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Article: Intensity-modulated radiation therapy for head and neck cancer.

De Neve, Wilfried / Duthoy, Wim

2004 Volume 4, Issue 3, Page(s) 425–434

Abstract: In head and neck cancer, intensity-modulated radiation therapy (IMRT) makes the use of electron beams for irradiation of the posterior neck obsolete, inherently performs missing tissue compensation, and allows concave and intentionally nonhomogeneous ... ...

Abstract	In head and neck cancer, intensity-modulated radiation therapy (IMRT) makes the use of electron beams for irradiation of the posterior neck obsolete, inherently performs missing tissue compensation, and allows concave and intentionally nonhomogeneous dose distributions. By clinical use of these physical characteristics, salivary or lacrimal glands, optic pathway and auditory structures can be selectively underdosed and good evidence of decreased radiation toxicity is available. Evidence for increased local control is still lacking. Recurrences are mainly located in the high-dose-prescription regions, suggesting the need for even higher doses in these areas. Image-aided design of IMRT dose distribution is an area of intense research. New positron emission tomography and magnetic resonance imaging developments might allow definition of volumes inside the tumor where treatment failure is most likely to occur. If these volumes are small, focused dose escalation of large magnitude can be attempted and the hypothesis of improved local control by IMRT can be tested.
MeSH term(s)	Dose Fractionation ; Head and Neck Neoplasms/radiotherapy ; Humans ; Imaging, Three-Dimensional ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Conformal/methods
Language	English
Publishing date	2004-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1586/14737140.4.3.425
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Article ; Online: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.

Ngabonziza, Jean Claude Semuto / Loiseau, Chloé / Marceau, Michael / Jouet, Agathe / Menardo, Fabrizio / Tzfadia, Oren / Antoine, Rudy / Niyigena, Esdras Belamo / Mulders, Wim / Fissette, Kristina / Diels, Maren / Gaudin, Cyril / Duthoy, Stéphanie / Ssengooba, Willy / André, Emmanuel / Kaswa, Michel K / Habimana, Yves Mucyo / Brites, Daniela / Affolabi, Dissou /

Mazarati, Jean Baptiste / de Jong, Bouke Catherine / Rigouts, Leen / Gagneux, Sebastien / Meehan, Conor Joseph / Supply, Philip

Nature communications

2020 Volume 11, Issue 1, Page(s) 2917

Abstract: The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we ... ...

Abstract	The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.
MeSH term(s)	Aged ; DNA, Bacterial/genetics ; Evolution, Molecular ; Genetic Variation ; Genome, Bacterial ; Genomics ; Genotype ; Humans ; Likelihood Functions ; Limit of Detection ; Male ; Mutation ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/isolation & purification ; Phenotype ; Phylogeny ; Rifampin/pharmacology ; Rwanda ; Tuberculosis, Multidrug-Resistant/microbiology ; Uganda
Chemical Substances	DNA, Bacterial ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-16626-6
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Article ; Online: Prevalence and prognosis of low-volume, oligorecurrent, hormone-sensitive prostate cancer amenable to lesion ablative therapy.

De Bruycker, Aurélie / Lambert, Bieke / Claeys, Tom / Delrue, Louke / Mbah, Chamberlain / De Meerleer, Gert / Villeirs, Geert / De Vos, Filip / De Man, Kathia / Decaestecker, Karel / Fonteyne, Valérie / Lumen, Nicolaas / Ameye, Filip / Billiet, Ignace / Joniau, Steven / Vanhaverbeke, Friedl / Duthoy, Wim / Ost, Piet

BJU international

2017 Volume 120, Issue 6, Page(s) 815–821

Abstract: Objectives: To describe the anatomical patterns of prostate cancer (PCa) recurrence after primary therapy and to investigate if patients with low-volume disease have a better prognosis as compared with their counterparts.: Materials and methods: ... ...

Abstract	Objectives: To describe the anatomical patterns of prostate cancer (PCa) recurrence after primary therapy and to investigate if patients with low-volume disease have a better prognosis as compared with their counterparts. Materials and methods: Patients eligible for an 18-F choline positron-emission tomography (PET)-computed tomography (CT) were enrolled in a prospective cohort study. Eligible patients had asymptomatic biochemical recurrence after primary PCa treatment and testosterone levels >50 ng/mL. The number of lesions was counted per scan. Patients with isolated local recurrence (LR) or with ≤3 metastases (with or without LR) were considered to have low-volume disease and patients with >3 metastases to have high-volume disease. Descriptive statistics were used to report recurrences. Cox regression analysis was used to investigate the influence of prognostic variables on the time to developing castration-resistant PCa (CRPC). Results: In 208 patients, 625 sites of recurrence were detected in the lymph nodes (N1/M1a: 30%), the bone (18%), the prostate (bed; 11%), viscera (4%), or a combination of any of the previous (37%). In total, 153 patients (74%) had low-volume recurrence and 55 patients (26%) had high-volume recurrence. The 3-year CRPC-free survival rate for the whole cohort was 79% (95% confidence interval 43-55), 88% for low-volume recurrences and 50% for high-volume recurrences (P < 0.001). Longer PSA doubling time at time of recurrence and low-volume disease were associated with a longer time to CRPC. Conclusions: Three out of four patients with PCa with a 18-F choline PET-CT-detected recurrence have low-volume disease, potentially amenable to local therapy. Patients with low-volume disease have a better prognosis as compared with their counterparts. Lymph node recurrence was the most dominant failure pattern.
MeSH term(s)	Ablation Techniques ; Adult ; Aged ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multimodal Imaging ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/therapy ; Positron Emission Tomography Computed Tomography ; Prevalence ; Prognosis ; Prospective Studies ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy
Language	English
Publishing date	2017-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.13938
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Article ; Online: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

Jean Claude Semuto Ngabonziza / Chloé Loiseau / Michael Marceau / Agathe Jouet / Fabrizio Menardo / Oren Tzfadia / Rudy Antoine / Esdras Belamo Niyigena / Wim Mulders / Kristina Fissette / Maren Diels / Cyril Gaudin / Stéphanie Duthoy / Willy Ssengooba / Emmanuel André / Michel K. Kaswa / Yves Mucyo Habimana / Daniela Brites / Dissou Affolabi /

Jean Baptiste Mazarati / Bouke Catherine de Jong / Leen Rigouts / Sebastien Gagneux / Conor Joseph Meehan / Philip Supply

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 11

Abstract: The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, ...

Abstract	The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

Jean Baptiste Mazarati / Bouke Catherine de Jong / Leen Rigouts / Sebastien Gagneux / Conor Joseph Meehan / Philip Supply

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 11

Abstract	The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surveillance or metastasis-directed Therapy for OligoMetastatic Prostate cancer recurrence (STOMP): study protocol for a randomized phase II trial.

Decaestecker, Karel / De Meerleer, Gert / Ameye, Filip / Fonteyne, Valerie / Lambert, Bieke / Joniau, Steven / Delrue, Louke / Billiet, Ignace / Duthoy, Wim / Junius, Sarah / Huysse, Wouter / Lumen, Nicolaas / Ost, Piet

BMC cancer

2014 Volume 14, Page(s) 671

Abstract: Background: Metastases-directed therapy (MDT) with surgery or stereotactic body radiotherapy (SBRT) is emerging as a new treatment option for prostate cancer (PCa) patients with a limited number of metastases (≤3) at recurrence - so called " ... ...

Abstract	Background: Metastases-directed therapy (MDT) with surgery or stereotactic body radiotherapy (SBRT) is emerging as a new treatment option for prostate cancer (PCa) patients with a limited number of metastases (≤3) at recurrence - so called "oligometastases". One of the goals of this approach is to delay the start of palliative androgen deprivation therapy (ADT), with its negative impact on quality of life. However, the lack of a control group, selection bias and the use of adjuvant androgen deprivation therapy prevent strong conclusions from published studies.The aim of this multicenter randomized phase II trial is to assess the impact of MTD on the start of palliative ADT compared to patients undergoing active surveillance. Methods/design: Patients with an oligometastatic recurrence, diagnosed on choline PET/CT after local treatment with curative intent, will be randomised in a 1:1 ratio between arm A: active surveillance only and arm B: MTD followed by active surveillance. Patients will be stratified according to the location of metastasis (node vs. bone metastases) and PSA doubling time (≤3 vs. > 3 months). Both surgery and SBRT are allowed as MDT. Active surveillance means 3-monthly PSA testing and re-imaging at PSA progression. The primary endpoint is ADT-free survival. ADT will be started in both arms at time of polymetastatic disease (>3 metastatic lesions), local progression or symptoms. The secondary endpoints include progression-free survival, quality of life, toxicity and prostate-cancer specific survival. Discussion: This is the first randomized phase 2 trial assessing the possibility of deferring palliative ADT with MDT in oligometastatic PCa recurrence. Trial registration: Clinicaltrials.gov identifier: NCT01558427.
MeSH term(s)	Adult ; Aged ; Disease-Free Survival ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/therapy ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Public Health Surveillance ; Quality of Life ; Radiosurgery ; Young Adult
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2014-09-15
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/1471-2407-14-671
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Article: [18F]fluoro-deoxy-glucose positron emission tomography ([18F]FDG-PET) voxel intensity-based intensity-modulated radiation therapy (IMRT) for head and neck cancer.

Vanderstraeten, Barbara / Duthoy, Wim / De Gersem, Werner / De Neve, Wilfried / Thierens, Hubert

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2006 Volume 79, Issue 3, Page(s) 249–258

Abstract: Background and purpose: Focused dose escalation may improve local control in head and neck cancer. Planning results of [(18)F]fluoro-deoxy-glucose positron emission tomography ([(18)F]FDG-PET) voxel intensity-based intensity-modulated radiation therapy ( ...

Abstract	Background and purpose: Focused dose escalation may improve local control in head and neck cancer. Planning results of [(18)F]fluoro-deoxy-glucose positron emission tomography ([(18)F]FDG-PET) voxel intensity-based intensity-modulated radiation therapy (IMRT) were compared with those of PET contour-based IMRT. Patients and methods: PET contour-based IMRT aims to deliver a homogeneous boost dose to a PET-based subvolume of the planning target volume (PTV), called PTV(PET). The present PET voxel intensity-based planning study aims to prescribe the boost dose directly as a function of PET voxel intensity values, while leaving the dose distribution outside the PTV unchanged. Two escalation steps (2.5 and 3 Gy/fraction) were performed for 15 patients. Results: PTV(PET) was irradiated with a homogeneous dose in the contour-based approach. In the voxel intensity-based approach, one or more sharp dose peaks were created inside the PTV, following the distribution of PET voxel intensity values. Conclusions: While PET voxel intensity-based IMRT had a large effect on the dose distribution within the PTV, only small effects were observed on the dose distribution outside this PTV and on the dose delivered to the organs at risk. Therefore both methods are alternatives for boosting subvolumes inside a selected PTV.
MeSH term(s)	Dose Fractionation ; Dose-Response Relationship, Radiation ; Feasibility Studies ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Humans ; Positron-Emission Tomography/methods ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated/methods
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2006-06
Publishing country	Ireland
Document type	Clinical Trial, Phase I ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2006.03.003
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Article: Implementation of biologically conformal radiation therapy (BCRT) in an algorithmic segmentation-based inverse planning approach.

Vanderstraeten, Barbara / De Gersem, Werner / Duthoy, Wim / De Neve, Wilfried / Thierens, Hubert

Physics in medicine and biology

2006 Volume 51, Issue 16, Page(s) N277–86

Abstract: The development of new biological imaging technologies offers the opportunity to further individualize radiotherapy. Biologically conformal radiation therapy (BCRT) implies the use of the spatial distribution of one or more radiobiological parameters to ... ...

Abstract	The development of new biological imaging technologies offers the opportunity to further individualize radiotherapy. Biologically conformal radiation therapy (BCRT) implies the use of the spatial distribution of one or more radiobiological parameters to guide the IMRT dose prescription. Our aim was to implement BCRT in an algorithmic segmentation-based planning approach. A biology-based segmentation tool was developed to generate initial beam segments that reflect the biological signal intensity pattern. The weights and shapes of the initial segments are optimized by means of an objective function that minimizes the root mean square deviation between the actual and intended dose values within the PTV. As proof of principle, [(18)F]FDG-PET-guided BCRT plans for two different levels of dose escalation were created for an oropharyngeal cancer patient. Both plans proved to be dosimetrically feasible without violating the planning constraints for the expanded spinal cord and the contralateral parotid gland as organs at risk. The obtained biological conformity was better for the first (2.5 Gy per fraction) than for the second (3 Gy per fraction) dose escalation level.
MeSH term(s)	Computer Simulation ; Fluorodeoxyglucose F18 ; Humans ; Image Interpretation, Computer-Assisted/methods ; Models, Biological ; Oropharyngeal Neoplasms/diagnostic imaging ; Oropharyngeal Neoplasms/radiotherapy ; Positron-Emission Tomography/methods ; Radiometry/methods ; Radiopharmaceuticals ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal/methods
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2006-08-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/0031-9155/51/16/N02
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Article: Definition and delineation of the clinical target volume for rectal cancer.

Roels, Sarah / Duthoy, Wim / Haustermans, Karin / Penninckx, Freddy / Vandecaveye, Vincent / Boterberg, Tom / De Neve, Wilfried

International journal of radiation oncology, biology, physics

2006 Volume 65, Issue 4, Page(s) 1129–1142

Abstract: Purpose: Optimization of radiation techniques to maximize local tumor control and to minimize small bowel toxicity in locally advanced rectal cancer requires proper definition and delineation guidelines for the clinical target volume (CTV). The purpose ... ...

Abstract	Purpose: Optimization of radiation techniques to maximize local tumor control and to minimize small bowel toxicity in locally advanced rectal cancer requires proper definition and delineation guidelines for the clinical target volume (CTV). The purpose of this investigation was to analyze reported data on the predominant locations and frequency of local recurrences and lymph node involvement in rectal cancer, to propose a definition of the CTV for rectal cancer and guidelines for its delineation. Methods and materials: Seven reports were analyzed to assess the incidence and predominant location of local recurrences in rectal cancer. The distribution of lymphatic spread was analyzed in another 10 reports to record the relative frequency and location of metastatic lymph nodes in rectal cancer, according to the stage and level of the primary tumor. Results: The mesorectal, posterior, and inferior pelvic subsites are most at risk for local recurrences, whereas lymphatic tumor spread occurs mainly in three directions: upward into the inferior mesenteric nodes; lateral into the internal iliac lymph nodes; and, in a few cases, downward into the external iliac and inguinal lymph nodes. The risk for recurrence or lymph node involvement is related to the stage and the level of the primary lesion. Conclusion: Based on a review of articles reporting on the incidence and predominant location of local recurrences and the distribution of lymphatic spread in rectal cancer, we defined guidelines for CTV delineation including the pelvic subsites and lymph node groups at risk for microscopic involvement. We propose to include the primary tumor, the mesorectal subsite, and the posterior pelvic subsite in the CTV in all patients. Moreover, the lateral lymph nodes are at high risk for microscopic involvement and should also be added in the CTV.
MeSH term(s)	Female ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Magnetic Resonance Imaging ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy ; Pelvis/diagnostic imaging ; Pelvis/pathology ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/pathology ; Rectal Neoplasms/radiotherapy ; Sex Factors ; Tomography, X-Ray Computed
Language	English
Publishing date	2006-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2006.02.050
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Article: Clinical implementation of intensity-modulated arc therapy (IMAT) for rectal cancer.

Duthoy, Wim / De Gersem, Werner / Vergote, Koen / Boterberg, Tom / Derie, Cristina / Smeets, Peter / De Wagter, Carlos / De Neve, Wilfried

International journal of radiation oncology, biology, physics

2004 Volume 60, Issue 3, Page(s) 794–806

Abstract: Purpose: In rectal cancer, combined radiotherapy and chemotherapy, either pre- or postoperatively, is an accepted treatment. Late small bowel (SB) toxicity is a feared side effect and limits radiation-dose escalation in a volume-dependent way. A ... ...

Abstract	Purpose: In rectal cancer, combined radiotherapy and chemotherapy, either pre- or postoperatively, is an accepted treatment. Late small bowel (SB) toxicity is a feared side effect and limits radiation-dose escalation in a volume-dependent way. A planning strategy for intensity- modulated arc therapy (IMAT) was developed, and IMAT was clinically implemented with the aim to reduce the volume of SB irradiated at high doses and thus reduce SB toxicity. We report on the treatment plans of the first 7 patients, on the comparison of IMAT with conventional 3D planning (3D), and on the feasibility of IMAT delivery. Methods and materials: Seven patients, who were referred to our department for preoperative (n = 4) or postoperative (n = 3) radiotherapy for rectal cancer, gave written consent for IMAT treatment. All patients had a planning CT in prone position. The delineation of the clinical target volume was done after fusion of CT and MRI, with the help of a radiologist. For the IMAT plan, arcs were generated using an anatomy-based segmentation tool. The optimization of the arcs was done by weight optimization (WO) and leaf position optimization (LPO), both of which were adapted for IMAT purposes. The 3D plans used one posterior and two lateral wedged beams, of which the outlines were shaped to the beam's-eye view projection of the planning target volume (PTV). Beam WO was done by constrained matrix inversion. For dose-volume histogram analysis, all plans were normalized to 45 Gy as median PTV dose. Polymer gel dosimetry (PGD) on a humanoid phantom was used for the validation of the total chain (planning to delivery). IMAT treatments were delivered by an Elekta SliPlus linear accelerator using prototype software with the same interlock class as in clinical mode. Results: The IMAT plan resulted in 3 to 6 arcs, with a mean delivery time of 6.3 min and a mean of 456 monitor units (MU) for a 180 cGy fraction. The minimal dose in the PTV was not significantly different between 3D and IMAT plans. Inhomogeneity was highest for the IMAT plans (14.1%) and lowest for the 3D plans (9.9%). Mean dose to the SB was significantly lower for the IMAT plans (12.4 Gy) than for the 3D plans (17.0 Gy). The volume of SB receiving less than any dose level was lower for the IMAT plans than for 3D plans. Integral dose was lower in the IMAT plans than for the 3D plans (respectively 244 J and 262 J to deliver 45 Gy). Differences between the PGD measured dose and the calculated dose were as small for IMAT as for 3D treatments. Conclusion: IMAT plans are deliverable within a 5-10-minute time slot, and result in a lower dose to the SB than 3D plans, without creating significant underdosages in the PTV. PGD showed that IMAT delivery is as accurate as 3D delivery.
MeSH term(s)	Adenocarcinoma/radiotherapy ; Algorithms ; Feasibility Studies ; Humans ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal/methods ; Rectal Neoplasms/radiotherapy ; Tomography, X-Ray Computed
Language	English
Publishing date	2004-11-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2004.04.016
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