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  1. Book ; Online: Diagnostic or therapeutic strategies for pregnancy complications

    Heazell, Alexander / Girard, Sylvie

    2022  

    Author's details edited by Alexander Heazell and Sylvie Girard
    Language English
    Size 1 Online-Ressource (vii, 218 Seiten), Illustrationen, Diagramme
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note Printed edition of the special issue published in "Journal of clinical medicine" ; Open Access
    HBZ-ID HT021593046
    ISBN 978-3-0365-4878-4 ; 9783036548777 ; 3-0365-4878-5 ; 3036548777
    DOI 10.3390/books978-3-0365-4878-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online: Diagnostic or Therapeutic Strategies for Pregnancy Complications

    Heazell, Alexander / Girard, Sylvie

    2022  

    Keywords Medicine ; ultrasonography ; elastography ; uterine cervix ; term pregnancy ; parturition ; genotyping ; preeclampsia ; MMP-9 ; MMP-2 ; SNPs ; tocolytic ; preterm birth ; preterm labor ; neonate ; prematurity ; pregnancy ; therapeutic ; progesterone ; fetus ; sex as a biological variable ; sex differences ; pregnancy complications ; placenta ; prenatal diagnosis ; fetal growth restriction ; miscarriage ; chorio-deciduitis ; grade ; amnionitis ; acute histologic chorioamnionitis ; intra-amniotic inflammatory response ; beta-blocker ; endothelial dysfunction ; cardiovascular disease ; pregnancy loss ; immunology ; vascular endothelial growth factor ; galectin-9 ; interleukin-4 ; proteomics ; urine ; biomarkers ; IBP4 ; SHBG ; RPL ; NK cells ; sildenafil ; PDE5A ; VEGF-A ; angiotensin ; infant ; newborn ; female ; abruptio placentae ; Apgar score ; pregnant women ; gestational age ; IL-1 blockade ; anakinra ; canakinumab ; human ; inflammation ; fetal growth restriction (FGR) ; intra-uterine growth restriction (IUGR) ; SPINT1 ; HAI-1 ; stillbirth ; placental insufficiency ; histopathology ; cardiovascular risk ; postpartum screening ; n/a
    Language English
    Size 1 electronic resource (238 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030374367
    ISBN 9783036548784 ; 3036548785
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Inflammation in pregnancies with preterm birth: potential contributing role of progesterone in relation to gestational age.

    Enninga, Elizabeth Ann L / Girard, Sylvie

    American journal of obstetrics and gynecology

    2023  Volume 228, Issue 6, Page(s) 764–765

    MeSH term(s) Pregnancy ; Female ; Infant, Newborn ; Humans ; Progesterone ; Premature Birth/epidemiology ; Gestational Age ; Progestins/therapeutic use ; Inflammation
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Progestins
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Pregnant individuals with uncomplicated pregnancies display pro-inflammatory immune changes when exposed to the COVID-19 pandemic.

    Bernier, Elsa / Brien, Marie-Eve / Girard, Sylvie

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2024  Volume 91, Issue 2, Page(s) e13828

    Abstract: Problem: The COVID-19 pandemic has been shown to have a detrimental impact on the mental health of pregnant individuals, and chronic stress can alter the immune profile. However, the effects of the COVID-19 pandemic on the immune system in pregnancy are ...

    Abstract Problem: The COVID-19 pandemic has been shown to have a detrimental impact on the mental health of pregnant individuals, and chronic stress can alter the immune profile. However, the effects of the COVID-19 pandemic on the immune system in pregnancy are still poorly understood. We aimed to evaluate the impact of pandemic exposure on the maternal immune profile in uncomplicated pregnancies.
    Method of study: We collected blood and placenta samples from pregnant individuals exposed and unexposed to the pandemic to compare their immune and inflammatory profiles. We performed co-culture with circulating maternal immune cells and endothelial cells to assess endothelial activation. Statistical analysis was performed using unpaired t-test, Mann-Whitney, or Fisher's exact test as appropriate.
    Results: In exposed individuals, we observed a decreased proportion of Th2 cells (p < .0001) and Treg/Th17 ratio (p < .05), as well as an increased Th1/Th2 ratio (p < .0001). Levels of IL-1β (p < .01) and IL-18 (p < .01) were increased in the circulation of exposed participants, whilst other mediators were significantly decreased (IFNγ, IL-8, MCP-1, amongst others). Furthermore, we observed increased production of ICAM, hallmark of endothelial activation, when we co-cultured endothelial cells with immune cells from exposed individuals. Vaccination status impacted the cellular profile with increased proportions of Th1 and B cells in vaccinated participants.
    Conclusion: Overall, we observed a pro-inflammatory bias in the circulation of pregnant individuals exposed to the COVID-19 pandemic, with otherwise uncomplicated pregnancies. Our work also supports an association between the increased risk of endothelial activation/hypertension and SARS-CoV2 infection, which might be driven in part by exposure to the pandemic and associated stressors.
    MeSH term(s) Pregnancy ; Female ; Humans ; COVID-19 ; Pandemics ; Endothelial Cells ; RNA, Viral ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2024-02-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Diagnostic or Therapeutic Strategies for Pregnancy Complications.

    Couture, Camille / Girard, Sylvie

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Pregnancy complications including preeclampsia, preterm birth, recurrent pregnancy loss, and fetal growth restriction affect over 12% of all pregnancies worldwide [ ... ]. ...

    Abstract Pregnancy complications including preeclampsia, preterm birth, recurrent pregnancy loss, and fetal growth restriction affect over 12% of all pregnancies worldwide [...].
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnostic or Therapeutic Strategies for Pregnancy Complications

    Camille Couture / Sylvie Girard

    Journal of Clinical Medicine, Vol 11, Iss 3144, p

    2022  Volume 3144

    Abstract: Pregnancy complications including preeclampsia, preterm birth, recurrent pregnancy loss, and fetal growth restriction affect over 12% of all pregnancies worldwide [.] ...

    Abstract Pregnancy complications including preeclampsia, preterm birth, recurrent pregnancy loss, and fetal growth restriction affect over 12% of all pregnancies worldwide [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Innate and Adaptive Immune Systems in Physiological and Pathological Pregnancy.

    Weng, Jessica / Couture, Camille / Girard, Sylvie

    Biology

    2023  Volume 12, Issue 3

    Abstract: The dynamic immunological changes occurring throughout pregnancy are well-orchestrated and important for the success of the pregnancy. One of the key immune adaptations is the maternal immune tolerance towards the semi-allogeneic fetus. In this review, ... ...

    Abstract The dynamic immunological changes occurring throughout pregnancy are well-orchestrated and important for the success of the pregnancy. One of the key immune adaptations is the maternal immune tolerance towards the semi-allogeneic fetus. In this review, we provide a comprehensive overview of what is known about the innate and adaptive immunological changes in pregnancy and the role(s) of specific immune cells during physiological and pathological pregnancy. Alongside this, we provided details of remaining questions and challenges, as well as future perspectives for this growing field of research. Understanding the immunological changes that occur can inform potential strategies on treatments for the optimal health of the neonate and pregnant individual both during and after pregnancy.
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12030402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Innate and Adaptive Immune Systems in Physiological and Pathological Pregnancy

    Jessica Weng / Camille Couture / Sylvie Girard

    Biology, Vol 12, Iss 402, p

    2023  Volume 402

    Abstract: The dynamic immunological changes occurring throughout pregnancy are well-orchestrated and important for the success of the pregnancy. One of the key immune adaptations is the maternal immune tolerance towards the semi-allogeneic fetus. In this review, ... ...

    Abstract The dynamic immunological changes occurring throughout pregnancy are well-orchestrated and important for the success of the pregnancy. One of the key immune adaptations is the maternal immune tolerance towards the semi-allogeneic fetus. In this review, we provide a comprehensive overview of what is known about the innate and adaptive immunological changes in pregnancy and the role(s) of specific immune cells during physiological and pathological pregnancy. Alongside this, we provided details of remaining questions and challenges, as well as future perspectives for this growing field of research. Understanding the immunological changes that occur can inform potential strategies on treatments for the optimal health of the neonate and pregnant individual both during and after pregnancy.
    Keywords pregnancy ; innate immune system ; adaptive immune system ; immunological tolerance ; maternal–fetal interaction ; immune cells ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Spatial proteomics reveals phenotypic and functional differences in T cell and macrophage subsets during villitis of unknown etiology.

    Lothert, Petra K / Fedyshyn, Bohdana / Girard, Sylvie / Chakraborty, Rana / Norgan, Andrew P / Enninga, Elizabeth Ann L

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 914

    Abstract: Villitis of unknown etiology (VUE) is a prevalent inflammatory pathology of the placenta characterized by infiltration of maternal T cells and accumulation of fetal macrophages into chorionic villi. VUE is associated with a variety of adverse clinical ... ...

    Abstract Villitis of unknown etiology (VUE) is a prevalent inflammatory pathology of the placenta characterized by infiltration of maternal T cells and accumulation of fetal macrophages into chorionic villi. VUE is associated with a variety of adverse clinical outcomes, including fetal growth restriction and fetal demise. Evaluation of the phenotypic and functional differences between two immune cell types associated with this pathology, namely T cells and macrophages, was completed to gain a deeper understanding of the immuno-pathogenesis of VUE. GeoMx Digital Spatial Profiling was performed on placental tissue from 4 high grade VUE cases and 4 controls with no underlying pathology. Placental tissues were fluorescently labeled with CD3 and CD68 antibodies and oligo-conjugated antibodies against 48 protein targets. Overall, T cells in VUE exhibited upregulated markers of activation, memory, and antigen experience compared to controls and were altered based on placental location (villi vs. decidua). Additionally, villous macrophages in VUE upregulated costimulatory and major histocompatibility complex class I and II molecules compared to controls and macrophage subtypes in the decidua. Data herein provides new mechanistic insights into T cell and macrophage biology in VUE which contribute to this abnormal immune response to pregnancy.
    MeSH term(s) Pregnancy ; Female ; Humans ; Placenta ; Proteomics ; T-Lymphocytes ; Chorioamnionitis ; Macrophages
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51545-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Circulating levels of inflammatory mediators in pregnant people living with HIV according to antiretroviral therapy regimen.

    Hindle, Stephanie / Girard, Sylvie / Cote, Helene C F / Money, Deborah / Mann, Evelyn / Boucoiran, Isabelle

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1282291

    Abstract: Introduction: The use of antiretroviral therapy (ART) during pregnancy, particularly protease-inhibitor-based regimens (PI), has been linked to adverse outcomes including preterm delivery. As this outcome may be related to systemic inflammation, we ... ...

    Abstract Introduction: The use of antiretroviral therapy (ART) during pregnancy, particularly protease-inhibitor-based regimens (PI), has been linked to adverse outcomes including preterm delivery. As this outcome may be related to systemic inflammation, we sought to characterize inflammatory profiles of pregnant people living with HIV (PLWH) by comparing their levels of inflammatory mediators at two timepoints during pregnancy according to ART regimen, and to HIV-negative controls.
    Methods: Second and third trimester samples from 144 pregnant PLWH treated with ART and 24 HIV-uninfected controls were retrieved from the CARMA-PREG cohort. Peripheral plasma levels of 12 inflammatory mediators previously linked to HIV infection and/or poor pregnancy outcomes were quantified by multiplex assay: HMGB1, GM-CSF, IFNα, IFNβ, IFNγ, IL-10, IL-17, IL-1β, IL-6, TNFα, AGP, and CRP. Levels were compared by ART regimen and HIV status.
    Results: Adjusted analyses showed that PLWH have higher levels of AGP throughout pregnancy and lower levels of IFNγ and IL-1β during the second trimester. PI-based regimens are associated with significantly higher levels of IFNα and IL-17 during the second trimester and IFNα, CRP, HMGB1, and IFNβ during the third trimester compared to InSTI-based regimens. The PI-subgroup was associated with preterm delivery and higher HIV-1 viral load.
    Discussion: Our results suggest that PI-based regimens are associated with a pro-inflammatory and antiviral immunological response and a high viral load, which may be a mechanism through which PI-based regimens increase the risk of preterm delivery. Further investigations into cellular mechanisms and pro-inflammatory cascades leading to preterm delivery are necessary to support this association.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1282291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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