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  1. Article ; Online: Interstitial hemophagocytosis in hemophagocytic lymphohistiocytosis.

    Sekulic, Miroslav / Santoriello, Dominick / Masud, Avais / Kudose, Satoru

    Kidney international

    2023  Volume 104, Issue 3, Page(s) 622

    MeSH term(s) Humans ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Novel approaches beyond standard immunofluorescence for kidney biopsies.

    Santoriello, Dominick / Nasr, Samih H

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 3, Page(s) 221–227

    Abstract: Purpose of review: Immunofluorescence on frozen tissue (IF-F) utilizing antibodies against immunoglobulin (Ig) heavy and light chains (IgA, IgG and IgM, kappa and lambda) and components of classical and alternative complement pathways (C1q, C3c and C4) ... ...

    Abstract Purpose of review: Immunofluorescence on frozen tissue (IF-F) utilizing antibodies against immunoglobulin (Ig) heavy and light chains (IgA, IgG and IgM, kappa and lambda) and components of classical and alternative complement pathways (C1q, C3c and C4) is the standard of renal pathology. However, conventional IF-F has limitations, particularly in nephropathies associated with organized and/or monoclonal Ig deposits. This review will discuss new applications of established methods beyond conventional IF-F and recent novel immunohistochemical methods.
    Recent findings: The combined application of paraffin immunofluorescence (IF-P) and IgG subtype staining excluded monotypic deposits in 62-66% of DNA J homolog subfamily B member 9-associated fibrillary glomerulonephritis (FGN) with apparent monotypic deposits by IF-F, whereas IF-P unmasks IgG deposits in a subset of cases of immunotactoid glomerulopathy. A novel IF technique targeting epitopes at the junction of the Ig heavy and light chains was introduced and unmasked polytypic deposits in a subset of glomerulonephritis with apparent monotypic deposits on IF-F. A recent study described the successful application of co-detection by indexing (CODEX) multiplexed IF to visualize more than a dozen target antigens within a single kidney tissue section. Finally, immunohistochemical protocols for detection of the novel antigens in membranous nephropathy have already entered the clinical practice of renal pathology.
    Summary: Novel ancillary techniques in renal pathology have the potential to significantly enhance our ability to evaluate renal biopsies.
    MeSH term(s) Biopsy ; Female ; Fluorescent Antibody Technique ; Glomerulonephritis ; Humans ; Immunoglobulin G/metabolism ; Kidney/metabolism ; Male ; Staining and Labeling
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Segmental NELL-1 Membranous Nephropathy Complicating Tiopronin Therapy.

    Santoriello, Dominick / Ramaswamy, Ravi / Kudose, Satoru / Markowitz, Glen S

    Kidney international reports

    2023  Volume 8, Issue 8, Page(s) 1683–1686

    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.05.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heavy and light chains all at once: A new immunofluorescence technique to evaluate monoclonal immunoglobulin deposits.

    Santoriello, Dominick / Markowitz, Glen S

    Kidney international

    2021  Volume 100, Issue 1, Page(s) 22–24

    Abstract: Tools to identify monoclonal Ig deposits within tissue specimens include immunofluorescence (IF) staining on frozen tissue for Ig heavy chains and light chains, pronase IF to unmask monoclonal Ig deposits not seen by IF staining on frozen tissue, and IF ... ...

    Abstract Tools to identify monoclonal Ig deposits within tissue specimens include immunofluorescence (IF) staining on frozen tissue for Ig heavy chains and light chains, pronase IF to unmask monoclonal Ig deposits not seen by IF staining on frozen tissue, and IF staining for IgG subclasses (IgG1-IgG4). In this issue of Kidney International, a novel diagnostic tool is introduced: IF staining for conformational epitopes at the junction of the Ig heavy chains and light chains. This technique has the potential to significantly enhance our ability to evaluate apparent monoclonal forms of renal disease.
    MeSH term(s) Biopsy ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin Heavy Chains ; Immunoglobulin Light Chains ; Kidney ; Kidney Diseases ; Paraproteinemias/diagnosis ; Staining and Labeling
    Chemical Substances Immunoglobulin Heavy Chains ; Immunoglobulin Light Chains
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Avacopan in Patients With Rapidly Progressive Glomerulonephritis Requiring Dialysis.

    Cortazar, Frank B / Cerda, Jorge / Dhanani, Rahim / Roglieri, Joseph / Santoriello, Dominick

    Kidney international reports

    2023  Volume 8, Issue 8, Page(s) 1687–1691

    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acute Kidney Injury in a Patient on High-dose Glucocorticoid Therapy.

    DiFranza, Lanny T / Santoriello, Dominick

    Kidney360

    2021  Volume 2, Issue 10, Page(s) 1686–1687

    MeSH term(s) Acute Kidney Injury/chemically induced ; Glucocorticoids/adverse effects ; Humans ; Nephrology
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0003072021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Case | Chronic kidney disease associated with nuclear inclusion bodies in proximal tubular cells.

    Santoriello, Dominick / Schilling, Kathrin / Glabonjat, Ronald A / Charlesworth, Jon E / Yoslov, Michael D / Nasr, Samih H / Markowitz, Glen S

    Kidney international

    2023  Volume 104, Issue 6, Page(s) 1231–1232

    MeSH term(s) Intranuclear Inclusion Bodies ; Renal Insufficiency, Chronic/diagnosis ; Humans ; Kidney Tubules, Proximal/cytology
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Collapsing glomerulopathy is likely a major contributing factor for worse allograft survival in patients receiving kidney transplants from black donors.

    DiFranza, Lanny T / Daniel, Emily / Serban, Geo / Thomas, Steven M / Santoriello, Dominick / Ratner, Lloyd E / D'Agati, Vivette D / Vasilescu, Elena-Rodica / Husain, Syed Ali / Batal, Ibrahim

    Frontiers in medicine

    2024  Volume 11, Page(s) 1369225

    Abstract: Although a few registry-based studies have shown associations between receiving kidney allografts from Black donors and shorter allograft survival, detailed, large, single-center studies accounting for common confounding factors are lacking. Furthermore, ...

    Abstract Although a few registry-based studies have shown associations between receiving kidney allografts from Black donors and shorter allograft survival, detailed, large, single-center studies accounting for common confounding factors are lacking. Furthermore, pathologic alterations underlying this potential disparity have not been systematically studied. We performed a retrospective clinical-pathological study of kidney transplant recipients who received kidney allografts from either Black (
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1369225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Validation Study on the Utility of Immunoglobulin Heavy/Light Chain Immunofluorescence in Kidney Biopsies With Potential Monoclonal Gammopathy of Renal Significance Lesions.

    Kudose, Satoru / Jagannathan, Geetha / Santoriello, Dominick / Sekulic, Miroslav / Batal, Ibrahim / Stokes, M Barry / D'Agati, Vivette D / Markowitz, Glen S

    Kidney international reports

    2022  Volume 7, Issue 5, Page(s) 1119–1122

    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.01.1071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunofluorescence Staining for IgG Subclass: Cause for Discrepancy in the Detection of IgG1.

    Kudose, Satoru / Sekulic, Miroslav / Walavalkar, Vighnesh / Batal, Ibrahim / Stokes, M Barry / Markowitz, Glen S / D'Agati, Vivette D / Santoriello, Dominick

    Kidney international reports

    2023  Volume 8, Issue 11, Page(s) 2416–2420

    Abstract: Introduction: Immunofluorescence (IF) staining for IgG subclasses plays an important role in the classification of kidney disease. However, widely used IgG subclass-specific antibodies are now commercially unavailable. Thus, we compared alternative ... ...

    Abstract Introduction: Immunofluorescence (IF) staining for IgG subclasses plays an important role in the classification of kidney disease. However, widely used IgG subclass-specific antibodies are now commercially unavailable. Thus, we compared alternative antibodies for performing IgG subclass staining.
    Methods: A total of 21 cases were stained by 3 different methods: direct IF using fluorescein isothiocyanate (FITC)-conjugated polyclonal antibodies against IgG1-4 (commercially unavailable method), direct IF using FITC-conjugated monoclonal antibodies (clones HP-6091, 6014, 6050, and 6025), indirect IF using monoclonal antibodies (clones HP-6069, 6002, 6050, and 6025), and FITC-conjugated polyclonal secondary antibody. For cases with discrepancy in IgG1 staining, additional direct IF using FITC-conjugated monoclonal antibody (clone 4E3) was performed.
    Results: Of 21 cases, 11 (52%) had no staining for IgG1 by direct IF using the clone HP-6091 despite ≥1+ staining by the direct IF using polyclonal antibodies. Similarly, direct IF for IgG1 using the clone 4E3 had negative result in all 10 cases with available tissue. However, indirect IF for IgG1 using the clone HP-6069 had similar staining intensity (within 1 order of magnitude) as direct IF using the polyclonal antibodies (10 of 10). Results of IF for IgG2, IgG3, and IgG4 were similar in most cases.
    Conclusion: The choice of antibodies influences the result of IgG subclass staining, especially for anti-IgG1 antibodies, in which 2 monoclonal antibodies (HP6091 and 4E3) appear less sensitive. Although this may be due to unaccounted variables and requires confirmation, our results may partially explain the difference in IgG1 staining in the literature and underscore the need for careful validation.
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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