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  1. Article ; Online: Endothelium and endothelin: regulators of arterial stiffness and fibrinolysis in ANCA-associated vasculitis.

    Barton, Matthias

    Kidney international

    2022  Volume 102, Issue 5, Page(s) 963–966

    Abstract: In this issue, Farrah et al. report clinical investigations in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). They demonstrate that endothelium-dependent vasodilatation, fibrinolytic capacity, and monocyte-dependent ... ...

    Abstract In this issue, Farrah et al. report clinical investigations in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). They demonstrate that endothelium-dependent vasodilatation, fibrinolytic capacity, and monocyte-dependent endothelin-1 clearance are reduced in patients with AAV, whereas circulating levels of endothelin-1 and vascular stiffness are increased. Acute infusion of an endothelin ET
    MeSH term(s) Humans ; Vascular Stiffness ; Antibodies, Antineutrophil Cytoplasmic ; Endothelin-1 ; Fibrinolysis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Endothelins ; Endothelium
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Endothelin-1 ; Endothelins
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.08.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  2. Article ; Online: The G protein-coupled oestrogen receptor GPER in health and disease: an update.

    Prossnitz, Eric R / Barton, Matthias

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 7, Page(s) 407–424

    Abstract: Oestrogens and their receptors contribute broadly to physiology and diseases. In premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic and neurological diseases and are involved in hormone-sensitive cancers such as breast ... ...

    Abstract Oestrogens and their receptors contribute broadly to physiology and diseases. In premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic and neurological diseases and are involved in hormone-sensitive cancers such as breast cancer. Oestrogens and oestrogen mimetics mediate their effects via the cytosolic and nuclear receptors oestrogen receptor-α (ERα) and oestrogen receptor-β (ERβ) and membrane subpopulations as well as the 7-transmembrane G protein-coupled oestrogen receptor (GPER). GPER, which dates back more than 450 million years in evolution, mediates both rapid signalling and transcriptional regulation. Oestrogen mimetics (such as phytooestrogens and xenooestrogens including endocrine disruptors) and licensed drugs such as selective oestrogen receptor modulators (SERMs) and downregulators (SERDs) also modulate oestrogen receptor activity in both health and disease. Following up on our previous Review of 2011, we herein summarize the progress made in the field of GPER research over the past decade. We will review molecular, cellular and pharmacological aspects of GPER signalling and function, its contribution to physiology, health and disease, and the potential of GPER to serve as a therapeutic target and prognostic indicator of numerous diseases. We also discuss the first clinical trial evaluating a GPER-selective drug and the opportunity of repurposing licensed drugs for the targeting of GPER in clinical medicine.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/drug therapy ; Estrogens/metabolism ; Estrogens/therapeutic use ; GTP-Binding Proteins/metabolism ; GTP-Binding Proteins/therapeutic use ; Receptors, Estrogen/metabolism ; Receptors, Estrogen/therapeutic use ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Estrogens ; GTP-Binding Proteins (EC 3.6.1.-) ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; ESR1 protein, human ; ESR2 protein, human
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00822-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Endothelin in renal physiology and disease

    Barton, Matthias / Kohan, Donald E.

    3 tables

    (Contributions to nephrology ; 172)

    2011  

    Author's details vol. ed. Matthias Barton ; Donald E. Kohan
    Series title Contributions to nephrology ; 172
    Collection
    Keywords Endothelins / physiology ; Kidney Diseases / drug therapy ; Receptor, Endothelin A / metabolism ; Kidney / physiopathology ; Niere ; Nierenkrankheit ; Endothelin ; Rezeptor ; Pharmakologischer Antagonist
    Subject Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie ; Nephros ; Ren
    Subject code 612.463 ; 616.6106
    Language English
    Size VIII, 266 S. : Ill., graph. Darst., 25 cm
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland ; Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016978493
    ISBN 978-3-8055-9794-4 ; 3-8055-9794-0 ; 9783805597951 ; 3805597959
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 3868 order for loan Magazin

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  4. Article ; Online: Primum Non Nocere: Why Calcitriol («Vitamin» D) Hormone Therapy Is Not a Magic Bullet

    Barton, Matthias

    Arteriosclerosis, thrombosis, and vascular biology

    2019  Volume 39, Issue 2, Page(s) 117–120

    MeSH term(s) Animals ; Calcitriol ; Cholecalciferol ; Disease Models, Animal ; Insulin Resistance ; Mice ; Obesity ; Vascular Calcification ; Vascular Remodeling ; Vitamin D
    Chemical Substances Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2019-02-12
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.312105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sex and sex steroids as determinants of cardiovascular risk.

    Cignarella, Andrea / Bolego, Chiara / Barton, Matthias

    Steroids

    2024  , Page(s) 109423

    Abstract: There are considerable sex differences regarding the risk of cardiovascular disease (CVD), including arterial hypertension, coronary artery disease (CAD) and stroke, as well as chronic renal disease. Women are largely protected from these conditions ... ...

    Abstract There are considerable sex differences regarding the risk of cardiovascular disease (CVD), including arterial hypertension, coronary artery disease (CAD) and stroke, as well as chronic renal disease. Women are largely protected from these conditions prior to menopause, and the risk increases following cessation of endogenous estrogen production or after surgical menopause. Cardiovascular diseases in women generally begin to occur at a later age than in men (on average with a delay of 10 years). Cessation of estrogen production also impacts metabolism, increasing the risk of developing obesity and diabetes. In middle-aged patients, hypertension develops earlier and faster in women than in men, and smoking increases cardiovascular risk to a greater degree in women than it does in men. It is not only estrogen that affects female cardiovascular health and plays a protective role until menopause: other sex hormones such as progesterone and androgen hormones generate a complex balance that differentiates heart and blood vessel function in women compared to men. Estrogens improve vasodilation epicardial coronary arteries and the coronary microvasculature by fostering the release of vasodilating factors such as nitric oxide and prostacyclin, which appears to be one of the main mechanism of coronary vasodilatation in women compared to men. Estrogens are also powerful inhibitors of inflammation, which in part explains their protective effects on CVD and chronic renal disease. Emerging evidence suggests that sex chromosomes also play a significant role in shaping cardiovascular risk. The cardiovascular protection conferred by endogenous estrogens can be prolonged by administration of safe exogenous estrogens and progestins, especially using bioidentical hormones and starting treatment in women early after menopause.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2024.109423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 87: Show issues Location:
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  6. Article ; Online: Heart Failure With Preserved Ejection Fraction in Women: New Clues to Causes and Treatment.

    Barton, Matthias / Meyer, Matthias R

    JACC. Basic to translational science

    2020  Volume 5, Issue 3, Page(s) 296–299

    Language English
    Publishing date 2020-03-23
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2020.02.001
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  7. Article ; Online: Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling.

    Cignarella, Andrea / Boscaro, Carlotta / Albiero, Mattia / Bolego, Chiara / Barton, Matthias

    The Journal of pharmacology and experimental therapeutics

    2023  Volume 386, Issue 3, Page(s) 288–297

    Abstract: Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional ... ...

    Abstract Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional mechanisms, estrogenic agents modulate the turnover of several proteins via post-transcriptional and post-translational pathways including epigenetics. For instance, the metabolic and angiogenic action of G-protein coupled estrogen receptor (GPER) in vascular endothelial cells has been recently elucidated. By interacting with GPER, 17
    MeSH term(s) Female ; Humans ; Endothelial Cells/metabolism ; Epigenesis, Genetic ; Estrogens ; Estradiol/metabolism ; Receptors, G-Protein-Coupled/metabolism ; MicroRNAs/genetics ; Neoplasms
    Chemical Substances Estrogens ; Estradiol (4TI98Z838E) ; Receptors, G-Protein-Coupled ; MicroRNAs
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER.

    Barton, Matthias

    Steroids

    2016  Volume 111, Page(s) 37–45

    Abstract: It has been 20years that the G protein-coupled estrogen receptor (GPER) was cloned as the orphan receptor GPR30 from multiple cellular sources, including vascular endothelial cells. Here, I will provide an overview of estrogen biology and the historical ... ...

    Abstract It has been 20years that the G protein-coupled estrogen receptor (GPER) was cloned as the orphan receptor GPR30 from multiple cellular sources, including vascular endothelial cells. Here, I will provide an overview of estrogen biology and the historical background leading to the discovery of rapid vascular estrogen signaling. I will also review the recent advances in the understanding of the mechanisms underlying GPER function, its role in physiology and disease, some of the currently available GPER-targeting drugs approved for clinical use such as SERMs (selective estrogen receptor modulators) and SERDs (selective estrogen receptor downregulators). Many of currently used drugs such as tamoxifen, raloxifene, or faslodex™/fulvestrant were discovered targeting GPER many years after they had been introduced to the clinics for entirely different purposes. This has important implications for the clinical use of these drugs and their modes of action, which I have termed 'reverse translational medicine'. In addition, environmental pollutants known as 'endocrine disruptors' have been found to bind to GPER. This article also discusses recent evidence in these areas as well as opportunities in translational clinical medicine and GPER research, including medical genetics, personalized medicine, prevention, and its theranostic use.
    MeSH term(s) Animals ; Estrogen Antagonists/pharmacology ; Humans ; Models, Biological ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/metabolism ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/metabolism ; Selective Estrogen Receptor Modulators/pharmacology ; Signal Transduction/drug effects
    Chemical Substances Estrogen Antagonists ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Selective Estrogen Receptor Modulators
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2016.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Early life stress determines insulin signalling in adulthood.

    Barton, Matthias / Prossnitz, Eric R

    The Journal of physiology

    2020  Volume 598, Issue 3, Page(s) 427–428

    MeSH term(s) Animals ; Female ; Insulin ; Islets of Langerhans ; Male ; Rats ; Rats, Wistar ; Stress, Psychological ; Weaning
    Chemical Substances Insulin
    Language English
    Publishing date 2020-01-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP279300
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  10. Article ; Online: Exercise is medicine: key to cardiovascular disease and diabetes prevention.

    Barton, Matthias / Cardillo, Carmine

    Cardiovascular research

    2020  Volume 117, Issue 2, Page(s) 360–363

    MeSH term(s) Adult ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/diagnosis ; Exercise ; Humans ; Male
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa226
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