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Article ; Online: Laser speckle contrast imaging to assess microcirculation.

Hellmann, Marcin / Kalinowski, Leszek / Cracowski, Jean-Luc

2022

Language	English
Publishing date	2022-11-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
DOI	10.5603/CJ.a2022.0097
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Article ; Online: Activation of Metabotropic Glutamate Receptor (mGlu

Wierońska, Joanna M / Cieślik, Paulina / Burnat, Grzegorz / Kalinowski, Leszek

Biomolecules

2023 Volume 13, Issue 7

Abstract: The Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic ( ... ...

Abstract	The Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M
MeSH term(s)	Animals ; Dizocilpine Maleate/pharmacology ; Receptors, Metabotropic Glutamate/metabolism ; Glutamic Acid ; N-Methylaspartate ; Morris Water Maze Test ; Receptors, Muscarinic
Chemical Substances	N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine ; 3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide ; VU0357017 ; Dizocilpine Maleate (6LR8C1B66Q) ; Receptors, Metabotropic Glutamate ; Glutamic Acid (3KX376GY7L) ; N-Methylaspartate (6384-92-5) ; Receptors, Muscarinic
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13071064
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Article ; Online: Anti-cancer management of head and neck cancers and oral microbiome-what can we clinically obtain?

Makarewicz, Jakub / Kaźmierczak-Siedlecka, Karolina / Sobocki, Bartosz Kamil / Dobrucki, Iwona T / Kalinowski, Leszek / Stachowska, Ewa

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1329057

Abstract: Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include ... ...

Abstract	Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein-Barr virus, tobacco, alcohol, and poor oral hygiene with approximately 4.5% of global cancers linked to HPV. Notably, differences in the microbiome between healthy individuals and patients with head and neck cancers (HNCs) have been identified. Recent studies highlight the significance of certain oral microbes in risk assessment and the potential of the microbiome as a biomarker for HNCs. Additionally, role of the microbiome in metastasis has been acknowledged. Treatment for HNCs includes local methods, such as surgery and radiotherapy, and systemic approaches, such as immunotherapy. Numerous side effects accompany these treatments. Emerging research suggests the beneficial role of preoperative immunonutrition and probiotics in patient outcomes, emphasizing the influence of the microbiome on treatment efficacy. This review explores the reciprocal effects of HNC treatment and the gut microbiome using radiotherapy, brachytherapy, surgery, immunotherapy, and chemotherapy.
MeSH term(s)	Male ; Humans ; Epstein-Barr Virus Infections ; Papillomavirus Infections ; Herpesvirus 4, Human ; Head and Neck Neoplasms/therapy ; Microbiota
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1329057
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Article ; Online: The Impact of LY487379 or CDPPB on eNOS Expression in the Mouse Brain and the Effect of Joint Administration of Compounds with NO

Płoska, Agata / Siekierzycka, Anna / Cieślik, Paulina / Dobrucki, Lawrence W / Kalinowski, Leszek / Wierońska, Joanna M

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 3

Abstract: The role of endothelial nitric oxide synthase (eNOS) in the regulation of a variety of biological processes is well established, and its dysfunction contributes to brain pathologies, including schizophrenia or Alzheimer's disease (AD). Positive ... ...

Abstract	The role of endothelial nitric oxide synthase (eNOS) in the regulation of a variety of biological processes is well established, and its dysfunction contributes to brain pathologies, including schizophrenia or Alzheimer's disease (AD). Positive allosteric modulators (PAMs) of metabotropic glutamate (mGlu) receptors were shown to be effective procognitive compounds, but little is known about their impact on eNOS expression and stability. Here, we investigated the influence of the acute and chronic administration of LY487379 or CDPPB (mGlu2 and mGlu5 PAMs), on eNOS expression in the mouse brain and the effect of the joint administration of the ligands with nitric oxide (NO) releasers, spermineNONOate or DETANONOate, in different combinations of doses, on MK-801- or scopolamine-induced amnesia in the novel object recognition (NOR) test. Our results indicate that both compounds provoked eNOS monomer formation, and CDPPB at a dose of 5 mg/kg exaggerated the effect of MK-801 or scopolamine. The coadministration of spermineNONOate or DETANONOate enhanced the antiamnesic effect of CDPPB or LY487379. The best activity was observed for ineffective or moderate dose combinations. The results indicate that treatment with mGluR2 and mGluR5 PAMs may be burdened with the risk of promoting eNOS uncoupling through the induction of dimer dissociation. Administration of the lowest possible doses of the compounds with NO
MeSH term(s)	Mice ; Animals ; Dizocilpine Maleate/pharmacology ; Nitric Oxide/pharmacology ; Scopolamine/pharmacology ; Nitric Oxide Synthase Type III ; Cognitive Dysfunction/drug therapy ; Brain ; Allosteric Regulation ; Nitroso Compounds ; Pyrazoles ; Benzamides ; Sulfonamides ; Pyridines
Chemical Substances	Dizocilpine Maleate (6LR8C1B66Q) ; N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine ; 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide ; Nitric Oxide (31C4KY9ESH) ; Scopolamine (DL48G20X8X) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine (146724-94-9) ; Nitroso Compounds ; Pyrazoles ; Benzamides ; Sulfonamides ; Pyridines
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29030627
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Article ; Online: Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets.

Janaszak-Jasiecka, Anna / Płoska, Agata / Wierońska, Joanna M / Dobrucki, Lawrence W / Kalinowski, Leszek

Cellular & molecular biology letters

2023 Volume 28, Issue 1, Page(s) 21

Abstract: Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the ... ...

Abstract	Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the pathogenesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L-arginine (L-Arg), with tetrahydrobiopterin (BH
MeSH term(s)	Humans ; Nitric Oxide Synthase Type III/metabolism ; Endothelial Cells/metabolism ; Vascular Diseases ; Superoxides ; Oxidative Stress
Chemical Substances	Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Superoxides (11062-77-4)
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Letter
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-023-00423-2
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Article ; Online: Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects.

Radulska, Adrianna / Pelikant-Małecka, Iwona / Jendernalik, Kamila / Dobrucki, Iwona T / Kalinowski, Leszek

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different ... ...

Abstract	Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs.
MeSH term(s)	Animals ; Arthritis, Psoriatic/metabolism ; Proteomics ; Psoriasis/metabolism ; Metabolomics ; Biomarkers/metabolism
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119507
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Article ; Online: Differences in cardiac adaptation to exercise in male and female athletes assessed by noninvasive techniques: a state-of-the-art review.

Lasocka-Koriat, Zofia / Lewicka-Potocka, Zuzanna / Kaleta-Duss, Anna / Siekierzycka, Anna / Kalinowski, Leszek / Lewicka, Ewa / Dąbrowska-Kugacka, Alicja

American journal of physiology. Heart and circulatory physiology

2024 Volume 326, Issue 5, Page(s) H1065–H1079

Abstract: Athlete's heart is generally regarded as a physiological adaptation to regular training, with specific morphological and functional alterations in the cardiovascular system. Development of the noninvasive imaging techniques over the past several years ... ...

Abstract	Athlete's heart is generally regarded as a physiological adaptation to regular training, with specific morphological and functional alterations in the cardiovascular system. Development of the noninvasive imaging techniques over the past several years enabled better assessment of cardiac remodeling in athletes, which may eventually mimic certain pathological conditions with the potential for sudden cardiac death, or disease progression. The current literature provides a compelling overview of the available methods that target the interrelation of prolonged exercise with cardiac structure and function. However, this data stems from scientific studies that included mostly male athletes. Despite the growing participation of females in competitive sport meetings, little is known about the long-term cardiac effects of repetitive training in this population. There are several factors-biochemical, physiological and psychological, that determine sex-dependent cardiac response. Herein, the aim of this review was to compare cardiac adaptation to endurance exercise in male and female athletes with the use of electrocardiographic, echocardiographic, and biochemical examination, to determine the sex-specific phenotypes, and to improve the healthcare providers' awareness of cardiac remodeling in athletes. Finally, we discuss the possible exercise-induced alternations that should arouse suspicion of pathology and be further evaluated.
MeSH term(s)	Humans ; Male ; Female ; Ventricular Remodeling ; Heart/diagnostic imaging ; Heart/physiology ; Electrocardiography ; Echocardiography ; Athletes ; Adaptation, Physiological/physiology
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00756.2023
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Article ; Online: Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro.

Jasiecki, Jacek / Targońska, Monika / Janaszak-Jasiecka, Anna / Kalinowski, Leszek / Waleron, Krzysztof / Wasąg, Bartosz

Chemico-biological interactions

2023 Volume 386, Page(s) 110783

Abstract: Alzheimer's disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ ... ...

Abstract	Alzheimer's disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5'UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant with a 69 amino acid signal peptide, designated N-BChE, could play a role in AD development. Here, we report that the signal sequence of the BChE, if produced in an extended 69 aa version, can self-aggregate and could form seeds that enhance amyloid fibril formation in vitro in a dose-dependent manner and create larger co-aggregates. Similar phenomena could have been observed in the human brain if such an extended form of the signal sequence had been, in some circumstances, translated.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Amyloid/metabolism ; Amyloid beta-Peptides/metabolism ; Butyrylcholinesterase/metabolism ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Protein Sorting Signals
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Butyrylcholinesterase (EC 3.1.1.8) ; Protein Sorting Signals ; BCHE protein, human (EC 3.1.1.8)
Language	English
Publishing date	2023-10-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2023.110783
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Article: The Unfolded Protein Response: A Double-Edged Sword for Brain Health.

Gebert, Magdalena / Sławski, Jakub / Kalinowski, Leszek / Collawn, James F / Bartoszewski, Rafal

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Efficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to ... ...

Abstract	Efficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to age-related cognitive decay and even neurodegenerative diseases. The regulation of this system requires a complex monitoring network to maintain proper oxygen homeostasis. Furthermore, the high content of mitochondria in the brain has elevated glucose demands, and thus requires a normal redox balance. Maintaining this is mediated by adaptive stress response pathways that permit cells to survive oxidative stress and to minimize cellular damage. These stress pathways rely on the proper function of the endoplasmic reticulum (ER) and the activation of the unfolded protein response (UPR), a cellular pathway responsible for normal ER function and cell survival. Interestingly, the UPR has two opposing signaling pathways, one that promotes cell survival and one that induces apoptosis. In this narrative review, we discuss the opposing roles of the UPR signaling pathways and how a better understanding of these stress pathways could potentially allow for the development of effective strategies to prevent age-related cognitive decay as well as treat neurodegenerative diseases.
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081648
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Article ; Online: Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia.

Wierońska, Joanna M / Cieślik, Paulina / Kalinowski, Leszek

Biomolecules

2021 Volume 11, Issue 8

Abstract: Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide ( ... ...

Abstract	Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide (NO
MeSH term(s)	Animals ; Apoptosis ; Brain Ischemia/pathology ; Disease Progression ; Free Radical Scavengers ; Humans ; Hypoxia, Brain/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation ; Ischemia ; Lymphocytes/metabolism ; Necrosis ; Neurons/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Oxidative Stress ; Reactive Nitrogen Species ; Reactive Oxygen Species
Chemical Substances	Free Radical Scavengers ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; NOS2 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
Language	English
Publishing date	2021-07-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11081097
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