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  1. Article: Posttraumatic epilepsy: a major problem in desperate need of major advances.

    Garga, Nina / Lowenstein, Daniel H

    Epilepsy currents

    2006  Volume 6, Issue 1, Page(s) 1–5

    Abstract: This brief review is meant to provide an update on the data from clinical and laboratory studies that have provided insight into the mechanisms underlying the development of epilepsy following traumatic brain injury (TBI). The link between severe brain ... ...

    Abstract This brief review is meant to provide an update on the data from clinical and laboratory studies that have provided insight into the mechanisms underlying the development of epilepsy following traumatic brain injury (TBI). The link between severe brain trauma and epilepsy in humans is well recognized. However, we have yet to identify an effective intervention to prevent the development of epilepsy in patients who are at risk after TBI. Laboratory studies, which have relied primarily on the fluid-percussion model, have documented long-term hyperexcitability associated with TBI, and recent studies are shedding light on the structural and electrophysiological abnormalities that may underlie epileptogenesis in this setting. Nonetheless, given the extent of the clinical problem and our current state of knowledge, this area of epilepsy research deserves far more attention.
    Language English
    Publishing date 2006-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1111/j.1535-7511.2005.00083.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6460: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Multicentric Castleman's disease with voltage-gated potassium channel antibody-positive limbic encephalitis: a case report.

    Rao, Vikram R / Lim, Leland E / Fong, Dean / Garga, Nina I / Parko, Karen L

    BMC neurology

    2015  Volume 15, Page(s) 4

    Abstract: Background: Castleman's disease is a rare lymphoproliferative disorder which occurs in localized and multicentric forms and can mimic lymphoma. Despite its well-known association with certain autoimmune diseases, including paraneoplastic pemphigus and ... ...

    Abstract Background: Castleman's disease is a rare lymphoproliferative disorder which occurs in localized and multicentric forms and can mimic lymphoma. Despite its well-known association with certain autoimmune diseases, including paraneoplastic pemphigus and myasthenia gravis, Castleman's disease has not previously been associated with limbic encephalitis.
    Case presentation: We report the case of a 47-year old Caucasian man who presented with subacute onset of constitutional symptoms, diffuse lymphadenopathy, and stereotyped spells involving olfactory aura, nausea, disorientation, and unresponsiveness. He was found to have focal dyscognitive seizures of temporal lobe origin, cerebrospinal fluid with lymphocytic pleocytosis, hyponatremia, and serum positive for voltage-gated potassium channel antibodies, consistent with limbic encephalitis. An extensive infectious workup was unrevealing, but lymph node biopsy revealed multicentric Castleman's disease. His symptoms improved with antiepileptic drugs and immunotherapy.
    Conclusion: This case highlights the clinical diversity of voltage-gated potassium channel autoimmunity and expands the association of Castleman's disease and autoimmune syndromes to include limbic encephalitis. Clinicians should be aware that paraneoplastic disorders of the central nervous system can be related to underlying hematologic disorders such as Castleman's disease.
    MeSH term(s) Antibodies/blood ; Castleman Disease/diagnosis ; Humans ; Limbic Encephalitis/diagnosis ; Male ; Middle Aged ; Potassium Channels, Voltage-Gated/immunology ; Seizures/etiology
    Chemical Substances Antibodies ; Potassium Channels, Voltage-Gated
    Language English
    Publishing date 2015-02-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-015-0266-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Toxic brainstem encephalopathy after artemisinin treatment for breast cancer.

    Panossian, Lori A / Garga, Nina I / Pelletier, Daniel

    Annals of neurology

    2005  Volume 58, Issue 5, Page(s) 812–813

    MeSH term(s) Adult ; Anti-Infective Agents/adverse effects ; Artemisinins/adverse effects ; Artemisinins/therapeutic use ; Brain Stem/drug effects ; Brain Stem/pathology ; Breast Neoplasms/drug therapy ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/pathology ; Sesquiterpenes/adverse effects ; Sesquiterpenes/therapeutic use
    Chemical Substances Anti-Infective Agents ; Artemisinins ; Sesquiterpenes ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2005-09-13
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.20620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 478: Show issues

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