2021-February 2022. Persons with sequence-confirmed Omicron infection and their household contacts were interviewed. Omicron transmission occurred in 124 (67.8%) of 183 households. Among 431 household contacts, 227 were classified as having a case of COVID-19 (attack rate [AR] = 52.7%).
    MeSH term(s) Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/transmission ; Child ; Child, Preschool ; Contact Tracing ; Family Characteristics ; Female ; Humans ; Incidence ; Infant ; Male ; Middle Aged ; SARS-CoV-2 ; Serial Infection Interval ; United States/epidemiology ; Vaccination
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Technical Report
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7109e1
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  9. Article ; Online: The Clinical Profile of Severe Pediatric Malaria in an Area Targeted for Routine RTS,S/AS01 Malaria Vaccination in Western Kenya.

    Akech, Samuel / Chepkirui, Mercy / Ogero, Morris / Agweyu, Ambrose / Irimu, Grace / English, Mike / Snow, Robert W

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 71, Issue 2, Page(s) 372–380

    Abstract: ... admissions ahead of the introduction of the RTS,S/AS01 vaccine.: Methods: Malaria admissions in children ...

    Abstract Background: The malaria prevalence has declined in western Kenya, resulting in the risk of neurological phenotypes in older children. This study investigates the clinical profile of pediatric malaria admissions ahead of the introduction of the RTS,S/AS01 vaccine.
    Methods: Malaria admissions in children aged 1 month to 15 years were identified from routine, standardized, inpatient clinical surveillance data collected between 2015 and 2018 from 4 hospitals in western Kenya. Malaria phenotypes were defined based on available data.
    Results: There were 5766 malaria admissions documented. The median age was 36 months (interquartile range, 18-60): 15% were aged between 1-11 months of age, 33% were aged 1-23 months of age, and 70% were aged 1 month to 5 years. At admission, 2340 (40.6%) children had severe malaria: 421/2208 (19.1%) had impaired consciousness, 665/2240 (29.7%) had an inability to drink or breastfeed, 317/2340 (13.6%) had experienced 2 or more convulsions, 1057/2340 (45.2%) had severe anemia, and 441/2239 (19.7%) had severe respiratory distress. Overall, 211 (3.7%) children admitted with malaria died; 163/211 (77% deaths, case fatality rate 7.0%) and 48/211 (23% deaths, case fatality rate 1.4%) met the criteria for severe malaria and nonsevere malaria at admission, respectively. The median age for fatal cases was 33 months (interquartile range, 12-72) and the case fatality rate was highest in those unconscious (44.4%).
    Conclusions: Severe malaria in western Kenya is still predominantly seen among the younger pediatric age group and current interventions targeted for those <5 years are appropriate. However, there are increasing numbers of children older than 5 years admitted with malaria, and ongoing hospital surveillance would identify when interventions should target older children.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Hospitalization ; Humans ; Infant ; Kenya/epidemiology ; Malaria/epidemiology ; Malaria Vaccines ; Malaria, Falciparum/epidemiology ; Vaccination
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2019-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz844
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  10. Article ; Online: Ultrasound probe use and reprocessing: Results from a national survey among U.S. infection preventionists.

    Carrico, Ruth M / Furmanek, Stephen / English, Connor

    American journal of infection control

    2018  Volume 46, Issue 8, Page(s) 913–920

    Abstract: ... preventionists from U.S. health care facilities were surveyed (N = 358). The anonymous survey had 31 multiple ... were stored in the REDCap system.: Results: A high degree of noncompliance with U.S. guidelines was ...

    Abstract Background: Improper infection prevention practice associated with ultrasound probe use has been linked to increased infection risk, outbreaks, and death. Although guidelines for reprocessing and use of probes exist, it is unclear how extensively these have been adopted in practice.
    Methods: Infection preventionists from U.S. health care facilities were surveyed (N = 358). The anonymous survey had 31 multiple choice, sliding scale, and text response questions. The survey was developed and deployed and the data were stored in the REDCap system.
    Results: A high degree of noncompliance with U.S. guidelines was identified. Surface probes used in invasive procedures were not high-level disinfected or sterilized 15% (intraoperative) to 78% (peripheral line placements) of the time. Of invasive procedures, 5%-47% did not use sterile gel (same procedures, respectively). Of the participants, 20% were aware of instances where an ultrasound probe was used but was not correctly reprocessed. Extensive breaches of infection control guidelines were reported. The rapid expansion in use of ultrasound has brought clinical benefit but may be exposing patients to preventable infection risk.
    Conclusions: Infection preventionists are well placed to act as major drivers of change based on their expertise and experience in the management of infection risk across facilities and health systems. They, along with clinicians responsible for probe use and reprocessing, should review practices relating to ultrasound in their facilities. Where practice does not comply with guidelines, policy and training should be updated to ensure patient safety.
    MeSH term(s) Decontamination/methods ; Disinfection/methods ; Equipment Contamination ; Health Facilities ; Humans ; Infection Control Practitioners ; Surveys and Questionnaires ; Ultrasonography/methods ; United States
    Language English
    Publishing date 2018-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2018.03.025
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