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  1. Book ; Online ; E-Book: Unravelling Long COVID

    Goldenberg, Don / Dichter, Marc A.

    2023  

    Abstract: An authoritative medical reference on the various ways in which Long-COVID presents and an in-depth discussion of its mechanisms and therapeutic options. Unravelling Long-COVID aims to provide a better awareness and understanding of the persistent ... ...

    Author's details Don Goldenberg, Marc Dichter
    Abstract "An authoritative medical reference on the various ways in which Long-COVID presents and an in-depth discussion of its mechanisms and therapeutic options. Unravelling Long-COVID aims to provide a better awareness and understanding of the persistent health problems that can arise following SARS-CoV-2 infection. Variously described as Long-COVID, Long-Haulers' Syndrome, and Post-Acute Sequelae of SARS-CoV-2, this newly designated disorder is estimated to have affected somewhere between 50 to 250 million people. It is in fact considered by many as the next global public health disaster. With such a broad and important topic, the authors of Unravelling Long-COVID have focused primarily on two major problems in the current understanding of Long-COVID: 1.) the failure to distinguish patients with organ damage--here called Long-COVID Disease -- and those with unexplained, persistent symptoms--what is termed Long-COVID syndrome, 2.) and the failure of current medical approaches to comprehend and treat those persistent unexplained symptoms"--
    Language English
    Size 1 Online-Ressource (xii, 244 Seiten), Illustrationen
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021686678
    ISBN 9781119891314 ; 9781119891307 ; 1119891310 ; 1119891302
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Adenosine Receptor Subtypes and Cardioprotection.

    Lee, Jang Eun / Wilcox, Karen / Jacobson, Kenneth A / Dichter, Marc / Liang, Bruce T

    Drug development research

    2023  Volume 45, Issue 3-4, Page(s) 394–401

    Abstract: Brief ischemia prior to a sustained period of ischemia reduces myocardial infarct size, a phenomenon known as preconditioning. A cardiac ventricular myocyte model has been developed to investigate the role and signaling mechanism of adenosine receptor ... ...

    Abstract Brief ischemia prior to a sustained period of ischemia reduces myocardial infarct size, a phenomenon known as preconditioning. A cardiac ventricular myocyte model has been developed to investigate the role and signaling mechanism of adenosine receptor subtypes in cardiac preconditioning. A 5-min exposure of cardiac myocytes to simulated ischemia, termed preconditioning ischemia, prior to a subsequent 90-min period of ischemia protected them against injury incurred during the 90-min ischemia. Preconditioning ischemia preserved ATP content, reduced percentage of cells killed, and decreased release of creatine kinase into the medium. Activation of the adenosine A
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/(sici)1098-2299(199811/12)45:3/4<394::aid-ddr40>3.0.co;2-j
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  3. Book ; Conference proceedings: Mechanisms of epileptogenesis

    Dichter, Marc A.

    the transition to seizure ; [proceedings of the Third Annual Graduate Hospital Research Symposium on Mechanisms of Epileptogenesis: From Membranes to Man, the Transition from Interictal to Ictal Activity, held September 25 - 26, 1986, in Philadelphia, Pa.]

    1988  

    Event/congress Research Symposium on Mechanisms of Epileptogenesis - from Membranes to Man, the Transition from Interictal to Ictal Activity (1986, PhiladelphiaPa.)
    Author's details ed. by Marc A. Dichter
    Keywords Brain / physiopathology / congresses ; Epilepsy / physiopathology / congresses ; Epilepsie
    Subject Fallsucht
    Size X, 287 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003406732
    ISBN 0-306-43010-X ; 978-0-306-43010-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1989 A 4957 order for loan Magazin

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  4. Article: Electrophysiologic recordings in traumatic brain injury.

    Schmitt, Sarah / Dichter, Marc A

    Handbook of clinical neurology

    2015  Volume 127, Page(s) 319–339

    Abstract: Following a traumatic brain injury (TBI), the brain undergoes numerous electrophysiologic changes. The most common techniques used to evaluate these changes include electroencepalography (EEG) and evoked potentials. In animals, EEGs immediately following ...

    Abstract Following a traumatic brain injury (TBI), the brain undergoes numerous electrophysiologic changes. The most common techniques used to evaluate these changes include electroencepalography (EEG) and evoked potentials. In animals, EEGs immediately following TBI can show either diffuse slowing or voltage attenuation, or high voltage spiking. Following a TBI, many animals display evidence of hippocampal excitability and a reduced seizure threshold. Some mice subjected to severe TBI via a fluid percussion injury will eventually develop seizures, which provides a useful potential model for studying the neurophysiology of epileptogenesis. In humans, the EEG changes associated with mild TBI are relatively subtle and may be challenging to distinguish from EEG changes seen in other conditions. Quantitative EEG (QEEG) may enhance the ability to detect post-traumatic electrophysiologic changes following a mild TBI. Some types of evoked potential (EP) and event related potential (ERP) can also be used to detect post-traumatic changes following a mild TBI. Continuous EEG monitoring (cEEG) following moderate and severe TBI is useful in detecting the presence of seizures and status epilepticus acutely following an injury, although some seizures may only be detectable using intracranial monitoring. CEEG can also be helpful for assessing prognosis after moderate or severe TBI. EPs, particularly somatosensory evoked potentials, can also be useful in assessing prognosis following severe TBI. The role for newer technologies such as magnetoencephalography and bispectral analysis (BIS) in the evaluation of patients with TBI remains unclear.
    MeSH term(s) Animals ; Brain Injuries/physiopathology ; Electroencephalography/methods ; Electrophysiological Phenomena/physiology ; Humans ; Magnetoencephalography
    Language English
    Publishing date 2015
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-52892-6.00021-0
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  5. Article: Epilepsy. Foreword.

    Engel, Jerome / Dichter, Marc A

    Advances in experimental medicine and biology

    2014  Volume 813, Page(s) v–xiii

    MeSH term(s) Animals ; Disease Models, Animal ; Epilepsy/physiopathology ; Humans ; Neuronal Plasticity
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
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  6. Article ; Online: Emerging concepts in the pathogenesis of epilepsy and epileptogenesis.

    Dichter, Marc A

    Archives of neurology

    2009  Volume 66, Issue 4, Page(s) 443–447

    Abstract: Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of ... ...

    Abstract Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of epileptogenesis, or the ways that a normal brain becomes epileptic, is also expanding, but comparable research into translation of laboratory findings into successful clinical interventions for those at high risk needs to be developed.
    MeSH term(s) Anticonvulsants/therapeutic use ; Brain/drug effects ; Brain/pathology ; Brain/physiopathology ; Brain Damage, Chronic/physiopathology ; Electroencephalography/drug effects ; Epilepsies, Partial/pathology ; Epilepsies, Partial/physiopathology ; Epilepsies, Partial/prevention & control ; Hippocampus/drug effects ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Neocortex/drug effects ; Neocortex/pathology ; Neocortex/physiopathology ; Neural Inhibition/physiology ; Risk Factors ; Sclerosis
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80049-1
    ISSN 1538-3687 ; 0003-9942
    ISSN (online) 1538-3687
    ISSN 0003-9942
    DOI 10.1001/archneurol.2009.10
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    Ui II Zs.191: Show issues Location:
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  7. Article ; Online: Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cure.

    Dichter, Marc A

    Epilepsia

    2009  Volume 50 Suppl 2, Page(s) 41–45

    Abstract: Translating laboratory discoveries into successful therapies for preventing epilepsy is a difficult task, but preventing epilepsy in those who are known to be at high risk needs to be one of our highest priorities. At present, we need to approach this ... ...

    Abstract Translating laboratory discoveries into successful therapies for preventing epilepsy is a difficult task, but preventing epilepsy in those who are known to be at high risk needs to be one of our highest priorities. At present, we need to approach this task as a parallel set of research endeavors-one concentrating on laboratory experiments designed to learn how to prevent epilepsy after brain trauma and the other focusing on how to perform the appropriate clinical research in humans to demonstrate that whatever is discovered in the laboratory can be appropriately tested. It is too important to let the second process await conclusion of the first. Initially, we need to create a consortium of groups in trauma centers that are dedicated to antiepileptogenic studies and develop funding sources for long-term studies. We need to experiment with clinical protocols, making the studies as cost-effective as possible, while performing continuous data mining of outcomes and surrogate markers. The limitations of current technology to assist in antiepileptogenesis trials must be acknowledged: There is no currently available method for continuously monitoring electroencephalography (EEG) over prolonged periods, and there are no validated biomarkers for the process of epileptogenesis. As we learn more about the process of epileptogenesis and its underlying mechanisms, it is hoped that we will be able to prevent the development of epilepsy after traumatic brain injury (TBI) and after many other known epileptogenic lesions.
    MeSH term(s) Animals ; Anticonvulsants/therapeutic use ; Brain/drug effects ; Brain/physiopathology ; Brain Injuries/complications ; Brain Injuries/physiopathology ; Drug Evaluation, Preclinical ; Epilepsy, Post-Traumatic/physiopathology ; Epilepsy, Post-Traumatic/prevention & control ; Humans ; Prognosis ; Research Support as Topic
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2009-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2008.02009.x
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    Zs.A 517: Show issues Location:
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  8. Article: Innovative clinical trial designs for future antiepileptic drugs.

    Dichter, Marc A

    Epilepsia

    2007  Volume 48 Suppl 1, Page(s) 26–30

    Abstract: Pharmacoresistance continues to be a challenging problem for a substantial number of epileptic patients and their attending physicians. In the past 10 years, we have made little progress in reducing the incidence of refractory epilepsy and have no ... ...

    Abstract Pharmacoresistance continues to be a challenging problem for a substantial number of epileptic patients and their attending physicians. In the past 10 years, we have made little progress in reducing the incidence of refractory epilepsy and have no innovative plans in place with the potential to do so. In this article, I propose two radical solutions to our present dilemma. The first involves the use of a novel clinical trial design that will rapidly screen for antiepileptic drugs with the highest safety and efficacy profiles. The second focuses on the prevention of epilepsy. The success of these approaches will depend upon our ability to identify individuals at high risk of developing epilepsy and to initiate effective and innovative clinical trial paradigms that will be able to identify more effective antiepileptic or antiepileptogenic agents. It will likely require significant changes from our current strategies to accomplish these goals.
    MeSH term(s) Anticonvulsants/therapeutic use ; Clinical Trials as Topic/methods ; Drug Resistance ; Epilepsy/drug therapy ; Epilepsy/prevention & control ; Forecasting ; Humans ; Research Design/trends
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2007.00996.x
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    Zs.MO 475: Show issues

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  9. Article: Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening.

    Dichter, Marc A

    Epilepsy research

    2006  Volume 68, Issue 1, Page(s) 31–35

    Abstract: Epileptogenesis is the process by which parts of a normal brain are converted to a hyperexcitable brain, often after an injury. Researchers must understand this process before they know where and how to change it. Animal models are used to evaluate the ... ...

    Abstract Epileptogenesis is the process by which parts of a normal brain are converted to a hyperexcitable brain, often after an injury. Researchers must understand this process before they know where and how to change it. Animal models are used to evaluate the process of epileptogenesis by studing status epelepticus, electrical kindling, or other methods that provoke injuries. All are associated with neuronal loss to more or less degree, synaptic reorganization, axon sprouting, neurogenesis, gliosis, and changes in gene expression in neurons and astrocytes. He describes several types of animal models and how they might be useful in developing effective strategies for preventing epilepsy.
    MeSH term(s) Animals ; Anticonvulsants/therapeutic use ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Epilepsy/etiology ; Epilepsy/pathology ; Epilepsy/prevention & control ; Kindling, Neurologic ; Rodentia ; Status Epilepticus/physiopathology
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2006-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2005.09.014
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  10. Article ; Online: Antiepileptogenesis and disease modification: Clinical and regulatory issues.

    French, Jacqueline A / Bebin, Martina / Dichter, Marc A / Engel, Jerome / Hartman, Adam L / Jóźwiak, Sergiusz / Klein, Pavel / McNamara, James / Twyman, Roy / Vespa, Paul

    Epilepsia open

    2021  Volume 6, Issue 3, Page(s) 483–492

    Abstract: This is a summary report of clinical and regulatory issues discussed at the 2018 NINDS workshop, entitled "Accelerating Therapies for Antiepileptogenesis and Disease Modification." The intent of the workshop was to optimize and accelerate development of ... ...

    Abstract This is a summary report of clinical and regulatory issues discussed at the 2018 NINDS workshop, entitled "Accelerating Therapies for Antiepileptogenesis and Disease Modification." The intent of the workshop was to optimize and accelerate development of therapies for antiepileptogenesis (AEG) and disease modification in the epilepsies. The working group discussed nomenclature for antiepileptogenic therapies, subdividing them into "antiepileptogenic therapies" and "disease modifying therapies," both of which are urgently needed. We use the example of traumatic brain injury to explain issues and complexities in designing a trial for disease-preventing antiepileptogenic therapies, including identifying timing of intervention, selecting the appropriate dose, and the need for biomarkers. We discuss the recent trials of vigabatrin to prevent onset and modify epilepsy outcome in children with tuberous sclerosis (Epistop and PreVeNT). We describe a potential approach to a disease modification trial in adults, using patients with temporal lobe epilepsy. Finally, we discuss regulatory hurdles for antiepileptogenesis and disease-modifying trials.
    MeSH term(s) Adult ; Anticonvulsants/therapeutic use ; Brain Injuries, Traumatic ; Child ; Epilepsy/drug therapy ; Humans ; National Institute of Neurological Disorders and Stroke (U.S.) ; United States ; Vigabatrin/therapeutic use
    Chemical Substances Anticonvulsants ; Vigabatrin (GR120KRT6K)
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12526
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