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  1. Article ; Online: Primary mesenchymal chondrosarcoma of the lung.

    Perry, William R / McHugh, Jonathan B / Konopka, Kristine E

    Pathology international

    2023  Volume 73, Issue 4, Page(s) 170–172

    MeSH term(s) Humans ; Chondrosarcoma, Mesenchymal ; Oncogene Proteins, Fusion ; Bone Neoplasms ; Lung
    Chemical Substances Oncogene Proteins, Fusion
    Language English
    Publishing date 2023-02-08
    Publishing country Australia
    Document type Letter
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interstitial lung disease pathology in systemic sclerosis.

    Konopka, Kristine E / Myers, Jeffrey L

    Therapeutic advances in musculoskeletal disease

    2021  Volume 13, Page(s) 1759720X211032437

    Abstract: Interstitial lung disease is a relatively frequent manifestation of systemic sclerosis with approximately one-third of patients developing clinical restrictive lung disease. Fibrotic nonspecific interstitial pneumonia is the most common cause of diffuse ... ...

    Abstract Interstitial lung disease is a relatively frequent manifestation of systemic sclerosis with approximately one-third of patients developing clinical restrictive lung disease. Fibrotic nonspecific interstitial pneumonia is the most common cause of diffuse parenchymal lung disease in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), followed by usual interstitial pneumonia (UIP). Radiographic pleuroparenchymal fibroelastosis-like changes may accompany other forms of interstitial lung disease, most commonly UIP. In an appropriate clinical setting with supportive high-resolution computed tomography findings, lung biopsy is not needed to confirm the presence of interstitial lung disease and surgical lung biopsies are often reserved for atypical presentations. In this review, we discuss the histological findings that define the most common patterns of SSc-ILD and outline other findings sometimes encountered in lung biopsies obtained from systemic sclerosis patients, including pulmonary vascular changes, aspiration, chronic pleuritis, and diffuse alveolar damage.
    Language English
    Publishing date 2021-07-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X211032437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosis of Lung Carcinoma on Small Biopsy.

    Jing, Jian / Konopka, Kristine E

    Surgical pathology clinics

    2020  Volume 13, Issue 1, Page(s) 1–15

    Abstract: Given the growing desire in clinical practice to detect lung carcinoma early, small biopsies are becoming more common and vital to the diagnostic process. Accurately diagnosing lung carcinoma on small biopsies is challenging but can significantly affect ... ...

    Abstract Given the growing desire in clinical practice to detect lung carcinoma early, small biopsies are becoming more common and vital to the diagnostic process. Accurately diagnosing lung carcinoma on small biopsies is challenging but can significantly affect patient management. The challenge is due in part to the overlapping features between benign, reactive, and malignant processes and the lack of discriminating biomarkers. Specimen preservation for ancillary tests is also increasingly important to provide targeted precision medicine. We focuses on the morphologic features and diagnostic pitfalls of the most common lung carcinoma seen in small biopsies and the appropriate specimen handling practice.
    MeSH term(s) Biopsy/methods ; Biopsy, Fine-Needle/methods ; Diagnosis, Differential ; Humans ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Neoplasm Staging ; Terminology as Topic
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2019.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Organizing pneumonia as a manifestation of coronavirus disease 2019.

    Edupuganti, Subhash / Kumar, Avnee J / Konopka, Kristine E

    Pathology international

    2021  Volume 71, Issue 3, Page(s) 210–212

    MeSH term(s) Adult ; Biopsy ; Bronchoscopy ; COVID-19/diagnostic imaging ; COVID-19/pathology ; COVID-19 Testing/methods ; Cryptogenic Organizing Pneumonia/diagnostic imaging ; Cryptogenic Organizing Pneumonia/pathology ; Cryptogenic Organizing Pneumonia/virology ; Female ; Humans
    Language English
    Publishing date 2021-01-27
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A 22-year-old man with a posterior left shoulder mass.

    Li, Joy / Winter, Stephen P / Gattu, Rishabh / Perry, Kyle D / Gaetke-Udager, Kara / Abdulfatah, Eman / McHugh, Jonathan B / Konopka, Kristine E / Bedewi, Mohamed Abdelmohsen / Soliman, Steven B

    Skeletal radiology

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country Germany
    Document type Editorial
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-024-04696-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Thymoliposarcoma with sebaceous differentiation and MDM2 amplification.

    Elliott, Daffolyn Rachael Fels / Myers, Jeffrey L / Konopka, Kristine E

    Pathology international

    2021  Volume 71, Issue 9, Page(s) 633–635

    MeSH term(s) Cell Differentiation ; Gene Amplification ; Humans ; In Situ Hybridization, Fluorescence ; Liposarcoma/diagnosis ; Liposarcoma/genetics ; Liposarcoma/pathology ; Male ; Middle Aged ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/genetics ; Thymus Neoplasms/pathology
    Chemical Substances MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
    Language English
    Publishing date 2021-07-02
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diagnostic Pathology of Lung Cancer.

    Konopka, Kristine E

    Seminars in respiratory and critical care medicine

    2016  Volume 37, Issue 5, Page(s) 681–688

    Abstract: In the past 5 years, there has arguably been a shift in the pathologic diagnosis of lung cancer, especially adenocarcinoma, moving toward a more patient-centered approach to reporting that works to incorporate information that may be clinically ... ...

    Abstract In the past 5 years, there has arguably been a shift in the pathologic diagnosis of lung cancer, especially adenocarcinoma, moving toward a more patient-centered approach to reporting that works to incorporate information that may be clinically meaningful to prognosis and impactful to clinical management strategy. As the demand for specialty team care surges, the need for effective communication between specialties continues to increase, particularly to ensure that we are all speaking the same language with regard to diagnostic certainty and the implementation of new terminology. This review of lung cancer pathology is not all-inclusive; but rather, in addition to providing salient histologic and immunohistochemical features of selected topics in adenocarcinoma, squamous cell carcinoma, neuroendocrine tumors, and large cell carcinoma, it also attempts to highlight problems in cancer diagnosis from the pathologist's perspective, including addressing variations in interobserver agreement and limitations to the diagnostic process with regard to immunohistochemistry. In the end, many times, problematic cases might reach resolution not through the narrow-sighted ocular of pathology, but rather through employment of a multidisciplinary approach.
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0036-1592172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Review of Smoking-Related Interstitial Fibrosis, Respiratory Bronchiolitis, and Desquamative Interstitial Pneumonia: Overlapping Histology and Confusing Terminology.

    Konopka, Kristine E / Myers, Jeffrey L

    Archives of pathology & laboratory medicine

    2018  Volume 142, Issue 10, Page(s) 1177–1181

    Abstract: Smoking-related lung diseases traverse a spectrum of clinicopathologic entities, with cases often comprising a complex mixture of findings. The complexity of the diagnostic process extends beyond the histologic findings to the nomenclature, which is ... ...

    Abstract Smoking-related lung diseases traverse a spectrum of clinicopathologic entities, with cases often comprising a complex mixture of findings. The complexity of the diagnostic process extends beyond the histologic findings to the nomenclature, which is murky from a seemingly unending expansion of terms being applied to a handful of pathologic changes. Here, we focus our review on smoking-related interstitial fibrosis, respiratory bronchiolitis, and desquamative interstitial pneumonia, 3 entities that perhaps show the most histologic overlap and suffer from competing terminology.
    MeSH term(s) Bronchiolitis/etiology ; Bronchiolitis/pathology ; Humans ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/pathology ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; Smoking/adverse effects
    Language English
    Publishing date 2018-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2018-0240-RA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019.

    Konopka, Kristine E / Wilson, Allecia / Myers, Jeffrey L

    Chest

    2020  Volume 158, Issue 3, Page(s) e99–e101

    Abstract: Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man ... ...

    Abstract Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for severe acute respiratory distress syndrome and died of COVID-19 less than 2 weeks after presentation to the hospital. His lungs showed mucus plugging and other histologic changes attributable to asthma, as well as early diffuse alveolar damage and a fibrinous pneumonia. The presence of diffuse alveolar damage is similar to descriptions of autopsy lung findings from patients with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, and the absence of a neutrophil-rich acute bronchopneumonia differs from the histologic changes typical of influenza. The relative contribution of mucus plugging to his hypoxemia is unknown.
    MeSH term(s) Adult ; Asthma/complications ; Asthma/pathology ; Autopsy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Fatal Outcome ; Humans ; Lung/pathology ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.04.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinically Occult Diffuse Pleural Mesothelioma in Patients Presenting With Spontaneous Pneumothorax.

    Fels Elliott, Daffolyn Rachael / Konopka, Kristine E / Hrycaj, Steven M / Lagisetty, Kiran H / Myers, Jeffrey L / Farver, Carol F / Huang, Tao

    American journal of clinical pathology

    2023  Volume 160, Issue 3, Page(s) 322–330

    Abstract: Objectives: To report histologic features of unsuspected diffuse pleural mesothelioma (DPM) in surgical specimens for pneumothorax and demonstrate how ancillary markers support a diagnosis of malignancy in this context. We explored whether pneumothorax ... ...

    Abstract Objectives: To report histologic features of unsuspected diffuse pleural mesothelioma (DPM) in surgical specimens for pneumothorax and demonstrate how ancillary markers support a diagnosis of malignancy in this context. We explored whether pneumothorax may be a clinical manifestation of mesothelioma in situ (MIS).
    Methods: A single-institution database search identified patients who underwent surgical resection for spontaneous pneumothorax (n = 229) and/or were diagnosed with DPM (n = 88) from 2000 to 2020.
    Results: Spontaneous pneumothorax without clinical, radiologic, or intraoperative suspicion of mesothelioma was the initial presentation in 2 (2.3%) of 88 patients diagnosed with DPM. This represented 0.9% (2/229) of all patients undergoing surgical management of pneumothorax but accounted for a larger proportion of older patients (12.5% older than 70 years). Immunohistochemistry for BAP-1 and/or MTAP confirmed the diagnosis of DPM in 2 cases. Mesothelioma in situ was identified retrospectively by immunohistochemistry in 1 case of spontaneous pneumothorax from a 77-year-old man who developed invasive DPM 25 months later. No additional cases of MIS were identified in 19 surgical lung resections for spontaneous pneumothorax.
    Conclusions: Histologic examination of bleb resections with ancillary testing for cases with ambiguous features is essential for detection of early DPM. It is uncertain whether spontaneous pneumothorax may represent a clinical manifestation of MIS.
    MeSH term(s) Male ; Humans ; Aged ; Pneumothorax/diagnosis ; Pneumothorax/surgery ; Retrospective Studies ; Mesothelioma, Malignant ; Mesothelioma/complications ; Mesothelioma/diagnosis ; Mesothelioma/surgery ; Pleural Neoplasms/complications ; Pleural Neoplasms/diagnosis
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad057
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