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  1. Article ; Online: A novel multi-layer modular approach for real-time fuzzy-identification of gravitational-wave signals

    Francesco Pio Barone / Daniele Dell’Aquila / Marco Russo

    Machine Learning: Science and Technology, Vol 4, Iss 4, p

    2023  Volume 045054

    Abstract: ... of effective GW detection algorithms is crucial. We propose a novel layered framework for real-time detection ... The key aspects of the newly proposed framework are: the well structured, layered approach, and the low ... computational complexity. The paper describes the basic concepts of the framework and the derivation ...

    Abstract Advanced LIGO and Advanced Virgo ground-based interferometers are instruments capable to detect gravitational wave (GW) signals exploiting advanced laser interferometry techniques. The underlying data analysis task consists in identifying specific patterns in noisy timeseries, but it is made extremely complex by the incredibly small amplitude of the target signals. In this scenario, the development of effective GW detection algorithms is crucial. We propose a novel layered framework for real-time detection of GWs inspired by speech processing techniques and, in the present implementation, based on a state-of-the-art machine learning approach involving a hybridization of genetic programming and neural networks. The key aspects of the newly proposed framework are: the well structured, layered approach, and the low computational complexity. The paper describes the basic concepts of the framework and the derivation of the first three layers. Even if, in the present implementation, the layers are based on models derived using a machine learning approach, the proposed layered structure has a universal nature. Compared to more complex approaches, such as convolutional neural networks, which comprise a parameter set of several tens of MB and were tested exclusively for fixed length data samples, our framework has lower accuracy (e.g. it identifies $45\%$ of low signal-to-noise-ration GW signals, against $65\%$ of the state-of-the-art, at a false alarm probability of 10 ^−2 ), but has a much lower computational complexity (it exploits only 4 numerical features in the present implementation) and a higher degree of modularity. Furthermore, the exploitation of short-term features makes the results of the new framework virtually independent against time-position of GW signals, simplifying its future exploitation in real-time multi-layer pipelines for gravitational-wave detection with new generation interferometers.
    Keywords gravitational-wave science ; analysis of noisy timeseries ; fuzzy-classification of signals ; speech-processing ; genetic programming ; artificial neural networks ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Can artificial intelligence simplify the screening of muscle mass loss?

    Buccheri, Enrico / Dell'Aquila, Daniele / Russo, Marco / Chiaramonte, Rita / Musumeci, Giuseppe / Vecchio, Michele

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e16323

    Abstract: Background: Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening ... ...

    Abstract Background: Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening in medical centers with a high prevalence of sarcopenia.
    Objectives: Developing a nearly zero-cost screening tool to emulate the performance of DEXA in identifying patients with muscle mass loss. This can crucially help the early diagnosis of sarcopenia at large-scale, contributing to reduce its prevalence and related complications with timely treatments.
    Methods: We exploit cross-sectional data for about 14,500 patients and 38 non-laboratory variables from successive NHANES over 7 years (1999-2006). Data are analyzed through a state-of-the-art artificial intelligence approach based on decision trees.
    Results: A reduced number of anthropometric parameters allows to predict the outcome of DEXA with AUC between 0.92 and 0.94. The most complex model derived in this paper exploits 6 variables, related to the circumference of key corporal segments and to the evaluation of body fat. It achieves an optimal trade-off sensitivity of 0.89 and a specificity of 0.82. Restricting exclusively to variables related to lower limb, we obtain an even simpler tool with only slightly lower accuracy (AUC 0.88-0.90).
    Conclusions: Anthropometric data seem to contain the entire informative content of a more complex set of non-laboratory variables, including anamnestic and/or morbidity factors. Compared to previously published screening tools for muscle mass loss, the newly developed models are less complex and achieve a better accuracy. The new results might suggest a possible inversion of the standard diagnostic algorithm of sarcopenia. We conjecture a new diagnostic scheme, which requires a dedicated clinical validation that goes beyond the scope of the present study.
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Artificial intelligence in health data analysis: The Darwinian evolution theory suggests an extremely simple and zero-cost large-scale screening tool for prediabetes and type 2 diabetes.

    Buccheri, Enrico / Dell'Aquila, Daniele / Russo, Marco

    Diabetes research and clinical practice

    2021  Volume 174, Page(s) 108722

    Abstract: Aims: The effective identification of individuals with early dysglycemia status is key to reduce the incidence of type 2 diabetes. We develop and validate a novel zero-cost tool that significantly simplifies the screening of undiagnosed dysglycemia.: ... ...

    Abstract Aims: The effective identification of individuals with early dysglycemia status is key to reduce the incidence of type 2 diabetes. We develop and validate a novel zero-cost tool that significantly simplifies the screening of undiagnosed dysglycemia.
    Methods: We use NHANES cross-sectional data over 10 years (2007-2016) to derive an equation that links non-laboratory exposure variables to the possible presence of undetected dysglycemia. For the first time, we adopt a novel artificial intelligence approach based on the Darwinian evolutionary theory to analyze health data. We collected data for 47 variables.
    Results: Age and waist circumference are the only variables required to use the model. To identify undetected dysglycemia, we obtain an area under the curve (AUC) of 75.3%. Sensitivity and specificity are 0.65 and 0.73 by using the optimal threshold value determined from external validation data.
    Conclusions: The use of uniquely two variables allows to obtain a zero-cost screening tool of analogous precision than that of more complex tools widely adopted in the literature. The newly developed tool has clinical use as it significantly simplifies the screening of dysglycemia. Furthermore, we suggest that the definition of an age-related waist circumference cut-off might help to improve existing diabetes risk factors.
    MeSH term(s) Artificial Intelligence/standards ; Cross-Sectional Studies ; Data Analysis ; Diabetes Mellitus, Type 2/diagnosis ; Evolution, Molecular ; Female ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Prediabetic State/diagnosis
    Language English
    Publishing date 2021-02-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2021.108722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: A novel multi-layer modular approach for real-time fuzzy-identification of gravitational-wave signals

    Barone, Francesco Pio / Dell'Aquila, Daniele / Russo, Marco

    2022  

    Abstract: ... gravitational wave detection algorithms is crucial. We propose a novel layered framework for real-time detection ... neural networks. The key aspects of the newly proposed framework are: the well structured, layered approach, and ... the low computational complexity. The paper describes the basic concepts of the framework and ...

    Abstract Advanced LIGO and Advanced Virgo ground-based interferometers are instruments capable to detect gravitational wave signals exploiting advanced laser interferometry techniques. The underlying data analysis task consists in identifying specific patterns in noisy timeseries, but it is made extremely complex by the incredibly small amplitude of the target signals. In this scenario, the development of effective gravitational wave detection algorithms is crucial. We propose a novel layered framework for real-time detection of gravitational waves inspired by speech processing techniques and, in the present implementation, based on a state-of-the-art machine learning approach involving a hybridization of genetic programming and neural networks. The key aspects of the newly proposed framework are: the well structured, layered approach, and the low computational complexity. The paper describes the basic concepts of the framework and the derivation of the first three layers. Even if the layers are based on models derived using a machine learning approach, the proposed layered structure has a universal nature. Compared to more complex approaches, such as convolutional neural networks, which comprise a parameter set of several tens of MB and were tested exclusively for fixed length data samples, our framework has lower accuracy (e.g., it identifies 45% of low signal-to-noise-ration gravitational wave signals, against 65% of the state-of-the-art, at a false alarm probability of $10^{-2}$), but has a much lower computational complexity and a higher degree of modularity. Furthermore, the exploitation of short-term features makes the results of the new framework virtually independent against time-position of gravitational wave signals, simplifying its future exploitation in real-time multi-layer pipelines for gravitational-wave detection with new generation interferometers.
    Keywords General Relativity and Quantum Cosmology ; Computer Science - Machine Learning ; Computer Science - Neural and Evolutionary Computing
    Subject code 006
    Publishing date 2022-06-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A systematic study of pulse and pulse reverse plating on acid copper bath for decorative and functional applications.

    Mariani, Elena / Giurlani, Walter / Bonechi, Marco / Dell'Aquila, Vincenzo / Innocenti, Massimo

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18175

    Abstract: Today industrial electroplating is mainly carried out using direct current even if the use of modulated currents could offer greats opportunities. Adjusting the amplitude and length of the current's pulses it is possible to control grain size, porosity ... ...

    Abstract Today industrial electroplating is mainly carried out using direct current even if the use of modulated currents could offer greats opportunities. Adjusting the amplitude and length of the current's pulses it is possible to control grain size, porosity and homogeneity of the deposits; the use of modulated currents could also decrease the environmental impact of deposition processes as they require a much lower percentage of organic additives. The aim of this work is to assess, through both theoretical and experimental investigation, how the deposition parameters affect the various characteristics of the deposit. We used a commercial acid copper bath for the depositions performing both pulse and reverse pulse sequences. The coatings have been characterised by estimating the deposition yield, homogeneity, hardness and reflectivity. Using pulsed currents, we obtained shinier and brighter films respect to those produced with stationary currents; the deposition efficiency was also improved. Bipolar currents, on the other hand, favour more homogeneous deposits over the entire deposition area, and are less affected by the edge effect.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-22650-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Primary Thyroid Lymphoma: How Molecular Biology and Ancillary Techniques Can Help the Cytopathologist Overcome This Diagnostic Challenge.

    Guidobaldi, Leo / Cafiero, Concetta / D'Amato, Gerardo / Dell'Aquila, Marco / Trimboli, Pierpaolo / Palmirotta, Raffaele / Pisconti, Salvatore

    Journal of personalized medicine

    2023  Volume 13, Issue 8

    Abstract: Primary thyroid lymphoma (PTL) occurs rarely, its diagnosis is a challenge, and the prognosis of these patients depends on the time of diagnosis. Even though fine-needle aspiration cytology (FNAC) is recognized as the most accurate tool for detecting ... ...

    Abstract Primary thyroid lymphoma (PTL) occurs rarely, its diagnosis is a challenge, and the prognosis of these patients depends on the time of diagnosis. Even though fine-needle aspiration cytology (FNAC) is recognized as the most accurate tool for detecting thyroid malignancies, its sensitivity for PTL is poor. Both clinical and ultrasound presentation of PTL can be atypical, and laboratory tests fail to furnish relevant data. Consequently, the reliability of a cytopathologist facing PTL can be poor, even when he is aware of its clinical information. In addition, the cases described in the literature are extremely rare and fragmentary, and consequently, the molecular data currently available for this neoplasm are practically negligible. Here, we present a case report in order to discuss the intrinsic limitations in achieving a final diagnosis of PTL and how using molecular diagnostics to identify potential mutational models can improve the evaluation of this neoplasm.
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13081203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Can artificial intelligence simplify the screening of muscle mass loss?

    Enrico Buccheri / Daniele Dell’Aquila / Marco Russo / Rita Chiaramonte / Giuseppe Musumeci / Michele Vecchio

    Heliyon, Vol 9, Iss 5, Pp e16323- (2023)

    2023  

    Abstract: Background: Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening ... ...

    Abstract Background: Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening in medical centers with a high prevalence of sarcopenia. Objectives: Developing a nearly zero-cost screening tool to emulate the performance of DEXA in identifying patients with muscle mass loss. This can crucially help the early diagnosis of sarcopenia at large-scale, contributing to reduce its prevalence and related complications with timely treatments. Methods: We exploit cross-sectional data for about 14,500 patients and 38 non-laboratory variables from successive NHANES over 7 years (1999–2006). Data are analyzed through a state-of-the-art artificial intelligence approach based on decision trees. Results: A reduced number of anthropometric parameters allows to predict the outcome of DEXA with AUC between 0.92 and 0.94. The most complex model derived in this paper exploits 6 variables, related to the circumference of key corporal segments and to the evaluation of body fat. It achieves an optimal trade-off sensitivity of 0.89 and a specificity of 0.82. Restricting exclusively to variables related to lower limb, we obtain an even simpler tool with only slightly lower accuracy (AUC 0.88–0.90). Conclusions: Anthropometric data seem to contain the entire informative content of a more complex set of non-laboratory variables, including anamnestic and/or morbidity factors. Compared to previously published screening tools for muscle mass loss, the newly developed models are less complex and achieve a better accuracy. The new results might suggest a possible inversion of the standard diagnostic algorithm of sarcopenia. We conjecture a new diagnostic scheme, which requires a dedicated clinical validation that goes beyond the scope of the present study.
    Keywords Muscle mass loss ; Sarcopenia ; Artificial intelligence ; Boost decision trees ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 006
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs.

    Dell'Aquila, Marco / Cafiero, Concetta / Micera, Alessandra / Stigliano, Egidio / Ottaiano, Maria Pia / Benincasa, Giulio / Schiavone, Beniamino / Guidobaldi, Leo / Santacroce, Luigi / Pisconti, Salvatore / Arena, Vincenzo / Palmirotta, Raffaele

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Background: The COVID-19 pandemic has been a health emergency with a significant impact on the world due to its high infectiousness. The disease, primarily identified in the lower respiratory tract, develops with numerous clinical symptoms affecting ... ...

    Abstract Background: The COVID-19 pandemic has been a health emergency with a significant impact on the world due to its high infectiousness. The disease, primarily identified in the lower respiratory tract, develops with numerous clinical symptoms affecting multiple organs and displays a clinical finding of anosmia. Several authors have investigated the pathogenetic mechanisms of the olfactory disturbances caused by SARS-CoV-2 infection, proposing different hypotheses and showing contradictory results. Since uncertainties remain about possible virus neurotropism and direct damage to the olfactory bulb, we investigated the expression of SARS-CoV-2 as well as ACE2 receptor transcripts in autoptic lung and olfactory bulb tissues, with respect to the histopathological features.
    Methods: Twenty-five COVID-19 olfactory bulbs and lung tissues were randomly collected from 200 initial autopsies performed during the COVID-19 pandemic. Routine diagnosis was based on clinical and radiological findings and were confirmed with post-mortem swabs. Real-time RT-PCR for SARS-CoV-2 and ACE2 receptor RNA was carried out on autoptic FFPE lung and olfactory bulb tissues. Histological staining was performed on tissue specimens and compared with the molecular data.
    Results: While real-time RT-PCR for SARS-CoV-2 was positive in 23 out of 25 lung samples, the viral RNA expression was absent in olfactory bulbs. ACE2-receptor RNA was present in all tissues examined, being highly expressed in lung samples than olfactory bulbs.
    Conclusions: Our finding suggests that COVID-19 anosmia is not only due to neurotropism and the direct action of SARS-CoV-2 entering the olfactory bulb. The mechanism of SARS-CoV-2 neuropathogenesis in the olfactory bulb requires a better elucidation and further research studies to mitigate the olfactory bulb damage associated with virus action.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ectopic deciduosis in a paratubal cyst: A report of the first case.

    Farì, Giorgia / Dell'Aquila, Marco / Moresi, Sascia / Lanzone, Antonio / Arena, Vincenzo

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 154, Issue 2, Page(s) 376–378

    MeSH term(s) Female ; Humans ; Parovarian Cyst
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can artificial intelligence simplify the screening of muscle mass loss?

    Buccheri, Enrico / Dell'Aquila, Daniele / Russo, Marco / Chiaramonte, Rita / Musumeci, Giuseppe / Vecchio, Michele

    Heliyon. 2023 May, v. 9, no. 5 p.e16323-

    2023  

    Abstract: Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening in medical ... ...

    Abstract Sarcopenia is a risk factor for morbidity and preventable mortality in old age, with consequent high costs for the national health system. Its diagnosis requires costly radiological examinations, such as the DEXA, which complicate screening in medical centers with a high prevalence of sarcopenia. Developing a nearly zero-cost screening tool to emulate the performance of DEXA in identifying patients with muscle mass loss. This can crucially help the early diagnosis of sarcopenia at large-scale, contributing to reduce its prevalence and related complications with timely treatments. We exploit cross-sectional data for about 14,500 patients and 38 non-laboratory variables from successive NHANES over 7 years (1999-2006). Data are analyzed through a state-of-the-art artificial intelligence approach based on decision trees. A reduced number of anthropometric parameters allows to predict the outcome of DEXA with AUC between 0.92 and 0.94. The most complex model derived in this paper exploits 6 variables, related to the circumference of key corporal segments and to the evaluation of body fat. It achieves an optimal trade-off sensitivity of 0.89 and a specificity of 0.82. Restricting exclusively to variables related to lower limb, we obtain an even simpler tool with only slightly lower accuracy (AUC 0.88-0.90). Anthropometric data seem to contain the entire informative content of a more complex set of non-laboratory variables, including anamnestic and/or morbidity factors. Compared to previously published screening tools for muscle mass loss, the newly developed models are less complex and achieve a better accuracy. The new results might suggest a possible inversion of the standard diagnostic algorithm of sarcopenia. We conjecture a new diagnostic scheme, which requires a dedicated clinical validation that goes beyond the scope of the present study.
    Keywords National Health and Nutrition Examination Survey ; algorithms ; artificial intelligence ; body fat ; early diagnosis ; models ; morbidity ; mortality ; muscle tissues ; risk factors ; sarcopenia ; Muscle mass loss ; Boost decision trees
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16323
    Database NAL-Catalogue (AGRICOLA)

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