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  1. Article ; Online: A Gold Needle Tip Array Ultrafast Electron Source with High Beam Quality.

    Brückner, Leon / Nauk, Constantin / Dienstbier, Philip / Gerner, Constanze / Löhrl, Bastian / Paschen, Timo / Hommelhoff, Peter

    Nano letters

    2024  

    Abstract: Electron sources are crucial elements in diverse applications such as electron microscopes, synchrotrons, and free-electron lasers. Nanometer-sharp needle tips are electron emitters with the highest beam quality, yet for a single needle the current is ... ...

    Abstract Electron sources are crucial elements in diverse applications such as electron microscopes, synchrotrons, and free-electron lasers. Nanometer-sharp needle tips are electron emitters with the highest beam quality, yet for a single needle the current is limited. Combining the emission of multiple needles promises large current yields while preserving the individual emitters' favorable properties. We present an ultrafast electron source consisting of a lithographically fabricated array of sharp gold tips illuminated with 25 fs laser pulses. The source provides up to 2000 electrons per pulse for moderate laser peak intensities of 10
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sodium Salicylate Influences the

    Gerner, Erik / Almqvist, Sofia / Thomsen, Peter / Werthén, Maria / Trobos, Margarita

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: Hard-to-heal wounds are typically infected with biofilm-producing microorganisms, such ... ...

    Abstract Hard-to-heal wounds are typically infected with biofilm-producing microorganisms, such as
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/physiology ; Quorum Sensing/drug effects ; Silver/pharmacology ; Sodium Salicylate/pharmacology ; Virulence Factors
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors ; Silver (3M4G523W1G) ; Sodium Salicylate (WIQ1H85SYP)
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031060
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  3. Book ; Thesis: Acinetobacter

    Gerner-Smidt, Peter

    epidemiological and taxonomic aspects

    (APMIS : Supplementum ; 47)

    1994  

    Author's details by Peter Gerner-Smidt
    Series title APMIS : Supplementum ; 47
    APMIS
    APMIS ; Supplementum
    Collection APMIS
    APMIS ; Supplementum
    Keywords Acinetobacter / isolation & purification ; Acinetobacter Infections / epidemiology ; Acinetobacter
    Language English
    Size 41 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis København, Univ., Diss., 1994
    Note Zsfassung in dän. Sprache
    HBZ-ID HT006518086
    ISBN 87-16-15127-5 ; 978-87-16-15127-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 73 -Suppl.47- verfügbar in Königswinter Königswinter
    95 E 395 order for loan Magazin

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  4. Book ; Thesis: Glykogenstoffwechsel in isolierten Lymphozyten und Thrombozyten von Patienten mit chronischer lymphatischer Leukämie, Haarzellen-Leukämie, chronischer myeloischer Leukämie und gesunden Kontrollpersonen

    Gerner, Peter

    1983  

    Size 28, II S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1983
    HBZ-ID HT002129675
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    83 D 3685 order for loan Magazin

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  5. Article ; Online: "Above all, do no harm": hippocrates.

    Gerner, Peter

    Anesthesiology

    2009  Volume 111, Issue 5, Page(s) 938–939

    MeSH term(s) Amides/administration & dosage ; Amides/toxicity ; Anesthetics, Local/administration & dosage ; Animals ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/toxicity ; Dose-Response Relationship, Drug ; Hypnotics and Sedatives/administration & dosage ; Nerve Block/methods ; Rats ; Sciatic Nerve/drug effects
    Chemical Substances Amides ; Anesthetics, Local ; Hypnotics and Sedatives ; Dexmedetomidine (67VB76HONO) ; ropivacaine (7IO5LYA57N)
    Language English
    Publishing date 2009-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0b013e3181bbcd2c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  6. Article: Postthoracotomy pain management problems.

    Gerner, Peter

    Anesthesiology clinics

    2008  Volume 26, Issue 2, Page(s) 355–67, vii

    Abstract: Pain after thoracotomy is very severe, probably the most severe pain experienced after surgery. Thoracic epidural analgesia has greatly improved the pain experience and its consequences and has been considered the standard for pain management after ... ...

    Abstract Pain after thoracotomy is very severe, probably the most severe pain experienced after surgery. Thoracic epidural analgesia has greatly improved the pain experience and its consequences and has been considered the standard for pain management after thoracotomy. This view has been challenged recently by the use of paravertebral nerve blocks. Nevertheless, severe ipsilateral shoulder pain and the prevention of the postthoracotomy pain syndrome remain the most important challenges for management of postthoracotomy pain.
    MeSH term(s) Acute Disease ; Animals ; Chronic Disease ; Humans ; Pain, Postoperative/drug therapy ; Pain, Postoperative/epidemiology ; Thoracotomy
    Language English
    Publishing date 2008-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2228899-5
    ISSN 2210-3538 ; 1932-2275 ; 0889-8537
    ISSN (online) 2210-3538
    ISSN 1932-2275 ; 0889-8537
    DOI 10.1016/j.anclin.2008.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Role of sodium salicylate in

    Turner, Adam Benedict / Gerner, Erik / Firdaus, Rininta / Echeverz, Maite / Werthén, Maria / Thomsen, Peter / Almqvist, Sofia / Trobos, Margarita

    Frontiers in microbiology

    2022  Volume 13, Page(s) 931839

    Abstract: The widespread threat of antibiotic resistance requires new treatment options. Disrupting bacterial communication, quorum sensing (QS), has the potential to reduce pathogenesis by decreasing bacterial virulence. The aim of this study was to investigate ... ...

    Abstract The widespread threat of antibiotic resistance requires new treatment options. Disrupting bacterial communication, quorum sensing (QS), has the potential to reduce pathogenesis by decreasing bacterial virulence. The aim of this study was to investigate the influence of sodium salicylate (NaSa) on
    Language English
    Publishing date 2022-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.931839
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  8. Article ; Online: Sodium Salicylate Influences the Pseudomonas aeruginosa Biofilm Structure and Susceptibility Towards Silver

    Erik Gerner / Sofia Almqvist / Peter Thomsen / Maria Werthén / Margarita Trobos

    International Journal of Molecular Sciences, Vol 22, Iss 3, p

    2021  Volume 1060

    Abstract: Hard-to-heal wounds are typically infected with biofilm-producing microorganisms, such as Pseudomonas aeruginosa, which strongly contribute to delayed healing. Due to the global challenge of antimicrobial resistance, alternative treatment strategies are ... ...

    Abstract Hard-to-heal wounds are typically infected with biofilm-producing microorganisms, such as Pseudomonas aeruginosa, which strongly contribute to delayed healing. Due to the global challenge of antimicrobial resistance, alternative treatment strategies are needed. Here, we investigated whether inhibition of quorum sensing (QS) by sodium salicylate in different P. aeruginosa strains (QS-competent, QS-mutant, and chronic wound strains) influences biofilm formation and tolerance to silver. Biofilm formation was evaluated in simulated serum-containing wound fluid in the presence or absence of sodium salicylate (NaSa). Biofilms were established using a 3D collagen-based biofilm model, collagen coated glass, and the Calgary biofilm device. Furthermore, the susceptibility of 48-h-old biofilms formed by laboratory and clinical strains in the presence or absence of NaSa towards silver was evaluated by assessing cell viability. Biofilms formed in the presence of NaSa were more susceptible to silver and contained reduced levels of virulence factors associated with biofilm development than those formed in the absence of NaSa. Biofilm aggregates formed by the wild-type but not the QS mutant strain, were smaller and less heterogenous in size when grown in cultures with NaSa compared to control. These data suggest that NaSa, via a reduction of cell aggregation in biofilms, allows the antiseptic to become more readily available to cells.
    Keywords Pseudomonas aeruginosa ; quorum sensing ; wound infection ; biofilm ; sodium salicylate ; silver ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Interrogating ligand-receptor interactions using highly sensitive cellular biosensors.

    Funk, Maximilian A / Leitner, Judith / Gerner, Marlene C / Hammerler, Jasmin M / Salzer, Benjamin / Lehner, Manfred / Battin, Claire / Gumpelmair, Simon / Stiasny, Karin / Grabmeier-Pfistershammer, Katharina / Steinberger, Peter

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7804

    Abstract: Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans. Here we ... ...

    Abstract Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans. Here we describe highly sensitive cellular biosensors as a tool to study receptor-ligand pairs. They consist of fluorescent reporter cells that express chimeric receptors harboring ectodomains of cell surface molecules and intracellular signaling domains. We show that a broad range of molecules can be integrated into this platform and we demonstrate its applicability to highly relevant research areas, including the characterization of immune checkpoints and the probing of cells for the presence of receptors or ligands. The platform is suitable to evaluate the interactions of viral proteins with host receptors and to test for neutralization capability of drugs or biological samples. Our results indicate that cellular biosensors have broad utility as a tool to study protein-interactions.
    MeSH term(s) Ligands ; Cell Membrane/metabolism ; Protein Binding ; Signal Transduction ; Membrane Proteins/metabolism ; Biosensing Techniques
    Chemical Substances Ligands ; Membrane Proteins
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43589-1
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  10. Article ; Online: Targeting

    Gerner, Erik / Giraldo-Osorno, Paula Milena / Johansson Loo, Anna / Firdaus, Rininta / Ben Amara, Heithem / Werthén, Maria / Palmquist, Anders / Thomsen, Peter / Omar, Omar / Almqvist, Sofia / Trobos, Margarita

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1183959

    Abstract: Introduction: Chronic infections are a major clinical challenge in hard-to-heal wounds and implanted devices. : Aim: This study investigates how secreted factors from : Material and methods: In vitro: Results: In vitro: Conclusion: In ... ...

    Abstract Introduction: Chronic infections are a major clinical challenge in hard-to-heal wounds and implanted devices.
    Aim: This study investigates how secreted factors from
    Material and methods: In vitro
    Results: In vitro
    Conclusion: In conclusion, treating
    MeSH term(s) Animals ; Rats ; Pseudomonas aeruginosa ; Quorum Sensing ; Sodium Salicylate/pharmacology ; Titanium ; Biological Transport
    Chemical Substances Sodium Salicylate (WIQ1H85SYP) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1183959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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