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Article ; Online: Cellular Alterations in Immune Checkpoint Inhibitor Therapy-Related Cardiac Dysfunction.

Michel, Lars / Ferdinandy, Peter / Rassaf, Tienush

2024

Abstract: Purpose of review: Immune checkpoint inhibitor (ICI) therapy has emerged as a pivotal advancement in cancer treatment, but the widespread adoption has given rise to a growing number of reports detailing significant cardiovascular toxicity. This review ... ...

Abstract	Purpose of review: Immune checkpoint inhibitor (ICI) therapy has emerged as a pivotal advancement in cancer treatment, but the widespread adoption has given rise to a growing number of reports detailing significant cardiovascular toxicity. This review concentrates on elucidating the mechanisms behind ICI-related cardiovascular complications, emphasizing preclinical and mechanistic data. Recent findings: Accumulating evidence indicates a more significant role of immune checkpoints in maintaining cardiac integrity than previously understood, and new key scientific data are available to improve our understanding of ICI-related cardiovascular toxicity, including hidden cardiotoxicity. New avenues for innovative concepts are hypothesized, and opportunities to leverage the knowledge from ICI-therapy for pioneering approaches in related scientific domains can be derived from the latest scientific projects. Cardiotoxicity from ICI therapy is a paramount challenge for cardio-oncology. Understanding the underlying effects builds the foundation for tailored cardioprotective approaches in the growing collective at risk for severe cardiovascular complications.
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151202-4
ISSN	1546-9549 ; 1546-9530
ISSN (online)	1546-9549
ISSN	1546-9530
DOI	10.1007/s11897-024-00652-2
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Zs.A 5936: Show issues

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Article ; Online: Primordial non-responsiveness: a neglected obstacle to cardioprotection.

Heusch, Gerd / Bøtker, Hans Erik / Ferdinandy, Péter / Schulz, Rainer

European heart journal

2023 Volume 44, Issue 19, Page(s) 1687–1689

MeSH term(s)	Humans ; Myocardial Infarction/prevention & control
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad160
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo.

Heger, Jacqueline / Szabados, Tamara / Brosinsky, Paulin / Bencsik, Péter / Ferdinandy, Péter / Schulz, Rainer

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO ... ...

Abstract	The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial infarct size (IS) following I/R in female and male MAO-B KO mice in vivo. Method and results: To induce the deletion of MAO-B, MAO-B KO mice (Myh6 Cre+/MAO-B Results: The mortality following I/R was higher in male compared to female mice, with the lowest mortality found in MAO-B KO female mice. IS was significantly higher in male WT mice compared to female WT mice. MAO-B KO reduced IS in male mice but had no further impact on IS in female MAO-B KO mice. Interestingly, there was no difference in the plasma estradiol levels among the groups. Conclusion: The cardiomyocyte-specific knockout of MAO-B protects male mice against acute myocardial infarction but had no effect on the infarct size in female mice.
MeSH term(s)	Female ; Male ; Mice ; Animals ; Monoamine Oxidase/genetics ; Mice, Knockout ; Sex Characteristics ; Myocardial Infarction/prevention & control ; Myocytes, Cardiac/metabolism ; Myocardial Reperfusion Injury/metabolism ; Mice, Inbred C57BL
Chemical Substances	Monoamine Oxidase (EC 1.4.3.4)
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: PCSK9: Importance in Physiology and Pathophysiology.

Schulz, Rainer / Andreadou, Ioanna / Ferdinandy, Péter

Frontiers in physiology

2021 Volume 12, Page(s) 706115

Language	English
Publishing date	2021-07-26
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.706115
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Article: Editorial: Cardiovascular sequelae of chemotherapy and radiotherapy in cancer survivors: current evidence and perspectives.

Felici, Tamara / Skinner, Roderick / Ferdinandy, Péter / Varga, Zoltan V / Lombardo, Antonella / Camilli, Massimiliano

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1230862

Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1230862
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Article ; Online: Frontiers in CardioVascular Biomedicine (FCVB) 2022 Budapest is on in person! The excellent programme proves that scientists won against COVID-19.

Ferdinandy, Péter / Koller, Ákos / Weber, Christian / Wojta, Johann / Waltenberger, Johannes

Cardiovascular research

2022 Volume 118, Issue 8, Page(s) e59–e61

MeSH term(s)	COVID-19 ; Cardiovascular System ; Heart ; Humans
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvac064
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Zs.A 565: Show issues

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Article ; Online: Cardiac side effects of RNA-based SARS-CoV-2 vaccines: Hidden cardiotoxic effects of mRNA-1273 and BNT162b2 on ventricular myocyte function and structure.

Schreckenberg, Rolf / Woitasky, Nadine / Itani, Nadja / Czech, Laureen / Ferdinandy, Péter / Schulz, Rainer

British journal of pharmacology

2023 Volume 181, Issue 3, Page(s) 345–361

Abstract: Background and purpose: To protect against SARS-CoV-2 infection, the first mRNA-based vaccines, Spikevax (mRNA-1273, Moderna) and Comirnaty (BNT162b2, Pfizer/Biontech), were approved in 2020. The structure and assembly of the immunogen-in both cases, ... ...

Abstract	Background and purpose: To protect against SARS-CoV-2 infection, the first mRNA-based vaccines, Spikevax (mRNA-1273, Moderna) and Comirnaty (BNT162b2, Pfizer/Biontech), were approved in 2020. The structure and assembly of the immunogen-in both cases, the SARS-CoV-2 spike (S) glycoprotein-are determined by a messenger RNA sequence that is translated by endogenous ribosomes. Cardiac side-effects, which for the most part can be classified by their clinical symptoms as myo- and/or pericarditis, can be caused by both mRNA-1273 and BNT162b2. Experimental approach: As persuasive theories for the underlying pathomechanisms have yet to be developed, this study investigated the effect of mRNA-1273 and BNT162b2 on the function, structure, and viability of isolated adult rat cardiomyocytes over a 72 h period. Key results: In the first 24 h after application, both mRNA-1273 and BNT162b2 caused neither functional disturbances nor morphological abnormalities. After 48 h, expression of the encoded spike protein was detected in ventricular cardiomyocytes for both mRNAs. At this point in time, mRNA-1273 induced arrhythmic as well as completely irregular contractions associated with irregular as well as localized calcium transients, which provide indications of significant dysfunction of the cardiac ryanodine receptor (RyR2). In contrast, BNT162b2 increased cardiomyocyte contraction via significantly increased protein kinase A (PKA) activity at the cellular level. Conclusion and implications: Here, we demonstrated for the first time, that in isolated cardiomyocytes, both mRNA-1273 and BNT162b2 induce specific dysfunctions that correlate pathophysiologically to cardiomyopathy. Both RyR2 impairment and sustained PKA activation may significantly increase the risk of acute cardiac events.
MeSH term(s)	Animals ; Humans ; Rats ; Myocytes, Cardiac ; COVID-19 Vaccines/adverse effects ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 ; RNA ; Ryanodine Receptor Calcium Release Channel/genetics ; COVID-19/prevention & control ; SARS-CoV-2 ; Cardiotoxicity ; RNA, Messenger
Chemical Substances	COVID-19 Vaccines ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; RNA (63231-63-0) ; Ryanodine Receptor Calcium Release Channel ; RNA, Messenger
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16262
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Article ; Online: An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients.

Fodor, Eszter / Nagy, Regina N / Nógrádi, András / Toovey, Stephen / Kamal, Mohamed A / Vadász, Péter / Bencsik, Péter / Görbe, Anikó / Ferdinandy, Péter

Clinical pharmacology and therapeutics

2023 Volume 115, Issue 2, Page(s) 318–323

Abstract: Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating ... ...

Abstract	Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza-like symptoms, at a standard dose of 75 mg oral oseltamivir twice daily for 5 days, were recruited in this phase IV clinical study during the 2011/2012 H1N1 pandemic seasons. Breast milk/colostrum and venous blood samples were taken at multiple timepoints, maternal urine samples were obtained from total output within the 12-hour observational period following the seventh dose of oseltamivir. Oseltamivir phosphate (OP) reached a maximum 69.5 ± 29.4 ng/mL concentration in breast milk, higher than that found in the plasma, and showed elimination within ~ 8 hours. Oseltamivir carboxylate (active metabolite of OP) showed a lower, nearly steady-state concentration in breast milk during the observational period (maximum plasma concentration (C
MeSH term(s)	Infant ; Humans ; Female ; Oseltamivir ; Influenza, Human/drug therapy ; Antiviral Agents/pharmacokinetics ; Lactation ; Influenza A Virus, H1N1 Subtype
Chemical Substances	Oseltamivir (20O93L6F9H) ; Antiviral Agents
Language	English
Publishing date	2023-12-03
Publishing country	United States
Document type	Clinical Trial, Phase IV ; Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3107
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Zs.A 20: Show issues

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Article ; Online: Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo

Jacqueline Heger / Tamara Szabados / Paulin Brosinsky / Péter Bencsik / Péter Ferdinandy / Rainer Schulz

International Journal of Molecular Sciences, Vol 24, Iss 6443, p

2023 Volume 6443

Abstract	The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial infarct size (IS) following I/R in female and male MAO-B KO mice in vivo. Method and Results: To induce the deletion of MAO-B, MAO-B KO mice (Myh6 Cre+/MAO-B fl/fl ) and wild-type (WT, Cre-negative MAO-B fl/fl littermates) were fed with tamoxifen for 2 weeks followed by 10 weeks of normal mice chow. Myocardial infarction (assessed by TTC staining and expressed as a percentage of the area at risk as determined by Evans blue staining)) was induced by 45 min coronary occlusion followed by 120 min of reperfusion. Results: The mortality following I/R was higher in male compared to female mice, with the lowest mortality found in MAO-B KO female mice. IS was significantly higher in male WT mice compared to female WT mice. MAO-B KO reduced IS in male mice but had no further impact on IS in female MAO-B KO mice. Interestingly, there was no difference in the plasma estradiol levels among the groups. Conclusion: The cardiomyocyte-specific knockout of MAO-B protects male mice against acute myocardial infarction but had no effect on the infarct size in female mice.
Keywords	monoamine oxidase B ; mitochondria ; ischemia/reperfusion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Balistreri, Carmela Rita / Madonna, Rosalinda / Ferdinandy, Peter

Current research in pharmacology and drug discovery

2021 Volume 2, Page(s) 100027

Abstract: It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is ...

Abstract	It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is a new branch of the medical science
Language	English
Publishing date	2021-05-13
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2590-2571
ISSN (online)	2590-2571
DOI	10.1016/j.crphar.2021.100027
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