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Article ; Online: Impact of cytidine diphosphocholine on oxygenation in client-owned dogs with aspiration pneumonia.

Young, Anda A / Rosas, Lucia E / Cooper, Edward S / Yaxley, Page E / Davis, Ian C

2022 Volume 36, Issue 3, Page(s) 1089–1099

Abstract: Background: New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza-infected mice with the liponucleotide cytidine diphosphocholine (CDP-choline) resulted ... ...

Abstract	Background: New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza-infected mice with the liponucleotide cytidine diphosphocholine (CDP-choline) resulted in decreased hypoxemia, pulmonary edema, lung dysfunction, and inflammation without altering viral replication. These findings suggested CDP-choline could have benefit as adjunctive treatment for ARDS in veterinary patients (VetARDS). Objectives: Determine if parenterally administered CDP-choline can attenuate mild VetARDS in dogs with aspiration pneumonia. Animals: Dogs admitted to a veterinary intensive care unit (ICU) for aspiration pneumonia. Methods: Subjects were enrolled in a randomized, double-blinded, placebo-controlled trial of treatment with vehicle (0.1 mL/kg sterile 0.9% saline, IV; n = 8) or CDP-choline (5 mg/kg in 0.1 mL/kg 0.9% saline, IV; n = 9) q12h over the first 48 hours after ICU admission. Results: No significant differences in signalment or clinical findings were found between placebo- and CDP-choline-treated dogs on admission. All dogs exhibited tachycardia, tachypnea, hypertension, hypoxemia, hypocapnia, lymphopenia, and neutrophilia. CDP-choline administration resulted in rapid, progressive, and clinically relevant increases in oxygenation as determined by pulse oximetry and ratios of arterial oxygen partial pressure (P Conclusions and clinical importance: Ctyidine diphosphcholine acts rapidly to promote gas exchange in dogs with naturally occurring aspiration pneumonia and is a potential adjunctive treatment in VetARDS patients.
MeSH term(s)	Animals ; Dogs ; Cytidine ; Cytidine Diphosphate Choline/therapeutic use ; Dog Diseases/drug therapy ; Hypoxia/drug therapy ; Hypoxia/veterinary ; Lung ; Oxygen/therapeutic use ; Pneumonia, Aspiration/veterinary ; Respiratory Distress Syndrome/veterinary ; Saline Solution
Chemical Substances	Cytidine (5CSZ8459RP) ; Cytidine Diphosphate Choline (536BQ2JVC7) ; Oxygen (S88TT14065) ; Saline Solution
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of cytidine diphosphocholine on oxygenation in client‐owned dogs with aspiration pneumonia

Anda A. Young / Lucia E. Rosas / Edward S. Cooper / Page E. Yaxley / Ian C. Davis

Journal of Veterinary Internal Medicine, Vol 36, Iss 3, Pp 1089-

2022 Volume 1099

Abstract: Abstract Background New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza‐infected mice with the liponucleotide cytidine diphosphocholine (CDP‐choline) ... ...

Abstract	Abstract Background New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza‐infected mice with the liponucleotide cytidine diphosphocholine (CDP‐choline) resulted in decreased hypoxemia, pulmonary edema, lung dysfunction, and inflammation without altering viral replication. These findings suggested CDP‐choline could have benefit as adjunctive treatment for ARDS in veterinary patients (VetARDS). Objectives Determine if parenterally administered CDP‐choline can attenuate mild VetARDS in dogs with aspiration pneumonia. Animals Dogs admitted to a veterinary intensive care unit (ICU) for aspiration pneumonia. Methods Subjects were enrolled in a randomized, double‐blinded, placebo‐controlled trial of treatment with vehicle (0.1 mL/kg sterile 0.9% saline, IV; n = 8) or CDP‐choline (5 mg/kg in 0.1 mL/kg 0.9% saline, IV; n = 9) q12h over the first 48 hours after ICU admission. Results No significant differences in signalment or clinical findings were found between placebo‐ and CDP‐choline‐treated dogs on admission. All dogs exhibited tachycardia, tachypnea, hypertension, hypoxemia, hypocapnia, lymphopenia, and neutrophilia. CDP‐choline administration resulted in rapid, progressive, and clinically relevant increases in oxygenation as determined by pulse oximetry and ratios of arterial oxygen partial pressure (PaO2 mmHg) to fractional inspired oxygen (% FiO2) and decreases in alveolar‐arterial (A‐a) gradients that did not occur in placebo (saline)‐treated animals. Treatment with CDP‐choline was also associated with less platelet consumption over the first 48 hours, but had no detectable detrimental effects. Conclusions and Clinical Importance Ctyidine diphosphcholine acts rapidly to promote gas exchange in dogs with naturally occurring aspiration pneumonia and is a potential adjunctive treatment in VetARDS patients.
Keywords	alveolar type II cell ; ARDS ; influenza ; P:F ratio ; phospholipid ; surfactant ; Veterinary medicine ; SF600-1100
Subject code	610 ; 630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of cytidine diphosphocholine on oxygenation in client‐owned dogs with aspiration pneumonia

Young, Anda A. / Rosas, Lucia E. / Cooper, Edward S. / Yaxley, Page E. / Davis, Ian C.

Journal of veterinary internal medicine. 2022 May, v. 36, no. 3

2022

Abstract: BACKGROUND: New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza‐infected mice with the liponucleotide cytidine diphosphocholine (CDP‐choline) resulted ... ...

Abstract	BACKGROUND: New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza‐infected mice with the liponucleotide cytidine diphosphocholine (CDP‐choline) resulted in decreased hypoxemia, pulmonary edema, lung dysfunction, and inflammation without altering viral replication. These findings suggested CDP‐choline could have benefit as adjunctive treatment for ARDS in veterinary patients (VetARDS). OBJECTIVES: Determine if parenterally administered CDP‐choline can attenuate mild VetARDS in dogs with aspiration pneumonia. ANIMALS: Dogs admitted to a veterinary intensive care unit (ICU) for aspiration pneumonia. METHODS: Subjects were enrolled in a randomized, double‐blinded, placebo‐controlled trial of treatment with vehicle (0.1 mL/kg sterile 0.9% saline, IV; n = 8) or CDP‐choline (5 mg/kg in 0.1 mL/kg 0.9% saline, IV; n = 9) q12h over the first 48 hours after ICU admission. RESULTS: No significant differences in signalment or clinical findings were found between placebo‐ and CDP‐choline‐treated dogs on admission. All dogs exhibited tachycardia, tachypnea, hypertension, hypoxemia, hypocapnia, lymphopenia, and neutrophilia. CDP‐choline administration resulted in rapid, progressive, and clinically relevant increases in oxygenation as determined by pulse oximetry and ratios of arterial oxygen partial pressure (PₐO₂ mmHg) to fractional inspired oxygen (% FᵢO₂) and decreases in alveolar‐arterial (A‐a) gradients that did not occur in placebo (saline)‐treated animals. Treatment with CDP‐choline was also associated with less platelet consumption over the first 48 hours, but had no detectable detrimental effects. CONCLUSIONS AND CLINICAL IMPORTANCE: Ctyidine diphosphcholine acts rapidly to promote gas exchange in dogs with naturally occurring aspiration pneumonia and is a potential adjunctive treatment in VetARDS patients.
Keywords	acute respiratory distress syndrome ; cytidine ; edema ; gas exchange ; hypertension ; hypoxia ; inflammation ; lungs ; oxygen ; oxygen partial pressure ; placebos ; pneumonia ; tachycardia ; tachypnea ; veterinary medicine ; virus replication
Language	English
Dates of publication	2022-05
Size	p. 1089-1099.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16434
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pulmonary function analysis in cotton rats after respiratory syncytial virus infection.

Martinez, Margaret E / Harder, Olivia E / Rosas, Lucia E / Joseph, Lisa / Davis, Ian C / Niewiesk, Stefan

PloS one

2020 Volume 15, Issue 8, Page(s) e0237404

Abstract: The cotton rat (Sigmodon hispidus) is an excellent small animal model for human respiratory viral infections such as human respiratory syncytial virus (RSV) and human metapneumovirus (HMPV). These respiratory viral infections, as well as other pulmonary ... ...

Abstract	The cotton rat (Sigmodon hispidus) is an excellent small animal model for human respiratory viral infections such as human respiratory syncytial virus (RSV) and human metapneumovirus (HMPV). These respiratory viral infections, as well as other pulmonary inflammatory diseases such as asthma, are associated with lung mechanic disturbances. So far, the pathophysiological effects of viral infection and allergy on cotton rat lungs have not been measured, although this information might be an important tool to determine the efficacy of vaccine and drug candidates. To characterize pulmonary function in the cotton rat, we established forced oscillation technique in uninfected, RSV infected and HDM sensitized cotton rats, and characterized pulmonary inflammation, mucus production, pulmonary edema, and oxygenation. There was a gender difference after RSV infection, with females demonstrating airway hyper-responsiveness while males did not. Female cotton rats 2dpi had a mild increase in pulmonary edema (wet: dry weight ratios). At day 4 post infection, female cotton rats demonstrated mild pulmonary inflammation, no increase in mucus production or reduction in oxygenation. Pulmonary function was not significantly impaired after RSV infection. In contrast, cotton rats sensitized to HDM demonstrated airway hyper-responsiveness with a significant increase in pulmonary inflammation, increase in baseline tissue damping, and a decrease in baseline pulmonary compliance. In summary, we established baseline data for forced oscillation technique and other respiratory measures in the cotton rat and used it to analyze respiratory diseases in cotton rats.
MeSH term(s)	Animals ; Antigens/immunology ; Female ; Lung Compliance ; Male ; Pyroglyphidae/immunology ; Respiratory Function Tests ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/physiopathology ; Sex Characteristics ; Sigmodontinae
Chemical Substances	Antigens
Language	English
Publishing date	2020-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0237404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cytidine 5'-Diphosphocholine Corrects Alveolar Type II Cell Mitochondrial Dysfunction in Influenza-infected Mice.

Doolittle, Lauren M / Binzel, Katherine / Nolan, Katherine E / Craig, Kelsey / Rosas, Lucia E / Bernier, Matthew C / Joseph, Lisa M / Woods, Parker S / Knopp, Michael V / Davis, Ian C

American journal of respiratory cell and molecular biology

2022 Volume 66, Issue 6, Page(s) 682–693

Abstract: Development of acute respiratory distress syndrome (ARDS) in influenza A virus (IAV)-infected mice is associated with inhibition of ATII (alveolar type II) epithelial ... ...

Abstract	Development of acute respiratory distress syndrome (ARDS) in influenza A virus (IAV)-infected mice is associated with inhibition of ATII (alveolar type II) epithelial cell
MeSH term(s)	Animals ; Cardiolipins ; Cytidine Diphosphate Choline ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/physiology ; Influenza A virus/physiology ; Influenza, Human ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Phosphatidylcholines ; Respiratory Distress Syndrome
Chemical Substances	Cardiolipins ; Phosphatidylcholines ; Cytidine Diphosphate Choline (536BQ2JVC7)
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2021-0512OC
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Zs.A 2851: Show issues

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Article ; Online: Pulmonary function analysis in cotton rats after respiratory syncytial virus infection.

Margaret E Martinez / Olivia E Harder / Lucia E Rosas / Lisa Joseph / Ian C Davis / Stefan Niewiesk

PLoS ONE, Vol 15, Iss 8, p e

2020 Volume 0237404

Abstract	The cotton rat (Sigmodon hispidus) is an excellent small animal model for human respiratory viral infections such as human respiratory syncytial virus (RSV) and human metapneumovirus (HMPV). These respiratory viral infections, as well as other pulmonary inflammatory diseases such as asthma, are associated with lung mechanic disturbances. So far, the pathophysiological effects of viral infection and allergy on cotton rat lungs have not been measured, although this information might be an important tool to determine the efficacy of vaccine and drug candidates. To characterize pulmonary function in the cotton rat, we established forced oscillation technique in uninfected, RSV infected and HDM sensitized cotton rats, and characterized pulmonary inflammation, mucus production, pulmonary edema, and oxygenation. There was a gender difference after RSV infection, with females demonstrating airway hyper-responsiveness while males did not. Female cotton rats 2dpi had a mild increase in pulmonary edema (wet: dry weight ratios). At day 4 post infection, female cotton rats demonstrated mild pulmonary inflammation, no increase in mucus production or reduction in oxygenation. Pulmonary function was not significantly impaired after RSV infection. In contrast, cotton rats sensitized to HDM demonstrated airway hyper-responsiveness with a significant increase in pulmonary inflammation, increase in baseline tissue damping, and a decrease in baseline pulmonary compliance. In summary, we established baseline data for forced oscillation technique and other respiratory measures in the cotton rat and used it to analyze respiratory diseases in cotton rats.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Crisis o convulsiones febriles: certezas y preguntas.

Cerisola, Alfredo / Chaibún, Eugenia / Rosas, Melania / Cibils, Lucía

Medicina

2018 Volume 78 Suppl 2, Page(s) 18–24

Abstract: A febrile seizure occurs in association with fever in a child aged 6 to 60 months, without central nervous system infection or other known cause of acute seizures in a child without a prior history of afebrile seizures. Febrile seizures occur in about 2- ... ...

Title translation	Febrile seizures: questions and answers.
Abstract	A febrile seizure occurs in association with fever in a child aged 6 to 60 months, without central nervous system infection or other known cause of acute seizures in a child without a prior history of afebrile seizures. Febrile seizures occur in about 2-5% of children. Central nervous system infections should be considered in patients with febrile seizures, even though the frequency of this possibility is low, especially when patients do not return to baseline. Simple febrile seizures are considered benign events and there are clear guidelines about evaluation and management, but the evaluation of complex febrile seizures is controversial. They are associated with a small increased risk of epilepsy which cannot be prevented. The role of electroencephalography is controversial. We analyzed the data of many studies and concluded that epileptiform discharges have poor positive predictive value. Neuroimaging is recommended to look for acute or pre-existing hippocampal abnormalities following febrile status or focal febrile seizures that could be associated to the risk of developing mesial temporal sclerosis and temporal lobe epilepsy. The relationship between these disorders and febrile seizures remains a controversial issue. An abnormal electroencephalography or magnetic resonance imaging studies will not change the clinical management and could contribute to overdiagnosis.
MeSH term(s)	Child, Preschool ; Diagnosis, Differential ; Electroencephalography ; Epilepsy, Temporal Lobe/diagnosis ; Epilepsy, Temporal Lobe/etiology ; Humans ; Infant ; Magnetic Resonance Imaging ; Prognosis ; Risk Factors ; Seizures, Febrile/diagnosis ; Seizures, Febrile/drug therapy
Language	Spanish
Publishing date	2018-09-08
Publishing country	Argentina
Document type	Journal Article ; Review
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic shifts modulate lung injury caused by infection with H1N1 influenza A virus.

Nolan, Katherine E / Baer, Lisa A / Karekar, Priyanka / Nelson, Andrew M / Stanford, Kristin I / Doolittle, Lauren M / Rosas, Lucia E / Hickman-Davis, Judy M / Singh, Harpreet / Davis, Ian C

Virology

2021 Volume 559, Page(s) 111–119

Abstract: Influenza A virus (IAV) infection alters lung epithelial cell metabolism in vitro by promoting a glycolytic shift. We hypothesized that this shift benefits the virus rather than the host and that inhibition of glycolysis would improve infection outcomes. ...

Abstract	Influenza A virus (IAV) infection alters lung epithelial cell metabolism in vitro by promoting a glycolytic shift. We hypothesized that this shift benefits the virus rather than the host and that inhibition of glycolysis would improve infection outcomes. A/WSN/33 IAV-inoculated C57BL/6 mice were treated daily from 1 day post-inoculation (d.p.i.) with 2-deoxy-d-glucose (2-DG) to inhibit glycolysis and with the pyruvate dehydrogenase kinase (PDK) inhibitor dichloroacetate (DCA) to promote flux through the TCA cycle. To block OXPHOS, mice were treated every other day from 1 d.p.i. with the Complex I inhibitor rotenone (ROT). 2-DG significantly decreased nocturnal activity, reduced respiratory exchange ratios, worsened hypoxemia, exacerbated lung dysfunction, and increased humoral inflammation at 6 d.p.i. DCA and ROT treatment normalized oxygenation and airway resistance and attenuated IAV-induced pulmonary edema, histopathology, and nitrotyrosine formation. None of the treatments altered viral replication. These data suggest that a shift to glycolysis is host-protective in influenza.
MeSH term(s)	Animals ; Epithelial Cells/metabolism ; Female ; Glycolysis ; Influenza A Virus, H1N1 Subtype/pathogenicity ; Lung/chemistry ; Lung/metabolism ; Lung/virology ; Lung Injury/prevention & control ; Lung Injury/virology ; Male ; Mice ; Mice, Inbred C57BL ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/antagonists & inhibitors ; Tyrosine/analogs & derivatives ; Tyrosine/analysis ; Tyrosine/metabolism ; Virus Replication
Chemical Substances	Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U)
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2021.03.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Trombosis venosa y de senos cerebrales en recién nacidos y niños.

Mora, Ricardo / Ibarra, Luis / Olivera, Valentina / Rosas, Melania / Cibils, Lucía / Baltar, Federico / Ruiz, Victoria / Turcatti, Emilio / Costa, Gonzalo / Mansilla, Santiago / Cerisola, Alfredo / González, Gabriel

Medicina

2023 Volume 83 Suppl 4, Page(s) 95–101

Abstract: Introduction: Cerebral venous sinus thrombosis (CVST) is a well-known, although underestimated, cause of stroke in childhood. Its diagnosis requires a high index of suspicion, a correct interpretation of neuroimaging studies and an interrelation between ...

Title translation	Venous and cerebral sinus thrombosis in newborns and children.
Abstract	Introduction: Cerebral venous sinus thrombosis (CVST) is a well-known, although underestimated, cause of stroke in childhood. Its diagnosis requires a high index of suspicion, a correct interpretation of neuroimaging studies and an interrelation between clinicians and radiologists. The clinical features, risk factors and neuroimaging of children under 15 years of age with CVST were analyzed. Methods: multicenter, retrospective, descriptive, study of a consecutive series of cases of children under 15 years of age, who were admitted due to CVST between January 1st, 2010, and March 1st, 2022. Results: The study included 51 patients: 39% with acute symptoms and 59% with subacute symptoms. Newborns predominantly presented encephalopathic symptoms and seizures, while children exhibited signs of intracranial hypertension (ICH). Risk factors were identified in 90% of the cases. Magnetic resonance with angiography in venous time confirmed the diagnosis in 80% of the patients, with the straight sinus being the most affected in newborns and the lateral sinus in children. Hemorrhagic complications were found in 30.5%, being more frequent in newborns. Anticoagulation was initiated in 82% without complications. Sequelae were present in 44.4% of newborns and 37.9% of children, being more frequent and severe in newborns. Conclusions: To make an early diagnosis, it is essential to consider CVST in newborns with encephalopathic symptoms and/or seizures, and in children with signs of ICH in the presence of predisposing or triggering conditions.
MeSH term(s)	Infant, Newborn ; Humans ; Child ; Retrospective Studies ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/etiology ; Brain Diseases ; Seizures/etiology ; Angiography
Language	Spanish
Publishing date	2023-09-13
Publishing country	Argentina
Document type	Multicenter Study ; English Abstract ; Journal Article
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Epistasis and Quantitative Resistance to Pyricularia oryzae Revealed by GWAS in Advanced Rice Breeding Populations

Rosas, Juan E. / Escobar, Maia / Martínez, Sebastián / Blanco, Pedro / Pérez, Fernando / Quero, Gastón / Gutiérrez, Lucía / Bonnecarrère, Victoria

Agriculture (Basel). 2020 Dec. 11, v. 10, no. 12

2020

Abstract: Rice blast caused by Pyricularia oryzae is a major rice disease worldwide. Despite the detailed knowledge on major resistance genes available to date, little is known about how these genes interact with quantitative blast resistance loci and with the ... ...

Abstract	Rice blast caused by Pyricularia oryzae is a major rice disease worldwide. Despite the detailed knowledge on major resistance genes available to date, little is known about how these genes interact with quantitative blast resistance loci and with the genetic background. Knowledge on these interactions is crucial for assessing the usefulness of introgressed resistance loci in breeding germplasm. Our goal was to identify quantitative trait loci (QTL) for blast resistance in rice breeding populations and to describe how they interact among each other and with the genetic background. To that end, resistance to blast was mapped by genome-wide association study (GWAS) in two advanced rice breeding subpopulations, one made of 305 indica type inbred lines, and the other of 245 tropical japonica inbred lines. The interactions and main effects of blast resistance loci were assessed in a multilocus model. Well known, major effect blast resistance gene clusters were detected in both tropical japonica (Pii/Pi3/Pi5) and indica (Piz/Pi2/Pi9) subpopulations with the GWAS scan 1. When these major effect loci were included as fixed cofactors in subsequent GWAS scans 2 and 3, additional QTL and more complex genetic architectures were revealed. The multilocus model for the tropical japonica subpopulation showed that Pii/Pi3/Pi5 had significant interaction with two QTL in chromosome 1 and one QTL in chromosome 8, together explaining 64% of the phenotypic variance. In the indica subpopulation a significant interaction among the QTL in chromosomes 6 and 4 and the genetic background, together with Piz/Pi2/Pi9 and QTL in chromosomes 1, 4 and 7, explained 35% of the phenotypic variance. Our results suggest that epistatic interactions can play a major role modulating the response mediated by major effect blast resistance loci such as Pii/Pi3/Pi5. Furthermore, the additive and epistatic effects of multiple QTL bring additional layers of quantitative resistance with a magnitude comparable to that of major effect loci. These findings highlight the need of genetic background-specific validation of markers for molecular assisted blast resistance breeding and provide insights for developing quantitative resistance to blast disease in rice.
Keywords	Magnaporthe oryzae ; agriculture ; blast disease ; epistasis ; genetic background ; genome-wide association study ; germplasm ; introgression ; models ; phenotypic variation ; quantitative traits ; resistance genes ; rice
Language	English
Dates of publication	2020-1211
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture10120622
Database	NAL-Catalogue (AGRICOLA)

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